공동주택 바닥충격음 차단성능 등급화에 관한 연구

송민정,기노갑,장길수,김선우 대한건축학회 2004 대한건축학회논문집 Vol.20 No.10

A sound classification system for floor impact sound insulation performance is needed to secure comfortable acoustical quality in apartment houses To achieve this goal, psycho-acoustic experiments were earned out with the sound sources of standard light and heavy impact source in a laboratory As a result of this study, followings are suggested 49dB for light impact sound source and 46dB for heavy impact sound source are recommended minimum level for inhabitants And level differences between classes are 5dB But the situation of sound insulation performance against floor impact sounds can't meet this recommended level Due to these kinds of matters, foreign countries set the minimum class 58dB for light impact source(Europe) and 55dB for heavy impact source(japan) So, the sound insulation classification system in which its minimum class are 58dB(light), 55dB(heavy) and its interval is 5dB is suggested And arithmetic mean value of testing frequencies shows a good relation coefficient between subjective response and rating value both in light and heavy impact sound source

殺蟲性 結晶蛋白質 特異的인 抗體의 生産

김기윤,이정민,유형진,백길현,권무식 성균관대학교 생명과학자원연구소 1996 生命資源科學硏究 Vol.3 No.1

Bacillus thuringiensis is a gram-positive soil bacterium characterized by its ability to produce crystalline inclusions during sporulation. These parasporal bodies consist of protoxins known as crystal proteins exhibiting highly specific insecticidal activities. The Lepidoptera-specific protoxin, Cry IAc, was purified from E.coli JM103 harboring the cry IAc gene. The gene was isolated from Bacillus thuringiensis kurstaki HD-73 and subcloned into an expression vector, pKK223-3. The recombinant DNA(pOS4201) was transformed into E.coli JM103. The Cry I Ac protoxin overexpressed in the E.coli was isolated from the total proteins by differential solubility. The protoxin were trypsinized to obtain activated toxin. The proteins was resolved on SDS gel. The molecular weights of the pro-and toxin were resistered about 130,000 and 65,000 Daltons respectively. The Cry IAc toxin was used as immunogen to produce anti-Cry IAc antiserum in a rabbit. The immunogen (200㎍/ 200㎕) was mixed with an equal volume of Freund's complete adjuvant, and the mixture was hypodermically injected to the hide back (30 spots) and paws (2 spots) of the rabbit. The immunization was performed four times every two weeks. The dosage of the immunogen was decreased by half, and incomplete adjuvant was substituted for the complete one from the second immunization. The serum was prepared from the blood as described elsewhere. Immunoreactivity of the serum was examined by dot-blotting with the aid of GAR-HRP indirect immunoassay kit. It has been found that the anti-Cry I Ac antiserum recognized nano-gram quantity of antigen under these experimental conditions. The antiserum will he used for the development of immunochemical mean(s) to screen transgenic plants transformed by the insecticidal characteristics of Cry I Ac.

Cyclophosphamide가 흰쥐 혀침샘의 점액질에 미치는 영향에 대한 조직화학

조운복,정길남,조기진,이응희 釜山大學校 師範大學 科學敎育硏究所 2006 科學敎育硏究報 Vol.33 No.-

항암 및 항종양 치료제인 CP가 흰쥐의 혀 미각샘과 점액샘의 형태 및 그 분비물인 점액질에 미치는 영향을 PAS, AB pH 2.5, AB pH 2.5-PAS, AB pH 1.0, AF pH 1.7-AB pH 2.5 및 HID-AB pH 2.5 염색법으로 연구하였다. 1. CP군의 혀 미각샘의 형태적인 변화는 장액샘꽈리의 위축 및 파괴, 장액세포의 세포질과립의 감소 및 소실, 세포질의 공포변성 그리고 일부 도관상피세포의 점액화였으며, 혀 점액샘의 형태적 변화는 점액샘꽈리의 확장, 융합, 파괴, 점액세포의 세포질과립 감소 및 소실, 세포질의 공포변성 그리고 도관상칙의 현저한 점액화였다. 2. 혀 미각샘의 중성점액질이 대조군에 비해 현저히 감소하였으며 극소수의 미각샘세포에서 산성 점액질이 나타났다. 혀 점액샘의 중성점액질과 산성점액질은 대조군에 비해 다같이 현저히 감소하였고 산성점액질 중 sulfomucin은 현저히 감소하였으나 sialomucin은 다소 증가하는 경향을 나타내었다. The effect of cyclophophamide(CP) on the mucins of rat lingual salivary gland was examined by prelectin histochemical methods. Sprague-Dawley rats weighing about 250-300 gm were divided into control and CP groups. Control group was administrated by only drinking water for one week, CP group which was admirdstrated by 0.04% CP in the drinking water for one week. Mucins properties were stained with PAS, AB pH 2.5, AB pH 2.5-PAS, AB pH 1.0, AF pH 1.7-AB pH 2.5 and HID-AB pH 2.5 methods. 1. For the morphologic changes, the lingual gustatory glands of CP group, compared with the control group, were noted atrophy of serous adrd, decrease and disapperance of zymogen granules and vacuolation tn the serous cell. The mucification of duct cells was appeared in CP group. And the lingual mucous glands of CP group, compared with the control group, showed atrophy of mucous acini, and decrease of mudgen granules in mucous cells. Especially, many enlarged, fused mucous acini, and vacuolated mucous cells were detected. The mucification of duct cells increased very notably in CP group. 2. Neutral mucin of the lingual gustatory gland, and add and neutral mucins of lingual mucous gland decreased very remarkably in CP group compared with the control group. Especially, the decrease of acid mucin was more remarkable than that of neutral mucin in the mucous gland. But, in CP group, the mucous cells which secrete sulfomudn decreased, and the mucous cells which secrete sialomucin increased remarkably.

흰쥐 혀 침샘 점액질에 미치는 paraquat 독성에 대한 녹차의 완화효과

조운복,정길남,조기진 釜山大學校 師範大學 2003 교사교육연구 Vol.42 No.-

흰쥐의 혀 미각샘 및 점액샘과 그 점액질에 미치는 paraquat 독성과 녹차의 paraquat 독성완화 효과를 대조군, paraquat 투여군, Paraquat-녹차 투여군, 녹차 3주 투여후 paraquat-녹차 투여군으로 나누어 prelectin 조직화학법으로 연구하였다. Paraquat 투여군 미각샘은 대조군에 비해 장액샘꽈리 위축, 장액세포의 과립의 감소 및 소실, 공포변성 등이, 점액샘은 점액샘꽈리의 위축, 확장 또는 융합, 점액세포의 과립의 감소, 공포변성 및 미성숙 샘꽈리 등이 대조군에 비해 많이 관찰되었다. 미각샘 및 점액샘 도관상피의 점액화도 관찰되었다. Paraquat-녹차 투여군과 녹차 3주 투여후 paraquat-녹차 투여군에서는 paraquat 투여군의 미각샘과 점액샘의 형태적 변화가 대조군으로 회복되는 경향을 나타내었으며 후자에서 더 현저하였다. Paraquat 투여군의 미각샘의 중성점액질과 점액샘의 산성 및 중성점액질 양이 대조군에 비해 현저히 감소하였다 Paraquat 투여군의 혀 점액샘에서 sulfomucin을 분비하는 점액세포는 대조군에 비해 현저히 감소하였으나 sialomucin을 분비하는 점액세포는 오히려 증가하는 경향을 나타내었다. Paraquat-녹차 투여군과 녹차 3주 투여후 paraquat-녹차 투여군에서 대조군으로 회복되는 경향을 보였으며 후자에서 더 현저하였다. 이상의 결과로 보아 paraquat는 혀 미각샘 및 점액샘과 그 분비물인 점액질에 강한 독성을 나타내며 이 독성에 대해 녹차가 완화효과를 나타냄을 알 수 있고 녹차 3주 투여후 paraquat-녹차 투여군에서 녹차-paraquat 투여군보다 완화효과가 더 크게 나타나는 것으로 보아 paraquat 독성에 대한 완화효과는 녹차를 투여하는 시기와 그 양에 따라 더 효과가 있고 녹차에 paraquat 독성 발현억제 및 예방물질이 있음이 사료되어진다. Paraquat toxicity and the alleviating effects of green tea on the toxicity to the rat lingual mucins were investigated through prelectin histochemical methods. Mucosubstances properties were stained with PAS, AB pH 2.5, AB pH 1.0, AB pH 2.5-PAS, AF pH 1.7-AB pH 2.5 and HID-AB pH 2.5 methods. Sprague-Dawley male adult rats(250∼300g) were divided into one control group and three experimental groups, DP group which was administrated by only 0.04% paraquat in the drinking water for one week, GP group which was fed by both 0.04% paraquat and 3% green tea for one week, and GGP group which was applied with both 0.04% paraquat and 3% green tea for one week after 3% green tea in the drinking water was dosed for three weeks. For the morphological changes, the lingual gustatory glands of DP group, compared with the control group, were noted atrophy of serous acini, decrease and disappearance of zymogen granules, and vacuolation in the serous cells. And the lingual mucous glands of DP group showed atrophy of mucous acini, and decrease of mucigen granules. Especially, many enlarged, fused mucous acini, and vacuolated mucous cells were detected. Mucification of duct cells increased very notably in DP group. The groups of feeding green tea showed recovering tendency. The recovery degree of GGP group was greater than that of GP group. And GGP group recovered almost up to the state of the control group. Neutral mucin of the gustatory gland, and acid and neutral mucins of mucous gland decreased very notably in DP group compared with the control group. The decrease of acid mucin was more notable than that of neutral mucin in the mucous gland. And DP group showed that the mucous acini which secrete strong sulfomucin decreased, but the mucous acini which secrete sialomucin increased remarkably. GP and GGP group appeared the recovering tendency to the control group. The recovery of GGP group, comparing the degree, was more remarkable than that of GP group. And GGP group recovered almost up to the state of the control group. Consequently, the above results suggest that paraquat exhibites the toxicity which affects the histological structure and mucosubstances properties in the lingual salivary glands, and also suggest that green tea alleviates this toxicity. The different results of recovering tendency of paraquat toxicity in GP and GGP group indicate that the alleviating effects of green tea on paraquat toxicity to the histological structure and mucosubstances in the lingual salivary glands depend on the dosing time and the amount of green tea. Furthermore, green tea is presumed to have effects to recover from paraquat toxicity, to suppress exhibition of paraquat toxicity and to prevent paraquat toxicity.

갑상선 항진증에 관한 외과적 치료의 임상적 연구

장일성,최길돈,하기정 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

A clinical study of hyperthyroidism was performed for 20 patient who received operation at the department of surgery of C. N. U. H. from March, 1973 to July, 1987. The results were as follows: 1) In clinical classification, 14 cases (80%) were diffuse toxic goiter and 6 cases (20%) were nodular toxic goiter. 2) Male to female ratio was 1 : 19 and the highest incidence in the 3rd decade. 3) Main symptoms and signs were, in the order of decreasing frequency, neck mass (95%), palpitation (85%), fatigability (80%), heat intolerance (75%), weight loss (65%), tremor (60%) headache (50%). 4) Pulse rate changed from 130 per minute preoperatively to 60 postoperatively. 5) Thyroid function test revealed high level above the normal in 16 (80%) and the mean value of T_3RI_4 4.06mg/ml, T_3RI_4 10.48mg/ml, free T_4 4.65/ug/dl, postoperatively all cases showed teuthyroid function. 6) Electro-cardiographic findings were sinus tachycardia 9 cases (45%), normal 6 cases (30%). sinus bradycardia 5 cases (25%). 7) In preoperative preparation, Lugol solution was more frequently used 8 cases (40%) and others prophylthiouracil plus lugol solution 4 cases (20%), Inderal plus lugol solution 4 cases (20%) Methimazole plus lugol solution 2 cases (10%), prophylthiouracil plus Inderal plus comthyroid plus lugol solution 2 cases (10%). Average mean duration of preoperative preparation was 12.8 days. 8) The types of operation were in the order of decreasing frequency near total thyroidectomy 9 cases (45%), subtotal thyroidectomy 6 cases (30%), Lobectomy 4 cases (20%) and total thyroide ctomy 1 case (5%), 9) Early postoperative complication were transient tremor 3 cases (15%) transient hoarseness 1 case (5%), hypothyroidism 1 case (5%), recurrent hyperthyrodism 1 case (53%), hypoparathyroidism l. case (53%) but there was no case of operative motality.

Glucose Oxidase가 척수지각신경절세포에 미치는 영향과 천마의 효과에 관한 연구

송호준,이용석,손영우,이강창,정종길,신민교,홍기연 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : To clarify the cytotoxic effect of glucose oxidase(GO) and protective effect of gastrodiae Rhizoma (GR) on spinal sensory ganglion(DRG) neurons, neurotoxicity mediated by GO was measured by MTT assay and neurofilament enzymeimmuno assay(EIA). Methods : DRG neurons were cultured in the media containing various concentrations of GO for 3 hours. In addition, neuroprotective effects of GR, on GO-induced neurotoxicity in DRG neurons were examined after DRG neurons were preincubated with various concentrations of GR for 2 hours before 15mU/ml GO for 3 hours. Results : GO decreased remarkably cell viability in dependently in these cultures, and also RG increased cell viability and amount of neurofilament in DRG neurons damaged by GO. Conclusion : It is suggested that GO has toxic effect in cultured mouse DRG neurons, and also RG was effective in the protection of GO-induced neurotoxicity in these cultures.

Development of Molecular Markers and Phylogenetic Analysis of the Schisandra chinensis Genetic Resources

Jeong Hee Jeong(정희정),Jae Bok Lee(이재복),Jin Su Gil(길진수),Kyoung Min Lee(이경민),Chang Pyo Hong(홍창표),Sin Gi Park(박신기),Hyo Jin Kim(김효진),Yi Lee(이이) 한국약용작물학회 2019 한국약용작물학회 학술대회논문집 Vol.2019 No.1

IPTV 환경에서 해쉬 체인을 이용한 미디어 콘텐츠 분배기법

이기정(Gi-Jeong Lee),Randy S. Tolentino,정윤수(Yoon-Su Jeong),김용태(Yong-Tae Kim),박길철(Gil-Cheol Park) 한국정보기술학회 2009 Proceedings of KIIT Conference Vol.2009 No.-

최근 방송 서비스에서는 IPTV을 이용한 멀티미디어 서비스가 점점 증가하고 있는 추세이다. 멀티미디어 콘텐츠를 제공하는 서버의 부하 및 비용을 줄이기 위해서 P2P 기반의 오버레이 네트워크를 이용하여 미디어 콘텐츠를 분배하는 기술들이 등장하고 있다. 그러나 현재까지 제안된 기술들은 효율성만큼이나 보안성이 보장되지 않고 있다. 이 논문에서는 IPTV에서 제공하는 미디어 콘텐츠의 보안성을 향상시키면서 현재 제공되고 있는 효율성을 유지할 수 있는 미디어 콘텐츠 분배기법을 제안한다. 제안기법은 해쉬체인을 이용하여 미디어 콘텐츠를 분배하여 암호화 한 후 새로운 패킷을 생성하기 위해 해쉬체인을 사용하여 사용자에게 서비스를 제공 한다. Recently, the multimedia service using IPTV is increasing more and more in broadcasting service. To decrease the expenses and load of server offering multimedia contents, the technologies which distribute media contents using P2P-based overlay network is appearing. However, the technologies proposed until now don't guarantee the security as much as the efficiency. This paper proposes a media-contents distribution technique which can improve the security of media contents provided by IPTV and maintain the efficiency which is providing now. The proposed technique provides service to user to create a new packet using hash chain after encrypts distributed media contents using hash chain.

경피적 관동맥 성형술의 임상적 경험 - 최초 성공율을 중심으로 -

이기운 ( Lee Gi Un ),안영근 ( An Yeong Geun ),박주형 ( Park Ju Hyeong ),조길우 ( Jo Gil U ),정명호 ( Jeong Myeong Ho ),조정관 ( Jo Jeong Gwan ),박종춘 ( Park Jong Chun ),강정채 ( Kang Jeong Chae ) 대한내과학회 1992 대한내과학회지 Vol.42 No.4

연구배경 : 경피적 관동맥 성형술은 1977년 Andreas Gruentzig에 의해 최초로 성공된 이후 유도철선과 풍선도자의 기구개선과 시술자의 경험의 축적 및 시술 깃ㄹ의 발달로 그 적응중이 초기의 고적전인 병변에서 보다 복잡하고 힘든 다혈관병변이나 완전폐쇄병변에 까지 늘어나고 있다. 이에 그 시술결과를 알아보기 위하여 전남대학교 병원에서의 시술경험을 검토하였다. 방법 : 본대학 병원 순환기내과에서 1987년 8월부터 1991년 4월초까지 78예의 관동맥질환자를 대상으로 103예의 협착 및 완전폐쇄병변에 대해 경피적 관동맥 성형술을 시행한 임상 경험을 분석하였다. 결과 : 1) 대상 환자는 안정형 협심증 11예, 불안전형 협십증 32예, 급성 심근경색증 31예, 진구성 심근경색증 4예등이었다. 2) 78명의 관동맥 질환자에서 103예의 병변에 대해 관동맥 성형술을 시행하여 77예(74.8%)에서 성공하였다. 3) 병변의 형태에 따른 성공률은 A형, B형, C형에서 각각 82.6%, 71.7%, 25.0%이었고 완전폐쇄된 경우에는 18예중 9예서 성공하였다. 4) 혈관별 성공률은 좌전하행지, 좌회선지, 우관동맥에서 각각 72.2%, 78.9%, 78.6%였다. 5) 관동맥 성형술에 실패한 26예중 16예는 기술적인 문제로 실패하였는데 유도철선이나 풍선도자의 병변부위 관통 실패가 12예로 가장 많았다. 6) 합병증은 12예(11.9%)에서 관찰되었고, 이중 내막 박리가 7예로 가장 많았고 사망이 2예있었다. 응급 관동맥 수술이 필요한 경우는 없었다. 결론 : 경피적 관동맥 성형술이 관동맥 우회로 이식술을 대신하여 다양한 관동맥 질환의 효과적인 치료방법의 하나가 될 수 있음을 알 수 있었으나 사망등의 합병증을 줄이기 위한 노력이 계속되어야 할 것으로 생각되었다. Background: Percutaneous transluminal coronary angioplasty (PTCA) has been applied to some patients with symptomatic coronary artery disease and become recently an alternative to coronary artery bypass graft in selected cases. So we reviewed the results of our cases of PTCA. Method: PTCA was performed for 103 coronary arterial lesions in 78 patients (66 male, 12 female: 56.4±9.1 years) at Chonnam University Hospital from Aug. 1987 to April 1991. The acute results were assessed. Subjects: Eleven patients had stable angina, 32 unstable angina, 31 acute myocardial infarction, and four old myocardial infarction. Fortyfour patients had single vessel disease, 21 two vessel disease, and 13 three vessel disease. Results: Primary angiographic success rate was 74.8% (77/103) in the total 103 attempted lesions: 82.6% (38/46) in type A, 71.7% (38/53) in type B, and 25.0% (1/4) in type C according to ACC/AHA classification of the attempted coronary arterial lesions. The angiographic diameter stenosis reduced from 70.7±17.2% to 19.2±13.8% after successful PTCA. Complications associated with PTCA were seven intimal dissections (1 occlusive, 6 non-occlusive), one coronary occlusion by thrombosis, one coronary artery rupture, one guide wire impaction and fracture, and two deaths. There was no case requiring emergency CABG. Conclusion: Percutaneous transluminal coronary angioplasty (PTCA) can be an effective treatment in variable coronary artery disease and become an alternative to coronary artery bypass graft.

Hepatitis B Prophylaxis after Liver Transplantation in Korea: Analysis of the KOTRY Database

Gil-Chun Park,Shin Hwang,김명수,Dong-Hwan Jung,Gi Won Song,Kwang-Woong Lee,Jong Man Kim,Jae Geun Lee,류제호,Dong Lak Choi,Hee-Jung Wang,Bong Wan Kim,Dong-Sik Kim,Yang Won Nah,Young Kyoung You,Koo Jeong Kang 대한의학회 2020 Journal of Korean medical science Vol.35 No.6

Background: Prophylaxis for hepatitis B virus (HBV) recurrence is essential after liver transplantation (LT) in HBV-associated recipients. We conducted real-world analysis of HBV prophylaxis after LT in the Korean population. Methods: Korean Organ Transplantation Registry (KOTRY) database and additionally collected data (n = 326) were analyzed with special reference to types of HBV prophylaxis. Results: The study cohort comprised 267 cases of living-donor LT and 59 cases of deceased-donor LT. Hepatocellular carcinoma (HCC) was diagnosed in 232 (71.2%) of these subjects. Antiviral agents were used in 255 patients (78.2%) prior to LT. HBV DNA was undetectable in 69 cases (21.2%) and detectable over wide concentrations in the other 257 patients (78.8%) prior to LT. Polymerase chain reaction analysis of the store blood samples detected HBV DNA in all patients, with 159 patients (48.9%) showing concentrations > 100 IU/mL. Post-transplant HBV regimens during the first year included combination therapy in 196 (60.1%), hepatitis B immunoglobulin (HBIG) monotherapy in 121 (37.1%), and antiviral monotherapy in 9 (2.8%). In the second post-transplant year, these regimens had changed to combination therapy in 187 (57.4%), HBIG monotherapy in 112 (34.4%), and antiviral monotherapy in 27 (8.3%). Trough antibody to hepatitis B surface antigen titers > 500 IU/mL and >1,000 IU/mL were observed in 61.7% and 25.2%, respectively. The mean simulative half-life of HBIG was 21.6 ± 4.3 days with a median 17.7 days. Up to 2-year follow-up period, HCC recurrence and HBV recurrence developed in 18 (5.5%) and 6 (1.8%), respectively. HCC recurrence developed in 3 of 6 patients with HBV recurrence. Conclusion: Combination therapy is the mainstay of HBV prophylaxis protocols in a majority of Korean LT centers, but HBIG was often administered excessively. Individualized optimization of HBIG treatments using SHL is necessary to adjust the HBIG infusion interval.