메탄올-물 혼합용매에서 전도도법에 의한 벤조산 및 치환된 벤조산의 해리에 관한 연구

조민수,박형련,이순기,이계수,이본수,Min Soo Cho,Hyoung Ryun Park,Soon Ki Rhee,Kye Soo Lee,Bon Su Lee 대한화학회 1991 대한화학회지 Vol.35 No.3

25$^{\circ}$C 때 벤조산과 메타 및 파라위치에 할로겐(F, Cl, Br)이 치환된 $pK_a$값을 메탄올-물 혼합용매(0∼80% 메탄올) 중에서 Fuoss-Kraus 식에 근거한 전도도법과 Gelb의 전도도법을 이용하여 결정하였다. 할로겐 치환기에 따른 벤조산의 $pK_a$ 변화를 전자받게 유도효과와 전자주게 공명효과로 복합시킨 치환기 상수(${\sigma}_1$ 및 ${\sigma}_R$)로써 논의하였다. ${\sigma}_1$가 $D^{-1}$에 대하여 양(+)의 기울기를 갖는 직선성을 보인 반면 ${\sigma}_R$은 $D^{-1}$에 대하여 음(-)의 기울기를 갖는 직선성을 보이고 있는데, 이를 field effect의 유전상수 의존성과 할로겐 치환기의 ${\pi}$-고립쌍 전자와 이온화 중심간의 through-space ${\pi}$-상호작용으로 해석하였다. The $pK_a$ values of benzoic acid and meta, para-halogen substituted benzoic acids in MeOH-$H_2O$ mixtures (0∼80% of MeOH) have been determined at 25$^{\circ}$C using a conductometric method on the basis of the Fuoss-Kraus equation, and further verified using modified conductometric method of Gelb. The dependence of $pK_a$ on halogen substituents has been discussed in terms of substituent-constant (${\sigma}$), which is devided into electron-withdrawing inductive contribution (${\sigma}_1$) and electron-donating ${\pi}$-resonance one (${\sigma}_R$). The linear-dependence of ${\sigma}_1$'s on $D^{-1}$ with positive slope and that of ${\sigma}_R$'s on $D^{-1}$ with negative slope have been interpreted on the basis of field effect and through-space interaction of ${\pi}$-lone pair of halogen substituent and ionization center via ${\pi}$-system of benzene ring.

광범위한 뇌경색증이 합병된 지발형 B군 사슬알균에 의한 수막염 증례

조민수,김용민,조혜경,최수한,Cho, Min Su,Kim, Yongmin,Cho, Hye-Kyung,Choi, Soo-Han 대한소아감염학회 2018 Pediatric Infection and Vaccine Vol.25 No.1

Group B streptococcus (GBS) is the leading cause of neonatal morbidity and mortality. Late-onset GBS disease commonly manifests as occult bacteremia or meningitis. Approximately 50% of survivors of late-onset meningitis have long-term neurologic sequelae. Cerebrovascular complications are often associated with unfavorable clinical outcomes of GBS meningitis. There have been a few reports of cerebral infarction accompanied by GBS meningitis. We report a 29-day-old girl with severe, widespread cerebral infarction due to late-onset GBS meningitis. Isolated GBS strain from this patient was serotype III, ST-19. Currently, she has cortical blindness and significant developmental delay.

에탄올-물 혼합용매에서 전도도법에 의한 벤조산의 해리상수에 관한 연구

조민수,이순기,이계수,Min Soo Cho,Soon Ki Lee,Lee, Gye Su 대한화학회 1981 대한화학회지 Vol.25 No.2

벤조산, 파라메톡시벤조산 및 파라니트로벤조산의 산해리상수를 $25^{\circ}C$에서 메탄올의 무게퍼센트가 0, 10, 20, 30, 40, 50, 65 및 80%인 에탄올-물 혼합용매중에서 직접 전도도를 측정하는 방법과 약산의 시료를 과염소산용액으로 적정하면서 전도도를 측정하는 방법으로 구하고, 이 두가지 방법으로 구한 결과를 검토하고 다른 방법과 비교하였다. The dissociation constants of benzoic acid, p-methoxybenzoic acid and p-nitrobenzoic acid have been determined at $25^{\circ}C$ in ethanol-water mixtures containing 0, 10, 20, 30, 40, 50, 65 and 80 weight % ethanol by the direct conductance measurements and the method involving titration of the acid sample with perchloric acid reagent. The results by the two methods have been discussed and compared with those by other methods.

CVI 에 의한 적층 화이버강화 C / SiC 세라믹 복합물질의 제조

조민수,정귀영 ( Min Soo Cho,Gui Yung Chung ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

2016년에서 2018년에 국내 말 인플루엔자 백신 접종 후 항체 양성률

조민수,이주연,이상규,송재영,이지현,현방훈,조수동,우인옥,Cho, Min-Su,Lee, Ju-Yeon,Lee, Sang Kyu,Song, Jae Young,Lee, Jienny,Hyun, Bang-Hun,Cho, Soo-Dong,Ouh, In-Ohk 대한수의학회 2019 大韓獸醫學會誌 Vol.59 No.3

Equine influenza (EI) is the main cause of respiratory illness in equines across the globe and is caused by equine influenza A virus (EIV-A), which has impacted the equine industry internationally because of the marginal mortality and high morbidity. In the present study, the immune responses after equine influenza vaccination were evaluated in 4,144 horses in Korea using the hemagglutination inhibition (HI) assay. The equine influenza virus (EIV), A/equine/South Africa/4/03 (H3N8), was used as the antigen in the HI assay. The mean seropositive rates were 89.2% (97.4% in 2016, 77.6% in 2017, and 92.4% in 2018). This paper highlights the advances in understanding the effects of vaccines and control strategies for mitigating the emerging menace by EIV.

다발성 간세포암 환자에서 다발 부위 간절제 또는 고주파 치료를 병합한 간절제술 후 장기 성적

조민수(Min Soo Cho),최기홍(Gi Hong Choi),김동현(Dong Hyun Kim),강창무(Chang Moo Kang),최진섭(Jin Sub Choi),박영년(Young Nyun Park),이우정(Woo Jung Lee) 한국간담췌외과학회 2009 한국간담췌외과학회지 Vol.13 No.4

Purpose: Hepatic resection is the standard treatment for hepatocellular carcinoma (HCC). In some patients with multiple HCC, one-block resection is not feasible due to either the tumor location or the underlying liver function. In this study, we attempted to compare the outcomes of multiple - site resection or combined resection and radiofrequency ablation with those of one-block resection in patients with multiple HCC. Methods: We retrospectively reviewed 507 patients who underwent surgical resection. Among 507 patients who received surgical treatment with potentially curative aim from January 1996 to August 2006 in Yonsei University Health System, 58 patients had a radiologically detected multiple HCC. Patients with multiple HCC were divided into: group A, patients treated with one-block resection (n=40) and group B, patients with multiple-site resection or combined resection and RFA (n=18). Results: The 1-, 3- and 5-year overall survival rates for patients with single and multiple HCC were 90.2%, 76.2% and 66.7% and 82.7%, 61.4% and 37.9%, respectively (p<0.001). In group B, 6 patients received multiple-site resection and 12 patients underwent combined resection and RFA. The clinicopathological variables were not significantly different between the two groups except the distribution of multiple tumors. The postoperative complication rates for group A and B were 32.5% and 33.3%, respectively. The 1-, 3- and 5-year disease-free survival rates for group A and B were 53.0%, 27.6% and 24.1% and 18.3%, 24.1% and 18.3%, respectively (p=0.386). The overall survival rates were also not significantly different between the two group (80.0%, 59.6%, and 36.9% for group A and 88.9%, 65.7% and 39.4% for group B, p=0.528). The multivariate analysis revealed that Edmondsons-Steiner grade (III-IV) and Indocyanine green retention rate at 15 minutes (ICG R15) >10% were adverse prognostic factors for overall survival. Conclusion: Active treatments including multiple-site resection and combined resection and RFA showed similar treatment outcomes compared with one-block resection in patients with multiple HCC.

고등학교 영어 교과서, EBS 수능 연계 교재, 대학 수학 능력 영어 시험의 어휘 수준 및 이독성 비교 연구

조민수(Cho, Min-Soo),박은수(Park Eun-Soo) 학습자중심교과교육학회 2016 학습자중심교과교육연구 Vol.16 No.7

본 연구는 고등학교 영어 교과서, EBS 수능 연계 교재, 그리고 수능 영어시험의 코퍼스 기반 어휘 수준과 이독성을 비교 조사하였다. 분석대상은 2015학년도 수능영 어시험에 채택된 2009개정 교육과정의 고등학교 ‘영어Ⅰ’, ‘영어Ⅱ’ 교과서 각각 8권, EBS 수능 연계교재 중 독해 영역 6권, 그리고 지난 3년간 수능 모의고사와 수능 영어시험으로 하였다. 분석 도구는 WordSmith Tools 6.0을 사용하였고, Flesch Reading Ease, Flesch-Kincaid Grade Level 과 Gunning Fog Index를 사용하여 이 독성 지수를 분석하였다. 연구 결과, 수능 연계교재의 어휘 타입 수는 4,603∼6,824 개, 수능 시험은 3,625개로 교과서 어휘 타입수의 1,650∼1,906개에 비해 타입 수가 두 배 이상이었다. 영어 교과서의 이독성 지수 범위는 8종 교과서 모두 59.89∼66.24 에 해당하며, 이는 학년 수준 환산표에 의하면 미국 학제 8학년과 9학년 수준에 해당 하였다. 반면 EBS 수능 연계 교재와 수능 영어시험의 어휘 수준은 미국 학제의 12학년 이상이었다. 결과를 통해 수능 연계교재와 수능 영어시험의 어휘 수준은 영어 교 과서의 어휘 수준과 비교해 큰 차이를 보이고 있음을 알 수 있었다. 이는 영어 교과 서와 EBS 수능 연계 교재, 수능 영어시험 간의 연계성에 심각한 문제가 있음을 시사한다. 영어 교과서가 교육 현장에서 학습의 주 자료로서의 역할을 하기 위해서는 영어 교과서, EBS 수능 연계 교재, 그리고 수능 영어시험 간의 어휘 수준에 대한 논의가 반드시 이루어져야 할 것이다. The purpose of this study is to determine the vocabulary levels and readability of high school English textbooks, EBS CSAT books, and Korean College Scholastic Ability Test(CSAT). In order to find out differences among them, the copora have been built and data were examined using WordSmith Tools 6.0 software program, Flesch Reading Ease, Flesch-kincaid Grade Level, and Gunning Fog Index. The results were as follows. EBS CSAT Books and College Scholastic Ability test contain more various words than high school English books do. In the comparison of Type/Token ratio, the results show that the numbers of EBS CSATs and College Scholastic Ability test s TTR are 47.47 and 47.75, while high school English books are 42.18, which indicates that EBS CSAT Books and College Scholastic Ability test have more various word-types and its lexical diversity is relatively higher. The vocabulary levels among high school English textbooks, EBS CSAT Books, and Korean College Scholastic Ability Test(CSAT) are quite different. Compared to the high school English textbooks, EBS CSAT books and Korean College Scholastic Ability Test are above 12th grade on the basis of the US school system. Due to these differences and washback effects, the amount of vocabulary that high school students should learn is dramatically increased. The results suggest the necessity of policy-related discussion to reduce the differences of vocabulary level among high school English textbooks, EBS CSAT books, and Korean College Scholastic Ability Test(CSAT).

내시경적 역행성 담췌관 조영술 후 발생한 십이지장 천공의 치료

조민수(Min-Soo Cho),박동은(Dong-Eun Park),채권묵(Kwon-Mook Chae) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.3

Purpose: Although duodenal perforation following ERCP is very rare compared to other complications, it can result in a fatal outcome. To find the most effective treatment strategy, the cases experienced at our hospital were reviewed and analyzed. Methods: A retrospective chart review, conducted at our hospital between December 1994 and April 2006, identified 15 periduodenal perforation cases related to ERCP; a rate of 0.53%. The following parameters were reviewed: clinical presentation of perforation, diagnostic methods, time to diagnosis and operation, method of management, length of stay and outcome. Results: Fourteen patients were managed by surgery and one conservatively. Eleven patients were cured without complications, but four suffered from severe complications, and required several re-operations. Two patients (50%) of the re-operated group died. The mean time to surgery was longer in the re-operated than non-re-operated group (34.3±12.4 hours vs. 17.2±21.7 hours). The causes for the reoperation were an anastomosis blowout in the duodenotomy for transduodenal sphincteroplasty in 3 and duodenal perforation at the site of transduodenal sphincteroplasty in the remaining patient. All re-operated cases had large retroperitoneal fluid collection, as seen on CT scanning, and had been operated on by inexperienced surgeons. Conclusion: The early detection is important for the treatment of a duodenal perforation following ERCP. If surgical treatment is needed, it must be performed within 24 hours. Although the type of surgical procedure will depend on the surgeon’s preference, a less invasive procedure, such as simple closure & drainage, will be adequate in cases with a delayed diagnosis, a septic condition or an inexperienced surgeon.

국가산업단지 공용파이프랙의 구조안전성 확보를 위한 현장점검 결과 (Part 3. 현장점검의 접근성 및 난이도)

조민수(Cho, Min Soo),김영민(Kim, Young Min) 한국강구조학회 2022 한국강구조학회 학술대회 발표집 Vol.33 No.1

Multiplexer / Demultiplexer를 이용한 적응 라우팅 능력을 가진 고정된 다단계 상호 연결망

조민수(Min-Soo Cho),김석수(Suk-Soo Kim),전문석(Moon-Seog Jun),이철희(Chul-Hee Lee) 한국정보과학회 1993 한국정보과학회 학술발표논문집 Vol.20 No.2

본 논문에서는 제한된 단계를 갖는 Clos 네트워크에 멀티플렉서와 디멀티플렉서를 추가하고, 적응 라우팅을 위해 네트워크의 한 열에 간선을 추가한 새로운 네트워크(Extra-Stage Clos Network)를 제안하였다. 이 네트워크는 추가된 멀티플렉서와 디멀티플렉서에 의해 네트워크의 분할을이루웠고, 적응 간선을 이용해 네트워크의 부하 균형을 이루었다. 복수개의 경로를 갖는 상호연결망은 신뢰성과 성능향상 그리고 폴트 톨러런스의 기능을 갖는데 중요한 요소가 된다. 그러한 의미에서 멀티플렉서와 디멀티플렉서를 이용한 EClos 네트워크의 라우팅은 복수개의 경로의 존재성을 보여주었다.