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Alexander J. Kassicieh,Kavelin Rumalla,Aaron C. Segura,Syed Faraz Kazim,John Vellek,Meic H. Schmidt,Peter C. Shin,Christian A. Bowers 대한척추신경외과학회 2023 Neurospine Vol.20 No.1
Objective: The endoscopic spine surgery (ESS) approach is associated with high levels of patient satisfaction, shorter recovery time, and reduced complications. The present study reports multicenter, international data, comparing ESS and non-ESS approaches for singlelevel lumbar decompression, and proposes a frailty-driven predictive model for nonhome discharge (NHD) disposition. Methods: Cases of ESS and non-ESS lumbar spine decompression were queried from the American College of Surgeons National Surgical Quality Improvement Program database (2017–2020). Propensity score matching was performed on baseline characteristics frailty score (measured by risk analysis index [RAI] and modified frailty index-5 [mFI-5]). The primary outcome of interest was NHD disposition. A predictive model was built using logistic regression with RAI as the primary driver. Results: Single-level nonfusion spine lumbar decompression surgery was performed in 38,686 patients. Frailty, as measured by RAI, was a reliable predictor of NHD with excellent discriminatory accuracy in receiver operating characteristic (ROC) curve analysis: C-statistic: 0.80 (95% confidence interval [CI], 0.65–0.94) in ESS cohort, C-statistic: 0.75 (95% CI, 0.73–0.76) overall cohort. After propensity score matching, there was a reduction in total operative time (89 minutes vs. 103 minutes, p = 0.049) and hospital length of stay (LOS) (0.82 days vs. 1.37 days, p < 0.001) in patients treated endoscopically. In ROC curve analysis, the frailty-driven predictive model performed with excellent diagnostic accuracy for the primary outcome of NHD (C-statistic: 0.87; 95% CI, 0.85–0.88). Conclusion: After frailty-based propensity matching, ESS is associated with reduced operative time, shorter hospital LOS, and decreased NHD. The RAI frailty-driven model predicts NHD with excellent diagnostic accuracy and may be applied to preoperative decisionmaking with a user-friendly calculator: nsgyfrailtyoutcomeslab.shinyapps.io/lumbar_decompression_dischargedispo.
Measurements of B→J/ψ at forward rapidity in p+p collisions at s=510 GeV
Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Akimoto, R.,Alexander, J.,Alfred, M.,Aoki, K.,Apadula, N.,Asano, H.,Atomssa, E. T.,Attila, A.,Awes, T. C.,Ayuso, C.,Azmoun, B.,Babintsev, V.,Bai, M.,Bai, X.,Banni American Physical Society 2017 Physical Review D Vol.95 No.9
<P>We report the first measurement of the fraction of J/psi mesons coming from B-meson decay (F (B -> J/psi)) in p + p collisions at root s = 510 GeV. The measurement is performed using the forward silicon vertex detector and central vertex detector at PHENIX, which provide precise tracking and distance-of-closest-approach determinations, enabling the statistical separation of J=. due to B-meson decays from prompt J/psi. The measured value of F (B -> J/psi) is 8.1% +/- 2.3% (stat) +/- 1.9% (syst) for J/psi with transverse momenta 0 < p(T) < 5 GeV/c and rapidity 1.2 < vertical bar y vertical bar < 2.2. The measured fraction F (B -> J/psi) at PHENIX is compared to values measured by other experiments at higher center of mass energies and to fixed-order-next-toleading- logarithm and color-evaporation-model predictions. The b (b) over bar cross section per unit rapidity [d sigma/dy(pp -> b (b) over bar)] extracted from the obtained F (B -> J/psi) and the PHENIX inclusive J/psi cross section measured at 200 GeV scaled with color-evaporation-model calculations, at the mean B hadron rapidity y = +/- 1.7 in 510 GeV p + p collisions, is 3.63(-1.70)(+1.92) mu b. It is consistent with the fixed-order-next-toleading- logarithm calculations.</P>
PHENIX Collaboration,Afanasiev, S.,Aidala, C.,Ajitanand, N.N.,Akiba, Y.,Alexander, J.,Al-Jamel, A.,Aoki, K.,Aphecetche, L.,Armendariz, R.,Aronson, S.H.,Averbeck, R.,Awes, T.C.,Azmoun, B.,Babintsev, V. North-Holland Pub. Co 2009 Physics letters: B Vol.679 No.4
We present the first measurement of photoproduction of J/ψ and of two-photon production of high-mass e<SUP>+</SUP>e<SUP>-</SUP> pairs in electromagnetic (or ultra-peripheral) nucleus-nucleus interactions, using Au+Au data at s<SUB>NN</SUB>=200 GeV. The events are tagged with forward neutrons emitted following Coulomb excitation of one or both Au<SUP>@</SUP>? nuclei. The event sample consists of 28 events with m<SUB>e<</SUB>SUP><SUB><</SUB>/SUP>+<SUB>e<</SUB>SUP><SUB><</SUB>/SUP>->2 GeV/c<SUP>2</SUP> with zero like-sign background. The measured cross sections at midrapidity of dσ/dy(J/ψ+Xn,y=0)=76+/-33(stat)+/-11(syst) μb and d<SUP>2</SUP>σ/dmdy(e<SUP>+</SUP>e<SUP>-</SUP>+Xn,y=0)=86+/-23(stat)+/-16(syst) μb/(GeV/c<SUP>2</SUP>) for m<SUB>e<</SUB>SUP><SUB><</SUB>/SUP>+<SUB>e<</SUB>SUP><SUB><</SUB>/SUP>-@?[2.0,2.8] GeV/c<SUP>2</SUP> have been compared and found to be consistent with models for photoproduction of J/ψ and QED based calculations of two-photon production of e<SUP>+</SUP>e<SUP>-</SUP> pairs.
ForwardJ/ψproduction in U + U collisions at<sub>sNN</sub>=193GeV
Adare, A.,Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Akimoto, R.,Alexander, J.,Alfred, M.,Aoki, K.,Apadula, N.,Asano, H.,Atomssa, E. T.,Awes, T. C.,Azmoun, B.,Babintsev, V.,Bai, M.,Bai, X.,Bandara, N. S.,B American Physical Society 2016 Physical Review C Vol.93 No.3
<P>The invariant yields, dN/dy, for J/psi production at forward rapidity (1.2 < vertical bar y vertical bar < 2.2) in U + U collisions at root S-NN = 193 GeV have been measured as a function of collision centrality. The invariant yields and nuclear-modification factor R-AA are presented and compared with those from Au + Au collisions in the same rapidity range. Additionally, the direct ratio of the invariant yields from U + U and Au + Au collisions within the same centrality class is presented, and used to investigate the role of c (c) over bar coalescence. Two different parametrizations of the deformed Woods-Saxon distribution were used in Glauber calculations to determine the values of the number of nucleon-nucleon collisions in each centrality class, N-coll, and these were found to give significantly different Ncoll values. Results using N-coll values from both deformed Woods-Saxon distributions are presented. The measured ratios show that the J/psi suppression, relative to binary collision scaling, is similar in U + U and Au + Au for peripheral and midcentral collisions, but that J/psi show less suppression for the most central U + U collisions. The results are consistent with a picture in which, for central collisions, increase in the J/psi yield due to c (c) over bar coalescence becomes more important than the decrease in yield due to increased energy density. For midcentral collisions, the conclusions about the balance between c (c) over bar coalescence and suppression depend on which deformed Woods-Saxon distribution is used to determine N-coll.</P>
Significance of Facet Fluid Index in Anterior Cervical Degenerative Spondylolisthesis
Lee Yunsoo,Heard Jeremy C.,Lambrechts Mark J.,Kern Nathaniel,Wiafe Bright,Goodman Perry,Mangan John J.,Canseco Jose A.,Kurd Mark F.,Kaye Ian D.,Hilibrand Alan S.,Vaccaro Alexander R.,Kepler Christophe 대한척추외과학회 2024 Asian Spine Journal Vol.18 No.1
Study Design: Retrospective cohort study.Purpose: To correlate cervical facet fluid characteristics to radiographic spondylolisthesis, determine if facet fluid is associated with instability in cervical degenerative spondylolisthesis, and examine whether vertebral levels with certain facet fluid characteristics and spondylolisthesis are more likely to be operated on.Overview of Literature: The relationship between facet fluid and lumbar spondylolisthesis is well-documented; however, there is a paucity of literature investigating facet fluid in degenerative cervical spondylolisthesis.Methods: Patients diagnosed with cervical degenerative spondylolisthesis were identified from a hospital’s medical records. Demographic and surgical characteristics were collected through a structured query language search and manual chart review. Radiographic measurements were made on preoperative MRIs for all vertebral levels diagnosed with spondylolisthesis and adjacent undiagnosed levels between C3 and C6. The facet fluid index was calculated by dividing the facet fluid measurement by the width of the facet. Bivariate analysis was conducted to compare facet characteristics based on radiographic spondylolisthesis and spondylolisthesis stability.Results: We included 154 patients, for whom 149 levels were classified as having spondylolisthesis and 206 levels did not. The average facet fluid index was significantly higher in patients with spondylolisthesis (0.26±0.07 vs. 0.23±0.08, p <0.001). In addition, both fluid width and facet width were significantly larger in patients with spondylolisthesis (p <0.001 each). Cervical levels in the fusion construct demonstrated a greater facet fluid index and were more likely to have unstable spondylolisthesis than stable spondylolisthesis (p <0.001 each).Conclusions: Facet fluid index is associated with cervical spondylolisthesis and an increased facet size and fluid width are associated with unstable spondylolisthesis. While cervical spondylolisthesis continues to be an inconclusive finding, vertebral levels with spondylolisthesis, especially the unstable ones, were more likely to be included in the fusion procedure than those without spondylolisthesis.
Phospholipid dynamics in ex vivo lung cancer and normal lung explants
Lesko Julia,Triebl Alexander,Stacher-Priehse Elvira,Fink-Neuböck Nicole,Lindenmann Jörg,Smolle-Jüttner Freyja-Maria,Köfeler Harald C.,Hrzenjak Andelko,Olschewski Horst,Leithner Katharina 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In cancer cells, metabolic pathways are reprogrammed to promote cell proliferation and growth. While the rewiring of central biosynthetic pathways is being extensively studied, the dynamics of phospholipids in cancer cells are still poorly understood. In our study, we sought to evaluate de novo biosynthesis of glycerophospholipids (GPLs) in ex vivo lung cancer explants and corresponding normal lung tissue from six patients by utilizing a stable isotopic labeling approach. Incorporation of fully 13 C-labeled glucose into the backbone of phosphatidylethanolamine (PE), phosphatidylcholine (PC), and phosphatidylinositol (PI) was analyzed by liquid chromatography/mass spectrometry. Lung cancer tissue showed significantly elevated isotopic enrichment within the glycerol backbone of PE, normalized to its incorporation into PI, compared to that in normal lung tissue; however, the size of the PE pool normalized to the size of the PI pool was smaller in tumor tissue. These findings indicate enhanced PE turnover in lung cancer tissue. Elevated biosynthesis of PE in lung cancer tissue was supported by enhanced expression of the PE biosynthesis genes ETNK2 and EPT1 and decreased expression of the PC and PI biosynthesis genes CHPT1 and CDS2 , respectively, in different subtypes of lung cancer in publicly available datasets. Our study demonstrates that incorporation of glucose-derived carbons into the glycerol backbone of GPLs can be monitored to study phospholipid dynamics in tumor explants and shows that PE turnover is elevated in lung cancer tissue compared to normal lung tissue.
Acton, Orb,Dubey, Manish,Weidner, Tobias,O’Malley, Kevin M.,Kim, Tae‐,Wook,Ting, Guy G.,Hutchins, Daniel,Baio, J. E.,Lovejoy, Tracy C.,Gage, Alexander H.,Castner, David G.,Ma, Hong,Jen, Alex K.& WILEY‐VCH Verlag 2011 Advanced functional materials Vol.21 No.8
<P><B>Abstract</B></P><P>An efficient process is developed by spin‐coating a single‐component, self‐assembled monolayer (SAM) to simultaneously modify the bottom‐contact electrode and dielectric surfaces of organic thin‐film transistors (OTFTs). This effi cient interface modifi cation is achieved using <I>n</I>‐alkyl phosphonic acid based SAMs to prime silver bottom‐contacts and hafnium oxide (HfO<SUB>2</SUB>) dielectrics in low‐voltage OTFTs. Surface characterization using near edge X‐ray absorption fi ne structure (NEXAFS) spectroscopy, X‐ray photoelectron spectroscopy (XPS), attenuated total reflectance Fourier transform infrared (ATR‐FTIR) spectroscopy, atomic force microscopy (AFM), and spectroscopic ellipsometry suggest this process yields structurally well‐defi ned phosphonate SAMs on both metal and oxide surfaces. Rational selection of the alkyl length of the SAM leads to greatly enhanced performance for both <I>n</I>‐channel (C<SUB>60</SUB>) and p‐channel (pentacene) based OTFTs. Specifi cally, SAMs of <I>n</I>‐octylphos‐phonic acid (OPA) provide both low‐contact resistance at the bottom‐contact electrodes and excellent interfacial properties for compact semiconductor grain growth with high carrier mobilities. OTFTs based on OPA modifi ed silver electrode/HfO<SUB>2</SUB> dielectric bottom‐contact structures can be operated using < 3V with low contact resistance (down to 700 Ohm‐cm), low subthreshold swing (as low as 75 mV dec<SUP>−1</SUP>), high on/off current ratios of 107, and charge carrier mobilities as high as 4.6 and 0.8 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>, for C60 and pentacene, respectively. These results demonstrate that this is a simple and efficient process for improving the performance of bottom‐contact OTFTs.</P>
Willful Blindness About Indigenous Peoples: The Democratic Deficit and Canadian Public Policy Making
C. J. Alexander(C. J. Alexander ),Mallory Crew(Mallory Crew ) 한국캐나다학회 2011 Asia-Pacific Journal of Canadian Studies (APJCS) Vol.17 No.1
Public policy officials, elected and appointed, continue to ignore the value dimensions of public policy making in ways that profoundly impact the individual and collective lives of Indigenous peoples in Canada. The au-thors examine two policy fields—health and communications—to highlight the peril of ignoring Indigenous cultural contexts. They conclude that the overarching policy of wilful blindness to Indigenous values, ways of being, and knowledge systems represents a continuation of the colonial mindset that has persisted since settlers arrived.
Adare, A.,Afanasiev, S.,Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Al-Bataineh, H.,Alexander, J.,Alfred, M.,Aoki, K.,Apadula, N.,Aphecetche, L.,Asai, J.,Atomssa, E. T.,Averbeck, R.,Awes, T. C.,Ayuso, C.,Az American Physical Society 2017 Physical Review C Vol.96 No.2
<P>We report a measurement of e(+)e(-) pairs from semileptonic heavy-flavor decays in p + p collisions at root S-NN = 200 GeV. The e(+)e(-) pair yield from b (b) over bar and c (c) over bar is separated by exploiting a double differential fit done simultaneously in dielectron invariant mass and p(T). We used three different event generators, PYTHIA, MC@NLO, and POWHEG, to simulate the e(+)e(-) spectra from c (c) over bar and b (b) over bar production. The data can be well described by all three generators within the detector acceptance. However, when using the generators to extrapolate to 4 pi, significant differences are observed for the total cross section. These difference are less pronounced for b (b) over bar than for c (c) over bar. The same model dependence was observed in already published d + A data. The p + p data are also directly compared with d + A data in mass and p(T), and within the statistical accuracy no nuclear modification is seen.</P>