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( Daeun Kang ),( In Beom Jung ),( Su Yel Lee ),( Se Jin Park ),( Wan Jin Hwang ),( Minhyeok Lee ),( Sun Jung Kwon ),( Dong Ho Park ),( Ji Woong Son ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Particulate matter (PM) has various systemic effects, such as respiratory, cardiovascular, endocrine, as well as having effects on the nervous systems. So far, there have been many epidemiologic studies, but studies related to the biological mechanisms are insufficient. We researched the effects of PM on lung epithelial cells with Next Generation Sequencing (NGS) and validated this with quantitative real-time polymerase chain reaction (qRT-PCR). We cultured the group treated with PM10 at a concentration of 50μg/mL and the untreated group for seven days in five lung cell lines: NCI-H358, HCC-827, A549, NCI-H292, BEAS-2B. Then, we extracted the RNA from the sample and performed NGS. As a result of NGS, various gene expressions were upregulated or downregulated. Among them, we selected the gene whose mean fold change was more than doubled and changed in the same direction in all five cell lines. Based on these genes, we selected the top 10 genes, either upregulated or downregulated, to validate with the qRT-PCR. There were the four genes that matched the NGS and qRT-PCR Results, all of which were upregulated genes(Table 1). The four genes are CYP1A1, CYP1B1, LINC01816, and BPIFA2. All four genes that matched the two Results were up-regulated genes and none of the down-regulated genes matched. CYP1A1 and CYP1B1 are known to cause lung cancer by metabolizing polycyclic aromatic hydrocarbons, and long non-coding RNA is also known to play an important role in lung cancer. Considering this, we thought that PM10 might be associated with lung cancer by activating CYP1A1, CYP1B1, and LINC01816.
다축-진동 시험기를 이용한 자동차 엔진룸 진동내구 시험 연구
성대운(Daeun Sung),정기섭(Giseob Jung),정승균(Seunggyoon Jung) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
The interest in the accelerated reliability test of engine mounts and engine wiring harness is increasing. This paper presents a lab-simulation test which has shortened the validation period for the durability of engine mounts and the reliability of engine sensor wiring/connecter. This paper also presents the making process of the durability test mode based on the severity comparison between proving ground and field road load data. The techniques for simulation by multi-axial simulation table (MAST) and some application are also described in this paper.
정다은 ( Daeun Jung ),양정은 ( Jeong Eun Yang ),정라나 ( Lana Chung ) 한국식생활문화학회 2016 韓國食生活文化學會誌 Vol.31 No.1
The objective of this study was to determine sensory profiles of rice confections. The samples used in this study obtained from Korea (traditional Korea rice snack and local specialty rice snack) and three countries (USA, Japan, and China) were evaluated and compared. The sensory characteristics of five kinds of rice confections were evaluated using a sensory test and were analyzed via quantitative description analysis (QDA), principal component analysis (PCA), and hierarchical cluster analysis (HCA). In the descriptive analysis, 10 trained panelists evaluated sensory characteristics consisting of 19 attributes, and there were significant differences (p<0.05) among the 16 characteristics. For the descriptive data, multivariate analysis of variance was carried out and identified differences among the samples. The PCA of rice confections for the first two principal components could explain 85.66% of the variations. The Korean, Japanese, and Chinese rice confections were savory, gritty, and particle-sized, the other Korean local specialty rice confections were fruity, sweet, honey-flavored, compact, and crispy, and those from the USA were glossy, grainy, bright, adhesive, cohesive, crispy, and sweet.