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Phenotype of Asthma-COPD Overlap in COPD and Severe Asthma Cohorts
조유숙,Park So-Young,Park So Young,Park Seo Young,Kim Sang-Heon,Cho You Sook,Yoo Kwang Ha,Jung Ki Suck,Rhee Chin Kook 대한의학회 2022 Journal of Korean medical science Vol.37 No.30
Background: Asthma and chronic obstructive pulmonary disease (COPD) are airway diseases with similar clinical manifestations, despite differences in pathophysiology. AsthmaCOPD overlap (ACO) is a condition characterized by overlapping clinical features of both diseases. There have been few reports regarding the prevalence of ACO in COPD and severe asthma cohorts. ACO is heterogeneous; patients can be classified on the basis of phenotype differences. This study was performed to analyze the prevalence of ACO in COPD and severe asthma cohorts. In addition, this study compared baseline characteristics among ACO patients according to phenotype. Methods: Patients with COPD were prospectively enrolled into the Korean COPD subgroup study (KOCOSS) cohort. Patients with severe asthma were prospectively enrolled into the Korean Severe Asthma Registry (KoSAR). ACO was defined in accordance with the updated Spanish criteria. In the COPD cohort, ACO was defined as bronchodilator response (BDR) ≥ 15% and ≥ 400 mL from baseline or blood eosinophil count (BEC) ≥ 300 cells/μL. In the severe asthma cohort, ACO was defined as age ≥ 35 years, smoking ≥ 10 pack-years, and postbronchodilator forced expiratory volume in 1 s/forced vital capacity < 0.7. Patients with ACO were divided into four groups according to smoking history (threshold: 20 pack-years) and BEC (threshold: 300 cells/μL). Results: The prevalence of ACO significantly differed between the COPD and severe asthma cohorts (19.8% [365/1,839] vs. 12.5% [104/832], respectively; P < 0.001). The percentage of patients in each group was as follows: group A (light smoker with high BEC) – 9.1%; group B (light smoker with low BEC) – 3.7%; group C (moderate to heavy smoker with high BEC) – 73.8%; and group D (moderate to heavy smoker with low BEC) – 13.4%. Moderate to heavy smoker with high BEC group was oldest, and showed weak BDR response. Age, sex, BDR, comorbidities, and medications significantly differed among the four groups. Conclusion: The prevalence of ACO differed between COPD and severe asthma cohorts. ACO patients can be classified into four phenotype groups, such that each phenotype exhibits distinct characteristics.
조유숙,임윤정,김성호,이재천,임미경,유빈,문희범 ( You Sook Cho,Yeun Jeong Lim,Jae Cheon Lee,Seoung Ho Kim,Mi Kyoung Lim,Bin Yoo,Hee Bom Moon ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Backgroand: Oral allergy syndrome(OAS) is composed of it,ching sense and edema in oral cavity, lips, throat, pharynx, and larynx following eating some fresh fruits or vegetables. It has been known that most of patients with OAS are allergic to pollens. Common epitopes were found among pollens, fruits and vegetables. Although OAS is a common farm of food allergy in adults, this is the first epidemiologic study of OAS in Korea. Muterial and metkod: One hundred and fifty one patients who showed positive skin reaction to pollens were telephone-interviewed. Investigation of the prevalence and clinical manifestations of OAS was possible in 81 patients. Result: The prevalence of OAS among these patients was 34.6% (28/81). OAS was found in 24(48%) out of 50 patients sensitized to tree pollens, whereas 4(13%) of 31 grass or weed pol- len-sensitized paients had OAS. Most common causative food was apple and all of 17 apple- OAS patients were sensitized to tree pollens. Peach was the second common food and 14 of 15 peach-OAS patients were sensitized to tree pollens. Besides oral symptoms, rhinitis, asthma, diarrhea, nausea, vomiting or generalized urticaria were accompanied in half of the OAS patients (14/28). Some patients showed OAS to some unique Korean foods such as dropwort, taro and Aster. Conclasion.' OAS was very common in pollen-sensitized patients. Larger epidemiologic studies are needed to find unique Korean foods and their antigensm causing OAS.
비정형 림프구증가증과 만성 Epstein-Barr virus 감염을 동반한 모기 침산 과민반응 1례
박소연 ( So Yeon Park ),조유숙 ( You Sook Cho ),김성호 ( Seung Ho Kim ),이창근 ( Chang Keun Lee ),유빈 ( Bin Yoo ),김상위 ( Sang Wi Kim ),오흥범 ( Heung Bum Oh ),박찬정 ( Chan Jeoung Park ),문희범 ( Hee Bom Moon ) 대한천식알레르기학회 2003 천식 및 알레르기 Vol.23 No.2
Hypersensitivity to mosquito bites is a disorder characterized by necrotic skin reactions and systemic generalized symptoms subsequent to mosquito bites. This disease has been reported mostly in Japanese patients in their first two decades of life. Recent
Propylthiouracil에 의한 약제 유발 루푸스
이재천 ( Jae Chun Lee ),유빈 ( Bin Yoo ),임윤정 ( Yun Jeong Lim ),김성호 ( Seong Ho Kim ),임미경 ( Mi Kyung Lim ),조유숙 ( You Sook Cho ),송영기 ( Young Kee Shong ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.1
Propylthiouracil(PTU) is one of lupus-inducing drugs, though rarely reported. We report a case of PTU-induced lupus, with the review of previous literatures. Lupus-like symptoms in a 28 year-old female patient, who had been suffering from relapsed Graves` disease, were presented during PTU therapy. The results of antinuclear antibody and anti-histone antibody were positive. After symptomatic treatment and discontinuation of PTU, all of the symptoms and the abnormalities in laboratory tests disappeared, which suggested drug-induced lupus.
원발성 부갑상선 기능저하증 및 당뇨병에 동반된 미만성 특발성 골격성 과골증
임윤정 ( Yun Jeong Lim ),최은광 ( Eun Kwang Choi ),이재천 ( Jae Chun Lee ),조유숙 ( Yoo Sook Cho ),임미경 ( Mi Kyoung Lim ),김성문 ( Sung Moon Kim ),홍성관 ( Sung Kwan Hong ),유빈 ( Bin Yoo ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.2
Diffuse Idiopathic Skeletal Hyperostosis(DISH) is a skeletal disease characterized by ligamentous ossification of the anterolateral side of the spine. Paravertebral and ligamentous ossification appears to be an usual complication of hypoparathy-roidism. Diabetes Mellitus has often been mentioned in associated with DISH. The patient was presented with back pain, stiffness and intermittent numbness of hands and feet. Spine X-ray showed extensive ligamentous ossification of the anterolateral side of the spine with normal disc space height. Sacroiliac joints are normal. Increased bone mineral density of the L-spine and femur neck was observed, as well. Hypocalcemia, hyperphophatemia and low intact parathyroid hormone level were detected. Postprandial sugar were elevated. HLA B27 was negative.
김성호 ( Seong Ho Kim ),임희영 ( Hee Young Lim ),조유숙 ( You Sook Cho ),김찬 ( Chan Kim ),유빈 ( Bin Yoo ),고윤석 ( Yoon Seok Ko ),김우성 ( Woo Seong Kim ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.1
Relapsing polychondritis, a rare multisystem disease, is characterized by widespread potentially destructive inflammatory lesions, involving cartilaginous structures throughout the body. Auricular chondritis is the most frequent presenting sign of this disease, with arthritis being the second. Other clinical menifestations include nasal chondritis, scleritis, damage to tracheobroncheal cartilage, and cardiovascular and renal involvement. We experienced three cases of relapsing polychondritis. One case is 66 year old male with bilateral auricular chondritis with histologic confirmation, episcleritis, polyarthritis, periarterial vasculitis, and sensorineural hearing loss. Another case is 42 year old male with respiratory, nasal, auricular chondritis and psoriasis with arthritis. The third case is 46 year old female with three year history of relapsing polychondritis, presenting bilateral auricular and nasal chondritis and severe respiratory tract involvement with histologic confirmation. We also reviewed the other case reports of relapsing polychondritis in Korea. The major presenting manifestations of relapsing polychondritis in Korea were respiratory tract symptoms of dyspnea, cough, and sputum. That is, auricular chondritis was less frequent than laryngotracheal-bronchial involvement.
김선희 ( Seon Hee Kim ),김영학 ( Young Hak Kim ),조유숙 ( You Sook Cho ),김찬 ( Chan Kim ),최승원 ( Seung Won Choi ),유빈 ( Bin Yoo ),이명종 ( Myoung Chong Lee ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1995 대한류마티스학회지 Vol.2 No.2
Sjogren`s syndrome is a heterogenous autoimmune disease characterized by progressive destruction of the exocrine glands and accompanied by a variety of autoimmune phenomena. Sjogren`s syndrome patients can develop symptoms of ocular and oral dryness as well as extraglandular complications including central and peripheral nervous system disease. Sometimes neuropathy precedes the diagnosis of Sjogren`s syndrome. Adie`s syndrome is characterized by tonic pupil and the absence of tendon reflex. Sweating abnormality and chronic peripheral polyneuropathy can also be present. We report a case of primary Sjogren`s syndrome preceded by Adie`s syndrome with peripheral neuropathy. A 26-year-old woman was admitted for photophobia and paresthesia. On examination. her pupils were anisocoric and did not react to light but constricted promptly to pilocarpin. Sensation decreased on her left side of body and deep tendon reflexes were absent. Biopsy of minor salivary gland demonstrated infiltration by lymphocyte consistent with Sjogren`s syndrome, but Schirmer test was negative. So she was diagnosed as Adie`s syndrome with peripheral neuropathy. Five month later she complained of dry eye and dizziness. Rose bengal staining was positive. Sjogren`s syndrome was diagnosed and she was discharged with local therapy for the sicca symptoms.
TGF-β1과 IL-1β에 의한 류마티스 관절염 활막세포 자사(apoptosis)의 억제
김성호 ( Seong Ho Kim ),변원철 ( Won Chul Byun ),임미경 ( Mi Kyoung Lim ),조유숙 ( You Sook Cho ),김찬 ( Chan Kim ),김미정 ( Mi Jung Kim ),유빈 ( Bin Yoo ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.2
Objective: To investigate the proliferative and anti-apoptotic effects of TGF-β1 and IL-1β on rheumatoid synovial cells. Methods: Synovial cells obtained from surgical procedure of the rheumatoid joint were cultured with TGF-β1 and IL-1. The proliferative response of synovial cells was examined by non-radioactive cell proliferation assay. Fas-mediated apoptosis of synovial cells was measured by flowcytometry after addition of anti-Fas antibody. Results: TGF-β1 and IL-1β proliferated synovial cells in a dose-dependent manner. They also made synovial cells resistant to anti-Fas antibody induced apoptosis. Conclusion: TGF-β1 and IL-1β promotes synovial cell proliferation possibly through interference with Fas-mediated apoptosis, suggesting their role in synovial hyperplasia in rheumatoid arthritis.