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      • B형 바이러스 감염의 가족내 전염양상

        김현정,홍성호,조주연 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

        Background : It is well known that Korea is and endemic area for viral hepatitis B and reported that the HBsAg positive rate reaches about 7.3% in korea. In this study we investigated intrafamilial spread of hepatitis B Virus infection, because the contact between family members is close. Methods : From January 1995 to August 2002, 104 patients who were diagnosed as hepatitis B in one college hospital in Seoul and their 289 family members were surveyed about HBsAg positive rate of patient's family members according to patient's HBeAg, IgM anti-HBc, liver function and family relation. Results : Cross HBsAg positive rate was 16.96%(49/289). When patient's HBeAg was positive, HBsAg positive rate was 22.14%(29/131), when negative, it was 17.02%(16/94). When patient's IgM anti-HBc was positive, it was 13.04%(6/46), when negative, it was 14.08%(12/81). When patient's liver function was abnormal, HBsAg positive rate was 9.28%(14/151), when normal, it was 23.7%(32/135). According to patient's family relation, HBsAg positive rate was' 8.3% between husband and wife, 1.64% father and son, 2.22% father and daughter, 44% mother and son, 29.64% mother and daughter, 28.57% among brothers and among sisters, 58.33% between brothers and sisters. Conclusion : The HBsAg positive rate in hepatitis B patient's family was 16.96% and higher than that of heathy adult's. In family, the HBsAg positive rate was high between brothers and sisters, mother and son, mother and daughter. According to patient's HBeAg, IgM anti-HBc, and liver function, the HBsAg positive rate was not statistically significant.

      • 직업 유무와 진균 감염

        오상철,홍성호,조주연 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

        Back ground : This study was designed to evaluate the relation fungal infection with the males and females with/without occupation and to evaluate cause of fungal infection Methods : This study was done via direct interview and KOH mount with 03 patients who are oupatients in a university hospital from July 2000 to Aprill 2001. They were divided into three groups, males with occupation, females with occupation, females withoup occupation and sudied by sex, age, duration, types of dermatophytosis, site of infection, infection in families. Results : The results were as follows 1. Fungal infection was 40% in males with occupation, 24% in females with occupation, 36% in females without occupation. 2. The site of fungal infection was the offices(42.5%), the families(30%) in men with occupation and the families(54.2%), the offices (41.7%) in females with occupation and the families(72%), the others(11.1%) in females withoup occupation. 3. The members of the families were the spouses(32.5%), the parents or children(32.5%) in men with occupation and the spouses(41.7%), the parents or children(25.0%) in females with occupation and the spouses(69.4%), the parents or children(13.9%) in females without occupation. Conclusions : In our study, the results showed no difference in the fungal infections among males with occupation, females with occupation and females without occupation. Fungal infection of females without occupation was spread in the families and by the pouse among the members of the families

      • 최근 5년간 급성 A형 간염으로 입원한 환자들에 대한 입원 내용 분석

        장재영,유병욱,조용진,오정은,홍성호,조주연 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.1

        Abstract Background : Due to improvements in Korea's sanitary conditions, antibody rates to the hepatitis A virus is decreasing rapidly and admission due to the disease is increasing, Patients who were admitted for hepatitis A during the last 5 years were selected and yearly differences in admission, clinical picture, medical fees, and differences according to age and gender were analyzed. Methods : Patients who were admitted to the Seoul Soonchunhyang University Hospital during the 5 year period between May of 2003 and April of 2008 and tested positive for IgM anti-HAV were selected and their medical records retrospectively analyzed. Results : 156 subjects [91 male (58%), 65 female (42%) were selected. The average age was 29.2 years (range; 21.4-37), average admission period 12.6 days (range; 12.5-1 7.7) days, and average medical fees 2,295,151 (range; 932,097-3,658,205) KRW(Korean Won), Yearly incidence rates were as follows : 10 for May, 2003 to April, 2004, 14 for May, 2004 to April, 2005, 23 for May, 2005 to April, 2006, 69 for May, 2006 to April, 2007, and 41 for May, 2007 to April, 2008, The maximum value median of AST, ALT, and bilirubin during admission was 989 IU/L, 1999 IU/L, and 5.6 mg/dL each, Each factors were all positively correlated with the patient's age. Conclusions : Recent decrease in antibody positivity of the hepatitis A virus and subsequent surge of acute hepatitis A is a cause of rising socioeconomic costs. A large scale epidemiologic research on whether HAV vaccination should be made mandatory and health insurance applied seems to be needed. Key words : Hepatitis A, Age, Medical fees, Vaccination

      • 혈청 감마지티(gamma glutamyl transferase)치와 대사증후군의 연관성

        장미,유병욱,조용진,오정은,홍성호,조주연 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

        Background: Serum gamma glutamyl transferase(GGT) level has been widely used as an index of liver dysfunction and a marker of alcohol intake. But, recently it is identified that the elevated GGT level was associated with insulin resistance. This study aimed to examine the association between metabolic syndrome and elevated GGT level in the women who had less alcoholic influence generally. Methods: From 585 women who received their annual health check-up, 577 women were selected for analysis except for 28 women who had hepatitis B surface antigen positive or antibody to hepatitis C virus positive, Categories of serum GGT were classified into four groups by quartile and then evaluated. Results: A abnormal GGT level(≥52U/L) was seen in 29(5.2%) of the 557 women. As GGT level increased, the prevalence rate of factors(body mass index≥25kg/m2, hypertension, hemoglobin≥14g/dL, total cholesterol≥220mg/dL, triglyceride≥150mg/dL, fasting plasma glucose≥110mg/dL, HDL-choles tero1<50mg/dL) except for hyperuhcemia was increased. The GGT level was correlated with age, body mass index, thglyceride and uric acid in women with fatty liver, but not in women without fatty liver. Factors independently contributing to elevated GGT level was diabetes, hyperthglycehdemia and obesity. Conclusion: The elevated, albeit normal, GGT level was strongly associated with the factors of metabolic syndrome in Korean women. Because measurement of serum GGT level is easy, reliable, and not expensive, it might have more important implication as predictive factor of metabolic syndrome.

      • KCI등재

        노인의 당뇨병성 근위축증

        조주연(Choo-Yon Cho),민병이(Byung-Yee Min),오태연(Tae-Yeon Oh),김지은(Ji-Eun Kim),김충열(Chung-Yeol Kim),이동민(Dong-Min Lee),장미(Mi Jang) 대한임상노인의학회 2013 대한임상노인의학회지 Vol.14 No.1

        당뇨병성 근위축증(diabetic amyotrophy)은 동통성 비대칭성 또는 대칭성 다발신경병증의 일종으로 발생율은 당뇨환자의 1% 정도이며 50세 이상의 경한 당뇨병 환자에서 발생하고, 대퇴부위의 통증과 함께 시작되어 근력의 약화와 근육위축을 야기할 수 있다. 진단기준은 신경학적 증상이 시작되거나 이전에 진단된 당뇨병과 갑자기 시작된 하지 동통, 한쪽 또는 양쪽의 하지 근육의 근력약화, 근전도상 근육질환 배제와 종양 혹은 다발성 척추 협착증의 배제 등을 포함한다. 당뇨병성 근위축증은 감각 신경에 의한 증상은 없는 것이 특징이며, 병리기전 및 임상 양상에 따라 비대칭적이거나 빠른 진행을 보이는 혈관성 또는 체중 감소가 선행되거나 대칭으로 서서히 진행하는 대사성의 두 가지 분류로 나눌 수 있다. 신경전도검사, 근전도검사 및 자율신경검사를 시행할 수 있으며 다른 다발성말초신경병증과의 감별이 필요할 경우에 한하여 말초신경생검을 시행할 수 있다. 예후는 당뇨 조절을 잘 하면 자연적으로 호전된다고 하나 그 기전에 대해서는 뚜렷이 밝혀지지는 않았다. Diabetic amyotrophy in the elderly is considered as a distinctive form of diabetic neuropathy. It is characterized by weakness of proximal muscles either unilaterally or bilaterally, and is associated with pain. It is usually seen in patients with poorly controlled or previously unrecognized diabetes mellitus, and weight loss is a common concomitant. We report a case of an elderly patient with recently uncontrolled diabetes mellitus who has diabetic amyotrophy. A 65-year-old woman diagnosed with diabetes mellitus 5 years ago, was admitted with weight loss, mild pain, and weakness in both calfs, causing difficulty in walking and abrupt gait disturbance and consequently repeated falls.

      • KCI등재

        한국 노인의학 교육과 진료의 현황과 발전 방향

        조주연(Choo yon Cho) 대한임상노인의학회 2017 대한임상노인의학회지 Vol.18 No.2

        The growth of elderly population accompanied by their chronic diseases and medical expenses following the extension of life expectancy may cause huge problems and conflicts in the family and socioeconomically. Furthermore, geriatrics is gaining stronger ground as measures for aging, frailty and geriatric syndromes. Geriatrics need to be strengthened in classes and clinical rotations at medical schools as well as in residency trainings and fellowships. Professional geriatricians should be cultivated by the cooperation of the current geriatric academies and associated organizations. The importance of long term care and assisted living facilities for management of geriatric chronic diseases are being noted, by which continuous and integrated care should be sought. For this, systematic improvements and perceptional changes in the society need to be made. Now is the time for discussions, in-depth analyses and self-evaluation to come up with measures, such as regular family doctor system, to improve the quality of elderly lives.

      • KCI등재

        Factors Associated with Functional Dependence in Alzheimer's Disease

        조주연(Choo-Yon Cho),조항석(Hang-Suk Cho),조경희(Kyung-Hee Cho),최경규(Kyoung-Gyu Choi),오희종(Hee-Jong Oh),김대현(Dae-Hyun Kim),정승필(Seung-Pil Jung),최규동(Kyu-Dong Choi),이홍수(Hong-Soo Lee),배철영(Chul-Young Bae) 대한임상노인의학회 2000 대한임상노인의학회지 Vol.1 No.1

        연구배경 : 노인의 인지장애는 노인성 치매로 잘 알려진 알쯔하이머병의 기능적 상태가 감소한 경우와 연관이 많다. 그러나 이러한 인지장애가 기타 신체적, 정신적, 사회적 및 가족적 문제와 어느 정도까지 병존하고 있는지는 아직도 많이 알려져 있지 않은 편이다. 이 연구의 목적은 흔한 노인성 조건들, 가족기능, 그리고 영양학적 문제들이 기능적 의존성과 독립적으로 연관되어 있는지를 알아보기 위하여 시행되었다. 방법 : 1997년도 12월부터 1998년도 6월까지 우리나라의 9개 종합병원 및 대학병원 가정의학과, 신경과 및 노인병클리닉에 내원하거나 입원한 53명의 알쯔하이머병 환자들이 대상이 되었다. 모든 환자들은 치매에 관한 DSM-IV 진단기준 및 NINCDS-ADRDA 기준상 probable Alzheimer's disease에 부합하였으며, 모두 경도 내지 중등도의 인지장애를 보였고, 언어소통이 가능하였다. 종속변수는 기본적 일상생활활동 (Basic Activities of Daily Living, BADLs) 및 도구적 일상생활활동 (Instrumental Activities of Daily Living, IADLs) 이었고, 주요 독립변수에는 정신상태, 우울, 흔한 노인성 조건들 19가지, 가족기능, 영양상태 등이 포함되었다. 기술통계학과 사회인구학적 및 건강변수들과 같은 혼란변수를 통제하기 위하여 다변량분석을 사용하였다. 결과 : 알쯔하이머병 환자들의 56%가 하나 이상의 ADLs 의존성을 보였으며, 그중 목욕하기 (55%), 옷입기 (47%) 등에서 어려움을 보였으며, IADLs 의존성중에서는 여행 (79%), 집안일 (79%), 재정관리 (79%) 등에서 의존성이 높았다. 알쯔하이머병 환자들에 영향을 미치는 일부노인성 조건들, 그중 특히 피로, 요실금, 구갈, 수면장애, 낙상력, 눈의 통증, 어지러움, 슬관절통, 체중감소, 요통 등의 경우 IADLs 의존성과 다발성 연관관계를 보였고, 낮은 교육수준, 요실금 등은 ADLs 의존성과 관련이 깊은 것으로 나타났다. 이러한 결과들은 ADLs, IADLs 개개항의 의존성, 조건들이 독립적인 예측인자가 될 수 있으므로 그에 대한 의학적 가료를 요할 것을 의미하며, 하나의 조건을 예방하는 것으로는 그 이상의 IADLs 의존성을 방지하는데 충분하지 못하다는 것이다. 즉, 여러 가지 활동의 의존성 및 조건들이 개개인의 결과변수에 독립적으로 관련하기 때문에 그들의 기능적 의존성 이 예견된다면 이러한 다발성 조건들은 동시에 치료하여야 할 필요가 있다고 할 수 있겠다. 결론 : 알쯔하이머병의 기능적 의존성과 흔한 노인성 조건들에 대하여 조사한 결과, 일부 조건들이 알쯔하이머병의 기능적 상태에 미치는 효과를 최소화하기 위한 노력이 개개인에 맞게 이루어져야 하고, 다발성 질환들을 다스려야 할 필요가 있다는 것이다. 알쯔하이머병에 대한 성공적인 평가 및 치료는 환자의 개개 의학적 조건들의 기능적 상태에 독립적으로 기여하는가에 대해 사려깊게 짚어보아야 할 것이다. 그 개연성의 문제에 대하여서는 알쯔하이머병에 대한 종적 및 기타 실험적 자료들이 계속 나와야 할 것이다. Background : The purpose of this study was to determine whether common geriatric conditions, family function, and nutritional problems had an independent association with functional dependence beyond the effect of cognitive impairment in 53 patients with Alzheimer's diseases. Methods : The ample for this study consisted of 53 in-patients and out-patients of nine hospitals in Korea. All subjects met DSM-IV criteria for dementia and NINCDS-ADRDA criteria for probable Alzheimer's disease. Among fifty-three patients with probable Alzheimer's disease, all were mildly to moderately impaired and communicable. Chi-square tests were performed to assess bivariate relationships between the selected social and demographic factors, common geriatric conditions, nutritional status, and functional status. Multivariate analyses were done using logistic regression models to adjust for the potentially co nfounding effects of sociodemographic and health variables. Results : 56.6% of the study population was dependent on one or more items in ADLs. The most prevalent items of ADL dependence were bathing (54.7%) and dressing (47.2%). Subjects with lower education level, poor cognition, and poor nutrition were more likely to be dependent. Low educational level, poor cognition, and urinary incontinence were associated with the increased risk of ADL dependence. Several conditions are independently associated with the specific items of IADLs. Each item of IADL dependence of the patient has its own set of independent predictors. Some conditions are more universal in independently predicting IADL dependence. Conclusion : It was found that some common geriatric conditions affecting patients with Alzheimer's diseases appear to have multiple and differential relationships with the specific instrumental activities of daily living (IADLs) dependences. These results have implications for medical care. Preventing one condition may not be sufficient to prevent future IADL dependences since in most cases more than one condition is independently related to each outcome variable. Thus, multiple conditions may need to be managed concurrently if further functional dependence is to be expected.

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