심한 하악골 전돌증 환자의 외과적 치험례

권대근,이상한,이근호,장도근 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

Obwegeser Ⅱ method and Rigid fixation conserving the condylar position has been performed on 5 patients with severe mandibular prognathism, and we obtained the result after the follow up study follows. 1. Obwegeser Ⅱ method is considered to move the distal segment passively when surgical correction of severe open bite correction and large amount of set back above 15mm is needed. 2. In one case that has more change of condylar position after operation, documented immediate post- operative relapse have been occurred 3. In the others that have adequate control of condylar position, passive set back and firm skeletal fixation, more functional and esthetic improvement and more post-operative stability has been achieved

Efficient Construction Process and Distribution System through Construction IT Convergence based on 4th Industrial Revolution Technology: Focused on Distribution Management of Free-form Structural External panel

Lee,Dong-Woon,Kim,Dae-Geon 한국유통과학회 2019 KODISA ICBE (International Conference on Business Vol.2019 No.-

The distribution of construction materials and the schedule management of a project are important elements in ensuring an effective construction system and reasonable construction duration and cost. Therefore, IT convergence technology of distribution to the construction industry, a BIM module is composed as a 4D model more easily, which is considered to contribute to a reduction in construction duration, an improvement in quality and a reduction in cost through efficient management of manpower and the minimization of errors arising from the site construction by reflecting information in real time through an RFID system.

상악골과 비사골동에 이환된 백악질 골화성 섬유종(cemento-ssifying fibroma)의 치험례

권대현,김신유,남정순,구명숙,이봉서,권대근,김종배 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

The cemento-ossifying fibroma is a benign fibro-osseous tumor that may behave in an aggressive pattern. Although found predominantly in the mandible, most of these unusual tumors may arise in the maxilla and paranasal sinuses. Especially these lesion in the maxilla and sinuses behave more aggressively and are more prone to recur compared to mandibular counterparts. Therefore, more radical approach may be recommended than expectant observation or curettage in the initial management of this neoplasm. This is a case report of cemento-ossifying fibroma extended to maxillary sinus and naso-ethmoidal area treated by wide surgical excision after repeated conservative treatments.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

Cao-MgO-SiO₂-P₂O -CaF₂계 생체활성 결정화 유리의 기계적 성질에 미치는 ZrO₂및 Al₂O₃의 분산 강화 효과

박찬운,강건구,원대희,이민호,배태성 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2

Bioactive glass-ceramics can form tight chemical bonds with bone, however, their poor mechanical properties may limit their clinical applications. Alumina ceramics show good biocompatibility and high strength but can't form chemical bonds with bone. Hydroxyapatite ceramics and bioglass form chemical bonds with bone but their strength and fracture are relatively low. Glass ceramics containing apatite and wollastonite crystals can form tight chemical bonds with bone and show relatively high strength and fracture toughness. Bioactive glass-ceramics toughened by alumina and tetragonal zirconia polycrystals show relatively high mechanical strength. Both bioactive and high strength ceramics will be widely applicable to many clinical applications. In this study, bioactive glass-ceramics toughened by alumina and zirconia polycrystals were fabricated, and crystallization behavior, biaxial flexure strength, fracture toughness, and bioactivity were measured. The results obtained were summarized as follows; 1. The major crystaline phase in the matrix glass were observed to be apatite, wollastonite, and β-TCP. 2. Biaxial flexure strength and fracture toughness values were more improved by the dispersion toughening of alumina and zirconia, and the improvement of mechanical strength was more higher in the dispersion toughening of zirconia than that of alumina. 3. The bioactivity, which was evaluted from apatite formation in the simulated body fluid, was higher in the dispersion toughening of Zr-O₂than that of Al₂O₃.

In vitro anti-skin-aging effects of dried pomegranate concentrated powder

Lee, Dae-Geon,Choi, Beom-Rak,Ku, Sae-Kwang,Kang, Su-Jin,Park, Hye-Rim,Sung, Mi-Sun,Lee, Young-Joon,Park, Ki-Moon Society of Preventive Korean Medicine 2018 대한예방한의학회지 Vol.22 No.2

Purpose : In this study, we intended to observe the anti-wrinkle and moisturizing effects of dried pomegranate juice concentration powder (PCP) using in vitro test. Materials and methods : Antioxidant effects of PCP were determined by free radical scavenging capacity (DPPH assay) and the cytotoxicity of PCP was examined in human keratinocyte (HaCaT) and human primary dermal fibroblast-neonatal (HDF) cells. To investigate the moisturizing effect of PCP, hyaluronan synthesis was examined in HaCaT cells. Activity of procollagen production were assessed in HDF cells and elastase inhibition properties of PCP were evaluated in cell free condition, to determine their anti-wrinkle effects. Metalloproteinase 1 (MMP-1) activity was also assessed following UVB irradiation, in the current in vitro experiment. Results : No PCP treatment related significant cytotoxic effects were demonstrated against to the both HDF and HaCaT cells. PCP showed favorable free radical scavenging activities in dose-dependent manner. In PCP-treated HaCaT cells, hyaluronan synthesis was non-significantly but markedly increased, and pro-collagen productions were significantly increased in HDF cells, at all three different concentrations (0.25, 0.75 and 1 mg/ml), and elastase inhibitory activities were observed by PCP treatment. A significant decrease in UVB-induced MMP-1 activity was also observed in 1 mg/ml PCP-treated HDF cells as compared to those of UVB-exposed cells. Conclusions : Taken together, these results suggest that PCP has favorable antioxidant, anti-wrinkle and moisturizing effects without meaningful cytotoxicity on HDF and HaCaT cell lines.

Development of SPICA FPC

Dae-Hee Lee,Woong-Seob Jeong,Toshio Matsumoto,Hyung Mok Lee,Young Sik Park,Chang Hee Rhee,Bong Gon Moon,Jeong Hyun Pyo,Sung Jun Park,Wonyong Han,Geon Hee Kim,Norihide Takeyama 한국천문학회 2010 天文學會報 Vol.35 No.2

HCC : PE-042 ; Feasibility of α-fetoprotein as a screening and diagnostic tool for hepatocellular carcinoma (multicenter study)

( Dae Geon Ahn ),( Hyung Joon Kim ),( Hyun Woong Lee ),( Si Hyun Bae ),( Joon Hyeok Lee ),( Yong Han Paik ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Recent systematic reviews show that the quality of evidence supporting the use of AFP as a diagnostic and screening test for hepatocellular carcinoma (HCC) is limited. The Korean Liver Cancer Study Group recommended the cutoff value of 200ng/mL as a diagnostic tool. The aim of this study was to evaluate the feasibility of AFP as a screening and and to explore the optimal level of AFP for HCC diagnosis Methods: We retrospectively reviewed the medical records of HCC (all cases were biopsy proven) and cirrhosis patient have available data in 3 hospitals. A total of 1,560 patients were classified into three groups: 564 were cirrhosis controls, 766 were patient with early stage HCC (n = 123 very early, n = 643 early) and 230 were patient with late stage HCC. The performance of AFP in three groups was compared with each other. The AFP sensitivity, specificity, positive and negative predictive values were calculated. Results: The mean age was 54 years in cases, and 56 years in control. Male was dominant in both groups (case, 81.1% vs. control, 65.7%). The mean AFP was significantly higher in patients with overall HCC (early, late) than in those with liver cirrhosis. [early HCC, 2,769ng/ml (1-200,000) , late HCC, 9,818ng/ml (1-639,100), control, 20ng/ml (0.61-1,753)]. (p< 0.0001) Area under the receiver operating characteristic curve for those overall HCC with cirrhosis is 0.78. The sensitivity, specificity, and PPV of AFP was 52.6%, 87.7%, 88.3% at a cutoff of 20ng/ml; 36.9%, 95.9%, 94.1% at a cutoff of 100ng/ml and 29.5%, 98.0%, 96.3% at a cutoff of 200 ng/ml. As a screening tool for HCC , a cutoff of 100ng/ml is more sensitive than 200 ng/ml with equivalent specificity and PPV. The optimal AFP cutoff value was 8.2ng/ml leading to a sensitivity of 66.9% and a specificity of 75.7%. Conclusions: Our study cautiously suggested that the optimal value of AFP in the diagnosis of HCC might be switched 200 ng/ml to 100ng/ml.

Estimation of the properties of silver nanoparticle ink during laser sintering via in-situ electrical resistance measurement.

Lee, Dae Geon,Kim, Dong Keun,Moon, Yoon Jae,Moon, Seung-Jae American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.9

<P>In this work, the in-situ properties of silver nanoparticle ink were estimated during laser sintering process. The silver nanoparticle ink was composed of 34 wt% silver nanoparticles with an average size of approximately 50 nm, and was deposited on a glass substrate via inkjet printing technology. A 532 nm continuous-wave laser was irradiated to the printed ink for 60 s under various laser intensities. During the laser irradiation, the in-situ electrical conductance of the sintered ink was measured to obtain the transient thermal conductivity of the silver nanoparticle ink using the Wiedemann Franz law. The 2-dimensional, transient heat-conduction equation was calculated to obtain the transient temperature of the silver nanoparticle ink. By coupling the calculated temperature with the measured, transient electrical conductance, the transient thermal conductivity of the ink during the laser sintering process was derived in the calculation. The calculated thermal conductivity of the ink sintered at a laser intensity of 467.9 W/cm2 with 598 K is 355.5 W/mK, which is 86.4% of the thermal conductivity of bulk silver, 411.4 W/mK, at that tempearture. The difference resulting from the porosity of the sintered ink has an effect on the thermal conductivity of the sintered ink.</P>

HCC : PE-042 ; Feasibility of α-fetoprotein as a screening and diagnostic tool for hepatocellular carcinoma (multicenter study)

( Dae Geon Ahn ),( Hyung Joon Kim ),( Hyun Woong Lee ),( Si Hyun Bae ),( Joon Hyeok Lee ),( Yong Han Paik ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Recent systematic reviews show that the quality of evidence supporting the use of AFP as a diagnostic and screening test for hepatocellular carcinoma (HCC) is limited. The Korean Liver Cancer Study Group recommended the cutoff value of 200ng/mL as a diagnostic tool. The aim of this study was to evaluate the feasibility of AFP as a screening and and to explore the optimal level of AFP for HCC diagnosis Methods: We retrospectively reviewed the medical records of HCC (all cases were biopsy proven) and cirrhosis patient have available data in 3 hospitals. A total of 1,560 patients were classified into three groups: 564 were cirrhosis controls, 766 were patient with early stage HCC (n = 123 very early, n = 643 early) and 230 were patient with late stage HCC. The performance of AFP in three groups was compared with each other. The AFP sensitivity, specificity, positive and negative predictive values were calculated. Results: The mean age was 54 years in cases, and 56 years in control. Male was dominant in both groups (case, 81.1% vs. control, 65.7%). The mean AFP was significantly higher in patients with overall HCC (early, late) than in those with liver cirrhosis. [early HCC, 2,769ng/ml (1-200,000) , late HCC, 9,818ng/ml (1-639,100), control, 20ng/ml (0.61-1,753)]. (p< 0.0001) Area under the receiver operating characteristic curve for those overall HCC with cirrhosis is 0.78. The sensitivity, specificity, and PPV of AFP was 52.6%, 87.7%, 88.3% at a cutoff of 20ng/ml; 36.9%, 95.9%, 94.1% at a cutoff of 100ng/ml and 29.5%, 98.0%, 96.3% at a cutoff of 200 ng/ml. As a screening tool for HCC , a cutoff of 100ng/ml is more sensitive than 200 ng/ml with equivalent specificity and PPV. The optimal AFP cutoff value was 8.2ng/ml leading to a sensitivity of 66.9% and a specificity of 75.7%. Conclusions: Our study cautiously suggested that the optimal value of AFP in the diagnosis of HCC might be switched 200 ng/ml to 100ng/ml.