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기본 소생술 e-러닝(e-Learning) 멀티미디어 컨텐츠 개발 연구
이영아,김태민,김효식,고재문 한국응급구조학회 2002 한국응급구조학회지 Vol.6 No.1
This study was designed to develop e-Learnig multimedia contents to provide the first aid rescuer with the basic resuscitation members of the public, corporations and any other institutions who wish to learn this skills. It is carried out from October to December in 2001. This program was constructed on the basic of the network-instructional system Design model, this model has several progressive steps, which includes the planning, analysis of the contents, development of the contents, instructional design, development of web-based and multimedia, pilot test, implement, and evaluation. The URL of this site is http://www.cyber.hc.ac.kr named as the cyber education program for the basic resuscitatingskill. This contents consisted of 8 chapters providing as follows : Introduction, anatomy and physiology of heart-ling. Adult Cardio-Pulmonary Resuscitation. Adult Foreign-body Air-Obstruction. Child Cardio-Pulmonary Resuscitation, Foreign-body Air-Obstruction. To make the learning more interesting, as much animation and videos were integrated. In conclusion, this e-Learning multimedia contents will be useful for student as well as members of the public. It significantly increases the chances of saving the life of person who has collapsed.
BALB/c 생쥐에서 천식 발생에 대한 dehydroepiandrosterone의 억제효과
최용,최인선,고영일,고영아,이현철 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1
Background : Dehydroepiandrosterone(DHEA). and adrenal androgen, may regulate Th1/Th2 cytokines. Objective : To determine whether DHEA have a preventive effect against the development of asthma, a Th2-associated disease. Materials and methods : Female BALB/c mice were fed with a standard diet incorporated with 0.1% (w/w) of DHEA for 1 week before sensitization with ovalbumin(OVA. 20㎍ i.p. twice with 2-week intervals). Enhanced pause (Penh) was monitored after 1% OVA inhalations for 3 successive days, and then the methacholine bronchoprovocation tests were performed using a whole-body plethysmography system. Analyses of inflammatory cells, cytokines, and OVA-specific IgE were carried out. Results : Both the excessive airway narrowing (maximum Penh) and the airway hypersensitivity (PC200, ㎎/mL) to methacholine were significantly suppressed with the DHEA pretreatment (F<.05 and F<.01, respectively). However, the numbers of the inflammatory cells and the levels of interleukin(IL)-4, IL-5, and IFN-γ in the bronchoalveolar lavage fluid, the production of IL-4, IL-5, and IFN-γ by Con A-stimulated splenocytes, and the serum IgE level in DHEA group were not significantly different from those in asthma group. Conclusion : DHEA pretreatment could suppress the development of asthmatic airway hyperresponsiveness without suppression of Th2 cytokines and airway inflammation. (J. Asthma Allergy Clin Immunol 24 : 116-26, 2004)
Involvement of heme oxygenase-1 in Korean colon cancer.
Kang, Kyoung Ah,Maeng, Young Hee,Zhang, Rui,Yang, Young Ro,Piao, Mei Jing,Kim, Ki Cheon,Kim, Gi Young,Kim, Young Ree,Koh, Young Sang,Kang, Hee Kyoung,Hyun, Chang Lim,Chang, Weon Young,Hyun, Jin Won Saikon Pub. Co 2012 TUMOR BIOLOGY Vol.33 No.4
<P>Heme oxygenase-1 (HO-1) catabolizes heme into carbon monoxide, biliverdin, and free iron which mediate its protective effect against oxidative stress. The aim of the present study was to determine the expression level and activity of HO-1 in Korean colon cancer tissues and cell lines. HO-1 protein expression was higher (>1.5-fold) in tumor tissues than in adjacent normal tissues in 14 of 20 colon cancer patients, and HO-1 protein expression was closely correlated with HO-1 enzyme activity in cancer tissues. Immunohistochemical data confirmed that HO-1 protein was expressed at a higher level in colon cancer tissues than in normal mucosa. Furthermore, HO-1 mRNA and protein expression and enzyme activity were higher in the colon cancer cell lines Caco-2, SNU-407, SNU-1033, HT-29, and SW-403 than in the normal fetal human colon cell line FHC. Treatment with the HO-1 inhibitor zinc protoporphyrin decreased the viability of colon cancer cell lines. These data indicate that HO-1 may serve as a clinically useful biomarker of colon cancer and as a target for anticolon cancer drugs.</P>
Young Kwon Koh,Su Hyun Yoon,Sung Han Kang,Hyery Kim,Ho Joon Im,Pyeong Hwa Kim,Ah Young Jung,Kyung-Nam Koh 대한소아혈액종양학회 2022 Clinical Pediatric Hematology-Oncology Vol.29 No.2
Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder characterized by het-erogenous lesions infiltrated with CD1a+/CD207+ cells. Although LCH has a relatively good prognosis, the prognosis for patients with LCH refractory to standard chemo-therapy is poor. Neurodegenerative LCH (ND-LCH) is a central nervous system com-plication of LCH that is characterized by progressive radiological and clinical abnormalities. Symptomatic ND-LCH is difficult to treat and therefore has a poor prognosis. A two-year-old boy presented with a scalp mass. Biopsy confirmed LCH. Whole-body imaging revealed LCH involvement in multiple bones of the skull, facial bones, and lungs. Prednisolone and vinblastine chemotherapy was initiated. One-year post-treatment, most of the lesions in the bones and lung nodules dis-appeared, and chemotherapy was discontinued. New neurodegenerative lesions ap-peared 4 months after chemotherapy was discontinued. Second-line chemotherapy using cytarabine, vincristine, and prednisolone was initiated. However, neurological manifestations of ND-LCH worsened post second-line treatment, and the treatment was switched to cytarabine and cladribine. Despite third-line chemotherapy, the le-sions progressed, and neurological deficits worsened. After identifying BRAF V600E mutation in the tumor tissue using next-generation sequencing, cytotoxic chemo-therapy was discontinued and vemurafenib treatment was initiated. One-year post-vemurafenib therapy, ND-LCH manifestations regressed, and the patient experi-enced neurological improvement.
고창순(Chang Soon Koh),이명철(Myung Chul Lee),이영우(Young Woo Lee),박영배(Young Bae Park),고은미(Eun Mi Koh),이경한(Kyung Han Lee),엄재호(Jae Ho Um),김명아(Myung Ah Kim),오병희(Byung Hee Oh) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.1
N/A To assess the usefulness of myocardial SPECT imaging to detect post-myocardial infarction ventricular aneurysms, we analyzed the Technetium-99m MIBI myocardial SPECT images of 16 patients with anterior and/or apical infarction, 9 had the previously reported findings of failure of convergence of the left ventricular walls toward the apex on SPECT images and 8 of them also had ventricular aneurysms. The ventriculography of the 2 patients with mixed pattern revealed 1 case of ventricular aneurysm and 1 case without aneurysm. Among the remaining 5 patients with converging pattern, none had ventricular aneurysm. Of the other 11 patients with inferior and/or lateral wall infarction, 1 patient had ventricular aneurysm and the SPECT image couldn't detect the aneurysm. Tc-99m-MIBI myocardial SPECT images for the detection of ventricular aneurysm had a sensitivity of 90%, a specificity of 88%, and an accuracy of 89%. Thus we could get the information about presence of ventricular aneurysm as well as the status of the myocardial perfusion from the Tc-99m MIBI myocardial SPECT images.
Comparative transcriptomic analysis of social hornets Vespa crabro and Vespa analis
Kyungjae Andrew Yoon,Kyungmun Kim,Hyo-min Ah,Ki-Gyoung Kim,Young Ho Koh,Young Ho Koh,Si Hyeock Lee 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
The hornets Vespa crabro and V. analis are widely distributed in Asia and are known to be aggressive when disturbed, resulting in frequent stinging accidents. To investigate the differences in venom properties and toxicities between these two hornets, the transcriptomic profiles of venom glands, in conjunction with the venom components, were analyzed and compared. A total of 35 venom-specific genes were identified in both venom gland transcriptomes, but their transcriptional profiles were different between V. crabro and V. analis. In addition, the major venom components were identified and confirmed by mass spectroscopy. Prepromastoparan, vespid chemotactic precursor and vespakinin were the top three genes most prevalently transcribed in the venom gland of V. crabro, and their transcription rates were 112-, 16- and 161-fold higher, respectively, compared with those in V. analis, as judged by FPKM values. In the venom gland of V. analis, however, vespid chemotactic precursor was the most abundantly transcribed gene, followed by premastoparan and vespakinin. In general, most major venom genes were more abundantly expressed in V. crabro, whereas some minor venom genes exhibited higher transcription rates in V. analis, including muscle LIM protein, troponin, paramyosin, calponin, etc. Our findings reveal that the overall venom components of V. crabro and V. analis are similar, but that their expression profiles and levels are considerably different. The comparison of venom gland transcriptomes suggests that V. crabro likely produces venom with more highly enriched major venom components, which has potentially higher toxicity compared with V. analis venom.