에너지 수지식을 통합한 단일 입자 모델을 통한 리튬 이온 전지의 방전 용량 및 온도 분석

홍창범,조현우,오세규,김연수 제어로봇시스템학회 2021 제어로봇시스템학회 국내학술대회 논문집 Vol.2021 No.6

Sensitivity analysis for parameter classification of energy balance-integrated single particle model for battery cells

홍창범,오세규,김연수 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.6

With the increasing use of electric vehicles (EVs), there is a growing interest in the thermal management ofEVs. In this study, we first reduced the computational complexity of single particle model (SPM) for the battery cell byintroducing a 4th order approximation for Li-ion concentration in the solid phase. In addition, by integrating it with anenergy balance, the constructed model can calculate the battery temperature along with the terminal voltage and stateof charge. To develop a model compatible with the experimental data requires parameter estimation. However, the estimationaccuracy for each parameter depends on its sensitivity. We investigated the influence of 16 parameters on themeasured data under general experimental conditions (constant C-rate discharge) through simulations and sensitivityanalysis. We classified the radius of the particle, total active surface areas, electrode maximum concentration, and a heattransfer coefficient as dominant parameters. When dominant parameters were estimated using the virtual experimentaldata, the percent error was smaller than 3.1%. For the parameters with minor influence, the estimation error waslarge even with the excellent agreement of the experimental data. We confirmed which parameter could be estimatedusing the C-rate experimental data accurately and which parameter should be estimated with additional experiments.

전기화학발광소자에서 전극구조와 발광효율의 상관관계 연구

홍창범(Chang-Beom Hong),홍석우(Seok-Woo Hong),황동하(Dong-Ha Hwang),송종원(Jong-Won Song),김지석(Ji-Seok Kim),양승준(Seung-Joon Yang),성열문(Youl-Moon Sung) 대한전기학회 2014 대한전기학회 학술대회 논문집 Vol.2014 No.7

클러스터 환경에서의 MPI 기반 병렬 서열 유사성 검색에 관한 연구

홍창범(Chang-Bum Hong),차정호(Jeoung-Ho Cha),이성훈(Sung-Hoon Lee),신승우(Seung-Woo Shin),박근준(Keun-Joon Park),박근용(Keun-Young Park) 한국컴퓨터정보학회 2006 韓國컴퓨터情報學會論文誌 Vol.11 No.6

생물정보학 연구 있어서 아미노산이나 염기서열에 대한 유사성이나 상동성을 찾아내는 작업은 유전자의 기능에 대한 예측이나 단백질 구조를 예측하는 연구의 기반이 된다. 이러한 서열 데이터는 컴퓨터의 도입으로 매우 빠르게 증가하고 있다. 이러한 시점에서 서열에 대한 검색 속도는 매우 중요한 요소이기 때문에 대량의 서열정보를 다루기 위해서는 SMP(Sysmmetric Multi-Processors) 컴퓨터나 클러스터를 이용하고 있다. 본 논문에서는 서열 검색에 사용되는 BLAST(Basic Local Alignment Search Tool)의 속도향상을 위한 방법으로 클러스터 환경에서 병렬화 하는 nBLAST 알고리즘의 병렬화에 대해 제안한다. nBLAST는 기존의 BLAST 소스코드에 대한 수정 없이 병렬라이브러리인 MPI(Message Passing Interface)를 이용하여 질의를 분할하여 병렬화 하기 때문에 환경설정 등의 복잡한 과정을 거치지 않고 손쉽게 BLAST에 알고리즘에 대한 병렬화를 할 수 있다. 또한, 실험을 통하여 28대의 리눅스 클러스터에서 nBLAST를 수행하여 노드 수의 증가에 따른 성능 향상을 확인하였다. In the field of the bioinformatics, it plays an important role in predicting functional information or structure information to search similar sequence in biological DB. Biological sequences have been increased dramatically since Human Genome Project. At this point, because the searching speed for the similar sequence is highly regarded as the important factor for predicting function or structure, the SMP(Sysmmetric Multi-Processors) computer or cluster is being used in order to improve the performance of searching time. As the method to improve the searching time of BLAST(Basic Local Alighment Search Tool) being used for the similarity sequence search, We suggest the nBLAST algorithm performing on the cluster environment in this paper. As the nBLAST uses the MPI(Message Passing Interface), the parallel library without modifying the existing BLAST source code, to distribute the query to each node and make it performed in parallel, it is possible to easily make BLAST parallel without complicated procedures such as the configuration. In addition, with the experiment performing the nBLAST in the 28 nodes of LINUX cluster, the enhanced performance according to the increase in the number of the nodes has been confirmed.

Identification of Causal and/or Rare Genetic Variants for Complex Traits by Targeted Resequencing in Population-based Cohorts

김윤경,홍창범,조윤신 한국유전체학회 2010 Genomics & informatics Vol.8 No.3

Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SNP microarray chip. In an effort to detect potential casual and/or rare variants for complex traits, such as type 2 diabetes (T2D) and triglycerides (TGs), we conducted a targeted resequencing of loci identified by the Korea Association REsource (KARE) GWAS. The target regions for resequencing comprised whole exons, exon-intron boundaries, and regulatory regions of genes that appeared within 1 Mb of the GWA signal boundary. From 124 individuals selected in population-based cohorts, a total of 0.7 Mb target regions were captured by the NimbleGen sequence capture 385K array. Subsequent sequencing, carried out by the Roche 454 Genome Sequencer FLX, generated about 110,000 sequence reads per individual. Mapping of sequence reads to the human reference genome was performed using the SSAHA2 program. An average of 62.2% of total reads was mapped to targets with an average 22X-fold coverage. A total of 5,983 SNPs (average 846 SNPs per individual) were called and annotated by GATK software, with 96.5% accuracy that was estimated by comparison with Affymetrix 5.0 genotyped data in identical individuals. About 51% of total SNPs were singletons that can be considered possible rare variants in the population. Among SNPs that appeared in exons, which occupies about 20% of total SNPs, 304 nonsynonymous singletons were tested with Polyphen to predict the protein damage caused by mutation. In total, we were able to detect 9 and 6 potentially functional rare SNPs for T2D and triglycerides, respectively, evoking a further step of replication genotyping in independent populations to prove their bona fide relevance to traits.

안전한 메시지교환을 위한 XML 기반의 변환시스템

오대균 ( Dae-gyun Oh ),홍창범 ( Chang-bum Hong ),송정길 ( Jung-gil Song ) 한국인터넷정보학회 2002 인터넷정보학회논문지 Vol.3 No.4

XML 스키마가 2001년 5월 W3C의 공식 표준안으로 확정되고, XSL과 Xpath, Namespace등의 XML 관련 기술이 발전됨에 따라 XML은 새로운 문서교환의 표준이 되어가고 있다. XML은 다양한 문서의 구조를 표현할 수 있기 때문에 ebXML, RosettaNet, BizTalk들이 e-Business 부분에서 XML을 핵심기술로 사용하고 있다. B2B 전자상거래 시스템에서 업무를 자동화하기 위해서는 표준의 XML 문서가 필요하다. 각 기업들의 내부 문서를 외부기업의 자동화 시스템에서 처리하기 위해서는 문서의 정보손실 없이 외부기업의 문서 형태로 변환하여야 한다. 본 논문에서는 자바 서블릿을 기반으로 XML 문서의 변환하여, 안전한 문서교환을 제공하는 XML 시스템을 설계 구현하였다. As a XML Schema has been settled to W3C as official standard at May. 2001 and technologies like as XSL, Xpath and NameSpace related with XML has been developing, XML is becoming the standard of the new document exchanging. Due to the ability expressing various types of documentstructure through XML, ebXML, RosettaNet, and BizTalk are using XML as a core technology in the part of e-Business, To make the task automatically in the B2B EC now, a standard XML document is needed. Internal documents in each company should be transformed differently without any loss to work with other companies. In this paper, transforming XML document based on JAVA servlet is considered as realization of a XML system to exchange documents safely.

La$_{0.875-x}$Yb$_{0.125}$)NbO$_4$:Tm$_x^{3+}$ 형광체의 형광특성

신상수,이성수,박세진,홍창범,신성재,김인기,추장우,홍영범,백민하,최정곤 한국물리학회 2016 새물리 Vol.66 No.10

Tm$^{3+}$and Yb$^{3+}$ co-doped LaNbO$_4$ polycrystalline powders were prepared by using a solid-state reaction method, and their crystallinities and surface morphologies were analyzed by using X-ray diffraction and scanning electron microscopy, respectively. According to the results of X-ray diffraction, the powders showed a polycrystalline monoclinic structure. The photoluminescence and the upconversion luminescence properties of (La$_{0.875-x}$Yb$_{0.125}$)NbO$_4$:Tm$_x^{3+}$($x$ = 0.006, 0.008, 0.01, 0.03 and 0.05) phosphors were investigated in detail. Blue upconversion emissions were observed in the phosphors under excitation by 980 nm laser diode. The powders exhibited strong blue upconversion emission peaks at 476 nm. The maximum emission intensity was obtained for the 0.006 mol Tm$^{3+}$-doped powders, and intensity decreased as the concentration of Tm$^{3+}$ ions was increased to 0.05 mol. 본 연구에서는 Yb$^{3+}$이온의 농도를 0.125 mol에 고정하고 Tm$^{3+}$이온의 농도를 변화시킨(La$_{0.875-x}$Yb$_{0.125}$)NbO$_4$:Tm$_x^{3+}$ ($x$ = 0.006, 0.008, 0.01, 0.03 and 0.05) 형광체 분말을 고상 반응법(solid state reaction)을 이용하여 합성하고 구조적특성 및 표면적특성, 형광특성 을 연구하였다. X-선 회절장치 및 주사전자현미경을 이용하여 형광체 분말의 결정성 및 표면형상을 측정하였으며, 형광광도계를 이용하여 형광특성을 관찰하였고, 980 nm 레이저 다이오드와 분광기를 이용하여 형광체의 상방전환 형광특성을 분석하였다. (La$_{0.875-x}$Yb$_{0.125}$)NbO$_4$:Tm$_x^{3+}$ 분말은 Tm$^{3+}$ 이온의 함유량에 관계없이 단사정계 구조의 다결정상으로 성장함을 알 수 있었다. (La$_{0.875-x}$Yb$_{0.125}$)NbO$_4$:Tm$_x^{3+}$ 분말의 경우 Tm$^{3+}$ 이온의 첨가량이 0.006 mol일 때 형광세가가 가장 강했고, Tm$^{3+}$의 첨가량이 증가할수록 형광의 세기가 감소함을 알 수 있었다.

전자상거래 통합을 위한 XML 매핑 정형화 기법

안우영(Woo-Young Ahn),홍창범(Chang-Bum Hong) 한국컴퓨터정보학회 2004 韓國컴퓨터情報學會論文誌 Vol.9 No.1

XML을 핵심 기술로 사용하는 RosettaNet이나 BizTalk 등의 다양한 전자상거래 프레임워크들이 생겨나기 시작하면서 프레임워크들은 각자의 표준에 따라 파트너 간에 비즈니스 프로세스를 수행하게 된다. 이러한 프레임워크간의 상이함은 전자상거래시 기업 간의 문서의 다양성으로 인하여 문서 교환에 어려움이 따르게 된다. 본 논문에서는 XML 문서의 정보를 추출 단계를 거쳐 문서정보를 기반으로 매핑 정보를 생성한 후 문서간의 매핑룰을 적용하여 변환할 수 있도록 설계하였다. 따라서 전자상거래 프레임워크 간정보의 손실 없이 상호 문서 교환이 가능할 뿐만 아니라 신뢰할 수 있는 교환이 가능하다. XML is becoming the standard of the new document exchanging. Due to the ablility expressing various types of document structure through XML, RosettaNet and BizTalk are using XML as a core technology in the part of e-Business. Framework is running Business process each other different standard. Internal documents in each company should be transformed differently without any loss to work with other companies. In this paper, transforming processor based on XML mapping information from XML document information.

심층 신경망과 랜덤포레스트를 이용한 유전암 관련 단일 염기 변이의 병원성 예측

이다빈,김선화,강문종,홍창범,황규백 한국정보과학회 2023 정보과학회논문지 Vol.50 No.9

The recent proliferation of genetic testing has made it possible to explore an individual's genetic variants and use pathogenicity information to diagnose and prevent genetic diseases. However, the number of identified variants with pathogenicity information is quite small. A method for predicting the pathogenicity of variants by machine learning was proposed to address this problem. In this study, we apply and compare deep neural networks with random forests and logistic regression, which have been widely used in previous studies, to predict variant pathogenicity. The experimental data consisted of 1,068 single-nucleotide variants in genes associated with hereditary cancers. Experiments on 100 random data-sets generated for hyperparameter selection showed that random forests performed best in terms of area under the precision-recall curve. On 15 holdout gene data-sets, deep neural networks performed best on average, but the difference in performance from the second-best random forest was not significant. Logistic regression was also statistically significantly worse than that of either model. In conclusion, we found that deep neural networks and random forests were generally better than logistic regression at predicting the pathogenicity of single-nucleotide variants associated with hereditary cancer.

(Gd$_{0.94-x}$Yb$_{0.06}$)VO$_4$:Er$_x^{3+}$ 형광체의 형광특성

최성우,신상수,이성수,김인기,추장우,홍영범,박세진,홍창범,신성재,최정곤 한국물리학회 2016 새물리 Vol.66 No.9

Er$^{3+}$and Yb$^{3+}$ co-doped GdVO$_4$ polycrystalline powders were prepared by using a solid-state reaction method, and their crystallinity and surface morphology were analyzed by using X-ray diffraction and scanning electron microscopy, respectively. According to the X-ray diffraction results, the crystallinity of the powders showed a polycrystalline tetragonal structure. Photoluminescence and the upconversion luminescence properties of (Gd$_{0.94-x}$Yb$_{0.06}$)VO$_4$:Er$_x$($x$ = 0, 0.02, 0.04 and 0.06) phosphors were investigated in detail. The red and the green upconversion emissions were observed in the phosphors under excitation by using a 980 nm laser diode. The powders exhibited strong green and red upconversion emission peaks at 553 and 660 nm, respectively. Also, their upconversion processes were explained by measuring the dependence of the upconversion luminescence on the pump's power intensity. Yb$^{3+}$이온의 농도를 0.06 mol에 고정하고 Er$^{3+}$이온의 농도를 변화시킨(Gd$_{0.94-x}$Yb$_{0.06}$)VO$_4$:Er$_x^{3+}$ 형광체 분말을 고상 반응법(solid state reaction)을 이용하여 합성하고 형광특성을 연구하였다. X-선 회절장치 및 주사전자현미경을 이용하여 형광체 분말의 결정성 및 표면형상을 측정하였으며, 형광광도계를 이용하여 형광특성을 관찰하였다. 980 nm 레이저 다이오드와 분광기를 이용하여 형광체의 상방전환 형광특성을 분석하였다. (Gd$_{0.94-x}$Yb$_{0.06}$)VO$_4$:Er$_x^{3+}$ 분말은 Er$^{3+}$ 이온의 함유량에 관계없이 정방정계 구조의 다결정상으로 성장하였음을 확인할 수 있었다. (Gd$_{0.94-x}$Yb$_{0.06}$)VO$_4$:Er$_x^{3+}$ 분말의 경우 Er$^{3+}$ 이온의 첨가량이 0.04 mol일 때 가장 좋은 형광세기를 나타내었으며, Er$^{3+}$ 이온의 함량이 0.06 mol로 증가 하였을 때에는 형광세기가 오히려 감소함을 알 수 있었다. 980 nm 레이저 다이오드로 여기한 GdVO$_4$:Er$^{3+}$ 형광체의 상방전환 발광스펙트럼은 553 nm 부근의 강한 녹색 형광과 660 nm에서의 적색 형광을 나타내었다.