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RISS 인기검색어
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- 저자 : Ahmed H. Moustafa(Ahmed H. Moustafa ) (검색결과 2 건)
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Ahmed H. Moustafa(Ahmed H. Moustafa ),Heba F. Pasha(Heba F. Pasha ),Manar A. Abas(Manar A. Abas ),Adel M. Aboregela(Adel M. Aboregela ) 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.1
Thioacetamide (TAA) exposure and hepatitis C virus infection are usually associated with renal dysfunction. Sofosbuvir (SFV) and daclatasvir (DAC) drugs combination has great value in the treatment of hepatitis C. The study aimed to identify the nephrotoxic effects of TAA and to evaluate the ameliorative role of SFV and DAC in this condition. Forty-eight adult male albino rats were divided into eight groups and received saline (control), SFV, DAC, SFV+DAC, TAA, TAA+SFV, TAA+DAC and TAA+SFV+DAC for eight weeks. Kidney and blood samples were retrieved and processed for histological (Hematoxylin and Eosin and Masson’s trichrome), immunohistochemical (α-smooth muscle actin), and biochemical analysis (urea, creatinine, total protein, albumin, malondialdehyde, reduced glutathione, superoxide dismutase, and tumor necrosis factor-α). Examination revealed marked destruction of renal tubules on exposure to TAA with either hypertrophy or atrophy of glomeruli, increase in collagen deposition, and wide expression of α-smooth muscle actin. Also, significant disturbance in kidney functions, oxidative stress markers, and tumor necrosis factor-α. Supplementation with either SFV or DAC produced mild improvement in the tissue and laboratory markers. Moreover, the combination of both drugs greatly refined the pathology induced by TAA at the cellular and laboratory levels. However, there are still significant differences when compared to the control. In conclusion, SFV and DAC combination partially but greatly ameliorated the renal damage induced by TAA which might be enhanced with further supplementations to give new hope for those with nephropathy associated with hepatitis.
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Al-Maliki, Ammar F.H.,Ahmed, Ridha A.,Moustafa, Nader M.,Faleh, Nadhim M. Techno-Press 2020 Advances in computational design Vol.5 No.2
In the present research, dynamic analysis of functionally graded (FG) graphene-reinforced beams under thermal loading has been carried out based on finite element approach. The presented formulation is based on a higher order refined beam element accounting for shear deformations. The graphene-reinforced beam is exposed to transverse periodic mechanical loading. Graphene platelets have three types of dispersion within the structure including uniform-type, linear-type and nonlinear-type. Convergences and validation studies of derived results from finite element approach are also presented. This research shows that the resonance behavior of a nanocomposite beam can be controlled by the GPL content and dispersions. Therefore, it is showed that the dynamical deflections are notably influenced by GPL weight fractions, types of GPL distributions, temperature changes, elastic foundation and harmonic load excitation frequency.
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