A Meta-Analysis of Association between Remdesivir and Mortality among Critically-Ill COVID-19 Patients

Razzack Aminah Abdul,Hassan Syed Adeel,Pasya Sai Kumar Reddy,Erasani Greeshma,Kumar Sham,Rocha-Castellanos Dario Missael,Lopez-Mendez Alfonso,Razzack Sarah Abdul 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.3

Background: The World Health Organization guidelines did not make a recommendation on use of remdesivir based on disease severity. Little is known regarding effectiveness of remdesivir in critically ill coronavirus disease 2019 (COVID-19) patients. This has led to a state of dilemma for doctors leaving them skeptical of whether they should continue to recommend the drug or not. Materials and Methods: A systematic search adhering to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines was conducted from inception until February 20, 2020. Electronic bibliographic databases (PubMed, Cochrane database, Scopus, Embase) were included. Using dichotomous data for select values, the unadjusted odds ratios (ORs) were calculated applying Mantel Haenszel (M-H) using random-effects model. The primary outcome of interest was all-cause mortality in ventilated and nonventilated patients. Results: The Remdesivir arm was associated with similar rates of 28-day all-cause mortality (OR: 0.93, 95% confidence interval [CI]: 0.80 - 1.08; P = 0.33). Remdesivir was not found to be favorable for ventilated patients. Non ventilated COVID-19 patients showed a significant lower in-hospital mortality rate as compared with patients requiring mechanical ventilatory support (OR: 6.86, 95% CI: 5.39 - 268.74; P <0.0001). Conclusion: Non-ventilated patients were associated with significant lower all-cause mortality rates. Prudent use of remdesivir is recommended in critically ill COVID-19 patients.

Seedless Synthesis of Monodisperse Cuboctahedral Gold Nanoparticles with Tunable Sizes

Umar, Aminah,Lee, Jeeun,Dey, Jahar,Choi, Sung-Min American Chemical Society 2016 Chemistry of materials Vol.28 No.14

<P>Polyhedral gold nanoparticles are of great current interest because of their unique optical and chemical properties which are attributable to their well-defined facets, corners, and size. While various polyhedral gold nanoparticles of different sizes mostly synthesized by the seed-mediated method have been reported, synthesis of gold cuboctahedra with tunable sizes still remains challenging. Here, we report for the first time a seedless method of synthesizing monodisperse gold cuboctahedra with finely tunable sizes ranging from 40 to 80 nm using cetyltrimethylammonium 4-vinylbenzoate (CTAVB) as a selective capping and mild reducing agent in the presence of a high concentration of HCl in aqueous solution. The HCl provides strong oxidative etching power to remove structural defects, resulting in single-crystal seeds, and significantly reduces the particle growth rate. This slow particle growth provides an easy and reliable way of tuning the particle size by stopping the reaction at different times and allowing sufficient time for the surface self-diffusion of Au atoms. Combined with the selective capping of {100} facets with CTA(+), the surface self diffusion of Au atoms from {111} to {100} facets is considered to be the key mechanism for the formation of Au cuboctahedra and their stable growth without morphological deformation.</P>

The Major Role of NF-κB in the Depth of Invasion on Acral Melanoma by Decreasing CD8+ T Cells

Hermin Aminah Usman,Bethy S. Hernowo,Maringan Diapari Lumban Tobing,Reti Hindritiani 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.3

Background: The tumor microenvironment including immune surveillance affects malignant melanoma (MM) behavior. Nuclear factor κB (NF-κB) stimulates the transcription of various genes in the nucleus and plays a role in the inflammatory process and in tumorigenesis. CD8+ T cells have cytotoxic properties important in the elimination of tumors. However, inhibitory receptors on the cell surface will bind to programmed death-ligand 1 (PD-L1), causing CD8+ T cells to lose their ability to initiate an immune response. This study analyzed the association of NF-κB and PD-L1 expression levels and CD8+ T-cell counts with depth of invasion of acral MM, which may be a predictor of aggressiveness related to an increased risk of metastasis. Methods: A retrospective cross-sectional study was conducted in the Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital using 96 cases of acral melanoma. Immunohistochemical staining was performed on paraffin blocks using anti–NF-κB, –PD-L1, and –CD8 antibodies and invasion depth was measured using dotSlide-imaging software. Results: The study showed significant associations between the individual expression of NF-κB and PD-L1 and CD8+ T-cell number, with MM invasion depth. NF-κB was found to be a confounding variable of CD8+ T-cell number (p < .05), but not for PD-L1 expression (p = .154). Through multivariate analysis it was found that NF-κB had the greatest association with the depth of invasion (p < .001), whereas PD-L1 was unrelated to the depth of invasion because it depends on the number of CD8+ T cells (p = .870). Conclusions: NF-κB plays a major role in acral MM invasion, by decreasing the number of CD8+ T cells in acral MM.

Aggregation Behavior of Oppositely Charged Gold Nanorods in Aqueous Solution

Umar, Aminah,Choi, Sung-Min American Chemical Society 2013 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.117 No.22

<P>The aggregation behavior of oppositely charged gold nanorods (GNRs) in aqueous solution has been investigated by zeta potential, UV–vis–NIR, DLS, and TEM measurements. The positively charged GNRs (p-GNRs) and negatively charged GNRs (n-GNRs) were prepared by layer-by-layer deposition of oppositely charged electrolytes on GNR surface. As p-GNRs are added into n-GNR solution (before reaching the isoelectric point), p-GNR/n-GNR aggregations of fairly constant size are formed with the minor component (p-GNRs) mostly at the center and the majority component (n-GNRs) at the outside. While the overall packing of the GNR aggregates is rather random, the local arrangements of GNRs show both side-by-side and end-to-end arrangements, resulting in elongated aggregates due to the anisotropic nature of GNRs. While no precipitation occurs before isoelectric point, the size of aggregates grows rapidly as the isotropic point is approached and rapid precipitation occurs at the isoelectric point, showing ionic-like behavior. Beyond the isoelectric point, partial dissolution of aggregates occurs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2013/jpccck.2013.117.issue-22/jp3102095/production/images/medium/jp-2012-102095_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp3102095'>ACS Electronic Supporting Info</A></P>

Sterols and Sterol Glycosides from the Leaves of Gynura procumbens

Sadikun, A.,Aminah, I.,Ismail, N.,Ibrahim, P. The Korean Society of Pharmacognosy 1996 Natural Product Sciences Vol.2 No.1

A mixture of sterols containing ${\beta}-sitosterol$ and stigmasterol (1), and sterol glycosides containing $3-O-{\beta}-D-glucopyranosyl$ ${\beta}-sitosterol$ and $3-O-{\beta}-D-glucopyranosyl$ stigmasterol (2) were isolated from the leaves of Gynura procumbens. After acetylation of 2 with pyridine-acetic anhydride, $3-0-{\beta}-D-tetra-O-acetylglucopyranosyl$ ${\beta}>-sitosterol$ (3) was isolated.

Nonlinear analysis of concrete-filled steel composite columns subjected to axial loading

Alireza Bahrami,Wan Hamidon Wan Badaruzzaman,Siti Aminah Osman 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.39 No.3

This paper investigates the nonlinear analysis of concrete-filled steel composite columns subjected to axial loading to predict the ultimate load capacity and behaviour of the columns. Finite element software LUSAS is used to conduct the nonlinear analyses. The accuracy of the finite element modelling is verified by comparing the result with the corresponding experimental result reported by other researchers. Nonlinear analyses are done to study and develop different shapes and number of cold-formed steel sheeting stiffeners with various thicknesses of cold-formed steel sheets. Effects of the parameters on the ultimate axial load capacity and ductility of the concrete-filled steel composite columns are examined. Effects of variables such as concrete compressive strength f_c and cold-formed steel sheet yield stress f_yp on the ultimate axial load capacity of the columns are also investigated. The results are shown in the form of axial load-normalized axial shortening plots. It is concluded from the study that the ultimate axial load capacity and behaviour of the concrete-filled steel composite columns can be accurately predicted by the proposed finite element modelling. Results in this study demonstrate that the ultimate axial load capacity and ductility of the columns are affected with various thicknesses of steel sheets and different shapes and number of stiffeners. Also, compressive strength f_c of the concrete and yield stress f_yp of the cold-formed steel sheet influence the performance of the columns significantly.

Structural behaviour of tapered concrete-filled steel composite (TCFSC) columns subjected to eccentric loading

Alireza Bahrami,Wan Hamidon Wan Badaruzzaman,Siti Aminah Osman 사단법인 한국계산역학회 2012 Computers and Concrete, An International Journal Vol.9 No.6

This paper deals with the structural behaviour of tapered concrete-filled steel composite (TCFSC) columns under eccentric loading. Finite element software LUSAS is used to perform the nonlinear analyses to predict the structural behaviour of the columns. Results from the finite element modelling and existing experimental test are compared to verify the accuracy of the modelling. It is demonstrated that they correlate reasonably well with each other; therefore, the proposed finite element modelling is absolutely accurate to predict the structural behaviour of the columns. Nonlinear analyses are carried out to investigate the behaviour of the columns where the main parameters are: (1) tapered angle (from 0o to 2.75o); (2) steel wall thickness (from 3 mm to 4 mm); (3) load eccentricity (15 mm and 30 mm); (4) L/H ratio (from 10.67 to 17.33); (5) concrete compressive strength (from 30 MPa to 60 MPa); (6) steel yield stress (from 250 MPa to 495 MPa). Results are depicted in the form of load versus mid-height deflection plots. Effects of various tapered angles, steel wall thicknesses, and L/H ratios on the ultimate load capacity, ductility and stiffness of the columns are studied. Effects of different load eccentricities, concrete compressive strengths and steel yield stresses on the ultimate load capacity of the columns are also examined. It is concluded from the study that the parameters considerably influence the structural behaviour of the columns.

Formulation for Free-standing Staircase

Saeid Zahedi Vahid,Mohammad Ali Sadeghian,Siti Aminah Bt. Osman,Abdul Khalim Bin Abdul Rashid 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.6

In the analysis of a free-standing staircase with slab elements, approximate analytical methods are sometimes used because of the absence of specific code provisions due to their inherent limitations. These approaches, however, cannot predict the actual threedimensional (3D) behavior of the stair slab system. In addition, analytical methods cannot predict the stress resultant distribution in any section. These drawbacks highlight the need for the development of more rational but simple analysis methods for design purposes. Thus, in this study, an extensive numerical study on the behavior of free-standing staircases was performed using the finite element package SAP2000. A sensitivity study on the different geometric parameters and material properties that affect the design force and moments was also conducted. As a result of this study, semi-empirical equations are proposed from which the design forces and moments can be calculated in a single step. The accuracy of the equations within an acceptable limit is established by comparison with the results of rigorous FE analyses. Finally, the proposed design equations lead to a simple, straightforward and safe design while simultaneously representing the true behavior of 3D free-standing stair slabs.

Delayed postpartum regression of theca lutein cysts with maternal virilization: A case report

Sanghwa Kim,Inha Lee,Eunhyang Park,Yeo Jin Rhee,Kyeongmin Kim,Aminah Ibrahim Aljassim,Joo Hyun Park,Jae Hoon Lee,Bo Hyon Yun,Seok Kyo Seo,Sihyun Cho,Young Sik Choi,Byung Seok Lee 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.4

Theca lutein cysts are rare, benign lesions responsible for gross cystic enlargement of both ovaries during pregnancy. This condition is also termed hyperreactio luteinalis. Elevated human chorionic gonadotropin (hCG) levels or states of hCG hypersensitivity seem to promote these changes, which in up to 30% of patients produce clinical signs of hyperandrogenism. Given the self-limiting course of theca lutein cysts, which are subject to spontaneous postpartum resolution, conservative treatment is the mainstay of patient management. Described herein is a rare case of theca lutein cysts with maternal virilization that failed to regress by 9 months after childbirth. Surgical intervention was eventually undertaken, necessitated by adnexal torsion.

Nonlinear analysis of concrete-filled steel composite columns subjected to axial loading

Bahrami, Alireza,Badaruzzamana, Wan Hamidon Wan,Osmanb, Siti Aminah Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.39 No.3

This paper investigates the nonlinear analysis of concrete-filled steel composite columns subjected to axial loading to predict the ultimate load capacity and behaviour of the columns. Finite element software LUSAS is used to conduct the nonlinear analyses. The accuracy of the finite element modelling is verified by comparing the result with the corresponding experimental result reported by other researchers. Nonlinear analyses are done to study and develop different shapes and number of cold-formed steel sheeting stiffeners with various thicknesses of cold-formed steel sheets. Effects of the parameters on the ultimate axial load capacity and ductility of the concrete-filled steel composite columns are examined. Effects of variables such as concrete compressive strength $f_c$ and cold-formed steel sheet yield stress $f_{yp}$ on the ultimate axial load capacity of the columns are also investigated. The results are shown in the form of axial load-normalized axial shortening plots. It is concluded from the study that the ultimate axial load capacity and behaviour of the concrete-filled steel composite columns can be accurately predicted by the proposed finite element modelling. Results in this study demonstrate that the ultimate axial load capacity and ductility of the columns are affected with various thicknesses of steel sheets and different shapes and number of stiffeners. Also, compressive strength $f_c$ of the concrete and yield stress $f_{yp}$ of the cold-formed steel sheet influence the performance of the columns significantly.