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      • Interleukin-1B(1L-1B) polymorphisms and gastric mucosal levels of IL-Iβ cytokine in Korean patients with gastric cancer

        Chang,,Young-Woon,Jang,,Jae-Young,Kim,,Nam-Hoon,Lee,,Jae,Won,Lee,,Hyo,Jung,Jung,,Woon,Won,Dong,,Seok-Ho,Kim,,Hyo-Jong,Kim,,Byung-Ho,Lee,,Joung-Il,Rin,Chang KYUNG HEE UNIVERSITY MEDICAL CENTER 2006 고황의학상 수상논문집 Vol.21-22 No.-

        Interleukin-1B and IL-1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL-1B-511T polymorphism and the risk of GC in Asians. We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1β and an increased risk of developing GC in a Korean population. Polymorphisms of IL-1A-889, IL-1B-31, IL-1B-511 and IL-1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL-1β cytokine was measured using an ELISA. The frequencies of IL-1A, IL-1B-511, IL-1B-31 and IL-1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal-type GC showed a higher frequency of IL-1B-31T homozygotes (OR = 2.2; 95% CI = 1.1-4.3) compared with controls. Risk was also significantly increased in these patients for IL-1B-31T homozygotes compared with patients with diffuse-type GC (OR = 3.4; 95% CI = 1.5-7.7). As in Caucasian populations, linkage disequilibrium between IL-1B-31 and IL-1B-511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL-1B-31T/IL-1B-511C) was opposite (IL-1B-511T/IL-1B-31C). Mucosal IL-1β levels in H. pylori-infected GC patients were higher in patients homozygous for IL-1B-31T compared with IL-1B-31C/T and IL-1B-31C/C. Thus, the combined effects of H. pylori infection and IL-1B-31T/IL-1B-511C polymorphisms with enhanced mucosal IL-1β production contributed to the development of intestinal-type GC in this Korean population.

      • SCOPUSSCIEKCI등재

        과도한 하안면 고경을 동반하는 하악전돌증한자의 하악골 후퇴술과 이부 감소 성형술식에 관한 연구

        장영일,임동혁,서정훈,김태우 대한치과교정학회 2000 대한치과교정학회지 Vol.30 No.3

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        본 연구는 과도한 하안면 고경을 동반하는 하악전돌증 환자의 악교정수술시 하악골후퇴 술과 이부 감소 성형술을 동시에 시행한 경우의 경조직과 연조직의 변화에 대해 살펴보고, 그 상관성을 평가하여 향후 진단시 보조자료로서 사용하고자 시행되었다. 골격성 Ⅲ급 부정교합으로 진단되어 술전 교정치료를 받고 하악골 후퇴 술만을 시행한 성인 환자 20명을 대조군(A군)으로, 안모의 수평적 및 수직적 부조화가 심한 골격성 Ⅲ급 부정교합으로 진단되어 술전 교정치료를 받고 하악골 후퇴술과 이부 감소 정형술을 함께 시행한 성인 환자 20명을 실험군(B군)으로 하였다. 두 군의 경조직 변화에 대한 연조직 변화 양상과, 경조직 변화에 따른 연조직의 이동 비율을 비교 분석하여 다음과 같은 결론을 얻었다. 1.A, B군 모두에서 경조직의 후방 이동과 하안면 하부 2/3의 연조직(Ils, Pog', Me')의 수평적 변화는 높은 상관성을 보였으며, B군에서는 A군에서보다 Ls, Stm, Li의 수평적 변화에도 중등도 이상의 상관성을 보였다. 2.B군의 경조직의 수직 이동에 따른 연조직의 수직적 변화의 상관성은 Point B-Ils, Me-Me'을 제외하고는 A군보다 적은 것으로 나타났다. 3.경조직의 변화에 대한 연조직의 변화율을 비교해 보면, B군의 경우 Pog'의 후방이동 비율이 A군에서보다 적게 나타났고, B군의 Ils, Pog', Me'의 상방이동 비율은 각각 32%, 54%, 60%로 나타났다. 4.안면의 수직 고경에 대해서는 A, B군 모두에서 하안면 고경의 유의한 감소로 전안면 고경에 대한 하안면 고경의 비율이 감소하였으나, B군에서는 하안면 상부 1/3(Sn-Stm)의 비율은 변화 양상이 유의성있게 나타나지 않았다. 5. 이부 감소 성형술은 하악후퇴술과 함께 시행시 하안면 상부 1/3(Sn-Stm)의 안모비율에 대한 변화가 적고, 하안면 하부 2/3(St-Me')의 고경을 감소시킬 수 있는 술식이다. The purpose of this study was to evaluate the amount and interrelationship of hard and soft tissue changes after mandibular setback osteotomy and reduction genioplasty in mandibular prognathism with long anterior facial height. The control group (Group A) consisted of 20 patients who had severe horizontal discrepancy. They experienced presurgical orthodontic treatment and orthognathic surgery via mandibular setback. The experimental group (Group B) consisted of 20 patients who had severe horizontal and vertical discrepancy. They experienced presurgical orthodontic treatment and orthognathic surgery via mandibular setback and reduction genioplasty. The presurgical and postsurgical lateral cephalograms were evaluated. The computerized statistical analysis was carried on with EXCEL 97 program. The results were as follows : 1.The correlation of hard and soft tissue horizontal changes in lower 2/3 of lower anterior facial height were high for both groups. The correlation coefficients of hard tissue changes and Ls, Stm, Li changes in Group B were moderately higher than Group A. 2.The correlation of hard and soft tissue vertical changes in Group B were lower than Group A. (except for pointB-Ils, Me-Me') 3.The ratio for soft tissue to Pog in Group B was lower than Group A. The ratios of hard and soft tissue vertical changes were 32% at Ils, 54% at Pog', and 60% at Me'. 4.The ratio of lower anterior facial height to total anterior facial height was reduced for both groups. But ratio of upper 1/3 of lower anterior facial height to total anterior facial height did not changed significantly in Group B. 5.Reduction genioplasty combined with mandibular setback procedure showed no change in upper one third(Sn-Stm) and significant decrease(Stm-Me') in the lower two thirds of the soft-tissue anterior lower facial height.

      • 화상환자에서 면역억제 기전

        정태호,황일우,장수일,김문규,서정민,정치영,김정철 慶北大學校 醫科大學 1995 慶北醫大誌 Vol.36 No.4

        목적 : 본 연구는 화상환자에서 면역이상의 기전을 조사코져 T-세포의 활성을 나타내는 가용성 interleukin-2 수용체(IL-2R), 대식세포의 활성을 나타내는 neopterin, tumor necrosis factor(TNF) 및 interleukin-6 (IL-6), 그리고 호중구의 활성을 반영하는 elastase-α1-antitrypsin을 측정하였다. 또한 lipopolysaccharide(LPS)가 이들 면역세포의 활성화에 미치는 영향을 조사하였다. 대상 및 방법 : 30예의 화상환자를 대상으로 화상후 1일, 7일, 14일, 21일, 28일에 각각 혈액을 채취하여 혈청중 가용성 IL-2R, TNF, IL-6, 그리고 elastase-α1-antitrypsin은 각각 효소면역법으로, 혈청중 neopterin은 radioimmunoassay법으로 측정하였다. LPS가 말초 단핵세포에 미치는 영향은 역전사 중합효소 연쇄반응을 통하여 각종 cytokines의 mRNA 발현을 측정하였다. 결과 : 화상환자에서 혈청중 가용성 IL-2R은 화상후 1일째부터 대조군에 비하여 유의성 있게 증가되어 7일과 14일째에 최고치를 나타냈으며 그 이후에는 다소 감소하였으나 대조군보다는 유의한 증가를 나타냈다. 화상환자를 중화상, 중등도화상, 경도화상으로 분류하여 혈청중 가용성 IL-2R 치를 비교해본 결과 중증 화상일수록 더욱 높은 치를 나타냈다. 화상환자에서 혈청중 neopterin 역시 화상후 1일째부터 증가되어 전 관찰기간 동안 대조군에 비해 유의한 높은 치를 나타냈다. 경도화상과 중등도 화상에서는 서로 유의한 차이를 보이지 않았으나 중환자에서는 경도 혹은 중등도 화상환자에 비해 유의한 증가를 보였다. 화상환자에서 혈청중 TNF 농도는 화상후 1일부터 증가되어 관찰전기간에 걸쳐 유의한 증가를 나타냈으며 중등도 화상환자에서 가장 높은 치를 보였다. 혈청중 IL-6치 역시 화상 전기간에 걸쳐 대조군보다 유의한 증가를 나타냈으며 중화상 환자에서 가장 높은 치를 나타냈다. 화상은 또한 혈청중 elastase-α1-antitrypsin 농도를 현저히 증가시켰다. 즉 화상후 1일에 elastase-α1-antitrypsin 농도는 정상인보다 5배 높았으며 그 이후 약 4주간 계속 높은 농도를 유지하다가 환자가 회복되면서 감소하는 경향을 나타내었다. 중등도화상 및 중화상환자의 혈청중 elastase-α1-antitrypsin 농도는 경도 화상환자에서 비해 유의한 증가를 보였다. 한편 화상환자에서 면역이상을 초래하는 주된 요인으로 여겨지는 lipopolysaccharide는 면역세포를 총체적으로 활성화시켜 IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF, IFN-γ, TGF-β, GM-CSF, IL-2R의 유전자발현을 현저히 증가시켰다. 결론 : 화상환자에서 T-세포, 대식세포, 호중구의 활성화를 반영하는 가용성 IL-2R, neopterin, ,TNF, IL-6, elastase-α1-antitrypsin치가 혈중에 증가되어 있으며 화상의 정도가 심할수록 더 높았다. Cell-mediated immunity frequently becomes severely impaired after thermal injury. However, the cause of postburn immune dysfunction is unclear and controversy exists over both pathophysiology and clinical relevance of these abnormalities. This study was undertaken to investigate the immune responses in vivo of patients with burn. Levels of soluble IL-2R, a sensitive marker of T-cell activation, levels of serum TNF, IL-6, and neopterin, an index of macrophage activation, and levels of serum elastase-α1-antitrypsin, an index of neutrophil activation, were measured in serial serum samples taken from 30 burned patients. In patients with burn, soluble IL-2R levels were increased over a 4-week interval with peak concentrations reached during the 2nd week after burn. Patients with severe burn showed a higher soluble IL-2R levels than those with mild or moderate burn. In addition soluble IL-2R significantly correlated with burn size. The levels of serum neopterin were already increased at the first day following burn, and remained at a high level throughout the total period studied (28 days). Patients with severe burn showed significantly higher concentration of serum neopterin than mild or moderate burn. There was positive relationship between the burn sizes and the levels of neopterin. A significant positive correlation was also found between serum soluble IL-2R levels and neopterin levels in burn patients. Levels of serum TNF and IL-6 were also significantly increased over a 4-week interval in burn patients. The levels of serum elastase-α1-antitrypsin were also already increased at the first day following burn, and remained at a high level over a 4-week. Patients with moderate or severe burn showed significantly higher concentration of serum elastase-α1-antitrypsin than those with mild burn. There was no significant relationship between the burn extent and the level of elastase-α1-antitrypsin. LPS increased the transcription of all the cytokines we examined in peripheral mononuclear cells, i.e., IL-1α, IL-1β, IL-2, IL-4, IL-5_IL-6, IL-8, IL-10, TNF, TGF-β, GM-CSF, and IL-2R. We conclude that soluble IL-2R, neopterin, TNF, IL-6, and elastase-α1-antitrypsin might be useful parameters for monitoring of the clinical course in burn patients. Moreover, they indicate that T-cell, macrophage, and neutrophil activation might play the central role in the pathogenesis of the immuno-logic and metabolic disturbance that follows thermal injury.

      • KCI등재

        폐포 대식세포 및 단핵구가 Interleukin-2 Enhanced Natural Killer 및 LAK Activity에 미치는 영향

        조철호,김병일,김세규,천선희,김형중,장준,안철민,김성규,이원영,윤정구 대한내과학회 1992 대한내과학회지 Vol.42 No.5

        저자들은 폐포 대식세포 및 말초혈액내의 단핵구가 NK 활성도 및 LAK 활성도에 미치는 영향을 보기위하여, 임파구에 여러 가지 농도(0, 100 : 1, 10 : 1, 1 : 1)의 폐포 대식세포와 단핵구를 넣어 IL-2 enhanced NK 활성도 및 LAK 활성도를 비교하여 다음과 같은 결과를 얻었다. 1) 여러 가지 농도의 단해구는 IL-2 enchanced NK 활성도 및 LAK 활성도에 영향을 미치지 않았다. 2) 동량의 페포대식세포(임파구 : 폐포 대식세포= 1 : 1)는 IL-2 enhanced NK 활성도를 의의있게 억제하였으나(p<0.05), 소량의 폐포대식세포(임파구 : 폐포 대식세포-10 : 1과 100 : 1)는 IL-2 enhanced NK 활성도를 억제하지 못하였다. 3) 임팍와 폐포 대식세포의 비율이 1 : 1과 10 : 1에서는 LAK 활성도를 의의있게 억제하였으나, 소량의 폐포대식세포(임파구 : 폐포 대식세포=100 : 1)는 LAK 활성도를 억제하지 못하였다(p<0.05). 이상의 결과로 IL-2 enhanced NK 활성도 및 LAK 활성도는 폐포 대식세포의 양에 비례하여 억제되었으나, 말초혈액내의 단핵구에 의해서는 영향받지 않는 것을 알 수 있었다. Alveolar macrophages (AM) are thought to function as primary effector cells against tumors growing in the lung. Systemic administration of lymphokine activated killer (LAK) cells and IL-2 resulted in partial antitumor response in patients with advanced cancer. LAK activity is influenced by various factors. We studied the effects of AM and blood monocytes from healthy donors on IL-2 enhanced NK activity against K-562 cells and LAK activity against Raji cells utilizing a 4h ^(51)Cr release assay. The following results were obtained: 1) The addition of different doses of human blood monocytes showed no suppression or enhancement of IL-2 enhanced NK and LAK activity. 2) The addition of high dose of AM (Lymphocyte: AM=1:1) significantly suppressed IL-2 enhanced NK activity. Smaller doses of AM (Lymphocyte: AM= 10:1and 100:1) did not suppress IL-2 enhanced NK activity. 3) The addition of high dose of AM (Lymphocyte: AM = 1:1 and 10:1) significantly suppressed LAK activity. The smallest dose of AM (Lymphocyte: AM= 100:1) did not suppress LAK activity. In conclusion, IL-2 enhanced NK and LAK activity were dose-dependently suppressed by human alveolar macrophages. However IL-2 enhanced NK and LAK activity were not suppressed by blood monocytes.

      • 전치개교의 교정치료후 과두위치 변화

        신수정,장영일 대한 두개하악장애학회 1993 대한두개하악장애학회지 Vol.5 No.2

        ABSTRACTThis study was aimed to evaluate the changes in condylar position when severe anterior open bite pa- tients were treated with MEAW.The subjects consisted of 11 patients(21 TMJs) who visited the departement of orthodontics in SNUH, having severe anterior open bite as a chief complain. They were supposed to wear the up and down elas- tics and MEAW after finishing the leveling. The condylar position was evaluated with individualized cor- rected tomography in centric occlusion taken before and after treatment.The results were as follows; 1. In the change of condylar position after treatment, there were no statistically significant differences in right and left TMJs. 2. In the change of condylar position after treatment, there were no statistically significant differences in each malocclusion groups. 3. There were no statistically significant differences in percent dispacement of condyle between before and after treatment. 4. There were no statistically significant differences in the amount of change in condylar change. This study was aimed to evaluate the changes in condylar position when severe anterior open bite patients were treated with MEAW. The subjects consisted of 11 patients(21 TMJs) who visited the departement of orthodontics in SNUH, having severe anterior open bite as a chief complain. They were supposed to wear the up and down elastics and MEAW after finishing the leveling. The condylar position was evaluated with individualized corrected tomography in centric occlusion taken before and after treatment. The results were as follows ; 1. In the change of condylar position after treatment, there were no statistically significant differences in right and left TMJs. 2. In the change of condylar position after treatment, there were no statistically significant differences in each malocclusion groups. 3. There were no statistically significant differences in percent dispacement of condyle between before and after treatment. 4. There were no statistically significant differences in the amount of change in condylar change.

      • 최빈국 지역정부의 기후변화적응계획 수립을 위한 기술적 가이드라인 개발 연구

        장훈 ( Hoon Chang ), 송영일 ( Young-il Song ), 심창섭 문지원 이명주) 한국환경정책평가연구원 2016 기후환경정책연구 Vol.2016 No.-

        전 세계적으로 기후변화가 가속화됨에 따라 이로 인한 영향과 피해가 더욱 심각해지고 있다. 선진국보다는 최빈국이 기후변화에 의한 위험에 더욱 취약함에 따라 유엔기후변화협약에서 는 최빈국을 대상으로 기후변화로 인한 피해 저감을 위하여 기후변화적응계획 수립을 권고하였다. 유엔개발계획, 유엔기후변화협약 등의 국제기구 혹은 몇몇 국가에서는 기후변화적응계획 수립 가이드라인을 마련하여 최빈국의 적응계획 수립을 지원하고 있으나 현재까지 적응계획의 수립은 저조한 상황이다. 2010년 COP16에서부터 기후변화적응계획 수립을 권고하였으나 48개 최빈국 중 현재까지 다섯 국가에서만 적응계획 수립을 완료하였다. 한편 유엔자본 개발기금5)에서는 최빈국 지자체의 기후변화적응 능력 향상을 위해 LoCAL 프로젝트를 추진하고 있으며, KEI는 국내에서의 기후변화적응계획 수립 노하우를 토대로 동 프로젝트에 기술적 측면의 지원을 하고 있다. 이러한 KEI 지원의 일환으로 본 연구에서는 최빈국 지역정부의 기후변화적응계획 수립을 위한 가이드라인을 개발하고 이를 최빈국 중 하나인 부탄에 적용하였다. 본 연구에서 제안하는 가이드라인의 세부적인 내용은 다음과 같다. 중앙정부뿐만 아니라 지자체에서도 활용 가능하도록 국내외 기후변화적응계획 수립 관련 가이드라인을 검토하여, 절차별 방법이나 특성을 파악하였다. 그리고 부탄 및 캄보디아와 같은 일부 최빈국을 방문하여 현지 조사를 통해 가이드라인의 개발 방향을 정립하였다. 본 연구에서 제안하고 있는 기후변화적응계획 수립의 절차는 국내 기초지자체의 계획 수립 절차를 참고하였고, 절차별 과학적인 평가 방법은 필요한 자료의 유무나 질을 고려하여 정성적 또는 정량적 측면의 방법을 총 8단계로 나누어 제안하였다. 지역의 일반 현황과 기후변화 현황을 분석하고, RCP 시나리오 기반의 기후변화 전망을 분석하여 향후 기온이나 강수량이 기후변화로 인해 어떻게 변화하는지 예측하는 방법을 제안하였다. 그리고 이해당사자를 대상으로 기후변화적응에 대한 니즈를 파악하여 우선적으로 고려해야 할 사항이 무엇인지 판단하고, 과거 구축된 자료를 바탕으로 기후변화로 인한 재해 및 영향이 무엇인지 분석하는 방안을 제안 하였다. 취약성 평가는 수행 여건에 따라 정량적, 정성적 방법으로 평가될 수 있으며, 리스크는 3회에 걸친 전문가 설문을 통해 정성적인 방법으로 분석하도록 하였다. 이와 같이 분석된 종합적인 평가 결과를 기존의 최빈국 개발사업(investment menu)과 비교하여 적응계획 이행을 위하여 우선적으로 추진해야 할 사업을 선정하고, 체계적인 평가 및 모니터링 전략을 구축하는 등 전반적인 적응계획 수립 및 이행에 걸친 방안을 제안하였다. Due to accelerated climate change, its impacts and devastations are increasing day by day. As developing countries are more vulnerable to climate change compared to developed countries, UNFCCC recommended the development of a climate change adaptation plan in order to reduce their exposure to risks derived by climate change. Since COP 16, 2010, developing countries were encouraged to establish National Adaptation Plans(NAPs). Including UNDP and UNFCCC, many organizations proposed guidelines to assist the development of NAPs. yet only 5 out of 49 countries have officially submitted them. Meanwhile, UNCDF has been supporting the developing countries to foster their climate change adaptation capacities through LoCAL projects, while the Korea Environment Institute(KEI) has been providing technical elements for the projects. In alignment to such activities, this research have employed the guideline for the formation of the adaptation plans for local governments in Bhutan as a pilot program. The guideline is comprised by the study of various climate change adaptation planning guidelines and its attributes of each procedures. As case studies, field missions were carried out in Bhutan and Cambodia to enhance the understanding of the research. In regards of the process on composing the National Adaptation Plans, this research referred to the Korean national adaptation plans of the local governments. In consideration of the availability and quality of statistical information, the scientific procedures has been comprised in eight qualitative and qualitative steps. Through the analysis of the region`s general circumstances, climatic factors and RCP based scenario examinations, this research presents how to estimate the shift of temperature and precipitation altered by climate change. Moreover it raises the necessity of the needs of climate change adaptation to be prioritized through stakeholders and added on to the accumulated data and reviewed in the aspects of climate change disasters. For the vulnerability assessment, depending on the circumstances, both qualitative and quantitative methods may be applied and the risk evaluation will be conducted by three stages of expert surveys. The outcome derived by such methodologies will be assessed with prior LDC investment menus and considered when selecting the priority projects for initiating the adaptation plans.

      • P223 : Long second toe: its nail and skin changes

        ( Geun-hwi Park ), ( Woo-il Kim ), ( Min-young Yang ), ( Won-ku Lee ), ( Tae-wook Kim ), ( Sung-min Park ), ( Hyun-joo Lee ), ( Gun-wook Kim ), ( Hoon-soo Kim ), ( Hyun-chang Ko ), ( Byung-soo Kim ), ( Moon-bum ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

        Background: Nail can be affected by trauma, infection, and systematic disorders. In particular, the toe nails are exposed to the repeated and cumulative minor traumas, which usually result in thickened, splitted, and discolorated nails. Considering these, it can be inferred that the long second toe can be related to various nail and skin changes by repeated minor traumas such as friction in shoes, but the study or report on this topic hasn't been done yet. Objectives: The purpose of this study was to introduce various nail and skin changes on long second toe. Methods: We analyzed the kinds of nail/skin changes of 50 patients with long second toe, enrolled at Pusan National University Hospitals (Busan and Yangsan) from 2013 to 2018. Results: There was no significant difference in the incidence of left and right toe and toenail, and 7 (14%) patients presented bilateral distribution. The most common nail change on long second toe was melanonychia (23, 46%), followed by subungual hematoma (15, 30%), onycholysis (2, 4%), subungual hyperkeratosis (2, 4%), onychomadesis (1, 2%), and retronychia (1, 2%). The most common skin change was corn (9, 18%), followed by paronychia (2, 4%). Twenty (20/50, 40%) patients also had other toe or toenail changes. Among them, the most common site was big toe/nail (13, 62%), and the most common change was subungual hematoma (8, 42%). Conclusion: Through this study, the dermatologists can recognize and diagnose the nail and skin changes of long second toe.

      • KCI등재

        퇴행성 관절염에서 Interleukin-6와 Soluble Interleukin-6 Receptor

        장재석 ( Jae Suk Chang ), 정용갑 ( Yong Gab Jeong ), 조우신 ( Woo Shin Cho ), 빈성일 ( Seong Il Bin ), 엄규황 ( Kyu Hwang Ym ), 김정화 ( Jung Hwa Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3

        Objective: Unlike other soluble receptors, the soluble interleukin-6 receptor (sIL-6R) cooperates with IL-6 to activate gp130 of effector cell. As the IL-6 and sIL-6R are important in the rheumatoid disease, this study was designed to measure concentration of IL-6 and sIL-6R in synovium and synovial fluid of the degenerative arthritis. Methods: The synovium and synovial fluid were obtained during total knee replacement arthroplasty. The synovium was taken from eleven patients, and synovial fluid taken from sixteen patients. Same patients between two groups were seven. Tissue cultures of the synovial tissues were done with 10% FBS for 72 hours. After irrigation, thery were incubated for 48 hours without FBS, and the culture media and the synovial fluid were collected after centrifuged at 2500rpm for 10 minutes. The level of IL-6 and sIL-6R were measured by quantitative sandwich enzyme immunoassay technique. Results: In the synovium, the IL-6 level was 5.1±0.12ng/ml, and the sIL-6R level was 0.41±0.25ng/ml. In the synovial fluid, the IL-6 level was 0.09± 0.15ng/ml, and the sIL-6R level was 10.37±3.28ng/ml. These results show that IL-6 concentration was measured highly in two groups, especially in synovium (sixty times), and the sIL-6R concentration was measured significantly high in synovial fluid (twenty-five times). Conclusion: The IL-6 and sIL-6R were elevated in degenerative arthrits. We confirmed the source of IL-6 was synovium (very high in synovial tissue culture media), but we need further study for the source of sIL-6R as it was remarkably elevated as IL-6 and its level was lower than serum.

      • SCOPUSSCIEKCI등재

        과도한 하안면 고경을 동반하는 하악전돌증환자의 하악골 후퇴술과 이부 감소 성형술식에 관한 연구

        장영일,임동혁,서정훈,김태우,Chang,,Young-Il,Im,,Dong-Hyuk,Suhr,,Jeong-Hoon,Kim,,Tae-Woo 대한치과교정학회 2000 대한치과교정학회지 Vol.30 No.3

        본 연구는 과도한 하안면 고경을 동반하는 하악전돌증 환자의 악교정수술시 하악골후퇴 술과 이부 감소 성형술을 동시에 시행한 경우의 경조직과 연조직의 변화에 대해 살펴보고, 그 상관성을 평가하여 향후 진단시 보조자료로서 사용하고자 시행되었다. 골격성 III급 부정 교합으로 진단되어 술전 교정치료를 받고 하악골 후퇴술만을 시행한 성인 환자 20명을 대조군(A군)으로, 안모의 수평적 및 수직적 부조화가 심한 골격성 III급 부정교합으로 진단되어 술전 교정치료를 받고 하악골 후퇴술과 이부 감소 성형술을 함께 시행한 성인 환자 20명을 실험군(B군)으로 하였다. 두 군의 경조직 변화에 대한 연조직 변화 양상과, 경조직 변화에 따른 연조직의 이동 비율을 비교 분석하여 다음과 같은 결론을 얻었다. 1. A, B군 모두에서 경조직의 후방 이동과 하안면 하부 2/3의 연조직(Ils, Pog', Me')의 수평적 변화는 높은 상관성을 보였으며, B군에서는 A군에서보다 Ls, Stm, Li의 수평적 변화에도 중등도 이상의 상관성을 보였다. 2. B군의 경조직의 수직 이동에 따른 연조직의 수직적 변화의 상관성은 Point B-Ils, Me-Me'을 제외하고는 A군보다 적은 것으로 나타났다. 3. 경조직의 변화에 대한 연조직의 변화율을 비교해 보면, B군의 경우Pog'의 후방이동 비율이 A군에서보다 적게 나타났고, B군의 Ils, Pog', Me'의 상방이동 비율은 각각 32%, 54%, 60%로 나타났다. 4. 안면의 수직 고경에 대해서는 A, B군 모두에서 하안면 고경의 유의한 감소로 전안면 고경에 대한 하안면 고경의 비율이 감소하였으나, B군에서는 하안면 상부 1/3(Sn-Stm)의 비율은 변화 양상이 유의성있게 나타나지 않았다. 5. 이부 감소 성형술은 하악후퇴술과 함께 시행시 하안면 상부 1/3(Sn-Stm)의 안모비율에 대한 변화가 적고, 하안면 하부 2/3(St-Me')의 고경을 감소시킬 수 있는 술식이다. The purpose of this study was to evaluate the amount and interrelationship of hard and soft tissue changes after mandibular setback osteotomy and reduction genioplasty in mandibular prognathism with long anterior facial height. The control group (Group A) consisted of 20 patients who had severe horizontal discrepancy. They experienced Presurgical orthodontic treatment and orthognathic surgery via mandibular setback. The experimental group (Group B) consisted of 20 patients who had severe horizontal and vertical discrepancy. They experienced presurgical orthodontic treatment and orthognathic surgery via mandibular setback and reduction genioplasty. The presurgical and postsurgical lateral cephalograms were evaluated. The computerized statistical analysis was tarried on with EXCEL 97 program. The results were as follows : 1. The correlation of hard and soft tissue horizontal changes in lower 2/3 of lower anterior facial height were high for both groups. The correlation coefficients of hard tissue changes and Ls, Stm, Li changes in Group B were moderately higher than Group A. 2. The correlation of hard and soft tissue vortical changes in Group B were lower than Group A. (except for pointB-Ils, Me-Me') 3. The ratio for soft tissue to Pog in Group B was lower than Group A. The ratios of hard and soft tissue vertical changes were 32% at Ils, 54% at Pog', and 60% at Me'. 4. The ratio of lower anterior facial height to total anterior facial height was reduced for both groups. But ratio of upper 1/3 of lower anterior facial height to total anterior facial height did not changed significantly in Group B. 5. Reduction genioplasty combined with mandibular setback procedure showed no change in upper one third(Sn-Stm) and significant decrease(Stm-Me') in the lower two thirds of the soft-tissue anterior lower facial height

      • SCIESCOPUSKCI등재후보

        Interleukin 2 에 의한 사람 종양침윤 림프구(TIL)의 활성화와 자가 고형 종야세포에 대한 항암효과

        하윤문,박재경,남상윤,최용묵,안창일,최규철 대한암학회 1989 Cancer Research and Treatment Vol.21 No.1

        To determine the effect of interleukin 2 (IL 2) on human tumor-infiltrating lymphocytes (TIL) from surgically excised solid tumors and to charscterize the antitwhor-cytotoxicity of activated TIL comparing with lymphokine-activated killer (LAK) cells generated from peripheral blood mononu- clear cells, this study wss performed. Single cell suspensions of TIL snd tumor cells were prepared from 20 surgical specimens (12 stomach canrers, 4 breast cancers, 1 lung cancer, 1 colon cancer, 1 ovarian cancer, and 1 cervix cancer) by mechanical and enzymatic means. And freshly isolated TIL were separated from tumor cells by fishing method. The amount of TIL obtained by the above means was 7.1x10+-6.7 (SD) cells/㎤ of tumor mass with range of 0.8~27.5 x 10^5. The TIL prepatrations contaminated partially with tumor cells (10~20%) were cultured in IL 2 containing media. Cell numbers were reduced from the initial seeding density until about 7 days of culture. After 10 days of culture with IL 2, TIL increased in number with a concomitant disappearance of tumor cells, whereas there were slow decreases of lymphocytes and increases of tumor cells in control cultures. TIL were expanded between 0.5 and 118,000 fold increases for 10 to 34 days (2~9 subcultures). Partially purified natural IL 2-induced expansions of TIL were more rapid than highly purified recombinant IL 2-induced expansions, and showed 10 times high for 18 days of culture. The majority of TIL were T lymphocytes with range of 56~68.8% of Leu4+, 25.0~40. 8%of Leu2a+, and 0~51. 5% of Leu3a+cells. With continued in vitro expansion for 14-20 days, there was a concomitant increase in T lymphocytes (Leu4+) to 71~76.8% but the changes af phenotypes of Leu2a+ and Leu3a+ were variable. TIL were tested for cytotaxicity against fresh autologous and alfogenic tumor cells, and Raji and K562 targets in a 4-hr Cr release assay. IL 2-activated TIL showed more potent cytotoxicity against autologous tumor targets than allogenic (P$lt;0.05). And cytotoxic activity of activated TIL in killing autologous tumor targets was higher level than that of LAK celis, but the defference was not statistically significant (0.05$lt;p$lt;0.1). The ability of activated TIL to kill K562 targets appeared to parallel that of LAK cells. In concluaon, TIL were induced in proliferation and augmented in their cytotoxixity by IL 2. IL 2-activated TIL preparations showed an apparent specific cytotoxicity and exhibited the combined preperties of cytotoxic T lymphocytea and LAK cells.

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