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갱년기 골다공증 환자의 HRT와 Alendronate 1년 병합치료 효과
오한진(Han Jin Oh),임창훈(Chang Hun Lim),정호연(Ho Yeon Chung),한기옥(Ki Ok Han),장학철(Hak Chul Jang),윤현규(Hyun Koo Yoon),한인권(In Kwon Han) 대한폐경학회 2000 대한폐경학회지 Vol.6 No.1
N/A Background; Rate of bone loss should be increased after menopause and then formation coupled with resoprtion also be increased. Alendronate (Fosamax ;MSD, Rahway, NJ, USA), an antiresorptive drug known to be helpful to prevent bone loss. Alendronate is one of antiresorptive drug for treatment of osteoporosis and resulted in a decrease of bone turnover, There are no available data about Korean people, So, we wanted to determine the effects of alendronate in Korean postmenopausal osteoporosis patients after 1- year treatment Subjects and Methods; We studied 42 women with postmenopausal osteoporosis (bone mineral density[BMD] T score<2.5) who visited osteoporosis clinic in Samsung Cheil Hospital from Jan. 1999 to Apr. 2000, Subjects were stratified in 2 groups. Group 1 treated with alendronate 10mg/day and estrogen, and Group 2 treated with estrogen alone. BMD at the lumbar spine were measured at baseline and 1-year after treatment. We also measured serum marker of bone formation (total alkaline phosphatase[Alk]), and marker of bone resorption (deoxypyridinoline [DPYD]) from urine at baseline, 3months and I-year after treatment. Results; The mean differences in changes of markers after 3 months and 1 year of treatment were remarked significantly (3-Month; delta Alk:-28,7±3.6%, delta DPYD:-31.0±5,4% vs 1-Year; delta Alk:-32.2±3.1%, delta DPYD:-23.0±3.5%). Markers of bone metabolism showed no significant responses between two groups at 3 months and 1year after treatment, Also, Bone mineral density at lumbar spine was significantly increased in Group treated with alendronatc and estrogen than estrogen only group (9.6±0,7% vs 5.3±0.6%, P<0,001). Conclusion; Our data showed that using alendronate with estrogen to the patients of Korean women with osteoporosis increase bone mineral density more, So, we concluded that alendronate therapy with estrogen was helpful to manage postmenopausal osteoporosis patients.
제7차 초등학교 과학과 교육과정 내용의 적정성 분석 및 평가
이양락 ( Yang Rak Lee ),박재근 ( Jae Keun Park ),이봉우 ( Bong Woo Lee ),한인옥 ( In Ok Han ) 한국초등과학교육학회 2005 초등과학교육 Vol.24 No.3
The purpose of this study was to examine the content relevance of the 7th national primary science curriculum and textbooks. To fulfill the purpose of the study, we 1) analyzed the 7th national science curriculum of Korea, Californian science standards, the national science curriculum of England and Japan, and current Korean and Japanese science textbooks, 2) conducted a nationwide survey to gather opinions from students, teachers, and professors of teachers` colleges about the relevance of the science curriculum and textbooks. Main findings of this study are as follows: First, the science contents at each grade level should be determined by the students` characteristics, not by an equal portion rule among physics, chemistry, biology and earth science. Second, the excessive overlapping and repetition of contents due to the spiral curriculum should be avoid. Third, the number of topics at each grade level should be reduced, and the similar topics and themes should be integrated for students` deeper understanding. Fourth, the number of science concepts and activities should be reduced to an appropriate level considering the time allotment for science classes, teachers` workload, laboratory conditions, etc. Fifth, differentiated curriculum, such as in-depth and supplementary course, should be described not in science contents, but in teaching and learning strategy.
정상 및 임신성 당뇨병 임신부의 임신 중 체중 증가량와 신생아 체중
김문영(Moon Young Kim),양재혁(Jae Hyug Yang),장학철(Hak Chul Jang),박정은(Jung Eun Park),임창훈(Chang Hoon Yim),정호연(Ho Yeun Chung),한기옥(Ki Ok Han),윤현구(Hyun Koo Yoon),한인권(In Kwon Han),김미정(Mi Jeong Kim),한혜경(Hye Kyung H 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
N/A Objective : The purpose of this study was to determine the independent factors that predict neonatal birthweight and find the relationship between maternal weight gain and neonatal birthweight in women with normal glucose tolerance (NGT) and gestational diabetes mellitus (GDM). Methods : Forty-six women with GDM and one hundred fifty women with NGT were included in the study. All subjects had singleton pregnancies and no medical diseases that may affect the fetal growth and were certain of gestational age by early ultrasonography. Maternal weight at each prenatal visit was recorded and neonatal anthropometic measurement was done within 2 days of birth. Results : The average rate of weight gain (kg/week) in NGT was lowest during the first trimester (0.09±0.10), peaked during the second trimester (0.52±0.14), and slowed after 34 gestational weeks (0.46±0.26). In women with GDM, the average rate of weight gain was also lowest during the first trimester (0.18±0.23), but it was twofold higher compared with women with NGT. There was a significant decrease of the rate of weight gain after 28 gestational weeks in women with GDM. Total weight gain during pregnancy was 3.4 kg less in women with GDM. Neonatal birthweight was correlated with maternal weight gain and the rate of weight gain during 14-27 and 28-33 weeks in NGT. However, birthweight was correlated with maternal weight gain and the rate of weight gain during the first trimester and 14-27 weeks in GDM. Conclusion : This result suggests that the women with GDM who have greater weight gain during the first and the second trimester have a increased risk of excessive fetal growth. Thus strict glycemic control during pregnancy is needed especially in these women.
폐경후 여성에서 경피적 에스트라디올 겔과 경구영 프로게스테론 주기적 병합요법의 임상적 유효성에 관한 연구
정호연 ( Ho Yeon Chung ),최규홍 ( Kyu Hong Choi ),이창욱 ( Chang Uk Lee ),김해성 ( Hae Sung Kim ),임창훈 ( Chang Hoon Yim ),한기옥 ( Ki Ok Han ),장학철 ( Hak Chul Jang ),윤현구 ( Hyun Koo Yoon ),한인권 ( In Kwon Han ) 대한폐경학회 2001 대한폐경학회지 Vol.7 No.1
N/A Objectives: The purpose of our study was to evaluate the effects of transdermal 17β -estradiol gel combined with oral progestogen in terms of serum lipid, bone markers and bone mineral density in Korean postmenopausal women Subjects and methods: Nine healthy postmenopausal women were asked to volunteer for pharmacokinetic analysis of estradiol gel. Subjects received daily application of 1.5 ㎎ of estrogen gel in the morning. Peripheral venous samples were drawn at 0, 0.5, 1, 2, 4, 8, 24, 48, 72 hours after the daily gel application and serum E2 levels were analyzed. 41 postmenopausal women with intact uterus and no menstruation for more than 12 months were treated with 1.5 ㎎ of estradiol gel (day 1-25) sequentially combined with 2.5㎎ of medroxyprogesterone acetate (day 16-25) orally for 1 year. Results: Although one volunteer showed increment of serum E2 one hour after application of estrogen gel, pharmacokinetic study showed increase of serum E2 after 24 hours in the most volunteers. The mean serum E2 level at 72 hour after application was 59.6±58.8 pg/㎖. The acceptability of the combined treatment was 73.2%. Only 1 (3.3%) woman complained skin irritation during treatment. The combined estradiol gel and oral progestogen therapy significantly decreased serum cholesterol levels by 7.8%, LDL by 8.5%. Markers of bone turnover significantly decreased 3 months after treatment. The increase of the annual percent change in bone density was 4.8% at the lumbar spine and 4.4% at the femoral neck. Conclusion: The combined estradiol gel with oral progestogen therapy is acceptable and effective treatment in postmenopausal women.
오한진,임창훈,정호연,한기옥,장학철,윤현구,한인권 대한비만학회 2000 The Korean journal of obesity Vol.9 No.2
In postmenopausal women, it has been noted that heavier women conserve bone better than those with lower body weight. The protective effect of obesity on bone mass has been ascribed to a high body fat content. The present study of 123 postmenopausal women was undertaken to determine the effects of obesity on sex hormone, FSH, SHBG, and BMD at lumbar spine of Korean postmenopausal women. Our result revealed that obese group has greater bone mineral density at lumbar spine than non-obese group. But, obese group was noted that have lower levels of FSH and SHBG than non-obese group significantly. But, we couldn't find out the differentiation of levels of estradio1 between two groups. Age adjusted values for BMD at lumbar spine, respectively, were positively correlated (r=0.219, p<0.05_ with BMI. And levels of FSH, adjusted with age, also revealed that have negative correlation (r=0.243, p<0.05) with BMI. so, we concluded that the protective effect of obesity on bone is related with FSH and SHBG, not with estradiol.
폐경후 여성에서 에스트로겐 치료에 대한 혈중 지질의 반응과 에스트로겐 수용체 다형성과의 관계
황정규,한인권,장학철,임창훈,정호연,한기옥,윤현구,박재은,박소라,정필호 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.3
Backgound: Several biologically plausible mechanisms have been proposed for estrogen-mediated caridoprotection, including estrogen-assocaited changes in lipid metabolism and endothelial function of vessel walls. These effects are thought to be mediated via estrogen receptor (ER). Relationships between ER polymorphisms and serum lipid levels were not investigated enoughly. Methods: Three restriction fragment length polymorphisms (RFLPs) at the ER gene locus, represented as B-variant, PvuII and XbaI, and their relationship to serum lipid levels were examined in 318 postmenopausal women. Their mean age was 54.5±6.5 years (mean+SD). An association between ER genotypes and changes in lipid levels after 1 year of estrogen replacement therapy was also investigated in follow-up 251 women. Results: The B-variant was not found in Korean women. The distribution of the PvuII and XbaI polymorphisms was as follows: PP 109 (34%), Pp 166 (52%), pp 43 (14%), and XX 204 (64%), Xx 95 (30%), xx 19 (6%). Significant relationshipwas found between genotypes and changes in serum total cholesterol levels after lyr estrogen replacement therapy. There was no significant relationship between ER genotypes and changes in HDL cholesterol, LDL cholesterol and triglyceride levels after estrogen therapy. Conclusion: These data indicate that these polymorphisms are possible predictor on lipid response to estrogen replacement therapy (J Kor Soc Endocrinol 14:553-561, 1999).
오한진,조동희,정호연,한기옥,윤현구,한인권 대한비만학회 2000 The Korean journal of obesity Vol.9 No.4
Background: It has been noted that heavier women conserve bone better than those with lower body weight. The protective effect of obesity on bone mass has been ascribed to a high body fat content. There were many results that obesity may affect bone density in postmenopausal women, but not in premenopausal women. Subjects and Methods: The present study of 306 pre and peri-menopausal Korean women was undertaken to determine the effects of obesity on bone density of lumbar spine and markers of bone turnover. BMI and percent body fat of the subjects were also estimated. Subjects were classified into 2 groups, one was Obesity group and the other Normal healthy group by BMI 25 kg/㎡ and we compared the BMD of 2 groups by independent sample t-test. Results: Our result revealed that obese group has greater bone mineral density at lumbar spine than non-obese group. And also, obese group was noted that have significantly higher numbers of delivery than non-obese group. Age adjusted values for RMD at lumbar spine, respctively, were positively correlated (r=0.241, p$lt;0.001) with BMI and total body fat (r=0.253, p$lt;0.001). Bone markers, especially total alkaline phosphatase and deoxypyridinoline were negatively correlated with BMD significantly (r=-0.128, p$lt;0.05 vs r=-0.124, p$lt;0.05). Conclusion: We concluded that obesity represented by large amount of body fat have protective effect on BMD in pre and peri-menopausal Korean women.