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Ryu, Shi-Yong,Lee, Hyun-Sun,Kim, Young-Kyoon,Kim, Sung-Hoon The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.5
All fifteen flavonoids (1-15) have been isolated from the roots of Sophora flavescens (Leguminosae) as active principles of the cytotoxic property toward human tumor cell lines such as A549, SK-OV-3, SK-Mel-2, XF498 and HCT15, in vitro. By means of spectral analyses, particularlyby the aid of various two dimensional NMR experiments, all $^1H-NMR$ ad $^{13}C$ -NMR signals of 1-15 were completely assigned, and thus the structures of 1-15 were established unambiguously.
The Structure of Kushenol M from Sophora flavescens
Ryu, Shi-Yong,Lee, Seung-Ho,No, Zaesung,Kim, Kye-Young,Lee, Sueg-Geun,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1995 Archives of Pharmacal Research Vol.18 No.1
The linkage pattem of two side chains i.e., a isopentenyl and a lavandulyl group in kushenol M(I), a flavonoid from Sophora flavescens was established by the aid of 2-D NMR techniques, especially DEPT, ${13}C-^1H$ COSY and COLOC experiments. Thus, I was unequivocally determined as (2R, 3R)-5, 7, 2', 4'-tetrahydroxy-6-isopentenyl-8-lavandulyflavanonol.
Antitumor Triterpense from Medicinal Plants
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Seung-Ho,Lee, Chong-Ock,No, Zaesung,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
Thirteen kinds of naturally occurring or derivatised thiterpenes, reported to have an antitumoral property, were reinvestigated on the basis of their direct cytotoxicity or the inhibitory activity on cell growth against five kinds of cultured human tumor cells, i.e., A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15, in vitro. Ursonic acid III, betulinic acid VIII, betulonic acid X and glycrrhetinic acid XI were exhibitied a marked inhibition on cell growth.
Antitumor activity of Trichosanthes kirilowii
Ryu, Shi-Yong,Lee, Seung-Ho,Lee, Sang-Un,Lee, Chong-Ock,No, Zaesung,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
The activity fractionation upon the MeOH extract of the root of trichosanthes kirilowii led to the isolation of eight cucurbitane tritepense namely cucurbitacin .betha. (I), isocucurbitacin .betha.(II), cucurbitacin D(III), isocucurbitacin D(IV), 3-epi-isocucurbitacin .betha(V), dihydrocucurbitain .betha. (VI), dihydroisocucurgbitachin .betha. (VII) and dihydrocucurbitacin E (VIII), as active principles. All isolates were shown to exhibit significant cytotoxicity against cultured human tumor cells, including A-549, Sk-OV-3, Sk-MEL-2, XF-498 and HCT 15, with an exceptionally high potency.
Ryu, Jae-Ha,Ryu, Shi-Yong,Han, Yong-Nam,Han, Byung-Hoon The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.1
A new celastraceae alkaloid, euojaponine C has been isolated from the methanol extract of the root bark of Euonymus japonica. With the relative stereochemistry of euojaponine C established by NOESY data, the absolute stereochemistry has been determined by circular dichroism (CD) exciton chirality method. The CD of the 2, 5-bis-phenyl benzoate of triacetonide derived from the LiAlH$_{4}$, hydrolysate, euonyminol shows that the configuration of C-2 and C-5 are both R.
Antitumor Activity of Psorelea corylifolia
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Chong-Ock,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.4
The activity-oriented fractionation of Psoralea corylifolia led to an isolation of a (+) bakuchio 1 as an activ eprinciple of its antitumoral property in vitro 1 was observed to exhibit a mild cytotoxicity against five kinds of cultured human cancer cell lines, i. e. the A549, SK-OV-3, SK-MEL-2, XF-498 and HCT15. The synthesized 2, 3-epoxide of (+)-bakuchiol 3 showed the similar activity as the (+) bakuchiol 1, whereas the other oxidation derivatives 4 and 5 including the acetyl (+) bakuchiol 2 showed a decreased activity.
In vitro antitumor activity of flavonoids from Sophora flavescens
Ryu, Shi Yong 대전대학교 韓醫學연구소 1997 한의학연구소 논문집 Vol.5 No.2
The cytotoxicity-guided fractionation of the roots of Sophora flavescens (Leguminosae) extracts led to the isolation of fifteen active principles 1∼15, responsible for the cytotoxicity against five kinds of cultured human tumor cell lines, i.e., A549(non small cell lung), SK-OV-3(ovary), SK-MEL-2(skin), XF498(central nerve system) and HCT-15(colon), evaluated by SRB method in vitro. Compounds 2∼14 were classified as unusual flavonoid occurred exclusively in this species and the proliferation of each examined tumor cells were significantly inhibited during the continuous exposure to compounds 1∼15 for 48 hours, respectively.