老齡者의 建康을 위한 生活習慣 實態調査

申東敏,長鳳愚,李揆文,金賢俊,金昌範,崔宗洙,崔鍾晥,李鍾珏,金圭碩,趙庚旭,金鍾聲,朴鍾振 平生體育硏究所 論文集 1987 平生體育硏究所 論文集 Vol.2 No.-

With a view to examining the habit and method in which old people maintain and improve their health, we consulted 551 men and 444 women who were over 65 years old, and concluded as follows: 1. Habit of eating It's been revealed that most of the old people keep a regular eating hour, control the quantity of meal or eat a little food, and prefer vegetables to meat. 2. Mental health Old people feel the necessity for mental health and most of them (about 80%) keep good mental health without becoming pessimistic. Their chief concenrs have turned out to be about their sons and daughters and their own health and finance. 3. Managing Good Health It has been revelaed that old people do not possess any special kind of secret to keep good health but taking plenty of rest, regular meal, and proper exercise, and many of them (about 60%) have been shown to eat invigorant food that they can easily get around their living area. 4. Physical Functions It has been revealed that many old people are conscious of some symptoms about their parts of body and about to percent of them suffers from neuralgia. Some measures like medical aid especially for old people need to be taken as soon as possible. As we have found that the health-keeping method of old people consists plenty of rest, proper exercise, and appropriate nutrition, we can conclude that the recreatonal and culture facilities and programs for keeping old people in good health should be developed. It is also necessary to study food that contribute to their health and develop ways to get rid of the stresses to which they are exposed in their daily life. Presides, it is natural that government found an administrative department to deal with these matters effectively.

RAPD(Random Amplified Polymorphic DNA)법을 이용한 한약재의 판별 연구

김대원,김도균,안선경,조동욱 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

Conventionally, identification and classification methods of natural products include the morphological survey and assay of chemical disposition. Using these methods, however, is not satisfying for the precise identification of natural products because they are often variable in the compositions, genomic DNA analysis such as RAPD, RFLP and Amp-FLP can be adopted for this purpose. In this study, various ginsengs and bear gall bladder were tested for the development of genetic identification and classification method. Varieties of ginsengs such as, P. ginseng, P. quinquefolium, P. japonicus and P. notohinseng, were genetically analyzed by RAPD. Also, DNA isolated form Bear blood and gall bladder, Ursus thibetanus, Ursus americanus and Ursus arctors, were analyzed by the same method. The results demonstrated that the identification and classification of bear gall bladder and various ginsengs were possible by RAPD analysis. Therefore, this method was thought to be used as a additional method for the identification of other natural products.

한국인의 신뢰 수준 및 영향 요인 : 단체참여 및 개인의 사회,경제적 배경과 대인신뢰, 단체신뢰, 대중매체 신뢰

박희봉,이희창,김동욱,김철수,박병래 한국정책학회 2003 韓國政策學會報 Vol.12 No.3

본 연구는 한국인의 신뢰수준과 단체참여를 중심으로 신뢰에 영향을 미치는 요인을 분석하여, 이를 토대로 신뢰 증진을 위한 방안을 논의하는데 목적이 있다. 이를 위하여 대인신뢰, 단체신뢰, 대중매체신뢰와 관견된 23개 항목에 대한 신뢰를 Likert 5점 척도로 각각 질문하여 항목별 평균을 신뢰 측정치로 이용하였다. 각종 신뢰 변수와 단체참여 변수는 요인분석을 통하여 유형화 하였다. 본 연구의 측정을 위한 모집단은 우리나라 14개 광역 자치단체에 거주하는 20세 이상의 성인이다. 분석 결과 우리나라 국민들의 전반적인 신뢰수준은 유형별 큰 편차를 보였다. 즉 개인적 네트워크를 통해 이미 알고 있는 지인에 대한 사적신뢰는 매우 높은 반면 개인적인 친분이 없는 일반인 신뢰는 매우 낮게 나타났고, 사회단체에 대한 신뢰와 대중매체 신뢰는 비교적 높게 나타난 반면 공공기관에 대한 신뢰는 상대적으로 낮게 나타났다. 한편, 수평적 단체 및 수직적 단체 변수가 대인 및 단체 신뢰에 영향을 미치고 있었다. 대부분의 단체참여가 각종 신뢰에 영향을 미치고 있음을 나타내었다. 개인의 사회경제적 배경에 따라 긍정적 또는 부정적 형태로 다양한 영향을 나타내었다. 이는 우리나라가 아직 공동사회에 기초한 신뢰에 의존하고 있어 시민사회 및 2차사회 중심의 신뢰가 제대로 형성되지 못하고 있음을 시사하고 있다. 본 연구에서는 이러한 결과를 토대로 신뢰증진의 필요성에 관해 논의하였다. This study examines the trust levels of Korean people, and clarifies the factors to affect the Korean people's trust. For the purpose of this study, how the factors including horizontal association participation, hierarchical association participation and individuals' socio-economic status affect Korean people's trust is analyzed. More than 7,000 surveys are used for data in 14 provinces in Korea. The major findings of this study as followings : First, the degree of Korean people's trust has distinct difference according to the relationship with them and the subjects of the trust. Korean people show high levels of trust for their family members, friends and colleagues who they know already, while they hardly trust the general people. They show comparatively high levels of trust for civil association and mass media, while they show comparatively low levels of trust for public institutions. Second, hierarchical social association participation as well as the horizontal participation positively affect personal, associational, and meas medial trust. Third, according to the individuals' socio-economic status, the levels of trust shows strikingly contrast. Some variables of individuals' socio-economic status positively affect some kinds of trust, and others negatively affect other kinds of trust. This means that Korean peoples' trust is formed mainly by the gemeinschaft, not by the gesellschaft yet. Overall, this paper discusses how to improve various kinds of trust and suggests research implications for further research.

허혈/재관류 세포 손상에서 청폐사간탕의 보호 효과

홍성길,강봉주,김윤진,강상모,조동욱 한국한의학연구원 1999 한국한의학연구원논문집 Vol.5 No.1

Free radicals are though to be the most important cause of the reperfusion injury subsequent to ischemia. The antioxidant status of the tissue affected by ischemia-reperfusion is of great importance for the primary endogenous defense against the free radical induced injury. Therefore, antioxidant therapy has been shown to be beneficial in neurological disorders such as Alzheimer's disease and cerebral ischemia. In this study, the protective effects of Chungpesagan-tang(CST) was investigated against ischemia/reperfusion-induced cytotoxicity in SK-N-MC neuronal cells it was found out that low concentration of CST we highly effective in protecting neuronal cells against ischemia/reperfusion-induced cytotoxicity. The inhibitory effect of CST on malondialdehyde formation during ischemia/reperfusion-induced oxidative stress in SK-N-MC cells showed obvious dose-dependent responses. Also, CST showed relatively high inhibitory activity to xanthine oxidase induced by ischemia/reperfusion environment. Therefore, it is thought that CST has both antioxidant and xanthine oxidase inhibitory effect and can be used for clinical applications for protection of neuronal cells from ischemia/reperfusion injury.

Clopidogrel Napadisilate Monohydrate Loaded Surface-Modified Solid Dispersion: Physicochemical Characterization and in Vivo Evaluation.

Kim, Young Hun,Kim, Dong Wuk,Kwon, Min Seok,Cho, Kwan Hyung,Kim, Jong Oh,Yong, Chul Soon,Choi, Han-Gon Pharmaceutical Society of Japan 2015 Biological & pharmaceutical bulletin Vol.38 No.7

<P>To develop a novel solid dispersion of clopidogrel napadisilate monohydrate (CNM) with improved stability and oral bioavailability, surface-modified solid dispersions were prepared by spray-drying using water as a solvent, Tween 80 as a surfactant, and hydroxypropylmethyl cellulose (HPMC) as a hydrophilic polymer, and optimized according to drug solubility. Its solid-state characterization was evaluated by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC). The stability study was performed at 50C/75% RH over a period of 6 weeks. Its dissolution profiles and oral bioavailability in rats were also compared with that of CNM and clopidogrel bisulfate (CB). The solid dispersion, composed of CNM/HPMC/Tween80 at a weight ratio of 10/2.5/2.5, in which CNM was in the crystalline state, increased the drug solubility approximately 4.6-fold. It showed a significantly better dissolution profile than that of CNM in all the dissolution media, and gave either similar or higher dissolution compared to that of CB. This solubility and dissolution enhancement was attributed to improved wetting and solubilization of CNM crystals due to hydrophilic carriers attached on the drug surface. It had excellent stability, thereby addressing the stability problem of CB powder. Furthermore, it increased the area under curve (AUC) values by about 4-fold and 1.6-fold compared to CNM and CB, respectively, suggesting that it improved the oral bioavailability of the drug in rats. Thus, this solid dispersion system prepared with water, HPMC and Tween 80 can be used to enhance the bioavailability of CNM as well as to solve the stability problem of CB.</P>

A Double-Layered (Comvi) Self-Expandable Metal Stent for Malignant Gastroduodenal Obstruction: A Prospective Multicenter Study

Kim, Yong Wuk,Choi, Cheol Woong,Kang, Dae Hwan,Kim, Hyung Wook,Chung, Chung Uk,Kim, Dong Uk,Park, Su Bum,Park, Kee Tae,Kim, Suk,Jeung, Eul Jo,Bae, Yong Mok Springer-Verlag 2011 Digestive diseases and sciences Vol.56 No.7

Life Science : Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier

( Dong Hoon Oh ),( Jun Hyeok Kang ),( Dong Wuk Kim ),( Beom Jin Lee ),( Jong Oh Kim ),( Chul Soon Yong ),( Han Gon Choi ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

In order to compare the effects of hydrophilic and hydrophobic solid carrier on the formation of solidself-microemulsifying drug delivery system (SMEDDS), two solid SMEDDS formulations were prepared by spray-drying the solutions containing liquid SMEDDS and solid carriers. Colloidal silica and dextran were used as a hydrophobic and a hydrophilic carrier, respectively. The liquid SMEDDS, composed of Labrafil M 1944 CS/Labrasol/Trasncutol HP (12.5/80/7.5%) with 2% w/v flurbiprofen, gave a z-average diameter of about 100 nm. Colloidal silica produced an excellent conventional solid SMEDDS in which the liquid SMEDDS was absorbed onto its surfaces. It gave a microemulsion droplet size similar to that of the liquid SMEDDS (about 100 nm) which was smaller than the other solid SMEDDSformulation. In the solid SMEDDS prepared with dextran, liquid SMEDDS was not absorbed onto the surfaces of carrier but formed a kind of nano-sized microcapsule with carrier. However, the drug was in an amorphous state in two solid SMEDDS formulations. Similarly, they greatly improved the dissolution rate and oral bioavailability of flurbiprofen in rats due to the fast spontaneous emulsion formation and the decreased droplet size. Thus, except appearance, hydrophilic carrier (dextran) and hydrophobic carrier (colloidal silica) hardly affected the formation of solid SMEDDS such as crystalline properties, dissolution and oral bioavailability.ⓒ2011 Elsevier B.B.All rights reserved.

Life Science : Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier

( Dong Wuk Kim ),( Jun Hyeok Kang ),( Dong Hoon Oh ),( Chul Soon Yong ),( Han Gon Choi ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

To develop a novel flurbiprofen-loaded solid self-microemulsifying drug delivery system (solid SMEDDS) with improved oral bioavailability using gelatin as a solid carrier, the solid SMEDDS formulation was prepared by spray-drying the solutions containing liquid SMEDDS and gelatin. The liquid SMEDDS, composed of Labrafil M 1944 CS/Labrasol/Transcutol HP (12.5/80/7.5%) with 2% w/v flurbiprofen, gave a z-average diameter of about 100 nm. The flurbiprofen-loaded solid SMEDDS formulation gave a larger emulsion droplet size compared to liquid SMEDDS. Unlike conventional solid SMEDDS, it produced a kind of microcapsule in which liquid SMEDDS was not absorbed onto the surfaces of carrier but formed together with carrier in it. However, the drug was in an amorphous state in it like conventional solidSMEDDS. It greatly improved the oral bioavailability of flurbiprofen in rats. Thus, gelatin could be used as a carrier in the development of solid SMEDDS with improved oral bioavailability of poorly water-soluble drug.

ORIGINAL ARTICLES : Development of a novel triamcinolone acetonide-loaded spray solution for the treatment of stomatitis

( Dong Wuk Kim ),( Yong Il Kim ),( Hong Hee Han ),( Fakhar Ud Din ),( Kwan Hyung Cho ),( Jong Oh Kim ),( Chul Soon Yong ),( Han Gon Choi ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

To develop a novel triamcinolone acetonide (TAA)-loaded spray for the treatment of stomatitis, several spray solutions were prepared using various amounts of TAA, Eudragit L100 (Eudragit L) and PEG 400, and 100 ml ethanol. Their viscosity and spraying potential were investigated, with the result that the spraying threshold was 9.5 cP. The effect of PEG 400 on the properties of films formed after spraying was assessed. Its anti-inflammatory effect in mice was evaluated and compared to a commercial product. As the PEG 400 concentration increased, the film elongation and washability by the saliva solution increased, and tensile strength decreased. PEG 400 had little effect on mucoadhesive force and drug release. The TAA-loaded spray solution containing TAA, Eudragit L, PEG 400 and ethanol at the ratio of 1:6:3:100 (w/w/w/v) was easy to spray onto stomatitis lesions in the mouth via a spraying vessel incorporating a long straw. After spraying, the TAA-loaded spray formed a film with suitable elongation, tensile strength and washability that attached onto the mucosal membrane and released the drug. Moreover, it had excellent anti-inflammatory properties, similar to those of the commercial product. Thus, this novel TAA-loaded spray solution was easy to administer, had good film properties and excellent anti-inflammatory efficacy, and is therefore a potential candidate for the treatment of stomatitis.

INFORMA : Flurbiprofen-loaded nanoparticles prepared with polyvinylpyrrolidone using Shirasu porous glass membranes and a spray-drying technique: nano-sized formation and improver bioavailability

( Dong Hoon Oh ),( Fakhar Ud Din ),( Dong Wuk Kim ),( Jong Oh Kim ),( Chul Soon Yong ),( Han Gon Choi ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

A unique flurbiprofen-loaded nanoemulsion was listed earlier using a Shirasu porous glass (SPG) membrane emulsification technique, which gave constant emulsion droplets with a thin size distribution. In this study, a flurbiprofen-loaded nanoemulsion was developed further into a solid form using polyvinylpyrrolidone (PVP) as a carrier by a spray-drying technique. The flurbiprofen-loaded nanoparticles with a weight ratio of flurbiprofen/PVP/surfactant mixture of 1/8/2 were connected with about 130,000-fold enhanced drug solubility and had a mean size of about 70nm. In these nanoparticles, flurbiprofen was found in an altered amorphous state. Additionally, the nanoparticles gave significantly shorter T(max), and greater AUC and C(max) compared to the commercially available product. Specially, the AUC of the drug from the nanoparticles was about 10-fold greater compared to the commercially available product. Therefore, these flurbiprofen-loaded nanoparticles can be convenient for distributing a poorly water-soluble flurbiprofen with improved bioavailability using uniform nano-sized particles.