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      • KCI등재후보

        그레이브스병에 있어서 항갑상선제와 티록신 병합요법의 효과

        조장현(Jang Hyun Cho),오기창(Ki Chang Oh),김명원(Myung Won Kim),김원석(Won Seok Kim),추진호(Jin Ho Choo),조형철(Hyung Cheol Cho),김순호(Soon Ho Kim),임중규(Joong Kyu Lim),허진득(Jin Duk Huh) 대한내과학회 1998 대한내과학회지 Vol.54 No.2

        N/A Objectives: It was recently reported that the administration of T during antithyroid drug(ATD) therapy resulted in a significant decrease of antibodies to TSH receptors as well as the rate of recurrence of active Graves' disease following discontinuance of ATD treatment. But, there is still controversy whether combination therapy is efficient. Therefore, the present study was undertaken to evaluate the effect of T4 administration of patient with Graves' disease who were being treated with ATD. Methods: We studied 56 patients received methimazole(MMI) alone(Group 1) and 48 patients received methimazole plus T4(Group 2). They are diagnosed active Graves' disease at department of internal medicine, Kwang ju Christian Hospital from January, 1994 to December, 1995. AU the patients were treated initially with 30mg of methimazole daily for one month after then, in the Group 1(methimazole alone), the dose of methimazole was adjusted as necessary to achieve normal serum concentrations of T3, T4, and TSH. The patients of Group 2(methimazole plus T4) continue to receive the combination of T4 at a dose of 100 μg daily. Simultaneously, we estimated the serum concentratio n of T3, T4, TSH and Thyroid-stimulating immunoglob ulin(TSI) antibody at every three months. Results : We obtained the following result. In the group 1, mean TSI values were 50.1%(first visit), 30.6%(6months), and 24.7%(1year). And, in the group 2 mean TSI values were 51.8%(first visit), 33.6%(6months), and 22.7% (1year). After 6 months of discontinuing of therapy, the recurrence rate was no significant difference in the two groups (the recurrence rate were 55.4%, 50.0%, respectively P>0.05). Conclusion : These results suggest that T4 administration in combination with MMI therapy have no significant effect in a decrease in levels of TSH receptors antibodies and recurrence rate within 6 months discontinuing MMI therapy as compared with MMI treatment alone.

      • 리모델링시 이중외피 시스템의 합리적인 적용을 위한 방위별 부하특성에 관한 연구

        조장현(Cho Jang-Hyun),김용식(Kim Yong-Sik) 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

        The purpose of this study is to present the method of selecting the most suitable Double Skin system in thermal performance, which is often applied when building Green building and renovating old constructions, by comparing load features in direction of system and types.<br/> By simulating heating and cooling load in summer and winter of an office-building before and after remodelling with Double Skin system, this study analyzed the energy saving effect. Also, by comparing the skin performance from stack effect when different types of double skin system have been applied will show the influence of application of the various double skin system on the construction's energy performance.

      • KCI등재

        아파트 동남향․서남향 배치에 따른 물리적 주거환경에 대한 비교연구

        조장현(Cho, Jang-Hyun),은미(Hyun, Eun-Mi),김용식(Kim, Yong-Sik) 한국실내디자인학회 2012 한국실내디자인학회논문집 Vol.21 No.5

        Apartments with a southern exposure are often thought to have advantages in receiving winter sunlights and summer natural ventilation. However, as due-south-apartments increase recently, the consideration for residential environment for households with no southern exposure is necessary. In case of due-south-apartments, residents prefer east-sided apartments than west facing apartments which might receive more hot sunlight in the afternoon; however in case of west-oriented apartments with active ventilation, the interior area is bright until late afternoon without unpleasant heat and has advantage in light environment aspects. This study aims to compare and analyze merits and demerits of air flow and sunlighted environment of buildings through sunshine duration simulation using CFD simulation ad sunlights about southeast-sided and southwest-sided apartments based on general opinions for apartment directions. As results of the interior natural ventilation analysis, as the average air flow speed in southwest-sided apartments was 1m/s faster than that of southeast-sided, it has effects of lowering sensory temperature of residents in summer, and for sunlighted environment, southwest-sided apartments are advantageous for sunlighted area for duration time inside. As a result of the research, the calculation of physical residential environment of apartment residential space should be reached through integrated evaluation of natural ventilation and sunlighted time from placement and facing direction of the buildings considering characteristics and environment of each apartment, not based on general opinions.

      • KCI등재후보

        Gene Expression of NeuroD/BETA2 during Development of the Mouse Central Nervous System

        조장현(Jang-Hyeon Cho),황우섭(Woo-Sup Hwang),김연수(Yeon-Soo Kim),이영돈(Young-Don Lee),서해영( Haeyoung Suh-Kim) 대한해부학회 2000 Anatomy & Cell Biology Vol.33 No.1

        basic helix-loop-helix 전사인자 (transcription factor)에 속하는 NeuroD/BETA2 유전자는 신경형성과정 중 종말분화에 중요한 기능을 하는 것으로 알려져 왔다. 신경계의 발생 및 분화과정에서 NeuroD/BETA2 유전자의 기능을 알기 위해서 본 연구에서는 생쥐의 배자발생과정, 출생초기 및 성숙한 생쥐를 대상으로 in situ hybridization방법을 이용하여 유전자의 발현 양상을 조사하였다. NeuroD/BETA2 유전자는 발생중인 생쥐의 신경계에서 매우 높게 발현되었다. 출생 초기에 NeuroD/BETA2 유전자는 소뇌 와 해마에서 시간이 경과할수록 지속적으로 증가하는 발현양상을 보여주었고 성숙 후에도 비교적 안정한 상태로 발현되었다. 출생 전 NeuroD/BETA2 유전자는 배자발생과정 동안 뇌실밑층의 분열을 마친 세포에서 발현되었다. 이러한 결과는 NeuroD/BETA2 유전자가 신경형성과정 중 종말분화과정에 중요한 역할을 담당한다는 사실을 확인시켜 준다. NeuroD/BETA2, a basic helix-loop-helix transcription factor, has been known to play a role in terminal differentiation during neurogenesis. To gain further insight into the function of NeuroD/BETA2 in the nervous system development, we examined the expression pattern of NeuroD/BETA2 during embryonic and postnatal development by in situ hybridization. Dynamic changes of NeuroD/BETA2 expression were observed in the developing nervous system. Gene expression of the NeuroD/BETA2 in developing cerebellum and hippocampus increased during the embryonic stages and persisted throughout postnatal development and remained at a stable level in the adult brain. NeuroD/ BETA2 expression was detected in postmitotic cells in the subventricular zone of the cerebrum during embryogenesis. This observation confirms that NeuroD/BETA2 may have a role in terminal differentiation during neurogenesis.

      • 러기지 다기능 레일 시스템 개발

        조장현(Cho, JangHyun),이호달(Lee, HoDal),김희철(Kim, HeeCheul) 한국자동차공학회 2019 한국자동차공학회 부문종합 학술대회 Vol.2019 No.5

        This is study of Development of multi-purpose rail system and mechanism applied to luggage rooms. Through those things, attractively appeal to especially SUV owners who would like to drive and purchase cars. In this study, we developed a novel storage mechanism that can lead new trends to appeal to consumer purchasing power of usability of luggage room. In terms of technology, we also secured source technologies that enable consumers to utilize various types of rugged spaces, and expanded the range of choices by creating specialized specifications that can appeal more to SUV purchasing power.

      • 소형공간을 위한 변형장작가마 축조

        조장현(Cho, Jangl-Hyun), 박재연(Park, Jae-Yeon) 조선대학교 조형미술연구소 2011 조형미술논문집 Vol.11 No.1

        Contemporary, the necessity and awareness about the importance of wood-kiln has emerged. But, many potters are difficult to build a wood kiln by reason of environmental constraints, economic burden and the experiment involves required time-consuming. therefore, this study is to reducing the problems by building a small transform kiln to fit the nature. Keywords : 장작 가마, 변형 가마, Bourry box가마

      • KCI등재

        피라미(Zacco platypus)의 정자형성과정에 관한 미세구조적 연구

        조장현,류동석,Cho, Jang-Hyeon,Reu, Dong-Suck 한국현미경학회 1998 Applied microscopy Vol.28 No.2

        The spermatogenesis of pale chub (Zacco platypus) was investigated morphologically. The testis of pale chub contained numerous testicular sacs. These testicular sacs were bounded on neighboring sacs by single layer of squamous cells. Also, differentiated sperms were filled in the sacs. In the stage of spermatogonium, the germ cells had a large nucleus and a distinct nucleolus, and mitochondrial development was prominent. In the primary and secondary spermatogonia, these cells had a round electron-dense nucleus, reduced cytoplasm, and mitochondria were congregated in the side of cytoplasm. The highly condensed chromatin of sperms was electron-dense, the acrosome was not found in the head of the sperm and a motile flagellum consisted of an axoneme with a typical 9+2 pattern of microtubules.

      • KCI등재

        창업 멘토링 척도 개발 및 타당화 연구

        조장현,박정열,Cho, Jang Hyun,Park, Cheong Yeul 한국벤처창업학회 2017 벤처창업연구 Vol.12 No.5

        The purpose of this study was to develop the entrepreneurial mentoring scale on start-up mentoring situation. In recent years, as the needs for entrepreneurship have grown from domestic to foreign, entrepreneurship education is actively being carried out. The entrepreneurial mentoring is strengthening its weight and contents in entrepreneurship education. However, research on the mentoring function scale designed to reflect the characteristics of entrepreneurial mentoring is rarely performed in Korea. In this study, we conducted a qualitative and quantitative research to achieve the research goal. First, we derive the entrepreneurial mentoring scales through literature review and expert group discussions, and we conducted the empirical analysis to draw conclusions. The results of this study are as follows. In the first step, literature review was conducted. In the second step, four major factors and questionnaires were derived through expert group discussion. In the third step, the doctoral level specialists developed 16 questionnaire items to measure the four factors of entrepreneurial mentoring derived from the second step and verified the content validity and the facial validity in fourth step. As a result of this survey, we conducted questionnaires on founding mentors who belonged to 17 Creation Economic Innovation Centers nationwide (153) and analyzed the problem solving, networking, communication, and motivation formation through exploratory factor analysis. This questionnaire was used to survey the entrepreneurial mentors who belonged to the 17 Center for Creative Economy and Innovation under the Ministry of Science, ICT & Future Planning of South Korea(153). In fifth step, as the results of factor analysis such as EFA and CFA, we could confirm four factors including problem solving, networking, communication, and motivation. The significance of this study is as follows. First, academic significance was the first study of the entrepreneurial mentoring function scale reflecting the characteristics of entrepreneur mentoring as a qualitative and quantitative approach in Korea. Second, it is hoped that practitioners will be able to better measure the mentoring function of entrepreneurial mentors and contribute to improving the quality of future entrepreneurial mentoring programs.

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