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Choi, Sooran,Kim, Hai-joong,Kim, Sunmi,Choi, Gyuyeon,Kim, Sungjoo,Park, Jeongim,Shim, Soon-sup,Lee, Inae,Kim, Sungkyoon,Moon, Hyo-Bang,Choi, Kyungho,Lee, Jeong Jae,Kim, Su Young Elsevier 2018 Science of the Total Environment Vol.618 No.-
<P><B>Abstract</B></P> <P>Despite the global ban, organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) have been a persistent and significant environmental health issue worldwide. Prenatal exposure to these persistent organic pollutants (POPs) has been identified as a major route of exposure among developing fetuses and newborn infants. Among Children's Health and Environmental Health of Korea (CHECK) cohort population, pregnant females (<I>n</I> =148) and their matching newborn infants (<I>n</I> =117) recruited from four cities of Korea in 2011 were investigated. The blood serum and cord blood serum were sampled at delivery, and measured for 19 OCPs and 19 PCBs. In addition, a questionnaire regarding demographic characteristics, and dietary habits were conducted. The most frequently detected POPs in both maternal blood and cord blood were <I>p,p</I>′-dichlorodiphenyl dichloroethylene (DDE) (99% detection in maternal, and 98% in cord blood serum) and PCB153 (95% in maternal, 74% in cord blood serum). The levels of dichlorodiphenyl trichloroethanes (DDTs) in both maternal (average 82.5ng/g lw) and cord blood serum (average 77.5ng/g lw) were comparable to or greater than those reported in Japan about a decade ago. Approximately two thirds of the pregnant women and newborn infants showed the <I>p,p</I>′-DDE concentrations exceeding the biological equivalent (BE) corresponding to 10<SUP>−6</SUP> excess cancer risk. In addition, less chlorinated PCBs were detected higher in both maternal and cord serum. Less chlorinated PCBs also showed greater transplacental ratio. Dairy consumption among the subjects was positively associated, and tea consumption was negatively associated with serum levels of several POPs. Our results show that the exposure to legacy POPs, especially DDTs, among pregnant women and newborn infants is still prevailing, thus warrants measures for exposure mitigation among these vulnerable populations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> OCPs and PCBs were measured in serum of Korean mothers and their matching newborns. </LI> <LI> Levels of most OCPs in maternal and cord serum are correlated. </LI> <LI> Less chlorinated PCBs are detected higher in cord serum than maternal serum. </LI> <LI> DDTs are of potential health concern, with 67% of subjects potentially at risk. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
인성덕목 관련 가정연계 그림책 대여 활동이 유아의 인성발달에 미치는 효과
최영해 ( Young Hai Choi ),정희정 ( Hee Jung Chung ) 한국유아교육학회 2014 유아교육연구 Vol.34 No.5
This study looks at what happens when picture books with themes of character virtues are lent to families to explore with their children using various activities. If such a home/school collaborative effort proves to be beneficial to the development of children, it can provide an extraordinary means for early childhood institutions to achieve vital, positive home/school connections. Subjects in this study were 58 children with a mean age of 74.41months enrolled in C kindergarten in Seoul. Child character diagnosis tools were developed and applied by the researchers. Pre-and post-tests were evaluated by each tool and the data analyzed with a t-test using SPSS Win 18.0. The results show that the experimental group had distinct post-test gains in the areas of consideration, cooperation, and filial duty. These findings clearly have multiple, positive ramifications for character development, home/school collaboration and parenting education. 본 연구의 목적은 가정과 연계하여 유아교육기관에서 활용할 수 있는 인성덕목 관련 가정연계 그림책 대여 활동을 구성하고 적용함으로써 유아의 인성발달에 미치는 효과를 검증하는데 있다. 본 연구의 대상은 서울시 소재 C 유치원에 재원중인 만 5세반 유아 58명으로 실험집단 29명, 비교집단 29명이며 평균 월령은 74.41개월이었다. 본 연구에서는 인성덕목 관련가정연계 그림책 대여 활동의 효과를 검증하기 위해 유아 인성 검사도구 및 프로그램을 개발하여 적용하였으며, 사전·사후 검사를 실시한 후 SPSS Win 18.0 프로그램을 이용하여 t검증으로 자료를 처리하였다. 본 연구의 결과, 인성덕목 관련 가정연계 그림책 대여 활동은 교육부에서 제시한 인성덕목 중 배려, 협력, 효 덕목에 효과가 있는 것으로 나타났다. 결론적으로 본 연구를 통해 인성덕목 관련 가정연계 그림책 대여 활동은 유아의 인성발달에 긍정적인 영향을 미치는 것으로 나타났다.
Helicobacter pylori 감염진단을 위한 13C - 효소호기검사의 유용성 평가 : 다기관 공개 비비교 임상시험
조주영(Joo Young Cho),심찬섭(Chan Sub Shim),진윤태(Yoon tae Jeen),전훈재(Hoon Jai Chun),이구(Goo Lee),이성준(Sung Joon Lee),김광희(kwang Hee Kim),현진해(Jin Hai Hyun),최종영(Jong Young Choi),양영상(Young Sang Yang),박두호(Doo Ho Par 대한내과학회 1999 대한내과학회지 Vol.56 No.6
N/A Objective : Helicobacter pylori(H. pylori) infection plays an importanat role in the pathophysiology of gastrointestinal diseases, and its diagnosis is crucial in clinical practice. Currently many diagnostic methods are introduced for its simple, and accurate diagnosis. 13C urea breath test(13C-UBT) is a convenient, non-invasive and reliable test for the diagnosis of H. pylori infection. To assess the clinical value of the 13C-UBT, we examined the sensitivity, specificity of 13C-UBT with regard to other tests. Methods : A prospective multicenter study was done in 107 subjects(mean age 36 years, 55 males, 52 females) presenting for endoscopy from three university hospitals. We tested for H. pylori infection by 13C-UBT, serum IgG antibody level, and multiple biopsies for rapid urease testing and histology. Either a positive histology result or a combined positive CLO test and IgG ELISA in the presence of a negative histology results, was interpreted as a positive finding for H. pylori infection. 13C-UBT was performed after 4hrs fast. Breath samples were collected at 0 and 30 minutes after giving 75mg 13C-urea. Results: Results were analysed by isotope ratio mass spectrometry and expressed as units of delta( 13C, 13CO2 /12CO2) and considered as positive for H. pylori if delta value was greater than 4.0. Sensitivity and specificity of 13C-UBT were 94.5%, and 100% respectively. No significant adverse events were noted. Conclusions : The 13C-UBT offers an easy, safe and accurate approach to the diagnosis of H. pylori infection in routine clinical practice
최홍규(Hong-Kyoo Choi),최대원(Dae-Won Choi),유해출(Hai-Chool Yoo),최신권(Shin-Gwon Choi),김용규(Young-Kyu Kim) 한국조명·전기설비학회 2009 조명·전기설비학회논문지 Vol.23 No.12
태양광발전소 두 곳을 샘플링하여 출력저하의 요인 중 우리나라 실정에 맞지 않는 입사각에 따른 태양전지 어레이 간의 음영에 의한 출력저하를 비교?분석하여 설비용량, 설비사양, 부지면적의 변화 없이 태양전지 어레이의 재배치를 통해 최대 출력을 낼 수 있는 태양전지 어레이의 최적 간격을 산정한다. 태양전지 어레이 1열 재배치 시에는 약 1.2[%], 2열 재배치 시에는 약 2.8[%], 3열 재배치 시에는 약 5.0[%]의 출력이 향상되었다. 또한 1열 재배치 시에는 태양전지 어레이 당 0.39[m], 2열 재배치 시에는 태양전지 어레이 당 0.82[m], 3열 재배치 시에는 태양전지 어레이 당 1.29[m]의 간격 이득을 얻었다. 태양전지 어레이 간격에 이득이 생기면서 음영의 영향을 받게 되는 시간이 점점 늦춰지게 되고 결국 출력의 향상이 나타나는 결과를 보였다. Photovoltaic array distance will be calculated that can have maximum output through the rearrangement of photovoltaic array by comparing and analyzing the power output decrease from the shadows of photovoltaic arrays according to the consideration of incidence angle that is not suitable to the situation of our country among the causes of power output decrease by sampling photovoltaic power generation plants. When relocate simulation result photovoltaic array 1 line, when relocate about 2.8[%], photovoltaic array 3 lines when relocate about 1.2[%], photovoltaic array 2 lines, output of about 5.0[%] improved. Also, gained space gains of photovoltaic array party 1.29[m] when relocate photovoltaic array party 0.82[m], 3 lines when relocate photovoltaic array party 0.39[m], 2 lines when relocate 1 line. As gains occur on photovoltaic array clearance, time that receive effect of shade was slowed down gradually and showed result that elevation of output shows finally.
권상미 ( Sang Mi Kwon ),장윤영 ( Yoon Young Jang ),김지영 ( Ji Young Kim ),박혜진 ( Hye Jin Park ),김우택 ( Woo Taek Kim ),김진경 ( Jin Kyung Kim ),최은진 ( Eun Jin Choi ),이계향 ( Kye Hyang Lee ),정혜리 ( Hai Lee Chung ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2008 소아알레르기 및 호흡기학회지 Vol.18 No.3
목적: 아연은 식이성 항산화제 중 하나로 면역반응에 관여하는 세포들의 발달과 기능에 필수적인 역할을 한다고 알려져 있다. 최근 어린 소아에서 아연의 보충이 급성 하기도 감염의 빈도를 낮추고, 심한 폐렴을 예방하는데 효과가 있다는 연구 결과들이 보고되고 있다. 본 연구에서 저자들은 재발성 천명을 동반하는 잦은 호흡기 감염을 나타내는 어린 소아들에서 혈청 아연을 측정하고 임상 양상 및 검사실 소견과 관련성이 있는지 알아보고자 하였다. 방법: 천명을 동반한 하부 호흡기 감염으로 입원하였던 8개월에서 6세 사이의 소아 73명을 대상으로 하였으며, 대상 환아들은 모두 입원 전 최소 3회 이상 천명의 재발을 경험한 경우였다. 유도결합 플라즈마 방출 분광기(inductively coupled plasma-optical emission spectrometry, ICP- OES)를 이용하여 혈청 아연을 측정하였고, 64 ?g/dL 미만을 아연 결핍으로 정의하였다. 혈청 아연치에 미치는 감염의 영향을 고려하여 대조군은 두 군으로 선정하였다: 정상 대조군 (제 1 대조군, 28명)과 급성 바이러스 감염으로 입원한 소아군 (제 2 대조군, 15명). 환아군과 대조군 간의 혈청 아연치를 비교하였고 또한 환아군 내에서 아연 결핍이 있는 군과 없는 군 간의 임상 양상과 검사 소견을 비교하였다. 결과: 혈청 아연의 중간값은 환아군에서 대조군에 비해 유의하게 낮았다. 환아군 73명 중 36명(49.3%)이 아연 결핍을 보였으며 이는 제 1 대조군(10.7%), 제 2 대조군(0%)에 비해 의미있게 높은 비율이었다. 아연 결핍이 있는 군과 없는 군 간에 총 백혈구수, 림프구수, 아토피 유무에는 차이가 없었다. CD4/CD8 비율은 아연 결핍이 있는 환아군에서 유의하게 낮았고 다른 면역 검사는 양 군간에 차이가 없었다. 결론: 본 연구의 결과는 천명을 동반한 잦은 호흡기 감염을 보이는 소아들에서 아연 상태 측정의 필요성을 제시하며 아연 결핍이 잦은 호흡기 감염과 그로 인한 천명 증상의 재발에 기여했을 가능성이 있음을 시사하는 것으로 생각된다. Purpose: Zinc is a dietary antioxidant which is crucial for normal development and function of the immune system. Zinc supplementation is reported to reduce respiratory infections and prevent severe pneumonia in children. We examined serum zinc levels in young children who had recurrent wheezing and evaluated the clinical and laboratory findings in relation to serum zinc levels. Methods: Seventy three patients admitted due to lower respiratory infections with wheezing were enrolled. All children had experienced more than 3 episodes of wheezing before admission. Serum zinc levels were measured by using inductively coupled plasma-optical emission spectrometry (ICP-OES), and serum zinc level of <64 ?g/dL was defined as zinc deficiency. Clinical and laboratory findings were evaluated and compared between the patients with zinc deficiency and those without it. Two age-matched control groups: normal controls (control 1) and patients with acute viral illnesses (control 2) were also studied. Results: Zinc levels were significantly lower in the patient group than in the 2 control groups.(P<0.0001) Zinc deficiency was observed in 49.3% of the patient group, which was significantly higher than in controls.(P<0.0001) Peripheral blood CD4/CD8 was significantly lower in the patients with zinc deficiency than in the subjects with a normal value.(P=0.01) Conclusion: This study showed that the serum zinc level was significantly lower and that zinc deficiency was more frequently observed in the patients with recurrent early wheeze. Zinc deficiency was found to be associated with lower CD4/CD8. Our results suggest that zinc deficiency may be associated with frequent respiratory infections, a likely trigger for recurrent early wheeze. [Pediatr Allergy Respir Dis(Korea) 2008;18: 253-259]