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이태호(TH Lee),홍영택(YT Hong),이애현(AH Lee),이진용(JY Lee),김현지(HJ Kim),최길수(KS Choi) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.4
Forbes and Albright described the amenorrhea-gaactorrhea syndrome associated with pituitary tumor in 1954. However, only since 1971, with the development of the sens- itⅳe and specific radioimmunoassay for the prolactin by Hwang et al, it has been demo- nstrated that high percentages of these tumors are associated with the hyperprolactin- emia. Authors experienced four cases of the pituitary adenoma associated with hyperprola- ctinemia, secondary amenorrhea and galactorrhea and presented them with a brief reⅵew of literatures.
자발성 두개강내 출혈에 대한 임상적 분석 : from Jan. - '80 to Sep. - '87
한대희,오창완,이선호,최길수,심보성 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.7-12
The authors analyzed 619 patients with spontaneous intracranial hemorrhage which had been diagnosed by brain CT scan. The following results were obtained; 1) The causes, in descending order of frequency, were aneurysm, hypertension, arteriovenous malformation, tumor, Moyamoya disease, blood dyscrasia and infarction. 2) The peak incidence age was in the 5th and 6th decades, but arteriovenous malformation cases showed peak incidence in the 3rd decade. 3) The peak incidence season was spring, but arteriovenous malformation cases showed even distribution around the year. 4) Of the 619 cases, 445 cases(71.9%) were treated operatively. Of them, 321 cases(51.9%) were treated radically, removing the cause of hemorrhage. 5) Regarding the frequent site of hemorrhage, SAH was present in 94% of aneurysm cases, ICH in 99% of hypertension cases and 85% of arteriovenous malformation cases, and SDH in 80% of blood dyscraesia cases. 6) Aneurysm cases showed best prognosis and hypertension cases showed most serious prognosis. 7) Cases with intraventricular hemorrhage showed poor prognosis.
뇌수막종에 있어서 유세포 측정 양상과 임상적 형태와의 관계
김정훈,정영섭,김동규,정희원,김현집,최길수,한대희 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.6
Meningiomas have a wide range of biological potential and clinical behavior. Histological findings are helpful in recognizing the malignant potential of a given tumor, but often fail to correlat with clinical and biological behavior such as a gross feature, the liability of recurrence, and the extent of associated cerebral edema. To find alternate approaches to improve the correlation between clinical and biological behavoir, 18 meningiomas were studied by flow cytometry(FCM) using paraffin embedded tissues for deoxyribonucleic acid(DNA). The results are summarized as follows: 1) Fifteen cases were diploid and remaining three cases were aneuploid. The latter were two cases of an angioblastic meningioma, and one case of a malignant meningioma which recurred two years later. 2) No relationships were found between the results of ploidy analysis and the age, sex, the site of neoplasms, the size of neoplasms, the degree of peripheral edema, mitotic index, recurrence and the histological subtypes(p>0.1), but it was interesting to note that all three aneuploid cases were clinically and biologically aggressive meningiomas. 3) The proliferative index(PI : %S+%G₂M) between diploid and aneuploid cases had a statistically significant trend(0.05<P<0.1). 4) No significant differences were found between the age, sex, site, histological subtype, mitotic index, recurrence and the proliferative index value(p>0.1). 5) The PI value was relatively correlated with the size and the extent of associated cerebral edema(0.05<P<0.1). These data do not support the suggestion that flow cytometry in meningiomas may be of predictive value concerning the clinical behavior of these neoplasms, but the possible association between tumor aneuploidy, high PI value and poor clinical outcome in meningiomas merits further investigation.
김영규,이선호,김동규,조병규,지제근,최길수,한대희 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.5
Malignant schwannomas in the cerebellopontine angle(CPA) are extremely rare. Two cases of malignant schwannoma in the CPA are presented. One is malignant schwannoma of the acoustic nerve and the other is malignant triton tumor(malignant schwannoma with rhabdomyoblastic differentiation) of the acoustic nerve. No stigmata of von Recklinghausen's disease were noted in both cases. The histological, ultrastructural and immunohistochemical properties were consistent with malignant schwannoma.
김정훈,신형진,이선호,정희원,김현집,최길수 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6
The authors report a rare case of meningioma originated from the diploic space. It manifested as an expansile diploic mass with a small intracranial extension disrupting the dura mater. The clinicopathological features, radiological findings and surgical treatments are discussed including a brief review of the literatures.
한종우,김정훈,이선호,김현집,한대희,심보성,최길수 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.5
The authors analyzed the surgical treated meningioma patients admitted to department of neurosurgery of Seoul National University Hospital between January, 1978 and December, 1987. The following results were obtained: 1) Meningioma was the most common in the 5th decade (46 cases, 37.7%) and the male to female ratio was 1:2.1 2) The pathologic types were meningothelial type (94 case, 77.0%), transitional type, fibroblastic type and angioblastic type in order of frequency. 3) Convexity represented the single most common site of tumor (36 cases, 29.5%), followed by the parasagittal-falx, sphenoid wing, and cerebellopontine angle (CPA) in order of frequency. 4) The most common initial presentation was ⅡCP sings and the mean duration of symptom was 22.5 months. 5) The most common CT finding was high density in PCT and strong homogeneous enhancement in ECT. Hypervascularity was seen in 83 cases (70.3%) on the angiography. 6) The total removal was done in 73.8% of patients and the postoperative mortality rate was 4.1%. 7) At the time of the analysis, 15 cases(12.3%) had shown evidence of recurrence, and the mean duration of recurrence was 3.18 months. 8) The follow up result was excellent in 75 cases(61.5%), good in 28 cases(23.0%), fair in 8 cases(6.6%), and poor in 6 cases(4.9%) and dead in 5 cases(4.1%).
왕규창,조병규,한대희,이선호,김현집,지제근,심보성,최길수 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.7-12
본 교실에서는 뇌혈관조영술 소견상 나타나지 않은 잠재성 뇌혈관기형 17예를 경험하여 이들에서 특징적인 임상 소견을 관찰할 수 있었으며 특히 MRI가 본 질환의 진단과 관리에 있어 큰 도움이 되었기에 문헌고찰과 함께 이를 보고하는 바이다. Authors report 17 cases of angiographically occult vascular malformation of the brain experienced from July 1978 to February 1989. In 11 cases the diagnosis was confirmed by the operative and pathological findings and in the other 6 cases the clinical course and the radiological findings suggested the diagnosis. All the cases had the evidences of hemorrhage. Five of those had episodes of repeated hemorrhage. The characteristic findings of magnetic resonance imaging improved the sensitivity and specificity of diagnosis. Case summary and illustrative cases were presented with the review of literature.
왕규창,권양,김동규,정희원,장기현,조병규,한대희,심보성,최길수 대한신경외과학회 1986 Journal of Korean neurosurgical society Vol.15 No.4
Authors describe 10 cases of syringomyelia. Metrizamide myelogram and spine CT were done in all cases and 6 - 8 hours delayed CT and MRI were done in 8 cases. Syrinx cavity was noticed as a low intensity signal within the isodense spinal cord in T₁ weighted image of MRI. Syringosubarachnoid shunt, foramen magnum decompression or total removal with associated cord tumor were done in 7 cases with good results.