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Fan Xia,Xuexin Yu,Yunke Li,Yuqi Chen,Wei Zhang,Chao You,Xin Hu 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.3
Background and Purpose As a leading cause of disability and death in China, stroke as well as its epidemiologic features have gained increasing attention. Prior studies, however, have overgeneralized the north-to-south gradient in China. Whether the differences exist across urban and rural areas remains unexplored. This study therefore aims to investigate the north-to-south gradient in stroke incidence across urban and rural China. Methods The present prospective cohort study analyzed data from the China Health and Nutrition Survey 1997 to 2015. By including 16,917 individuals from diverse social contexts, we calculated the age-standardized incidence of stroke across regions and the age-adjusted risk ratio (aRR). Cox proportional hazards models with time-varying covariates were employed to analyze variations in incident stroke. Results During the follow-up, age-standardized incidence of stroke ranged from 4.17 per 1,000 person-years (95% confidence interval [CI], 3.38 to 4.96) in the north region to 1.95 (95% CI, 1.60 to 2.30) in the south region (aRR, 2.04; 95% CI, 1.58 to 2.64; P<0.001). The north-to-south gradient of stroke incidence was observed only in rural areas, but not in urban areas. Hierarchical modelling analyses further indicated that the regional differences could be mostly explained by the disparities in the prevalence of hypertension. Conclusions The present study extends the current evidence on the north-to-south gradient by demonstrating that the difference varied across urban and rural China. Our findings highlight the importance of hypertension management as the measure for alleviating regional differences in stroke incidence.
Xia, Fan,Kim, Seong Been,Cheng, Huanyu,Lee, Jung Min,Song, Taeseup,Huang, Yonggang,Rogers, John A.,Paik, Ungyu,Park, Won Il American Chemical Society 2013 NANO LETTERS Vol.13 No.7
<P>We propose a facile method for synthesizing a novel Si membrane structure with good mechanical strength and three-dimensional (3D) configuration that is capable of accommodating the large volume changes associated with lithiation in lithium ion battery applications. The membrane electrodes demonstrated a reversible charge capacity as high as 2414 mAh/g after 100 cycles at current density of 0.1 C, maintaining 82.3% of the initial charge capacity. Moreover, the membrane electrodes showed superiority in function at high current density, indicating a charge capacity >1220 mAh/g even at 8 C. The high performance of the Si membrane anode is assigned to their characteristic 3D features, which is further supported by mechanical simulation that revealed the evolution of strain distribution in the membrane during lithiation reaction. This study could provide a model system for rational and precise design of the structure and dimensions of Si membrane structures for use in high-performance lithium ion batteries.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2013/nalefd.2013.13.issue-7/nl401629q/production/images/medium/nl-2013-01629q_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl401629q'>ACS Electronic Supporting Info</A></P>
Effect of Ambient Pressure on the Selective Growth of Square In2O3 Nanowires
Fan Xia,박태근,이동현,이정민,백운규,박원일 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.3
Single crystalline indium oxide (In2O3) nanowires (NWs), formed via a simple vapor transport route, were synthesized by a selective growth approach on patterned SiO2/Si substrates. The selective growth approach enabled us to have a more systematic analysis of the effects of the synthesizing parameters on the growth of the NWs. In this study, the ambient pressure in the quartz tube was controlled in the range of 250-1,000mTorr, and the dependence of NW size and density was investigated. Statistical analyses demonstrate that the ambient pressure plays an important role in determining the nucleation and crystal growth of In2O3NWs, thereby affects the diameter, length, and density of the NWs. Our result indicates that the interplay between the source export and the absorption import as well as the coalescence of catalyst droplets are mainly affected by ambient pressure in the quartz tube, which eventually contributes to the yield of NWs on catalytic substrates.
Xia, Fan,Kwon, Sunsang,Lee, Won Woo,Liu, Zhiming,Kim, Suhan,Song, Taeseup,Choi, Kyoung Jin,Paik, Ungyu,Park, Won Il American Chemical Society 2015 NANO LETTERS Vol.15 No.10
<P>Managing interfacial instability is crucial for enhancing cyclability in lithium-ion batteries (LIBs), yet little attention has been devoted to this issue until recently. Here, we introduce graphene as an interfacial layer between the current collector and the anode composed of Si nanowires (SiNWs) to improve the cycling capability of LIBs. The atomically thin graphene lessened the stress accumulated by volumetric mismatch and inhibited interfacial reactions that would accelerate the fatigue of Si anodes. By simply incorporating graphene at the interface, we demonstrated significantly enhanced cycling stability for SiNW-based LIB anodes, with retentions of more than 2400 mAh/g specific charge capacity over 200 cycles, 2.7 times that of SiNWs on a bare current collector.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2015/nalefd.2015.15.issue-10/acs.nanolett.5b02482/production/images/medium/nl-2015-02482j_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl5b02482'>ACS Electronic Supporting Info</A></P>
Xiaofan Xia,Jinxiu Fan,Zhongjie Fan 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.2
Compelling evidence has demonstrated the critical role of circular RNAs (circRNAs) during lung adenocarcinoma (LUAD) progression. Herein, we explored a novel circRNA, circ_0129047, and detailed its mechanism of action. The expression of circ 0129047, microRNA-665 (miR-665), and protein tyrosine phosphatase receptor type B (PTPRB) in LUAD tissues and cells was determined using reverse transcription quantitative polymerase chain reaction and Western blotting. Cell Counting Kit- 8 and colony formation assays were conducted to detect LUAD cell proliferation, and western blotting was performed to quantify apoptosis-related proteins (Bcl- 2 and Bax). Luciferase reporter and RNA immunoprecipitation assays were used to validate the predicted interaction between miR-665 and circ_0129047 or PTPRB. A xenograft assay was used for the in vivo experiments. Circ_0129047 and PTPRB were downregulated in LUAD tissues and cells, whereas miR-665 expression was upregulated. Overexpression of circ_0129047 suppresses LUAD growth in vivo and in vitro. Circ_0129047 is the target of miR-665, and the miR-665 mimic ablated the antiproliferative and pro-apoptotic phenotypes of LUAD cells by circ_0129047 augmentation. MiR-665 targets the 3ʹUTR of PTPRB and downregulates PTPRB expression. PTPRB overexpression offsets the pro-proliferative potential of miR-665 in LUAD cells. Circ_0129047 sequestered miR-665 and upregulated PTPRB expression, thereby reducing LUAD progression, suggesting a promising approach for preventing LUAD.
Cheng Xia,Rui-Tang Guo,Zhen-rui Zhang,Chen-yuan Fan,Yu-zhe Liu,Yu-cheng Lin,Chu-fan Li,Wei-Guo Pan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Recently, the photocatalytic CO2 reduction technology is an effective solution to remit the energy crisis. Inorder to improve the photocatalytic performance, Z-scheme W18O49/NiAl-LDH composite catalysts wereprepared by hydrothermal method. Fortunately, the prepared catalysts revealed excellent photocatalyticperformance under the simulated sunlight, and CO and CH4 could be detected in the reduction products. WO/LDH-0.5 catalyst possessed the optimal activity, with CO and CH4 yield of 37.09 and 8.01 lmol g-1h1separately, which were 7.9 and 3.6 times that of NiAl-LDH monomer. In addition, W18O49 endowedW18O49/NiAl-LDH catalysts with photothermal effect, which raised the surface temperature andfacilitated the catalytic reaction. Meanwhile, the Z-scheme heterojunction composed of flower-likeNiAl-LDH and urchin-like W18O49 accelerated the separation of photoexcited carriers and enhanced theredox ability. Through a series of characterizations and investigations, this work is promising to breaknew ground for the design of photocatalysts with photothermal effect.
Chun-Xia Fan,Fuwen Yang,Ying Zhou 제어·로봇·시스템학회 2012 International Journal of Control, Automation, and Vol.10 No.3
A state estimation problem is studied for a class of coupled outputs discrete-time networks with stochastic measurements, i.e., the measurements are missing and disturbed with stochastic noise. The considered networks are coupled with outputs rather than states, are coupled with different inner coupling matrices rather than identical inner ones. By using Lyapunov stability theory combined with stochastic analysis, a novel state estimation scheme is proposed to estimate the states of discrete-time complex networks through the available output measurements, where the measurements are stochastic missing and are disturbed with Brownian motions which are caused by data transmission among nodes due to communication unreliability. State estimation conditions are derived in terms of linear matrix inequalities (LMIs). A numerical example is provided to demonstrate the validity of the proposed scheme.