http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Christopher Chen,Jaecheol Kim,Keum Taek Hwang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Radish (Raphnus sativus) sprouts are well known for their considerable amount of phenolic compounds. This study aimed to investigate the effect of blue and red LEDs on the phenolic content and antioxidant capacities in radish sprouts. The radish seeds were germinated in darkness and cultivated under red or blue LED (12 h of darkness+12 h of LED exposure per day). Sprouts were collected on the 4th and 7th days after germination and extracted with 70% methanol to evaluate total phenolic content (TPC), total flavonoid content (TFC), and DPPH and ABTS free radical scavenging activities. The radish sprouts cultivated under red LED contained the highest TFC (120±7.7 mg quercetin equivalent/100 g dry weight) (p<0.05), but there were no significant differences (P>0.05) between the both LED groups. DPPH and ABTS free radical scavenging activities of the red LED group were significantly higher (73.2±3.2% and 99.8 ± 0.02 % respectively) than the other groups on the 4th day after germination (P<0.05). It is suggested that exposure of radish sprouts to red LED might increase the phenolic contents, contributing to their higher antioxidant activities.
Amanda G.Y. Chen,Marleen S.L. Offereins,Christopher J. Mulder,Christopher M. Frampton,Richard B. Gearry 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.12
We investigated the impact of the ingestion of two green kiwifruit (Actinidia deliciosa var. Hayward) and one Royal Gala apple on breath hydrogen and methane production in humans. Consumption of two green kiwifruit led to no evidence of carbohydrate malabsorption (0/20), whereas consumption of one apple was associated with carbohydrate malabsorption in 6/20 participants (P = .008). There were no significant differences in the area under the curve for hydrogen or methane breath concentrations after consumption of the two fruits. Rates of lactose and fructose breath tests in this cohort were within expected parameters. Green kiwifruit are not associated with clinically significant carbohydrate malabsorption compared with apples in this pilot study.
Chen, Changkun,Nicolet, Christophe,Yonezawa, Koichi,Farhat, Mohamed,Avellan, Francois,Tsujimoto, Yoshinobu Korean Society for Fluid machinery 2009 International journal of fluid machinery and syste Vol.2 No.3
The effects of acoustic modes in the penstock on the self-excited oscillation in hydraulic power system were studied by assuming a finite sound velocity in the penstock. The flow in the draft tube is considered to be incompressible assuming that the length of the draft tube is smaller than the wavelength of the oscillation. It was found that various acoustic modes in the penstock can become unstable (amplified) by the diffuser effect of the draft tube or the effect of swirl flow from the runner. Their effects on each mode are discussed.
Experimental Study and Numerical Simulation of Cavity Oscillation in a Conical Diffuser
Chen, Chang-Kun,Nicolet, Christophe,Yonezawa, Koichi,Farhat, Mohamed,Avellan, Francois,Miyazawa, Kazuyoshi,Tsujimoto, Yoshinobu Korean Society for Fluid machinery 2010 International journal of fluid machinery and syste Vol.3 No.1
Based on the one-dimensional stability analysis, the self-excited oscillation in hydraulic power generating systems was studied by a simple experiment and numerical simulation. It was shown that a cavity in a conical diffuser can cause surge. With the diffuser, a high amplitude and low frequency oscillation occurs at low cavitation number. This oscillation was not observed with the straight pipe. It was confirmed that the diffuser effect of the draft tube can be the cause of the full load surge in hydraulic power system. Numerical results were also analyzed to check the validity of the one-dimensional stability analysis.
Utility of skull X-rays in identifying recurrence of coiled cerebral aneurysms
Chen Peng Roc,Lopez-Rivera Victor,Conner Christopher R,Sanzgiri Aditya,Sheth Sunil A.,Erkmen Kadir,Kim Dong H,Day Arthur L. 대한뇌혈관외과학회 2021 Journal of Cerebrovascular and Endovascular Neuros Vol.23 No.2
Objective A high rate of cerebral aneurysm recurrence following endovascular coiling has prompted the use of digital subtraction angiography (DSA) for interval follow-up. However, the utility of skull x-rays as an alternative screening method for aneurysm recurrence is unproperly characterized. Methods Retrospective review of a prospective registry of ruptured and unruptured cerebral aneurysms. Anteroposterior and lateral skull x-rays were obtained immediately at the end of the procedure and at 6-month follow-up. Aneurysm recurrence was defined by comparing post-procedure and 6-month DSA imaging. A true positive was defined as a change in coil mass morphology on at least one projection with aneurysm recurrence on DSA, and a true negative defined as a stable coil mass on both projections and no recurrence on DSA. Receiver operating characteristic area under the curve (AUC) statistics was used to assess the performance of skull x-rays in identifying aneurysm recurrence. Results A total of 118 cerebral aneurysms were evaluated with DSA imaging and skull x-rays. A change in coil mass morphology on one projection of skull x-rays correctly detected all true recurrences with a sensitivity of 100% (95% confidence interval [CI], 91-100%). Skull x-rays failed to identify a stable aneurysm coil mass in 15 cases, with a specificity of 79% (68-88%). Skull x-rays performed with AUC 0.8958 (95% CI, 0.8490-0.9431) in identifying aneurysm recurrence. Conclusions The findings of our study suggest that skull x-rays may represent a low-cost, non-invasive screening tool to rule out aneurysm recurrence, which can potentially aid in decreasing the utilization of DSA in the follow-up of patients with coiled cerebral aneurysms. Objective A high rate of cerebral aneurysm recurrence following endovascular coiling has prompted the use of digital subtraction angiography (DSA) for interval follow-up. However, the utility of skull x-rays as an alternative screening method for aneurysm recurrence is unproperly characterized. Methods Retrospective review of a prospective registry of ruptured and unruptured cerebral aneurysms. Anteroposterior and lateral skull x-rays were obtained immediately at the end of the procedure and at 6-month follow-up. Aneurysm recurrence was defined by comparing post-procedure and 6-month DSA imaging. A true positive was defined as a change in coil mass morphology on at least one projection with aneurysm recurrence on DSA, and a true negative defined as a stable coil mass on both projections and no recurrence on DSA. Receiver operating characteristic area under the curve (AUC) statistics was used to assess the performance of skull x-rays in identifying aneurysm recurrence. Results A total of 118 cerebral aneurysms were evaluated with DSA imaging and skull x-rays. A change in coil mass morphology on one projection of skull x-rays correctly detected all true recurrences with a sensitivity of 100% (95% confidence interval [CI], 91-100%). Skull x-rays failed to identify a stable aneurysm coil mass in 15 cases, with a specificity of 79% (68-88%). Skull x-rays performed with AUC 0.8958 (95% CI, 0.8490-0.9431) in identifying aneurysm recurrence. Conclusions The findings of our study suggest that skull x-rays may represent a low-cost, non-invasive screening tool to rule out aneurysm recurrence, which can potentially aid in decreasing the utilization of DSA in the follow-up of patients with coiled cerebral aneurysms.
Experimental Study and Numerical Simulation of Cavity Oscillation in a Diffuser with Swirling Flow
Chen, Chang-Kun,Nicolet, Christophe,Yonezawa, Koichi,Farhat, Mohamed,Avellan, Francois,Miyazawa, Kazuyoshi,Tsujimoto, Yoshinobu Korean Society for Fluid machinery 2010 International journal of fluid machinery and syste Vol.3 No.1
The cavity oscillation with swirling flow in hydraulic power generating systems was studied by a simple experiment and numerical simulation. Several types of fluctuation were observed in the experiment, including the cavitation surge caused by the diffuser effect and the vortex precession by the swirling flow. Both cavitation surge and vortex precession were simulated by CFD. Detailed flow structure was examined through flow visualization and CFD.
Absorbate-Induced Piezochromism in a Porous Molecular Crystal
Hendon, Christopher H.,Wittering, Kate E.,Chen, Teng-Hao,Kaveevivitchai, Watchareeya,Popov, Ilya,Butler, Keith T.,Wilson, Chick C.,Cruickshank, Dyanne L.,Miljanić,, Ognjen Š,.,Walsh, Aron American Chemical Society 2015 Nano letters Vol.15 No.3
<P/><P>Atmospherically stable porous frameworks and materials are interesting for heterogeneous solid–gas applications. One motivation is the direct and selective uptake of pollutant/hazardous gases, where the material produces a measurable response in the presence of the analyte. In this report, we present a combined experimental and theoretical rationalization for the piezochromic response of a robust and porous molecular crystal built from an extensively fluorinated trispyrazole. The electronic response of the material is directly determined by analyte uptake, which provokes a subtle lattice contraction and an observable bathochromic shift in the optical absorption onset. Selectivity for fluorinated absorbates is demonstrated, and toluene is also found to crystallize within the pore. Furthermore, we demonstrate the application of electronic structure calculations to predict a physicochemical response, providing the foundations for the design of electronically tunable porous solids with the chemical properties required for development of novel gas-uptake media.</P>
RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure
Gao, Chen,Ren, Shuxun,Lee, Jae-Hyung,Qiu, Jinsong,Chapski, Douglas J.,Rau, Christoph D.,Zhou, Yu,Abdellatif, Maha,Nakano, Astushi,Vondriska, Thomas M. American Society for Clinical Investigation 2016 The Journal of clinical investigation Vol.126 No.1
Photoinitiated ring‐opening metathesis polymerization
Joo, Wontae,Chen, Christopher H.,Moerdyk, Jonathan P.,Deschner, Ryan P.,Bielawski, Christopher W.,Willson, Carlton Grant John WileySons, Inc. 2019 Journal of polymer science Part A, Polymer chemist Vol.57 No.17
<P>This study is based on a latent ruthenium catalyst that includes a Schiff base moiety. This catalyst was formulated with a photoacid generator and a ring‐opening metathesis polymerization (ROMP) active monomer such as cyclooctadiene or dicyclopentadiene. Exposure of this mixture to ultraviolet light generates acid that protonates the Schiff base and thereby renders the latent catalyst active, leading to ROMP of the monomer. A resist system based on new photoinitiated ROMP chemistry has been developed. This type of formulation has been used to produce high‐resolution replicas of a transparent mold by imprint lithography.</P>
Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer's Disease Patients in Asia
박기형,양영순,Chen Christopher,심용수,Domingueze Jacqueline C.,이찬녕,강경훈,김희진,정슬기,정지향,Hong Zhen,윤수진,Zhang Zhen-Xin,김은주,장재원,Li Yansheng,Xu Yun,Lin Yu-Te,Qu Qiumin,Hu Chaur-Jong,Chou Chih-Ho,Fan Dongsheng,Kandiah N 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.3
Background and Purpose The rate of donepezil discontinuation and the underlying reasons for discontinuation in Asian patients with Alzheimer’s disease (AD) are currently unknown. We aimed to determine the treatment discontinuation rates in AD patients who had newly been prescribed donepezil in routine clinical practice in Asia. Methods This 1-year observational study involved 38 institutions in seven Asian countries, and it evaluated 398 participants aged 50–90 years with a diagnosis of probable AD and on newly prescribed donepezil monotherapy. The primary endpoint was the rate of donepezil discontinuation over 1 year. Secondary endpoints included the reason for discontinuation, treatment duration, changes in cognitive function over the 1-year study period, and compliance as assessed using a clinician rating scale (CRS) and visual analog scale (VAS). Results Donepezil was discontinued in 83 (20.9%) patients, most commonly due to an adverse event (43.4%). The mean treatment duration was 103.67 days in patients who discontinued. Among patients whose cognitive function was assessed at baseline and 1 year, there were no significant changes in scores on the Mini-Mental State Examination, Montreal Cognitive Assessment, and Trail-Making Test–Black and White scores, whereas the Clinical Dementia Rating score increased significantly (p<0.001). Treatment compliance at 1 year was 96.8% (306/316) on the CRS and 92.6±14.1% (mean±standard deviation) on the VAS. Conclusions In patients on newly prescribed donepezil, the primary reason for discontinuation was an adverse event. Cognitive assessments revealed no significant worsening at 1 year, indicating that continuous donepezil treatment contributes to the maintenance of cognitive function.