K562 세포주에서 Genistein에 의해 억제되는 Radiation-induced Apoptosis의 조절 유전자

정수진,진영희,유여진,도창호,정민호,허기영,배혜란,양광모,문창우,오신근,허원주,이형식,Jeong, Soo-Jin,Jin, Young-Hee,Yoo, Yeo-Jin,Do, Chang-Ho,Jeong, Min-Ho,Huh, Gi-Yeong,Bae, Hye-Ran,Yang, Kwang-Mo,Moon, Chang-Woo,Oh, Sin-Geun,Hur, Won-Jo 대한방사선종양학회 2001 대한방사선종양학회지 Vol.19 No.3

Prupose : The genes involved on the suppression or radiation-induced apoptosis by genistein in K562 leukemia cell line was investigated. Materials and methods : K562 cells in exponential growth phase were irradiated with a linear accelerator at room temperature. For X-ray irradiation and drug treatment, cultures were prepared at $2\times10^5\;cells/mL$. The cells were irradiated with 10 Gy (Clinac 1800C, Varian, USA), Stock solutions of herbimycin A (HMA, Calbiochem, UK) and genistein (Calbiochem, UK) were prepared in dimethylsulfoxide (DMSO, Sigma, UK). After incubation at $37^{\circ}C$ for 24 h, PCR-select cDNA subtractive hybridization, dot hybridization, DNA sequencing and Northern hybridization were examined. Results : Smad6 gene was identified from the differentially expressed genes in K562 cells incubated with genistein which had been selected by PCR-select cDNA subtractive hybridization. The mRNA expression of Smad6 in K562 cells incubated with genistein was also higher than control group by Northern hybridization analysis. Conclusion : We have shown that Smad6 involved on the suppression of radiation-induced apoptosis by genistein in K562 leukemia cell line. It is plausible that the relationship between Smad6 and the suppression of radiation-induced apoptosis is essential for treatment development based on molecular targeting designed to modify radiation-induced apoptosis.

사료내 미량광물질 강화 복합미생물 첨가가 산란노계의 계란생산 및 난질개선에 마치는 영향

정수진,주은정,이우식,윤병선,이주삼,남기택,황성구,Jeong, Soo-Jin,Joo, Eun-Jung,Lee, Woo-Sic,Yon, Byeng-Sun,Lee, Ju-Sam,Nam, Ki-Taek,Hwang, Seong-Gu 한국유기농업학회 2004 한국유기농업학회지 Vol.12 No.2

In recent years, the consumption of livestock products were markedly decreased by awareness of world-widely occurred diseases including mad cow disease, Foot and mouth disease, Hog cholera, and Poultry Influenza virus. the consumers ara also wanting to have highly safe food such as organic animal products because of concerning about residual of antibiotics in animal products. However, disease control and impairment of productivity are the major problem in organic animal production. On these points of view, the present study was undertaken to investigate the effects of 1% or 2% of dietary probiotics fortified with various minerals on improvement of egg production and egg quality in old lay6r feeding low quality feed mainly composed of food waste, sesame meal, and rice bran. After 4 weeks of experimental feeding, the diameter of spreading of egg white was clearly decreased from 11.2cm of control eggs to 10.5m and 10.1m in 1% and 2% treatment group eggs, respectively. The color of egg yolk was 9.3 in control eggs but remarkably increased in treatment groups showing 10.1~10.2. Egg production was 75.8% in control layers but significantly increased to 79.8% of 1% treatment group and 82.9% of 2% treatment group layers. Egg weights (C : 66.3g, 1% : 73.2g, and 2% : 76.7g) and egg shell thickness (C : 0.33mm, 1% : 0.35mm and 2% : 0.36mm) were also increased by the addition of 1% or 2% of probiotics when compared to those of control group eggs. All together, it has been suggested that dietary addition of probiotics fortified with various minerals can improve the egg quality and egg production in layer's productivities by the recycling of organic waste resources such as food waste and agricultural by-products.

자동차용 촉매변환기의 최적설계를 위한 열 및 유동특성에 대한 수치적 연구

정수진,김우승,Jeong, Soo-Jin,Kim, Woo-Seung 대한기계학회 1999 大韓機械學會論文集B Vol.23 No.7

In the present work, the effect of a flow maldistribution on the thermal and conversion response of 8 monolith catalytic converter is Investigated. To achieve this goal, a combined chemical reaction and multi-dimensional fluid dynamic mathematical model has been developed. The present results show that flow uniformity within the monolith brick has 8 great impact on light-off performance of the catalytic converter. In the case of lower flow uniformity, large portions of the monolith remain cold due to locally concentrated high velocities and CO, HC are unconverted during warm-up period, which loads to retardation of light-off. It has been also found that the heat-up pattern of the monolith ill similar to the flow distribution profile, In the early stage of the reaction. It may be concluded that flow maldistribution can cause a significant retardation of the light-off and hence can eventually worsen tho conversion efficiency of automotive catalytic converter.

건강 진단 수검 여성들의 유방 자가 검진에 대한 인식도 및 실천정도에 관한 연구

정수진,최순석,박준한,엄상화,정귀원,이채언,배기택,Jeong, Soo-Jin,Choi, Soon-Seok,Park, Jun-Han,Urm, Sang-Hwa,Jeong, Kui-Won,Lee, Chae-Un,Bae, Ki-Taek 대한예방의학회 1998 예방의학회지 Vol.31 No.4

The methods for the early diagnosis of breast cancer are mammography, physical examination, breast self-examination(BSE). This study was conducted to investigate the knowledge and practice of BSE by structured questionnaire which included questions on general characteristics, performance of mammography, physical examination of breast, knowledge and practice of BSE. The subjects in this study were 412 females between 20 and 69 year old who visit to the Health Care Center of College of medicine of Inje University from December 1997 to February 1998. The results were as follows. 1. Women who have Soften the regular mammography are 8.19% of these subjects and women who have gotten the regular physical examination by doctors are 4.19% of these subjects. 2. Regarding BSE, 77.4% of these subjects said that they knew BSE and 3.88% of these subjects said that they practiced BSE regularly. It was that women who knew BSE were more younger, better-educated and higher economic status(p=0.001) and lived a normal life with he. husband(p=0.033). And women who practiced BSE regularly were more younger, and married(p=0.001). 3. The most common barrier to doing BSE is 'Do not see the needs/worry unnecessarily', and the most common reasons for doing BSE is 'Early detection of Breast cancer'. 4. The overall frequency and percentage distribution of recommended BSE step in Korea is lower than U.S.A.

커먼레일 연료분사 시스템을 장착한 경량 DME 트럭의 연구 및 개발

정수진,전문수,박정권,Jeong, Soo-Jin,Chon, Mun Soo,Park, Jung-Kwon 한국교통대학교 융복합기술연구소 2012 융ㆍ복합기술연구소 논문집 Vol.2 No.1

In this study, the trucks(2.9-liter) have been developed to use DME as fuel, and performance test of the vehicle's DME engine, power, emissions, fuel economy and vehicle aspects was conducted. For experiments, the fuel system(common-rail injectors and high-pressure pump included) and the engine control logic was developed, and ECU mapping was performed. As a result, the rail pressure from 40MPa to approximately 65% increase compared to the base injector has been confirmed that. Also, the pump discharge flow is 15.5 kg/h when the fuel rail pressure is 400rpm(40 MPa), and the pump discharge flow is 92.1 kg/h when the fuel rail pressure is 2,000rpm(40MPa). The maximum value of full-load torque capability is 25.5kgfm(based on 2,000rpm), and more than 90% compared to the level of the diesel engine were obtained. The DME vehicle was developed in this study, 120 km/h can drive to the stable, and calculated in accordance with the carbon-balance method of fuel consumptions is 5.7 km/L.

냉간시동시 자동차용 저온활성촉매의 성능 향상을 위한 수치적 설계

정수진,김우승,Jeong, Soo-Jin,Kim, Woo-Seung 대한기계학회 2000 大韓機械學會論文集B Vol.24 No.9

Light-off catalyst has been used for minimization of cold-start emissions. Improved cold-start performance of light-off catalyst needs the optimal design in terms of flow distribution, geometric surface area, precious metal loading, cell density and space velocity. In this study, these influential factors are numerically investigated using integrated numerical technique by considering not only 3-D fluid flow but also heat and mass transfer with chemical reactions. The present results indicate that uneven catalyst loading of depositing high active catalyst at upstream of monolith is beneficial during warm-up period but its effect is severely deteriorated when the space velocity is above 100,000 $hr^{-1}$ To maximize light-off performance, this study suggests that 1) a light-off catalyst be designed double substrate type; 2) the substrate with high GSA and high PM loading at face be placed at the front monolith; and 3) the cell density of the rear monolith be lower to reduce the pressure drop.

맵 기반 제어알고리즘 Urea 분사시스템을 장착한 승용디젤자동차의 배출가스 성능 특성

정수진(Soo-Jin Jeong),이호길(Ho-Kil Lee),오세두(Se-Doo Oh),박정권(Jung-Kwon Park),김영득(Young-Deuk Kim),심성민(Sung-Min Shim),김우승(Woo-seung Kim) 한국자동차공학회 2009 한국자동차공학회 학술대회 및 전시회 Vol.2009 No.11

The selective catalytic reduction(SCR) system is a highly-effective aftertreatment device for NOx reduction of diesel engines. Generally, the ammonia(NH₃) was generated from reaction mechanism of urea solution in the SCR system using the liquid urea as the reductant. Therefore, the precise urea dosing control is a very important key factor for reducing NOx and NH₃ slip in the SCR system. This paper discussed about emission characteristics of diesel passenger car with urea dosing system of map-based control algorithm. In the map-based control algorithm of this study, the urea injection was determined by mass flow rate of exhaust gas based on the engine rpm, torque, O₂ and NOx concentration measured by NOx sensor. Finally, this paper investigated the characteristics of NOx emission and NH₃ slip of diesel SCR exhaust system under NEDC mode by using the optimized map-based dosing control algorithm.

수소연료 자동차용 액화수소탱크의 열 및 가압성능 예측을 위한 수치모델 개발

정수진(Soo-Jin Jeong) 한국자동차공학회 2019 한국자동차공학회 지부 학술대회 논문집 Vol.2019 No.5

There is worldwide understanding that hydrogen has a great potential as the fuel of the future. In addition to the challenge of developing appropriate hydrogen propulsion systems, the development of hydrogen storage systems is the other big issue. The stored liquid hydrogen must be kept at a temperature of about 20 K. Therefore the space between outer jacket and inner tank is mainly used for the thermal insulation. The permanent heat input during the time the vehicle is not used, leads to pressure and temperature increase of the hydrogen fuel. Therefore, this study is focusing on the development of three-dimensional CFD model of liquified hydrogen storage systems in view of boil-off management for controlled evaporation, pressurization in ullage, flow characteristics of liquid and vapor, thermal stratification and evaporation characteristics on the free surface. Two-phase CFD compressible VOF models with Ranz-Marshall interfacial model by using a customized in-house version of AVL, Fire® for liquid hydrogen tank self-pressurization and pressure control were used to show the impact of interfacial and vapor phase turbulence on evolution of pressure and temperatures in the cryogenic storage tanks. The results show that the present CFD model has a good adaptability in the prediction of pressurization behaviors and is a useful tool for the design and optimization of a pressurization system.

알루미늄 박판 결함 검사를 위한 인공지능 기반 비전 시스템 개발

정수진(Soo-Jin Jeong),곽호택(Hotaek Kwak),김진구(Jingu Kim),문성준(Seong-Joon Moon),노한상(Hansang Roh) 한국자동차공학회 2023 한국자동차공학회 부문종합 학술대회 Vol.2023 No.5

유동특성을 고려한 촉매변환기의 활성화(Light-off) 성능에 관한 연구

정수진(Soo-Jin Jeong),김우승(Woo- Seung Kim) 한국자동차공학회 1999 한국 자동차공학회논문집 Vol.7 No.5

Catalytic converters are the most fascinating and complicated chemical reactors. They are most often operated in the transient state with respect to composition, flow rate, temperature, etc. The mathematical model developed in this work accounts for simultaneous heat and mass transfer, chemical reaction, and multi dimensional flow characteristics to analyze the light-off performance of monolithic catalytic converter with comparable mass flow rate. To validate the mathematical model, comparison between experimental and numerical results has been performed. The numerical results show a good agreement with experimental data. [t is found that inflow rate shows major effect on the characteristics of thermal response of catalytic converter.<br/>