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WIND ENERGY POTENTIAL ASSESMENT and SITING a WIND FARM in CHEJU ISLAND
고경남,김건훈,조경호,고장권,허종철 濟州大學校 産業技術硏究所 1997 산업기술연구소논문집 Vol.8 No.2
The possibility in the practical use and supply of the wind turbine in Cheju island was investigated. The wind data measured in three regions which have a plenty wind energy potential were utilized to quantify the wind power resources by statistical analysis. Power output was calculated for 600 kW wind turbine. The coastal area of Guja was superior to Daejung and Hoichun in wind power energy densities. The calculated capacity factor of 600 kW wind turbine in this site was high as much as 30%. Hoichun site. the intermediate region between the Halla mountain and the sea. was rich in wind power energy resources in winter. Hourly ideal energy density at three regions increased at sunrise, reached the maximum a t 13-16 O'clock, decreased steadily, and finally remained constant at sunset.
방사선 조사를 받은 두경부 병소의 재건을 위한 유리피판술
채수욱,고경석,김주봉,박상훈,한상훈,이택종,남순열,김상윤 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3
Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30∼75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.
WIND ENERGY POTENTIAL ASSESMENT and SITING a WIND FARM in CHEJU ISLAND
김건훈,조경호,고장권,허종철,고경남 濟州大學校 工科大學 産業技術硏究所 1997 尖端技術硏究所論文集 Vol.8 No.2
본 연구는 제주도내 풍력발전기 보급 및 적지선정을 검토하는데 그 목적을 두었다. 이를 위하여 제주도내 다풍지역으로 예상되는 3개지역을 선정하여 1년간 풍력자원조사를 행하였고, 계측된 자료는 통계분석으로 풍력자원을 정량화하였으며 또한 세계적으로 경제성이 인증된 600kW 풍력발전기를 모델로하여 가상 출력을 산출함으로서 최적 풍력단지를 제시하였다. The possibility in the practical use and supply of the wind turbine in Cheju island was investigated. The wind data measured in three regions which have a plenty wind energy potential were utilized to quantify the wind power resources by statistical analysis. Power output was calculated for 600 kW wind turbine. The coastal area of Guja was superior to Daejung and Hoichun in wind power energy densities. The calculated capacity factor of 600 kW wind turbine in this site was high as much as 30%. Hoichun site, the intermediate region between the Halla mountain and the sea, was rich in wind power energy resources in winter. Hourly ideal energy density at three regions increased at sunrise, reached the maximum at 13-16 O'clock, decreased steadily, and finally remained constant at sunset.
구조화된 환자교육에 대한 연구논문 분석 : 고혈압 환자를 중심으로 forcused on the patients with hypertension
박청자,이경희,고효정,권영숙,김정남,박영숙 대한보건협회 2003 대한보건연구 Vol.29 No.2
This study was conducted to analyze the nursing research methodology and the key concepts used in articles related hypertension published in the RICH. The purpose of this study was for reflecting the trends of the research on the structured patient education focused the hypertensives. The results were as following. 1. There were 119 research studies related hypertension in RICH from 1994 to 2002. The number increased in 1997. Research studies of 98 have done since 1997 and it is 82% of the total research studies. 2. The most of the research studies are non-degree research studies. Research studies with fund have been rapidly increased in 2000 year. 3. The prevailing research design were the non-experimental design, quasi-experimental and pre-experimental designs in order. 4. The data collection method used most often physiologic measures(32.8%). 5. The domain of the key concepts that prevailed was health domain(51.8%), nursing domain(22.9%), and human being domain(20.5%) in order. And environmental domain (4.8%) were relatively low.
Koh, Kyung Nam,Park, Meerim,Kim, Bo Eun,Im, Ho Joon,Seo, Jong Jin Korean Society of Hematology; Korean Society of Bl 2010 Blood Research Vol.45 No.3
<P><B>Background</B></P><P>Central nervous system (CNS) complications after allogeneic hematopoietic stem cell transplantation (HSCT) have not been well characterized in the pediatric population.</P><P><B>Methods</B></P><P>We retrospectively analyzed data of 202 consecutive children who underwent allogeneic HSCT (60 from matched related donors, 9 from mismatched related donors, and 133 from unrelated donors) at Asan Medical Center between 1998 and 2009.</P><P><B>Results</B></P><P>Twenty-seven children (13.5%) developed CNS complications within 6 months after HSCT. Calcineurin inhibitor (CNI)-associated neurotoxicity was the most common CNS complication (n=16), followed by CNS infection (n=2), cerebrovascular events (n=2), thrombotic microangiopathy-associated events (n=2), metabolic encephalopathy (n=2), irradiation/chemotherapy injury (n=1), and encephalopathy/myelopathy of unknown causes (n=2). Univariate analysis showed that a transplant from an alternative donor and the occurrence of acute graft-versus-host disease (GVHD) (>grade 2) were associated with a significantly increased risk of CNS complications. In the multivariate analysis, acute GVHD >grade 2 was identified as an independent risk factor for early CNS complications. The 5-year overall survival rate was significantly lower in patients with CNS complications (52.1% vs. 64.9%, <I>P</I>=0.014), whereas CNI-associated neurotoxicity did not affect the survival outcome.</P><P><B>Conclusion</B></P><P>CNS complications are frequent among children undergoing HSCT, contributing to early death after transplant. More attention should be paid to the development of CNS complications for recipients of alternative donor transplants and patients with severe acute GVHD who are at increased risk for CNS complications.</P>
Koh, Kyung-Nam,Im, Ho Joon,Kim, Hyery,Kang, Hyoung Jin,Park, Kyung Duk,Shin, Hee Young,Ahn, Hyo Seop,Lee, Ji Won,Yoo, Keon Hee,Sung, Ki Woong,Koo, Hong Hoe,Lim, Young Tak,Park, Jun Eun,Park, Byung-Kiu KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.4
<P>This multicenter, prospective trial was conducted to develop an effective and safe reinduction regimen for marrow-relapsed pediatric acute lymphoblastic leukemia (ALL) by modifying the dose of idarubicin. Between 2006 and 2009, the trial accrued 44 patients, 1 to 21 years old with first marrow-relapsed ALL. The reinduction regimen comprised prednisolone, vincristine, L-asparaginase, and idarubicin (10 mg/m<SUP>2</SUP>/week). The idarubicin dose was adjusted according to the degree of myelosuppression. The second complete remission (CR2) rate was 72.7%, obtained by 54.2% of patients with early relapse < 24 months after initial diagnosis and 95.0% of those with late relapse (<I>P</I> = 0.002). Five patients entered remission with extended treatment, resulting in a final CR2 rate of 84.1%. The CR2 rate was not significantly different according to the idarubicin dose. The induction death rate was 2.3% (1/44). The 5-year event-free and overall survival rates were 22.2% ± 6.4% and 27.3% ± 6.7% for all patients, 4.2% ± 4.1% and 8.3% ± 5.6% for early relapsers, and 43.8% ± 11.4% and 50.0% ± 11.2% for late relapsers, respectively. Early relapse and slow response to reinduction chemotherapy were predictors of poor outcomes. In conclusion, a modified dose of idarubicin was effectively incorporated into the reinduction regimen for late marrow-relapsed ALL with a low toxic death rate. However, the CR2 rate for early relapsers was suboptimal, and the second remission was not durable in most patients.</P>
Koh, Kyung-Nam,Park, Mee-Rim,Kim, Bo-Eun,Im, Ho-Joon,Park, Chan-Jeoung,Jang, Seong-Soo,Chi, Hyun-Sook,Seo, Jong-Jin The Korean Pediatric Society 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.11
Purpose: Our study attempted to determine the prognostic significance of minimal residual disease (MRD) detected by a simplified flow cytometric assay during induction chemotherapy in children with B-cell acute lymphoblastic leukemia (B-ALL). Methods: A total of 98 patients were newly diagnosed with precursor B-ALL from June 2004 to December 2008 at the Asan Medical Center (Seoul, Korea). Of those, 37 were eligible for flow cytometric MRD study analysis on day 14 of their induction treatment. The flow cytometric MRD assay was based on the expression intensity of CD19/CD10/CD34 or aberrant expression of myeloid antigens by bone marrow nucleated cells. Results: Thirty-five patients (94.6%) had CD19-positive leukemic cells that also expressed CD10 and/or CD34, and 18 (48.6%) had leukemic cells with aberrant expression of myeloid antigens. Seven patients with ${\geq}1%$ leukemic cells on day 14 had a significantly lower relapse-free survival (RFS) compared to the 30 patients with lower levels (42.9 % [18.7%] vs. 92.0% [5.4%], $P$=0.004). Stratification into 3 MRD groups (${\geq}1%$, 0.1-1%, and <0.1%) also showed a statistically significant difference in RFS (42.9% [18.7%] vs. 86.9% [8.7%] vs. 100%, $P$=0.013). However, the MRD status had no significant influence on overall survival. Multivariate analysis demonstrated that the MRD level on day 14 was an independent prognostic factor with borderline significance. Conclusion: An MRD assay using simplified flow cytometry during induction chemotherapy may help to identify patients with B-ALL who have an excellent outcome and patients who are at higher risk for relapse.
Koh, Kyung-Nam,Yoo, Keon Hee,Im, Ho Joon,Sung, Ki Woong,Koo, Hong Hoe,Kim, Hyo Sun,Han, Jung Woo,Yoon, Jong Hyung,Park, Hyeon Jin,Park, Byung-Kiu,Baek, Hee Jo,Kook, Hoon,Lee, Jun Ah,Lee, Jae Min,Lee, The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.8
<P>This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors of childhood cancer from multiple institutions in Korea. A total of 102 patients from 11 institutions who developed SMN after childhood cancer treatment between 1998 and 2011 were retrospectively enrolled. The most common primary malignant neoplasms (PMNs) were central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia (n = 16), non-Hodgkin lymphoma (n = 13), and osteosarcoma (n = 12). The most common SMNs were therapy-related myeloid neoplasms (t-MNs; acute myeloid leukemia [AML], 29 cases; myelodysplastic syndrome [MDS], 12 cases), followed by thyroid carcinomas (n = 15) and CNS tumors (n = 10). The median latency period was 4.9 years (range, 0.5–18.5 years). Among 45 patients with solid tumors defined as an SMN, 15 (33%) developed the lesion in a field previously subjected to radiation. The 5-year overall survival (OS) rate of patients with an SMN was 45% with a median follow-up time of 8.6 years. Patients with AML, MDS, and CNS tumors exhibited the poorest outcomes with 5-year OS rates of 18%, 33%, and 32%, respectively, whereas those with second osteosarcoma showed comparable outcomes (64%) to patients with primary counterpart and those with second thyroid carcinoma had a 100% OS rate. Further therapeutic efforts are recommended to improve the survival outcomes in patients with SMNs, especially in cases with t-MNs and CNS tumors.</P>