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      • SCOPUSKCI등재

        침윤성 흉선종에 속발한 조기식도암 1예

        김정태,강영진,박희욱,강대식,이기범,성수동,옥종한 대한소화기내시경학회 1995 Clinical Endoscopy Vol.15 No.2

        Metachronous double cancer of primary early esophageal squamous cell carcinoma and invasive thymoma is a very rare condition. The invasive thymoma had been detected during the myathenia gravis evaluation and treated by radiation therapy 5 years ago. The esophageal lesion had a nodular-surfaced flat elevation at the mid-esophagus that was found by esophagoscopy. Radical resection for the lesions was undertaken after histologic confirmation. Postoperative pathologic examination documented that the esophageal squamous cell carcinoma was in the $quot;early$quot; stage involving the mucosal and submucosal layer only. We report a case of early esophageal cancer associated with invasive thyrnoma with literatures review.

      • KCI등재

        발달성협응장애 중학생과 비장애 중학생의 인지적 부하량에 따른 정보처리속도 비교 연구

        김동민 ( Dong-min Kim ),한범석 ( Byum-suk Han ),이용호 ( Yong-ho Lee ) 한국특수체육학회 2019 한국특수체육학회지 Vol.27 No.2

        본 연구의 목적은 발달성협응장애 중학생의 정보처리속도와 관련하여 인지적 부하량에 따라 나타나는 반응속도가 비장애 중학생과 비교하였을 때 어떠한 차별적 특징을 나타내는지 알아보고자 하였다. 대상자 선정을 위해 연령, 키, 몸무게, DCDQ-K, BOTMP-2 결과를 고려하여 발달성협응장애(DCD) 중학생 21명, 비장애(TD) 중학생 18명을 연구대상자로 선정하였으며 3가지 과제유형(단순, 선택, 변별)의 반응시간을 측정하였다. 측정된 데이터는 SPSS 23.0 프로그램을 사용하여 이원 반복측정 분산분석, 독립 t검정을 실시하였다. 연구결과는 다음과 같다. 첫째, 단순반응과제에서 시각-단순반응시간(t=5.391, p<.001)과 청각-단순반응시간(t=2.386, p<.05)에서 유의한 차이가 나타났다. 둘째, 선택반응과제에서 발달성협응장애 중학생 집단이 모든 과제에서 비장애 중학생 집단에 비해 반응시간이 더 긴 것(F(1,37)=58.9, p<.001)으로 나타났으며, 자극선택 과제에 따라 반응시간의 차이(F(2,36)=61.8, p<.001)가 있는 것으로 나타났다. 모든 과제에서 자극 선택의 수가 증가할수록 반응시간의 증가폭이 비장애 중학생 집단에 비해 더 큰 것으로 나타났다. 셋째, 변별반응 과제에서 발달성협응장애 중학생 집단이 모든 과제에서 비장애 중학생 집단에 비해 반응시간이 더 긴 것(F(1,37)=35.4, p<.001)으로 나타났으며, 자극변별 과제에 따라 반응시간에 차이(F(2,36)=18.3, p<.001)가 있는 것으로 나타났다. 자극변별 과제 간 차이 검정에서는 시각변별 2개 반응시간이 시각-단순반응시간(p<.001), 시각변별 3개 반응시간(p<.05)과 통계적으로 유의미한 차이로 더 오래 걸리는 것으로 나타났고, 시각-단순반응시간과 시각변별 3개 반응시간은 유의한 차이(p=.65)가 나타나지 않았다. 따라서, 본 연구결과는 발달성협응장애 중학생이 전형적인 발달과정에 있는 비장애 중학생들보다 정보처리에 어려움을 겪고 있음을 시사하며, 특히 인지적 부하량이 늘어날수록 과제에 따른 반응패턴 양상의 차이보다는 반응시간이 늘어나는 양상에 향후 연구에 계속적인 초점을 맞추어야 할 필요가 있다고 사료된다. The purpose of this study was to distinguish characteristics of the reaction time in respect to the information processing speed of a middle school student with developmental coordination disorder(DCD) compared to a typical developing(TD) middle school student. 21 DCD middle school students and 18 TD middle school students were selected as subjects of the study considering their result of DCDQ-K and BOTMP-2 test. They were introduced to three types of reaction time assignment (simple, selective and discriminative). The results was then analyzed with two-way repeated measured analysis and independent t-test by the SPSS 23.0 program. First, there was a significant difference in visual-simple reaction time in simple response tasks (t=5.391, p<.001) and auditory-simple reaction time (t=2.386, p<.05). Second, DCD students showed longer reaction time than TD students in all selective response task (F(1,37)=58.9, p<.001). Moreover, there were difference in reaction time (F(2,36) = 61.8, p<.001) depending on the stimuli selection task given. The reaction time increased greatly in DCD than that of TD students as the number of stimulation options increased in each tasks. Third, in the specific response task, the group of DCD students had a longer response time than the group of TD students in all tasks (F(1,37)=35.4, p<.001); difference in response time (F(2,36)=18.3, p<.001) were found depending on the stimuli-discrimination tasks. Two response times for each visual-discrimination task were visual-simple reaction times (p<.001), 3 response times per visual variation (p<.05), and statistically significant differences, while 3 response times per visual variation (p=).65) did not appear. Therefore, the findings suggest that DCD students are having difficulty processing information during the typical development process than TD students, and it is suggested for the future research to focus on patterns of response times than the differences in response patterns due to tasks as cognitive load increases.

      • KCI등재

        발달장애인의 평형성 향상을 위한 운동프로그램 중재유형별 효과에 대한 메타분석

        한범석(Byum-Suk Han),김동민(Dong-Min Kim) 한국발달장애학회 2021 발달장애연구 Vol.25 No.3

        본 연구의 목적은 2000년부터 2021년 7월까지 보고된 운동프로그램을 통해 발달장애인의 평형성에 미친 효과를 중재유형별로 분석하여 객관적이고 종합적인 결과를 도출해내기 위해 수행되었다. 연구대상은 지적장애(다운증후군 포함)와 자폐스펙트럼장애이며 개입방법(Intervention)은 운동프로그램(기초체력, 신체활동, 스포츠), 종속변인은 평형성(눈뜨고 외발서기, 눈감고 외발서기, 동적평형성)이다. 최종 선정된 연구 63편(학위 31편, 학술지 32편)을 CMA ver.3와 SPSS 23.0을 통해 분석하였으며 전체효과크기, 연구별 효과크기, 연구변인별 효과크기를 산출하였다. 연구 결과 운동프로그램은 모든 장애유형에 큰 효과크기를 나타냈으며, 성별 결과는 남자집단(1.296, 40.15%)에서 가장 큰 효과크기가 나타났다. 프로그램 유형은 신체활동교육(1.129, 36.86%), 스포츠활동(0.986, 33.65%), 기초체력활동(0.869, 30.51%) 순으로 나타났다. 시간은 80∼90분(1.277, 39.8%)에서, 빈도 결과는 주 5회(1.162, 37.7%)에서, 기간 결과는 16∼19주(1.185, 38.1%)에서, 총 회차수는 37∼48회(1.095, 36.21%)에서 가장 큰 효과크기가 나타났다. 종속변인 중 눈뜨고 외발서기는 스포츠활동(1.185, 38.1%)에서, 눈감고 외발서기는 신체활동교육(1.393, 41.77%)에서, 동적평형성은 기초체력활동(1.080, 35.99%)에서 가장 큰 효과크기가 나타났다. 이에 본 연구는 발달장애인의 평형성 향상을 위한 운동프로그램 중재를 위한 근거 자료로 제공될 수 있을 것이다. The purpose of this study was to derive objective and comprehensive results by analyzing by intervention type the effects of exercise programs on the balance of persons with developmental disabilities from 2000 to 2021. This study complied with methodological standards based on 11 evaluation items of AMSTAR(Assessment of Multiple Systematic Review). The subjects of the study were intellectual disability(including Down s syndrome) and autism spectrum disorder, and the intervention was an exercise program(basic fitness, physical activity, sports). The dependent variables were balance (standing with eyes open, standing with eyes closed, dynamic equilibrium). The final selected studies were 63 articles (31 dissertations, 32 academic journal articles). For analysis, meta-analysis programs CMA ver.3 and SPSS 23.0 were used, and the total effect size, effect size for each study, and effect size for each study variable were calculated. As a result of this study, the exercise program showed a large effect size for all types of disability, and the gender results showed a large effect size in the male group (1.296, 40.15%). The largest effect size was achieved in 80∼90minutes (1.277, 39.8%) of time, 5times a week (1.162, 37.7%) of frequency, 16∼19weeks (1.185, 38.1%) of duration, and 37∼48 times (1.095, 36.21%) of total number of program. The largest effect size of one-legged standing with eyes open was found in sports (1.185, 38.1%), one-legged standing with closed eyes in physical activity (1.393, 41.77%), and dynamic balance in basic fitness (1.080, 35.99%). Our findings suggest considering different intervention strategies to improve the balance of persons with developmental disabilities.

      • KCI등재

        과도 안정도를 고려한 수송능력 산정 알고리즘의 개발에 관한 연구

        金龍河(Yong-Ha Kim),崔祥圭(Sang-Kyu Choi),李范(Byum Lee),趙成麟(Sung-rin Cho),吳錫賢(Seok-Hyun Oh),金東槿(Dong-keun Kim) 대한전기학회 2006 전기학회논문지A Vol.55 No.1

        This paper presents a power transfer capability calculation algorithm considering transient stability. The theoretical development is straightforward: dynamic equations are converted to numerically equivalent algebraic equation and then integrated into the standard formulation for power transfer capability calculation. The proposed method is applied to IEEE-24 Reliability Test System and the results shows the effectiveness of the method.

      • KCI등재

        Insilico Analysis for Expressed Sequence Tags from Embryogenic Callus and Flower Buds of Panax ginseng C. A. Meyer

        Subramaniyam Sathiyamoorthy,Jun-Gyo In,Byum-Soo Lee,Woo-Seang Kwon,Dong-Uk Yang,Ju-Han Kim,Deok-Chun Yang 고려인삼학회 2011 Journal of Ginseng Research Vol.35 No.1

        Panax ginseng root has been used as a major source of ginsenoside throughout the history of oriental medicine. In recent years, scientists have found that all of its biomass, including embryogenic calli and fl ower buds can contain similar active ingredients with pharmacological functions. In this study, transcriptome analyses were used to identify different gene expressions from embryogenic calli and fl ower buds. In total, 6,226 expressed sequence tags (ESTs) were obtained from cDNA libraries of P. ginseng. Insilico analysis was conducted to annotate the putative sequences using gene ontology functional analysis, Kyoto Encyclopedia of Genes and Genomes orthology biochemical analysis, and interproscan protein functional domain analysis. From the obtained results, genes responsible for growth, pathogenicity, pigments, ginsenoside pathway, and development were discussed. Almost 83.3% of the EST sequence was annotated using one-dimensional insilico analysis.

      • SCIESCOPUSKCI등재

        Insilico Analysis for Expressed Sequence Tags from Embryogenic Callus and Flower Buds of Panax ginseng C. A. Meyer

        Sathiyamoorthy, Subramaniyam,In, Jun-Gyo,Lee, Byum-Soo,Kwon, Woo-Seang,Yang, Dong-Uk,Kim, Ju-Han,Yang, Deok-Chun The Korean Society of Ginseng 2011 Journal of Ginseng Research Vol.35 No.1

        Panax ginseng root has been used as a major source of ginsenoside throughout the history of oriental medicine. In recent years, scientists have found that all of its biomass, including embryogenic calli and flower buds can contain similar active ingredients with pharmacological functions. In this study, transcriptome analyses were used to identify different gene expressions from embryogenic calli and fl ower buds. In total, 6,226 expressed sequence tags (ESTs) were obtained from cDNA libraries of P. ginseng. Insilico analysis was conducted to annotate the putative sequences using gene ontology functional analysis, Kyoto Encyclopedia of Genes and Genomes orthology biochemical analysis, and interproscan protein functional domain analysis. From the obtained results, genes responsible for growth, pathogenicity, pigments, ginsenoside pathway, and development were discussed. Almost 83.3% of the EST sequence was annotated using one-dimensional insilico analysis.

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