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        • KCI등재

          A Qualitative Approach of Psychosocial Adaptation Process in Patients Undergoing Long-term Hemodialysis

          Chun-Chih,Lin,Chin-Yen,Han,I-Ju,Pan 한국간호과학회 2015 Asian Nursing Research Vol.9 No.1

          Purpose: Professional hemodialysis (HD) nursing tends to be task-oriented and lack consideration of the client's viewpoint. This study aims to interpret the process of psychosocial adaptation to dealing with HD in people with end-stage renal disease (ESRD). Methods: A grounded theory guided this study. Theoretical sampling included 15 people receiving HD at the HD center of a hospital from July to November 2010. Participants received an information sheet in writing, a verbal invitation, and informed consent forms before interviews were conducted. A constantcomparative data analysis was analyzed using open, axial and selective coding. The computer software ATLAS.ti assisted data management. Credibility, transferability, dependability, and confirmability ensured the rigor of study process. Results: This study identified “adopting life with hemodialysis”, which captures the process of the psychosocial adaptation in people with ESRD as one transformation. Four categories that evolved from “adopting HD life” are (a) slipping into, (b) restricted to a renal world, (c) losing self control, and (d) stuckin an endless process. Conclusions: The findings of this investigation indicate the multidimensional requirements of people receiving maintenance dialysis, with an emphasis on the deficiency in psychosocial and emotional care. The study's findings contribute to clinical practice by increasing the understanding of the experience ofchronic HD treatment from the recipient's viewpoint. The better our understanding, the better the care provided will meet the needs of the people receiving HD.

        • KCI등재SCOPUS

          FDG PET or PET/CT in Evaluation of Renal Angiomyolipoma

          Chun-Yi,Lin,Hui-Yi,Chen,Hueisch-Jy,Ding,Kuo-Yang,Yen,Chia-Hung,Kao 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.2

          Objective: Angiomyolipoma is the most common benign kidney tumor. However, literature describing FDG PET findings on renal angiomyolipoma (AML) is limited. This study reports the FDG PET and PET/CT findings of 21 cases of renal AML. Materials and Methods: The study reviews FDG PET and PET/CT images of 21 patients diagnosed with renal AML. The diagnosis is based on the classical appearance of an AML on CT scan with active surveillance for 6 months. The study is focused on the observation of clinical and radiographic features. Results: Six men and 15 women were included in our study. The mean age of the patients was 57.14 ± 9.67 years old. The mean diameter of 21 renal AML on CT scans was 1.76 ± 1.00 cm (Min: 0.6 cm; Max: 4.4 cm). CT scans illustrated renal masses typical of AMLs, and the corresponding FDG PET scans showed minimal FDG activities in the area of the tumors. None of the 21 AMLs showed a maximum standardized uptake value (SUVmax) greater than 1.98. No statistically significant correlation was present between SUVmax and tumor size. Conclusion: Renal AMLs demonstrate very low to low uptake on FDG PET and PET/CT imaging in this study. When a fatcontaining tumor in the kidney is found on a CT scan, it is critical to differentiate an AML from a malignant tumor including an RCC, liposarcoma, and Wilms tumor. This study suggests that FDG PET or PET/CT imaging is useful for differentiating a renal AML from a fat-containing malignant tumor.

        • KCI등재

          Nucleophosmin modulates the alleviation of atopic dermatitis caused by the marine-derived compound dihydroaustrasulfone alcohol

          Han-Chun,Hung,Chien-Wei,Feng,Yen-You,Lin,Chun-Hong,Chen,Kuan-Hao,Tsui,Wu-Fu,Chen,Chieh-Yu,Pa,Jyh-Horng,Sheu,Chun-Sung,Sung,Zhi-Hong,Wen 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

          Atopic dermatitis (AD) is a chronic inflammatory skin disease, and its prevalence is increasing. AD usually elicits skin barrier dysfunction, dry skin and itching. As the mechanisms of AD remain unknown, there is an urgent need to find effective therapies. Because of the diversity and complexity of marine environments, the discovery of drugs from marine organisms as novel therapeutic agents for human diseases has seen renewed interest. Dihydroaustrasulfone alcohol (WA-25), the synthetic precursor of austrasulfone, which is a natural product isolated from a Formosan soft coral, has been shown to possess many therapeutic effects in our previous studies. However, the detailed mechanisms and therapeutic effects of WA-25 on AD are incompletely understood. We performed in vitro and in vivo studies to examine the effects of WA-25 on AD. We showed that WA-25 blocks inflammation and oxidative stress. Simultaneously, we also found that WA-25 reduces the AD scores and AD-induced transepidermal water loss (TEWL), scratching behavior, and alloknesis. WA-25 is more effective in cases of AD than are the drugs that are currently used clinically. Importantly, we also found that when nucleophosmin (NPM) was inhibited or when its expression was reduced, the anti-inflammatory and anti-AD effects of WA-25 were blocked. These data suggest that NPM plays dual roles in inflammation and AD. Overall, these results suggest that WA-25 is a potential anti-inflammatory and AD therapeutic agent that is modulated by NPM.

        • KCI등재

          The Environmental Civil Society and the Transformation of State-Society Relations in China: Building a Tri-level Analytical Framework

          Teh-chang,Lin,Jean,Yen-chun,Lin 인하대학교 국제관계연구소 2007 Pacific Focus Vol.22 No.2

          State-society relations is a conventional tool used in analyzing the relational behavioral pattern of between the state and the society. In China, market reforms and open policy since 1978 have engendered the growth of environmental civil society organizations and thereby enhanced the changes in the nature of state-society relations. However, the analysis of Chinese state-society relations has in the past largely been two-dimensional, focusing on domestic relations. However, changing patterns of state-society relations in China has called for a more elaborate tri-level analytical framework of the state, its main civil society representative, domestic non-governmental organizations, and international non-governmental organizations. Through the study of environmental protests such as anti-dam construction demonstrations, we have found that domestically, Chinese environmental non- governmental organizations not only act as a challenger to the state, but at times collaborate with the state. From an external perspective, international non-governmental organizations not only directly challenge the Chinese state, but also network with local Chinese NGOs in their protests. This article thus adds a new level to the conventional analysis of state-society relations in China.

        • KCI등재SCOPUS

          Positive Symptoms in Antipsychotic-naïve Schizophrenia are Associated with Increased Body Mass Index after Treatment

          Shih-Hsien,Lin,Huai-Hsuan,Tseng,Hsin,Chun,Tsai,Mei,Hung,Chi,I,Hui,Lee,Po,See,Chen,Kao,Chin,Chen,Yen,Kuang,Yang 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.1

          Objective: Weight gain is an important risk factor for morbidity and mortality among patients with schizophrenia. We speculated that positive symptoms, related to dopaminergic hyperactivity and altered mesolimbic function, are associated with weight gain. Methods: Twenty-two antipsychotic-naïve, first-episode patients with schizophrenia were enrolled. The Positive and Negative Syndrome Scale was completed at enrollment and follow-up. Body mass index (BMI) was also measured. Results: The increase in BMI, after 6.04 ± 2.16 years of follow-up, was associated with positive symptoms, but not negative symptoms, before treatment with antipsychotics in antipsychotic-naïve patients with schizophrenia. Conclusion: This finding implied that dopaminergic hyperactivity could be an important factor to predict the treatment outcome. Body weight control is important for the health management of patients with schizophrenia with more severe positive symptoms.

        • KCI등재SCOPUS

          Heart Rate Variability Biofeedback Increased Autonomic Activation and Improved Symptoms of Depression and Insomnia among Patients with Major Depression Disorder

          I-Mei,Lin,Sheng-Yu,Fan,Cheng-Fang,Yen,Yi-Chun,Yeh,Tze‐Chun,Tang,Mei-Feng,Huang,Tai-Ling,Liu,Peng-Wei,Wang,Huang-Chi,Lin,Hsin-Yi,Tsai,Yu-Che,Tsai 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.2

          Objective: Autonomic imbalance is considered a psychopathological mechanism underlying major depressive disorder (MDD). Heart rate variability (HRV) is an index for autonomic activation. Poor sleep quality is common among patients with MDD. HRV biofeedback (BF) has been used for regulating autonomic balance among patients with physical illness and mental disorders. The purpose of present study was to examine the effects of HRV-BF on depressive symptoms, sleep quality, pre-sleep arousal, and HRV indices, in patients with MDD and insomnia. Methods: In this case-controlled study, patients with MDD and Pittsburgh Sleep Quality Index (PSQI) score higher than 6 were recruited. The HRV-BF group received weekly 60-minute protocol for 6 weeks, and the control group who have matched the age and sex received medical care only. All participants were assessed on Beck Depression Inventory-II, Back Anxiety Inventory, PSQI, and Pre-Sleep Arousal Scale. Breathing rates and electrocardiography were also performed under resting state at pre-testing, and post-testing conditions and for the HRV-BF group, also at 1-month follow-up. Results: In the HRV-BF group, symptoms of depression and anxiety, sleep quality, and pre-sleep arousal were significantly improved, and increased HRV indices, compared with the control group. Moreover, in the HRV-BF group, significantly improved symptoms of depression and anxiety, decreased breathing rates, and increased HRV indices were detected at post-testing and at 1-month follow-up, compared with pre-testing values. Conclusion: This study confirmed that HRV-BF is a useful psychosocial intervention for improving autonomic balance, baroreflex, and symptoms of depression and insomnia in MDD patients.

        • SCOPUSKCI등재

          The Environmental Civil Society and the Transformation of State-Society Relations in China: Building a Tri-Level Analytical Framework

          ( The Chang Lin ), ( Jean Yen Chun Lin ) 인하대학교 국제관계연구소 2007 Pacific Focus Vol.22 No.2

          State-society relations is a conventional tool used in analyzing the relational behavioral pattern of between the state and the society. In China, market reforms and open policy since 1978 have engendered the growth of environmental civil society organizations and thereby enhanced the changes in the nature of state-society relations. However, the analysis of Chinese state-society relations has in the past largely been two-dimensional, focusing on domestic relations. However, changing patterns of state-society relations in China has called for a more elaborate tri-level analytical framework of the state, its main civil society representative, domestic non-governmental organizations, and international non-governmental organizations. Through the study of environmental protests such as anti-dam construction demonstrations, we have found that domestically, Chinese environmental non- governmental organizations not only act as a challenger to the state, but at times collaborate with the state. From an external perspective, international non-governmental organizations not only directly challenge the Chinese state, but also network with local Chinese NGOs in their protests. This article thus adds a new level to the conventional analysis of state-society relations in China.

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