수용성 조영제의 항응고 효과에 대한 실험적 연구

임덕,진수일,김학수,박재형,Lim, Duk,Chin, Soo-Yil,Kim, Hak-Soo,Park, Jae-Hyung 대한영상의학회 1989 대한영상의학회지 Vol.25 No.6

It has been reported that newly developed nonionic contrast material is less effective in anticoagulation than ionic contrast media. Anticoagulation properties were studied with high osmolar ionic contrast medium(diatrizoate) low osmolar ionic medium(ioxaglate) and low osmolar nonionic contrast medium(iopromide) as well as with normal saline for control Arterial blood was taken from 10 adults before angiography. Two ml. of the arterial blood was introduced into the plastic syringes containing 2 cc. of each contrast medium and saline. The syringes were kept undisturbed in room temperature for 10 minutes 30 minutes 60 minutes 90 minutes and then the blood-contrast mixture was poured on the filter paper to detect the clots formed in the syringes. Delay of the clotting time was also checked in the contrast media with various concentraions of 100% 30% 10% and 3% Chi-square test of the data shows very significant difference in antico-agulation effect between the ionic group(diatrizoate ioxag-late) and the nonionic one (iopromide) Clotting time in the nonionic medium(iopromide) was shorter in 30% concentration than that of the ionic material(diatrizoate ioxaglate) Nonionic contrast medium(iopromide) has anticoagulation effect but less effective than ionic media(diat-rizoate ioxaglate).

Radioiodine의 체내오염(體內汚染)에 대(對)한 긴급처치연구(緊急處置硏究)

정인용,김태환,정현우,진수일,윤택구,Chung, In-yong,Kim, Tae-hwan,Chung, Hyun-woo,Chin, Soo-yil,Yun, Taik-koo 대한수의학회 1988 大韓獸醫學會誌 Vol.28 No.2

Appreciable radiation exposures certainly occur in the workers who handle radioiodine in biochemical research, nuclear medicine diagnostics with the development of nuclear industries. But in the case of occurring the nuclear accidents, the early medical treatment of radiation injury should be necessary but little was reported in korea till now. Accordingly, to achieve of the basic data for protective roles and medical treatment of radiation injury, the present studies were carried out to evaluate the decontamination of radioiodine by the administration of the antithyroid drugs. The results observed are summarized as follows: 1. The administration of sodium iodide and potassium iodide results in rapid excretion of radioiodine and reduction of the whole body retention than the saline-only group. 2. Reguarding to thyroid protective effects, sodium iodide, potassium iodide and saline were effected significant in order. 3. In the control(saline) group, if administered with enough fluids, the whole body retention of radioiodine is reduced temporary shifts. But as far as radioprotective effects is concerned, saline was not more in the protective effects than the other groups. In conclusion, in case of nuclear accidents, if being administered sodium iodide and saline as quickly as possible, the radioprotective effects against the radiation hazard might be markedly increased in the internal contamination of radioiodine.

골육종의 경피적 동맥내 항암화학요법 (속보)

임덕,변홍식,김기환,진수일,정진엽,이수용,Lim, Duk,Byun, Hong-Sik,Kim, Kie-Hwan,Chin, Soo-Yil,Chung, Jin-Youb,Lee, Soo-Yong 대한영상의학회 1990 대한영상의학회지 Vol.26 No.2

Intra-arterial Chemotherapy (IAC) was performed to the 34 patients with nonmetastatic osteosarcoma using Cisplatin and surgery was done in 26 cases out of 34. We analysed the therapeutic effect of IAC in the view of local control rate and distant metastasis for two and half years. local control rate was 94% on the base of the radiologic studies including simple X-ray, angiography and CT. No viable cells were observed in 50% of the cases on the pathologic examination of the surgical specimens. Distant metastasis developed in 14 cases 9415) , mainly in the lung, No significant complications occurred except each case of acute renal failure, congestive heart failure and peripheral embolism, which were improved by proper management. IAC is one of the most effective methods in controlling the regionally confined osteosarcoma, but it may be incorperated with other adjuvant protocols to decrease the chance of delayed metastasis.

방사선에 의한 EL4 마우스 백혈병세포 및 정상 마우스 비장 임파구 DNA strand breaks의 측정

김성호,김태환,정인용,류성렬,조철구,진수일,Kim, Sung-ho,Kim, Tae-hwan,Chung, In-yong,Yoo, Seong-yul,Cho, Chul-koo,Chin, Soo-yil 대한수의학회 1991 大韓獸醫學會誌 Vol.31 No.3

The filter elution technique was used to assay $^{60}Co$ $\gamma$ ray-induced DNA strand breaks(SB) in EL4 mouse leukemia cell and mouse spleen lymphocyte. The lymphocytes were stimulated with lipopolysaccharide (LPS, $20{\mu}g/ml$) to label $[^3H]$ thymidine. EL4 cells and lymphocytes in suspension were exposed at $0^{\circ}C$ to 0Gy, 1Gy, 5Gy, 10Gy or l5Gy for DNA single strand breaks(SSB) assay and 0Gy, 25Gy, 50Gy, 75Gy or 100Gy for DNA double strand breaks(DSB) assay of $^{60}Co$ radiation and elution procedure was performed at pH12.1 and 9.6. The number of DNA strand breaks increased with increasing doses of r rays. The strand scission factor(SSF) was estimated in each experiment (eluted volume 21ml). The slope of SSB EL4 cells was $0.01301{\pm}0.00096Gy^{-1}$ (n=5), the slope of SSB for lymphocytes was $0.01097{\pm}0.00091Gy^{-1}$ (n=5) and the slope of DSB for lymphocytes was $0.001707{\pm}0.0000573Gy^{-1}$ (n=5). Thus EL4 cells were more sensitive to induction of DNA SSB by ionizing radiation than lymphocytes (p<0.005). The ratio of slope of dose-response relationship (SSF versus dose) of lymphocytes DNA SSB as compared with the slope of DNA DSB was 6.4.

단순 유방촬영술상 동반되는 종괴 없이 보이는 군집성 미세석회화 : 양성과 악성의 예측

한윤희,도영수,조병제,한헌,최연현,박정미,한부경,오훈일,김기환,진수일,Han, Yoon-Hee,Do, Young-Soo,Cho, Byung-Jae,Han, Heon,Choi, Yeun-Hyeun,Park, Jung-Mi,Han, Boo-Kyung,Oh, Hoon-Il,Kim, Ki-Hwan,Chin, Soo-Yil 대한영상의학회 1996 대한영상의학회지 Vol.35 No.5

Purpose : The purpose of this study is to evaluate the accuracy of differentiation between benign andmalignant clustered microcalcifications without mass on mammogram. Material and Methodes : Fourty six mammogramsof 44 patients showing clustered microcalcifications without mass were interpreted blindly by five independentobservers majoring in breast imaging from different institutions. Twenty two were malignant (10 infiltratingductal carcinomas, 12 intraductal carcinomas) and 24 were benign (all fibrocystic disease). The observers judgebenignancy or malignancy of microcalcifications. The authors assess the accuracy of differential diagnosis ofclustered microcalcifications. Result : Of 24 cases proved benign microcalcifications, five radiologists correctlyinterpreted 20 on average as benign and of malignant 22 cases, 16 on average were correctly interpreted asmalignant. The diagnostic accuracy of malignant microcalcifications was 71.8% on average(63.6%~81.8%) and thediagnostic accuracy for benign microcalcifications was 83% on average(71%~ 92%). It was 9 among total 46 casesthat were misinterpreted by more than three radiologists. Among these 9 cases, malignant microcalcifications thathad been misinterpreted as benign were seven, benign microcalcifications misinterpreted as malignant were two.Conclusion : The diagnostic accuracy of clustered malignant microcalcifications(71.8%) without mass on mammogramwas lower than that of benign microcalcifications(83.3%). So, in case of suspected malignant microcalcification onmammogram, it is preferable that along with magnification view, histopathologic confirmation by core biopsy mustbe obtained.

위암환자에서 복부 임파절 전이에 대한 초음파검사 및 전산화 단층촬영의 진단적 의의

김석균(Seok Kyun Kim),현인영(In Young Hyun),차중직(Joong Jik Cha),홍원선(Weon Seon Hong),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang),백남선(Nam Sun Paik),김기환(Kie Hwan Kim),진수일(Soo Yil Chin) 대한내과학회 1990 대한내과학회지 Vol.39 No.2

N/A Preoperative findings of abdominal ultrasonography (US) and computed tomography (CT) were compared with the postoperative findings with special emphasis on abdominal lymphnode (LN) metastasis in patients with stomach cancer. The 98 patients' enrolled in this study had no evidence of LN and distant metastasis in preoperative abdominal US or CT and underwent operation from January, 1988 to December, 1988 in the Department of General Surgery III, Korea Cancer Center Hospital. Sixty-two (63%) of the 98 patients were confirmed to have LN metastasis in the postoperative pathologic examination: 62%, in 50 patients without LN metastasis in preoperative US and 65%, in 48 patients without LN metastasis in preoperative CT. The senstivity of US was similar to that of CT in predicting LN metastasis. We analyzed the effects of age, sex, abdominal pain, performance status, Borrmann type and size of the tumor on the predictability of LN metastasis, demonstrating that no significant relation- ship was found between these factors and LN metastasis except for the size of the tumor. In patients with a tumor less than 2 cm in diameter, LN metastasis was found in 25%(N1, N2, 0%); in 2-4 cm, 53% (N1, 47%, N2, 6%); in 4-6 cm, 79%(N1 62%, N2 17%); in 6-8 cm, 92% (N1 84%, N2 8%); in more than 8 cm, 839p (N1 66%, N2 17%). The incidence of early gastric cancer (EGC), diagnosed by postoperative pathologic findings, was significantly higher in small-sized tumors compared to the large-sized tumors (p<0.01): in less than 2 cm, 0%. Staging of stomach cancer was performed according to TNM staging grouping approved by UICC and AJC in 1985. The stage showed a progress with the increase in size of the tumor (p<0.01). In less than 2 cm, stage I, II, III and IV were 68, 7, 25and 0%, respectively. In 2-4 cm, stage I, II, IIIand IV were 26, 18.53and 3%, respectively. In 4-6 cm, stage I, II, IIIand IV were 8, 16, 56and 20%, respectively. In 6-H cm, stage I, II, IIIand IV were 0, 15, 75and 15%, respectively. In more than 8 cm, stage I, II, IIIand IV were 0, 0, 50and 50%, respectively. These results suggest that abdominal LN metastasis can not be predicted by US or CT alone. However, dy the addition of size of the tumor to US or CT findings, the predictability of LY, metastasis can be significantly increased in stomach cancer patients.

간동맥 색전술에 의한 간세포암의 치료

진수일 대한의학협회 1990 대한의학협회지 Vol.33 No.9

위암의 병기결정을 위한 초음파검사의 유용성

진수일,김기환,변홍식 대한초음파의학회 1987 ULTRASONOGRAPHY Vol.6 No.2

軟組織撮影法을 利用한 乳房撮影에 關한 考察

陳秀一 중앙대부설한국의과학연구소 1977 한국의과학 Vol.9 No.1

DDC,MEA,WR-2721의 放射線 防護效果에 關한 硏究

柳星烈,陳秀一,鄭鉉佑,鄭引溶,高柱煥,고경환 대한방사선 방어학회 1986 방사선방어학회지 Vol.11 No.2

放射線障害 豫防藥劑의 人體適用은 副作用으로 臨床的 利用이 되지 못한 實情으로서 生理學的 및 藥理學的 毒性, 物理學的 諸性質, 藥劑의 作用機轉究明 및 臨床的 技術開發이 未洽하여 放射線 障害者에 對한 治療는 對症療法에 不過한 實情이다. 著者들은 放射線에 依한 人體障害豫防에 必要한 基礎資料를 얻기 위하여 現在까지 比較的 毒性이 적고 化學的으로 安定하며 藥效가 優秀하다고 알려진 DDC, MEA, WR-2721을 選定하여 實驗動物 非近交系 Swiss Webster(NIH-GP)마우스에 利用한 放射線 防護作用에 關한 實驗結果는 다음과 같다. 1) 各種 放射線 防護劑(DDC, MEA, WR-2721)의 마우스에 대한 適定 投與量은 各各 DDC; 1,000, MEA; 200, WR-2721; 400mg/kg이었다. 2) 實驗動物에 放射線 反致死線量 LD50/10에 對한 藥劑의 防護效果을SMS DDC;1.2, MEA; 1.4, WR-2721; 1.9이었고 LD50/30에 對 한 DMF는 DDC; 1.7, MEA; 1.8, WR-2721; 2.5이었다. 3) 空腹 小?腺(Jejunum crypt)의 放射線平均致死線量(Do)에 對한 防護效果 DMF는 DCC; 1.07, MEA; 1.21, WR-2721; 1.76이었고, 小?腺細胞의 致死線 平均致死線量에 對한 DMF는 DDC; 1.04, MEA; 1.08, WR-2721; 1.38이었다. 4) 以上으로 上記 3種의 放射線 防護劑中 WR-2721의 放射線 防護效果가 가장 優秀하였고 이 結果는 向後 臨床的 適用에 關한 硏究의 基礎資料가 될 것으로 思料된다. At present, the treatments of the radiation-induced diseases are only performing by the palliative treatment technique. Moreover, radiation protective agents are a little toxic for human being and this seriously limits their applicability with various complications in clinical uses. Accordingly, as a part of the aim of gain of the basic data for protective roles of some radioprotectors, the present investingation was carried out to evaluate the comparative radioprotective effects by the administration of DDC, MEA, WR-2721. Results are shown for statistically significant analysis and correlation with each group as follows; 1. The proper doses of the radioprotectors were DDC; 1,550mg/kg, MEA; 450mg/kg, WR-2721; 780mg/kg of the mouse body weight. 2. DMF(Dose modification factor) of LD50/10 and LD50/30 for whole body irradiation was DDC; 1.2, MEA; 1.4, WR-2721; 1.9 and DDC; 1.7, MEA; 1.8 and WR-2721; 2.5 respectively. 3. DMF for radiation reaction of jejunal crypt was DDC; 1.07, MEA; 1.21 and WR-2721; 1.76 and that of jejunal crypt cell was DDC; 1.04, MEA; 1.08 and WR-2721; 1.38 respectively. 4. Conclusively, WR-2721 was the most effective drung among the three radioprotectors and this result must be a supportive data for further study for clinical application.