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      • KCI등재

        Characterization of alanyl aminopeptidase from insecticide resistant and susceptible strains of Musca domestica L.

        Sohail AHMED1,Waqas WAKIL,David MANTLE,Richard M. WILKINS,권용정 한국곤충학회 2008 Entomological Research Vol.38 No.3

        To investigate the high activity of intracellular proteases in insecticide resistant strains of Musca domestica L., purification by anion-exchange chromatography and gel filtration of one of the enzymes, alanyl aminopeptidase (Ala AP), in three strains of Musca domestica was carried out. The fractions collected by gel filtration of soluble homogenates of the three strains (571ab, 17bb and Cooper) showed a single peak of Ala AP activity. Partially purified Ala AP of the three strains showed high activity at pH 7.5. The presence or absence of Ca2+ in the assay medium did not produce any difference in activity of Ala AP in the 571ab and Cooper strains, but there was a significant difference in the 17bb strain. The activity of Ala AP in all three strains was essentially unaltered in the presence of inhibitors of serine (PMSF), cysteine (E-64) proteases and carboxypeptidases (pepstatin). Ala AP hydrolyzed alanine amino methylcoumarin (Ala-AMC) maximally, followed by phenyl alanine amino methylcoumarin (Phe-AMC), leucyl amino methylcoumarin (Leu-AMC) and ornithine amino methylcoumarin (Orn-AMC). Ala AP from the three strains showed differential activity towards various substrates. The comparison of alanyl aminopeptidase’'s activity from different sources is discussed.

      • KCI등재후보

        A modified trans-anconeus approach to facilitate fixation of a posterior radial head fracture: a cadaveric feasibility study

        Ahmed Mohamed Desouky(Ahmed Mohamed Desouky ),Ahmed Naeem Atiyya(Ahmed Naeem Atiyya ),Mohamed Elbishbishi(Mohamed Elbishbishi ),Marwa Mohamed El Sawy(Marwa Mohamed El Sawy ) 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.1

        Fixation of radial head fracture with minimally invasive posterior approach remains a significant challenge. The aim of this study was to determine the feasibility of trans-anconeus posterior elbow approach and to observe lateral ulnar collateral ligament (LUCL) in extended elbows. This cadaveric study was performed in twenty upper limbs of fresh fixed adult male cadavers. An oblique incision was made in the middle segment of anconeus until the lateral ligament complex and the joint capsule had been revealed. A deep dissection was explored to observe the anatomical relationship of the LUCL to the anconeus. Measurements of the LUCL were recorded while the elbow was fully extended. The mean distance between the edge of the radial head and the proximal insertion of the LUCL was 13.3 mm (11.5–16.2 mm); the mean distance between the edge of the radial head and the distal insertion of the LUCL was 20.9 mm (19.2–23.4 mm); the distance between the edge of the radial head and the distal edge of the annular ligament was 11.2 mm (8.22–11.7 mm). By estimate correlation of the previous measurements, the direct and accessible way to expose the posterolateral articular capsule of the elbow joint was through a window in medial 2/3 of the middle segment of anconeus muscle. These trans-anconeus approach is useful. It provides good visualization, facilitates applying the implants, and lessens the risk of radial nerve injury. Awareness of the anatomy is mandatory to avoid injury of LUCL.

      • KCI등재
      • KCI등재

        Minimally Invasive Transforaminal Lumbar Interbody Fusion for the Surgical Management of Post-Discectomy Syndrome

        Ahmed Bahaa Al Din AlShazli,Ashraf Yassin Amer,Ahmed Maher Sultan,Ahmed Samir Barakat,Wael Koptan,Yasser ElMiligui,Hesham Shaker 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.2

        Study Design: This was a prospective case series of 30 patients with post-discectomy syndrome with an average of 18 months of follow-up (level IV). Purpose: The efficacy of post-discectomy syndrome managed by minimally invasive surgery transforaminal lumbar interbody fusion (MIS-TLIF) was evaluated. Overview of Literature: In post-discectomy syndrome wherein conservative treatment had failed, the best surgical treatment modality still remains controversial. Methods: Patients were functionally assessed using the Visual Analog Scale (VAS) for low back pain (LBP) and leg pain (LP) and Oswestry Disability Index (ODI). Radiological fusion was confirmed with plain X-rays and when indicated with computed tomography scan at 12 months postoperatively. A total of 30 patients with 37 operated at lumbar levels with failed discectomy surgery who met our inclusion criteria were treated with MIS-TLIF. Results: The ODI of all patients showed significant improvement from a mean of 73.78% preoperatively to 16.67% at 1 month and 14.13% at 12 months postoperatively. The preoperative LBP VAS score (mean, 4.37) showed a significant decrease (p<0.001) to 1.90 at 1 month and 1.10 at 12 months. Preoperative LP VAS score of limb pain averaged 7.53 and showed a significant (p<0.001) decrease to 3.47 at 1 month and 1.10 at 12 months. All patients attained radiological fusion at 12 months. Conclusions: MIS-TILF constitutes a valid and effective treatment option for patients with post-discectomy syndrome.

      • KCI등재후보

        The ameliorating role of sofosbuvir and daclatasvir on thioacetamide-induced kidney injury in adult albino rats

        Ahmed H. Moustafa(Ahmed H. Moustafa ),Heba F. Pasha(Heba F. Pasha ),Manar A. Abas(Manar A. Abas ),Adel M. Aboregela(Adel M. Aboregela ) 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.1

        Thioacetamide (TAA) exposure and hepatitis C virus infection are usually associated with renal dysfunction. Sofosbuvir (SFV) and daclatasvir (DAC) drugs combination has great value in the treatment of hepatitis C. The study aimed to identify the nephrotoxic effects of TAA and to evaluate the ameliorative role of SFV and DAC in this condition. Forty-eight adult male albino rats were divided into eight groups and received saline (control), SFV, DAC, SFV+DAC, TAA, TAA+SFV, TAA+DAC and TAA+SFV+DAC for eight weeks. Kidney and blood samples were retrieved and processed for histological (Hematoxylin and Eosin and Masson’s trichrome), immunohistochemical (α-smooth muscle actin), and biochemical analysis (urea, creatinine, total protein, albumin, malondialdehyde, reduced glutathione, superoxide dismutase, and tumor necrosis factor-α). Examination revealed marked destruction of renal tubules on exposure to TAA with either hypertrophy or atrophy of glomeruli, increase in collagen deposition, and wide expression of α-smooth muscle actin. Also, significant disturbance in kidney functions, oxidative stress markers, and tumor necrosis factor-α. Supplementation with either SFV or DAC produced mild improvement in the tissue and laboratory markers. Moreover, the combination of both drugs greatly refined the pathology induced by TAA at the cellular and laboratory levels. However, there are still significant differences when compared to the control. In conclusion, SFV and DAC combination partially but greatly ameliorated the renal damage induced by TAA which might be enhanced with further supplementations to give new hope for those with nephropathy associated with hepatitis.

      • Bending of axially functionally graded carbon nanotubes reinforced composite nanobeams

        Ahmed Drai,Ahmed Amine Daikh,Mohamed Oujedi Belarbi,Mohammed Sid Ahmed Houari,Benoumer Aour,Amin Hamdi,Mohamed A. Eltaher Techno-Press 2023 Advances in nano research Vol.14 No.3

        This work presents a modified analytical model for the bending behavior of axially functionally graded (AFG) carbon nanotubes reinforced composite (CNTRC) nanobeams. New higher order shear deformation beam theory is exploited to satisfy parabolic variation of shear through thickness direction and zero shears at the bottom and top surfaces.A Modified continuum nonlocal strain gradient theoryis employed to include the microstructure and the geometrical nano-size length scales. The extended rule of the mixture and the molecular dynamics simulations are exploited to evaluate the equivalent mechanical properties of FG-CNTRC beams. Carbon nanotubes reinforcements are distributed axially through the beam length direction with a new power graded function with two parameters. The equilibrium equations are derived with associated nonclassical boundary conditions, and Navier's procedure are used to solve the obtained differential equation and get the response of nanobeam under uniform, linear, or sinusoidal mechanical loadings. Numerical results are carried out to investigate the impact of inhomogeneity parameters, geometrical parameters, loadings type, nonlocal and length scale parameters on deflections and stresses of the AFG CNTRC nanobeams. The proposed model can be used in the design and analysis of MEMS and NEMS systems fabricated from carbon nanotubes reinforced composite nanobeam.

      • Poster Session : PS 0590 ; Critical Care Medicine ; Early CT Scan to Detect Anastomotic Leak: Is It Worth It?

        ( Ahmed Ahmed ),( Ayan Banerjea ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Early diagnosis of anastomotic leakage after colorectal surgery and adequate treatment is crucial to reduce both morbidity and mortality. Computed tomography(CT) scanning is the diagnostic investigation of preference, but its role is questionable in the early postoperative days. The accuracy of CT scanning in the early postoperative period within the fi rst few days after surgery may even be lower when compared to a CT scan more than a week after surgery. Methods: 185 patients underwent 1 or more bowel anastomosis during the period of 6 months. A prospective data sheet was updated regularly with post op morbidity and mortality. The type of anastomosis, timing of postoperative CT scan, diagnosis of leakage and accuracy of the CT scan in detecting it were all recorded. Results: 54 patients (29%) had CT scans post operatively, of whom 48 happened during the same admission with a mean time of 5±3 days postoperatively.A total of 9 patients had their fi rst CT scan onday 3 or earlier postoperatively with one leak detected on that. The mean time for diagnosing a leak was 14±8 days. Conclusions: Timely and correct diagnosis and treatment of anastomotic leakage after bowel surgery remains to be a major challenge.Clinical decision remains of utmost importance in the individual patient and should therefore not depend on one specifi c clinical or additional diagnostic factor.

      • KCI등재

        Control of Open-Loop PWM Delta-Connected Motor-Drive Systems under One Phase Failure Condition

        Ahmed Sayed-Ahmed,Nabeel A. O. Demerdash 전력전자학회 2011 JOURNAL OF POWER ELECTRONICS Vol.11 No.6

        A new fault-tolerant control topology for open-loop motor-drive systems with Delta-connected stator windings is introduced in this paper. This new control topology enables the operation of a three-phase induction machine as a two-phase machine fed by a three-phase inverter upon a failure in one of the motor phases. This topology utilizes the “open-Delta” configuration to independently control the current in each of the two remaining healthy phases. This new control technique leads to the alleviation of any torque pulsations resulting from the consequences of the asymmetrical conditions associated with this class of faults.

      • SCOPUS

        The Interplay between Comprehensive Use of Performance Management Systems and Corporate Financial and Non-Financial Performance: Evidence from Saudi Arabia

        Ahmed Abdullah Saad AL-DHUBAIBI(Ahmed Abdullah Saad AL-DHUBAIBI ) 한국유통과학회 2023 The Journal of Asian Finance, Economics and Busine Vol.10 No.1

        A significant body of prior research on performance management systems (PMSs) either explains the components and the design of the systems or investigates the link between particular system/s and organizational functions, capabilities, or performance. In contrast, this study investigates the comprehensive use of PMSs and relates them to corporate financial and non-financial performance. Further, this study examines whether the association between PMSs and performance varies between industries or is moderated by the size of the company. Data was collected using a questionnaire that was sent to companies from different industries operating in Riyadh province, where the most important businesses in Saudi Arabia are located. A total of 152 usable responses were received. The results of this study revealed that companies use a variety of PMSs at a balanced level. The extent of each category of PMS use is associated with the extent of other PMS categories’ use. However, the larger the company, the more PMSs it uses. Importantly, the results showed a positive and significant association between PMSs’ extent of use and both financial and non-financial performance. This association was minimally moderated by the company size and industry for specific categories of PMSs and performance.

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