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제2형 당뇨병 남자 환자에서 복부 비만과 관련된 인체 계측치들과 경동맥 내중막두께와의 연관성
허규연 ( Heo Gyu Yeon ),김수경 ( Kim Su Gyeong ),정지영 ( Jeong Ji Yeong ),이재혁 ( Lee Jae Hyeog ),김혜진 ( Kim Hye Jin ),최성희 ( Choe Seong Hui ),안철우 ( An Cheol U ),차봉수 ( Cha Bong Su ),임승길 ( Im Seung Gil ),김경래 ( Kim 한국지질동맥경화학회 ( 구 한국지질학회 ) 2003 韓國脂質學會誌 Vol.13 No.2
자유연제 : 다낭성난소증후군환자에서 Rosiglitazone 투여가 인슐린 저항성 개선에 따른 Adiponectin, TNF-α, resistin 및 고안드로겐혈증에 미치는 영향
김경욱 ( Kim Gyeong Ug ),남수연 ( Nam Su Yeon ),이병석 ( Lee Byeong Seog ),김똘미 ( Kim Ttol Mi ),윤수지 ( Yun Su Ji ),안철우 ( An Cheol U ),김경래 ( Kim Gyeong Lae ),차봉수 ( Cha Bong Su ),임승길 ( Im Seung Gil ),이현철 ( Lee Hye 대한비만학회 2003 대한비만학회 학술대회 Vol.2003 No.-
한국인의 경동맥 내중막 두께 정상치와 죽상경화증 위험인자와의 상관관계
조유리 ( You Lee Cho ),김대중 ( Dae Jung Kim ),김하동 ( Ha Dong Kim ),최성희 ( Sung Hee Choi ),김수경 ( Su Kyung Kim ),김형진 ( Hyung Jin Kim ),안철우 ( Chul Woo Ahn ),차봉수 ( Bong Soo Cha ),임승길 ( Sung Kil Lim ),김경래 ( Kyung 대한내과학회 2003 대한내과학회지 Vol.64 No.3
목적: 죽상경화증은 중노년층의 주요 사망원인인 관상동맥 및 뇌동맥 질환의 가장 중요한 원인으로 임상적인 증상이 나타나기 전에는 진단이 쉽지 않기 때문에 조기발견이 중요하다. 국내에서도 제2형 당뇨병 환자에서의 죽상경화증과 경동맥 내중막 두께의 상관관계에 대해서는 잘 알려져 있으나 정상인에서의 경동맥 내중막 두께 측정에 관한 연구는 없었다. 이에 저자들은 당뇨병, 고혈압, 이상지혈증, 관상동맥 및 뇌동맥 질환이 없는 건강한 성인을 대상으로 성별, 연령별 Background: Atherosclerosis is an important cause of cardiovascular and cerebrovascular diseases, which are the major cause of death in middle-aged and older adults. However atherosclerotic lesions are not easily detected before they cause symptoms and si
한국인 인슐린 비의존형 당뇨병 및 이차성 당뇨병 환자에서 글루코키나제 유전자 변이
남재현(Jae Hyun Nam),이현철(Hyun Chul Lee),김연의(Youn Euy Kim),권석호(Suk Ho Kwon),윤용석(Yong Suk Yoon),박석원(Suk Won Park),원영준(Young Jun Won),차봉수(Bong Su Cha),송영득(Young Duk Song),이은직(Eun Jig Lee),임승길(Sung Kil Lim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6
N/A Objectives: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this gene to the development of non insulin dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM) and post-renal transplantation diabetes mellitus (PTDM). Method: Identification of GCK mutation was attempted on 39 NIDDM patients, 2 GDM patients and 58 selected renal allograft recipients with PTDM and 45 normal controls. The exons in the GCK gene were examined by polymerase chain reaction (PCR), followed by analysis of single-stranded DNA conformational polymorphism (SSCP). The abnormal bands were also confirmed by DNA sequencing analysis. The exons of affected family members were also investigated for mutations of the GCK gene. Results: Two of the 58 PTDM patients (3.4%) were found to have CKK mutations. One had the mutation on exon 5 and the other on intron 7. One control subject had the mutation on intmn 9. The mutation of exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has not ever reported before. The family members of the PFDM patient with mutation of exon 5 were analyzed by PCR followed by SSCP, and two of them revealed the same mutation. The abnormal band on the SSCP analysis of exon 7 was identified as the insertion of base C/T at the 39th nucleotide in intron 7. Two family members of this patients also had same band on SSCP. The one mutation of 45 normal controls was CT located at the 8th nucleotide in intron 9, which was a common polymorphism. Conclusion: We found GCK mutations in subjects with PTDM and we speculate that these mutations may be one of the contributing cause of PTDM.
정혜원 ( Jeong Hye Won ),김유미 ( Kim Yu Mi ),김대중 ( Kim Dae Jung ),남재현 ( Nam Jae Hyeon ),안철우 ( An Cheol U ),차봉수 ( Cha Bong Su ),송영득 ( Song Yeong Deug ),임승길 ( Im Seung Gil ),김경래 ( Kim Gyeong Lae ),이현철 ( Lee 대한내과학회 2003 대한내과학회지 Vol.64 No.6
목적 : Staged Diabetes Management (SDM)는 당뇨병의 혈당조절과 합병증 관리에 있어서 임상연구자료에 근거를 둔 과학적이고, 체계적인 치료지침을 제공하기 위하여 시작되었다. 본 연구는 한국인 당뇨병의 임상적 특성을 고려한 새로운 치료지침을 만들고 그 지침의 유용성을 평가하기 위한 연구이다. 방법 : 제2형 당뇨병 환자를 대상으로 인슐린 감수성검사(Insulin Sensitivity Test)를 시행하여 구한 인슐린 저항성의 지표인 Background : There are a few limitations in application of staged diabetes management (SDM) program to Korean type 2 diabetic patients because of their unique characteristics, such as non-obese but centrally obese anthropometry and variable relationships