Blood-Blister Aneurysms of the Internal Carotid Artery in Tibetan and Han Populations : A Retrospective Observational Study

Bowen Huang,Yanming Ren,Hao Liu,Anqi Xiao,Lunxin Liu,Hong Sun,Yi Liu,Hao Liu,Lu Ma,Chang-Wei Zhang,Chao-Hua Wang,Min He,Yuekang Zhang,Chao You,Jin Li 대한신경외과학회 2024 Journal of Korean neurosurgical society Vol.67 No.3

Objective : Blood-blister aneurysms (BBAs) of the internal carotid artery (ICA) are challenging lesions with high morbidity and mortality rates. Although research on BBAs is well documented in different populations, the study of BBAs in the Tibetan population is extremely rare. This study aimed to evaluate the characteristics of BBAs and analyze the treatment modalities and long-term outcomes in the Tibetan population in comparison with the Han population. Methods : The characteristics of patients with BBAs of the ICA from January 2009 to January 2021 at our institution were reviewed. The features of aneurysms, treatment modalities, complications, and follow-up outcomes were retrospectively analyzed. Results : A total of 130 patients (41 Tibetan and 89 Han patients) with BBAs of the ICA who underwent treatment were enrolled. Compared with the Han group, the Tibetan group significantly demonstrated a high ratio of BBAs among ICAs (8.6%, 41/477 vs. 1.6%, 89/5563; p<0.05), a high ratio of vasospasm (34.1%, 14/41 vs. 6.7%, 6/89; p=0.001), a high risk of ischemic events (43.9%, 18/41 vs. 22.5%, 20/89; p<0.05), and a low ratio of good outcomes (modified Rankin scale, 0–2) at the 1-year follow-up (51.2%, 21/41 vs. 74.2%, 66/89; p<0.05). The multivariate regression model showed that ischemic events significantly contributed to the prediction of outcomes at 1 year. Further analysis revealed that microsurgery and vasospasm were associated with ischemic events. Conclusion : In comparison with Han patients, the Tibetan population had a high ratio of BBA occurrence, a high incidence of ischemic events, and a high ratio of poor outcomes. The endovascular approach showed more benefits in BBA patients.

Modeling and Virtual Screening of Antisense Peptides Targeting the Divergent Region of Tumor-Associated MT1-MMP Protein

Bowen Tan,Yijie Zhou,Zhilei Song,Yinxuan Peng,Fang Wu,Yue Kang,Xiaomin Liu,Li Zeng,Tingting Huang,Zongying Liu,Lili Xiong,Zhiyun Guo,Jian Cui,Canquan Mao 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.9

Membrane type-1 matrix metalloproteinase (MT1-MMP; also known as MMP14) is a key enzyme involved in tumor invasion and metastasis, and is a potential target for drug discovery for cancer therapy. However, till now there is no MT1-MMP- or MMP-based anticancer drugs in the market mainly because of the high conservation of the MMP family and also because there is no elucidated crystal structure for the mature MT1-MMP. The modeling of the three-dimensional structure of mature MT1-MMP and the finding of MT1-MMP targeted peptides by virtual screening are highly desired. In this study, the three-dimensional structure of mature MT1-MMP is constructed by homology and de novo modeling and later rationalized and optimized by molecular dynamics simulations. An antisense peptide library was constructed against the divergent sense peptide DEGTEEET in the specific region of MT1-MMP, which was found by multiple alignment of the whole MMP family. The antisense peptide library was virtually screened against the constructed three-dimensional model of MT1-MMP. The top 20 novel peptides were further studied, which were found well docked with MT1-MMP at the region of DEGTEEET, again confirming their specific binding to MT1-MMP. Preliminary study of one of the top-ranked peptide SFLLSPFV showed that it could inhibit the viabilities of MG63 and MDA-MB-231 tumor cells. We thus not only successfully modeled the three-dimensional structure of mature MT1-MMP but also provided a new way for the finding of peptide candidates targeting MT1-MMP based on antisense peptide library.

Spindle Spinel CoFeCoO4 Microparticles/rGO as an Oxygen Reduction and Oxygen Evolution Catalyst

Bowen Wang,Nian Tao,Junchen Liu,Hao Wang,Yinxiao Du,Hujiang Yang,Yonggang Wang,Kai Huang,Ru Zhang,Ming Lei 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.4

The representative spinel-type materials AB2O4 (both A and B are transition metals) electrocatalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) have been investigated and significant improvements have been achieved in the activity and durability for ORR and OER in the alkaline solution. But CoFeCoO4 was not explored widely like ZnCo2O4 (or NiCo2O4) as the ORR electrocatalyst for its relatively complicated atomic site occupation. CoFeCoO4 has a typical cubic spinel structure with Co2+ in the tetrahedron and Co3+ and Fe3+ in the octahedron. A mixture of Co3+ and Fe3+ in the B site makes the oxide have a wider overlap between transition metal 3d orbit and O 2p orbit, which can lead to an effective charge transfer in the rate-determining steps of ORR process and then enhance the ORR activity. The high electronic conductivity and specific surface area of rGO can accelerate charger transfer and provide more catalytic sites, which would contribute to a faster ORR process. In this work, the porous spindle CoFeCoO4 microparticles which were synthesized by hydrothermal technology, were assembled on the rGO surface to obtain the CoFeCoO4/rGO composite, which exhibited enhanced ORR activity and catalytic stability comparable to that of Pt/C. On the other hand, the OER catalytic activity of the prepared samples was also studied to explore the potential of CoFeCoO4/rGO as a bifunctional oxygen catalyst.

Photocatalytic conversion of nitrite in aqueous solution over nanocomposite photocatalyst Er3+:Y3Al5O12/BiPO4 using different photosources

Yidi Wang,Bowen Li,Guanshu Li,Yingying Huang,Dawei Fang,Jun Wang,Youtao Song 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.47 No.-

Three crystal phases of BiPO4 (HBIP, nMBIP and mMBIP), corresponding photocatalysts (Er3+:Y3Al5O12/HBIP, Er3+:Y3Al5O12/nMBIP and Er3+:Y3Al5O12/mMBIP) and their nanocomposite photocatalyst (Er3+:Y3Al5O12/(H-nM-mM)BIP) were prepared by hydrothermal, ultrasonic dispersion and liquid boilingmethods. The prepared photocatalysts were characterized by X-ray diffractometer (XRD), energydispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM) and UV–vis diffuse reflectancespectra (DRS). The catalytic activity of prepared photocatalysts was evaluated via photocatalyticconversion rate of nitrite under ultraviolet-light, visible-light and simulated solar-light irradiations. These three photocatalysts all exhibited excellent performance under simulated solar-light irradiationand reached 85.36%, 84.42% and 78.53% conversion rates, respectively, for Er3+:Y3Al5O12/mMBIP, Er3+:Y3Al5O12/nMBIP and Er3+:Y3Al5O12/HBIP. Particularly, Er3+:Y3Al5O12/(H-nM-mM)BIP was also found toplay a high catalytic activity, resulting in 78.68%, 70.04% and 82.57% conversion rates, respectively, underultraviolet-light, visible-light and simulated solar-light irradiation. In addition, the study of used timesshowed that the prepared photocatalysts can be effectively recycled without an apparent inactivation onthe photocatalytic activity. This research may provide a potential way for converting nitrite and othercontaminants by utilizing solar energy efficiently.

Design and Output Characteristic Analysis of 3-D Micron-scale Actuator

Yafang Li,Bowen Wang,Wenmei Huang 한국자기학회 2020 Journal of Magnetics Vol.25 No.1

A new type of 3-D micron-scale actuator is designed, which is mainly composed of four Galfenol rods, drive coils, base, magnetic yoke and output head. According to magnetostrictive model and structural dynamic model, the output characteristics of the actuator have been analyzed. The 3-D moving trail of the output head is controlled by the drive coils of the four rods. The actuator prototype is fabricated and experimental investigated. Good agreement is observed between the simulation and experimental results. The maximum output displacements of the X, Y and Z direction are 46 μm, 46 μm and 8.2 μm. Furthermore, when a pair of opposing rods works, the actuator has two modes of vibration under 1000 Hz. The resonant frequencies of the actuator are 522 Hz in Y direction and X direction. The results have proved that the actuator can realize varied 3-D displacement according to actual demands, and can be used in 3-D micron-scale field, such as surface mold polishing.

Magnetostrictive and Magnetic Properties of Tb<SUB>0.29</SUB>Dy<SUB>0.48</SUB>Ho<SUB>0.23</SUB>Fe<SUB>1.9</SUB> Fiber/Epoxy Composites

Ran Zhao,Bowen Wang,Shuying Cao,Wenmei Huang,Quanguo Lu,Jianwu Yan 한국자기학회 2018 Journal of Magnetics Vol.23 No.2

In this paper, we fabricated novel magnetostrictive composites by embedding <110>-oriented Tb-Dy-Ho-Fe fibers in an epoxy matrix. The magnetostrictive and magnetic properties (magnetostriction, magnetization, piezomagnetic coefficient and relative permeability) of the proposed composites were measured, analyzed, and compared to those of Tb0.29Dy0.48Ho0.23Fe1.9 alloy and Tb0.3Dy0.7Fe₂ continuous-fiber/epoxy composites. Tb0.29Dy0.48Ho0.23Fe1.9 continuous-fiber/epoxy composites have a saturation magnetostriction (λs) of 840 ppm and saturation magnetization (Ms) of 0.75 T. Their piezomagnetic coefficient exhibits a maximum value (8.2 μm/kA) at 19 kA/m. These proposed composites exhibit a large magnetostriction in high magnetic fields (> 400 kA/m) and a large relative permeability in low magnetic fields (< 100 kA/m). This result indicates that the given composites perform better than the Tb0.29Dy0.48Ho0.23Fe1.9 alloy and Tb0.3Dy0.7Fe₂ fiber/epoxy composites. Thus, the composites with characteristics of high sensitivity and large magnetostriction can be used in the field of ultrasonic sensing.

Synthesis and Characterization of Novel Homopolyimides Containing Pyridine and Morpholine Groups for Gas Separation by Molecular Design and Simulation

Jing Ni,Jinling Li,Bowen Wei,Yufei Shi,Chanjuan Liu,Li Zhou,Xiaohua Huang 한국섬유공학회 2023 Fibers and polymers Vol.24 No.12

A novel 4-(4-(1-morpholinyl)phenyl)-2,6-bis(4-aminophenyl)pyridine (MPAP) diamine monomer was designed and synthesized by introducing non-coplanar morpholine groups and pyridine heterocyclic structures. By one-step homopolymerization of MPAP and different dianhydrides, three new polyimides (PIs) were synthesized. The obtained PIs are easily soluble in common organic solvents, such as NMP, DMAc, and CHCl3. Simultaneously, PIs have high thermal performance (Tg = 277–377 °C) and excellent thermal stability (Td,5% and Td,10% are 460–487 °C and 525–545 °C). They also have good optical transparency (λcutoff = 380–394 nm, λ80% = 469–482 nm) and hydrophobicity (θ = 87–92º). The free volume and gas adsorption are simulated by Materials Studio 2019 software, and the simulation results match the gas separation performance obtained from experimental test. They show good gas separation performance as well, especially PI-3 for the CO2/N2 (up to 23.26), O2/N2 (up to 5.02) and He/N2 (up to 59.78) separations, which is close to the 1991 Robeson upper bound.

Laser-activatable Oxygen Self-supplying Nanoplatform for Efficiently Overcoming Colorectal Cancer Resistance by Enhanced Ferroptosis and Alleviated Hypoxic Microenvironment

Hao Jiang,Hailong Tian,Zhihan Wang,Bowen Li,Rui Chen,Kangjia Luo,Shuaijun Lu,Edouard C. Nice,Wei Zhang,Canhua Huang,Yuping Zhou,Shaojiang Zheng,Feng Gao 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Colorectal cancer (CRC) is the second most deadly cancer worldwide, with chemo-resistance remaining a major obstacle in CRC treatment. Notably, the imbalance of redox homeostasis-mediated ferroptosis and the modulation of hypoxic tumor microenvironment are regarded as new entry points for overcoming the chemo-resistance of CRC. Methods Inspired by this, we rationally designed a light-activatable oxygen self-supplying chemo-photothermal nanoplatform by co-assembling cisplatin (CDDP) and linoleic acid (LA)-tailored IR820 via enhanced ferroptosis against colorectal cancer chemo-resistance. In this nanoplatform, CDDP can produce hydrogen peroxide in CRC cells through a series of enzymatic reactions and subsequently release oxygen under laser-triggered photothermal to alleviate hypoxia. Additionally, the introduced LA can add exogenous unsaturated fatty acids into CRC cells, triggering ferroptosis via oxidative stress-related peroxidized lipid accumulation. Meanwhile, photothermal can efficiently boost the rate of enzymatic response and local blood flow, hence increasing the oxygen supply and oxidizing LA for enhanced ferroptosis. Results This nanoplatform exhibited excellent anti-tumor efficacy in chemo-resistant cell lines and showed potent inhibitory capability in nude mice xenograft models. Conclusions Taken together, this nanoplatform provides a promising paradigm via enhanced ferroptosis and alleviated hypoxia tumor microenvironment against CRC chemo-resistance.

Design and evaluation of an innovative LWR fuel combined dual-cooled annular geometry and SiC cladding materials

Deng, Yangbin,Liu, Minghao,Qiu, Bowen,Yin, Yuan,Gong, Xing,Huang, Xi,Pang, Bo,Li, Yongchun Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.1

Dual-cooled annular fuel allows a significant increase in power density while maintaining or improving safety margins. However, the dual-cooled design brings much higher Zircaloy charge in reactor core, which could cause a great threaten of hydrogen explosion during severe accidents. Hence, an innovative fuel combined dual-cooled annular geometry and SiC cladding was proposed for the first time in this study. Capabilities of fuel design and behavior simulation were developed for this new fuel by the upgrade of FROBA-ANNULAR code. Considering characteristics of both SiC cladding and dual-cooled annular geometry, the basic fuel design was proposed and preliminary proved to be feasible. After that, a design optimization study was conducted, and the optimal values of as-fabricated plenum pressure and gas gap sizes were obtained. Finally, the performance simulation of the new fuel was carried out with the full consideration of realistic operation conditions. Results indicate that in addition to possessing advantages of both dual-cooled annular fuel and accident tolerant cladding at the same time, this innovative fuel could overcome the brittle failure issue of SiC induced by pellet-cladding interaction.

Back-analysis by UDEC of the Failure Process of Wangjiayan Co-seismic Landslide during 2008.5.12 Wenchuan Earthquake.

( Yu Zou ),( Shengwen Qi ),( Songfeng Guo ),( Zhifa Zhan ),( Xiaolin Huang ),( Bowen Zheng ),( Ning Liang ),( Jiaguo Xia ),( Xingxing Li ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

Strong earthquakes such as the 2008 Wenchuan earthquake often induced numerous landslides, which resulted in a large number of casualties and property losses. Under a strong earthquake, a rock slope often produced a dynamic progressive failure. Understanding the process of the dynamic progressive failure of the rock slope is of great significance for the prediction and prevention of the co-seismic landslide. Generally, the numerical method is a feasible and economic alternative to solve this problem. However, previous studies presumed the failure surface and area in the numerical model, which cannot reproduce the dynamic progressive failure of the rock slope. In this paper, we applied the Universal Discrete Element method (UDEC) was adopted to quantitatively characterize the dynamic progressive failure process of the Wangjiayan co-seismic landslide triggered by 2008 Wenchan earthquake. Different from previous studies, there exists no presumed failure surface and area was was presumed in the UDEC model. The initiation, coalescence of the local fractures and the formation of the final failure surface were well simulated in a real-time way. Some key factors influencing the dynamic progressive failure of the rock slope were systematically explored. This study provided a new insight to understand the disaster-pregnant mechanism, evolution, and formation of the co-seismic landslide.