항결핵제(抗結核劑)의 결핵균(結核菌)에 대(對)한 작용(作用) 및 미세구조(微細構造) 변화(變化)

등영건,정성덕,김성광,Deung, Young-Kun,Cheung, Sung-Douk,Kim, Sung-Kwang 한국현미경학회 1978 Applied microscopy Vol.8 No.1

The aim of this research was to discover the action mechanism of various antituberculosis agents (isoniazid, paraaminosalicylic acid and streptomycin) which act on Mycobacteria tuberculosis hominis $H_{37}R_v$ and also to study the relationship of ultrastructural changes and the growth pattern in Mycobacterium tuberculosis hominis. The ultrastructural change was observed with an electron microscope while the growth pattern was studied through in vitro culture. The results are summarized as follows: 1. The ultrastructural changes found in the group treated only with isoniazid were the loss of nuclear materials and the appearence of electron dense granules. 2. In the group treated with paraaminosalicylic acid, thickening of nuclear filaments and meso some arrangement disorders were observed. 3. In the group treated with streptomycin, the ribosome particles appeared indistinct and the cytoplasm was denaturalized. 4. In the group cross treated with all three agents, all the ultrastructural changes mentioned above could be observed in the cell just as they appeared in the single treated groups. 5. In all of the single and in the crossly treated group, there were no significant changes note in the cell wall or cytoplasmic membranes of any of the cells observed. 6. In the cultural data in vitro, through the crossly treated group and single treated group. growth was observed in 3-5 weeks of culture.

신불안.우울척도에 의한 대학 신입생의 정신건강 평가

박형배,김진성,김창수,박병탁,이종범,이중훈,정성덕,Park, Hyeong-Bae,Kim, Jin-Sung,Kim, Chang-Su,Park, Byung-Tak,Lee, Jong-Bum,Lee, Jung-Hoon,Cheung, Seung-Douk 영남의대학술지편집위원회 1987 Yeungnam University Journal of Medicine Vol.4 No.1

1986년 영남대학교 신입생 4,834명 (남학생 ; 3,499명, 여학생 ; 1,335명)을 대상으로 1986년 1월부터 동년 2월에 걸쳐 신불안 우울척도를 사용하여 평가한 불안 우울성적의 결과는 다음과 같다. 1. 불안 우울성적의 평균총점은 남학생이 $31.49{\pm}6.57$이었고 여학생이 $33.37{\pm}6.84$로 양군간의 유의한 차이가 있었다(P<0.001). 2. 신불안 우울척도의 항목별 성적이 남녀학생 공히 높은 항목은 수면장애, 후회감, 성욕감퇴 및 피로감 등이었고 남녀학생 공히 낮은 항목은 두려움, 정신운동흥분과 지연, 졸도감 및 절망감 등이었다. 3. 신불안 우울척도의 총점이 50점 이상인 고득점자는 남학생이 99명(2.8%), 여학생이 40명(3.0%)이었다. 4. 사회정신의학적 요인들중 남녀학생의 불안 우울성적에 공히 유의한 영향을 끼친 것은 소속대학이나 소속학과에 대하여 불만인 경우, 가족분위기나 부모와의 친숙도에 대하여 불만인 경우, 과거, 현재, 미래의 자아상에 대한 태도가 비관적인 경우(이상 각각 P<0.0001) 등이며, 성장지가 시단위 이하인 경우(각각 P<0.05)등이었다. 5. 신불안 우울척도와 Zung의 자가평가 불안척도 및 우울척도간의 상관관계는 각각 0.64, 0.61의 다소 높은 상관관계를 보였다. 또 신불안 우울척도와 Leeds대학의 불안 우울척도간에는 상관계수 0.77의 높은 상관관계를 보였다. The authors studied anxiety-depression using New Anxiety-Depression Scale(NADS), in the subjects of 3,499male and 1,335 female college freshmen of Yeungnam University. The authors collected the reports of NADS during the periods from January to February, 1986, and applied ANOVA and t-test on anxiety-depression scores in order to compare them between various psychosocial factors, and sexs. The results are as follows : There was significant difference in the mean awerages of total scores between male and female students: male students scored $31.49{\pm}6.57$ female students scored $33.37{\pm}6.84$ (P<0.001) The anxiety-depression scores relating to the items of sleep disturbance, apprehension, decreased libido and fatigue were relatively higher in both groups. Ninety-nine male students(2.8%) showed seriously high degree anxiety-depression scores of 50 or higher, while forty female students(3.0%) showed the same scores. There was a strong tendency toward higher anxiety-depression scores in the students who were dissatisfied with their home atmosphere, colleges, departments and familiarity of parents, and those who had pessimistic views of self image in the past, present, or fartare in both groups (P<0.001) The students whose maturation locations were below city level, showed higher level of anxiety-depression scores in both groups (P<0.05) NADS and SAS, SDS, and Leeds scale were correlated significantly in 0.64, 0.61, and 0.77 of correlation coefficient.

양로원 현황과 재원자 건강상태에 관한 예비조사

권복순(Kwon Bok Soon),이중훈(Lee Jung Hoon),정성덕(Cheung Sung Douk) 한국노년학회 1986 한국노년학 Vol.6 No.1

The purpose of this study is to review the current social service provisions and health service provisions of the homes for the aged (HFA) on the government subsidy, by analyzing the residents' living situations and their mental health conditions in the hope that the data obtained would then be utilized for the old age welfare policy-making in the future. The authors looked into the compositions of residents by age and sex and the personnel and the facilities such as housing, dorms, dining room, recreation hall and dispensary of the HFA. They studied organic brain syndrom (OBS) by using 25-itemed Diagnoistic interview schedule for DSM-III and depression by using 20-itemed Zung's self-rating depression scale in the residents of the HFA and, as control groups, community elderly residents and elderlies on a Life-long education program. In the HFA, the residents' sex ratio (female: male=2.3:1),age strata and handicapping conditions require sophisticate activity programs and appropriate care provisions. The qualification status and numbers of the personnel do not meet the regulated standards, nor the health care needs of the elderly. The conditions of facilities are inconvenient and present service provisions do not seem to be conducive to the enhancement of the residents' morale. In both OBS and depression tests, the residents of HFA are found to be in poorer health conditions than control groups. Environmental factor analysis indicates that there are strong correlations between the psychosocial factors such as age, monthly pocket money, religion, past occupation, growing place, separation period from family, and supporter and the mental health of the elderly, especially of the HFA. The authors conclude that the quality and quantity of the social service provisions have an important impact on the maintenance of the mental health of the residents of the HFA and suggest that, to make the HFA a better living place for the underprivileged elderly, the welfare policy should take more considerations on the improvement of the facilities, living standards, social service planning and delivery system, personnel's qualification, and health service provisions.

노인의 우울에 관한 연구

이종범(Lee Jong Bum),서혜수(Suh Hae Seo),정성덕(Cheung Sung Douk) 한국노년학회 1984 한국노년학 Vol.4 No.1

The authors studied depression, using Zung's self-rating depression scales in 339 older males, and compared the results with those of 522 older females who lived in the Seoul, Taegu, and Gyong San areas during the period from the beginning of october 1983 until the end of June 1984. The summary of results is as follows, 1. There was a significant difference in the means of total depression scores between the two groups. The older female were more depressive than the older male. 2. The depression scores relating to hopelessness, personal devaluation, dissatisfaction, psychomotor retardation and emptiness were relatively high in both groups. The scores of psychomotor agitation, crying spells, constipation and suicidal rumination were lower in both groups. 3. The 111 older males (33.7%) showed rather serious depression levels with scores of 50 or higher, while the 295 older female(56.5%) showed the same score. 4. Among these psychosocial factors, aging, occupation, supporter and living places are related to depression scores significantly in both male and female aging. And older females are more depressive than older male in the case of supporter(self, sons), no occupation, illiteracy and no religion.

Iproniazid 및 Lithium이 가토 혈중주정농도에 미치는 영향에 관한 실험적 연구

정성덕 大韓神經精神醫學會 1973 신경정신의학 Vol.12 No.4

In recent years, it has been known that lithium has marked psychotropic effects in controlling manic excitement, various other psychotic excitements and the recurrence of both manic and depressive symptoms. Iproniazid is the very first antidepressant which first introduced in medicine as a antituberculous agent in 1951. Thereafter many investigators established that iproniazid was of particular value in treating patients with depression and that it was an inhibitor of monoamine oxidase. Its usage, however, had been discontinued around 1960 due to svere hepatotoxicity. It has lately been reported that lithium and several other psychotrophic drugs elevated the blood alcohol level in rabbits. In view of these reports the author conducted an animal experiment to investigate the effects of iproniazid, alone or in combination with lithium ion, on blood alcohol level in rabbits. Materials and Method 1. The experimental work was done with mature rabbits of both sexes, weighting between 2.0㎏ and 3.0㎏ 2. The experimental animals were divided into 2 groups : control and experimental. The control group was given alcohol alone and the experimental group was divided into 3 subgroup: alcohol+iproniazid group, alcohol+lithium group and alcohol+iproniazid +lithium group. 3. Iproniazid was given orally in a capsule form, 30㎎/㎏ of body weight, in 3 divided doses, a day for 5 days. The last dose of iproniazid was given 1.5 hours before alcohol administration. 4. Lithium chloride solution, 6.3%, was given in a dose of 3.0 mEq/㎏ of body weight a day for 4 days by intravenous route. The last dose was given 1 hour before alcohol administration. 5. In all groups, 20 Vol. % ethanol solution was given in a dose of 5.0 ㎖/㎏ of body weight in 5 minutes by intravenous route. 6. All of the blood specimens were obtained by cardiac puncture at 10 and 30 minutes respectively after alcohol administration, but additional blood specimens were obtained from the alcohol+iproniazid group at 20 minutes after alcohol administration. 7. The blood alcohol level was determined by Cavett's method. 8. In order to observe histopathological changes of the liver cell, the experimental animals were divided into 2 groups, control and experimental. To control group, normal saline was given in a dose of 5.0 ㎖/㎏ of body weight for 5 days by intravenous route. Experimental group, was divided into 3 subgroups. To the first subgroup, iproniazid was given for 10 days, to the second subgroup, lithium was given for 9 days and to the third subgroup, iproniazid combined with lithium were given. All animals were sacrlfied by intravenous injection of air. 9. For the light microscopic examinations, histoathological alteration of the liver cells was bserved by the routine hematoxilin-eosin staining chique. 10. For the electron microscopic examinations, e liver tissue was fixed in 1% osmium tetroxide (OsO₄), dehydrated with graded alcohol and embeded with Epon 812. The sections were cut with a ass knife in 400-500 Å thickness and stained with ranyl acetate and lead hydroxide. The pictures were taken with the Hitachi model Hu 11E-1 type electron microscope. Results 1. Alcohol+iproniazid group: Iproniazid significantly elevated the blood alcohol level at 10, 20 and 30 minutes after alcohol administration(P<0.05). 2.Alcohol+lithium group: Lithium elevated the blood alcohol level significantly at both 10 (P<0.01) and 30 minutes (P<0.05) after alcohol administration. 3. Alcohol+iproniazid+lithium group: Iproniazid combined with lithium elevated significantly the blood alcohol level at both 10 and 30 minutes after alcohol administration (P<0.01). The blood alcohol levels of these groups were significantly higher than those of alcohol+iproniazid group and alcohol +lithium group (P<0.05). 4. Electron microscopic findings: Iproniazid group revealed mild swelling of mitochondria, loss of cristae and dense body in cytoplasm. Lithium group revealed enlarged nucleus and nucleous and scattered glycogen in cytoplasm. Ipronizid+lithium group reveled separated nucleolus in enlarged nucleus with irregular nuclear membrane and dilatated rough endopiasmic reticulum and several vacuoles in cytoplasm. Conclusions 1. The orally administered iproniazid in a dose of 30 ㎎/㎏ a day for 5 days elevated significantly the blood alcohol level in rabbits at 10, 20 and 30 minutes after alcohol administration. 2. The intravenous injection of lithium chloride in a dose of 3.0mEq/㎏ a day for 4 days elevated significantly the blood alcohol level in rabbits at both 10 and 20 minutes after alcohol administration. 3. The iproniazid combined with lithium chloride elevated significantly the blood alcohol level in rabbits at both 10 and 30 minutes after alcohol administration. 4. On electron microscopy, iproniazid group, in which iproniazid was given orally in a dose of 30 ㎎/㎏ body weight a day for 10 days revealed mild swelling of mitochondria, loss of cristae and dense body in cytoplasm, lithium group, in which lithium chloride solution, 6.36% was given intravenously in a dose of 3.0 mEq/㎏ of body weight a day for 9 days revealed enlarged nucleus and nucleolus and scattered glycogen in cytoplasm and iproniazid combined lithium group, in which iproniazid was given for 10 days and lithium was given for 9 days revealed sparated nucleolus in enlarged nucleus with irregular nuclear membrane and dilatated rough endoplasmic reticulum and vacuoles in cytoplasm.

여성근로자와 여대생의 불안과 우울에 관한 조사

정성덕 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.2

The author studied on anxiety and depression, using Zung's self-rating scales, in 460 female industrial workers and compared the results with those of 755 female college students. The results showed that there was no significant difference in the means of total anxiety and depression scores between the two groups. The anxiety scores in items of apprehension, sweating, dyspnea, restlessness and insomnia and the depression score in items of decreased libido, confusion, psychomotor retardation, indecisiveness and diurnal variation ware relatively high in both groups. But the anxiety scores of dizziness and paresthesia and the depression scores of irritability, hopelessness, decreased appetite, and crying spells were higher in industrial workers than in college students. The scores of tremor, faintness, mental disintegration, suicidal rumination, psychomotor agitation, tachycardia, weight loss and sleep disturbance were lower in both groups, but scores in facial flushing and nightmare were lower in industrial workers and the scores of dizziness and paresthesia were lower on college students. One hundred and four industrial workers (22.06%) showed rather serious anxiety level of score 50 or higher, while 72 college students (9.18%) showed the same score, and one hundred and fifty industrial workers (32.77%) showed rather serious depression level of score 50 or higher while 166 college students (21.99%), showed the same, score. Among the industrial workers, the high school graduates were more anxious than the primary school graduates, and those without religion were more depressed. Also, college students living in their homes than those who live in dormitory and older students than the younger ones were more depressed.

양로원 재원노인의 정신건강에 관한 연구 : I. 기질성 뇌증후군을 중심으로

박병탁,정성덕,김진성 영남대학교 의과대학 1998 Yeungnam University Journal of Medicine Vol.3 No.1

1986년 6월부터 동년 8월까지 대구직할시 및 경북지역에 소재된 9개 양로원에 재원한 296명의 노인을 대상으로 진단적 면담검사(DIS) 중 기질성 뇌증후군 척도를 사용하여 평가한 결과는 다음과 같다. ① OBS척도에서 기질성 뇌증후군 범주에 속하는 노인은 100명(34%)이었고 남자노인 10명(15%), 여자노인 90명(39%)이었으며, 이중 노인성 치매에 속하는 노인은 12명(4%)이었다. ② 사회정신의학적 요인들과 기질성 뇌증후군성적의 상호관계는 나이가 많은 경우, 학력이 낮은 경우, 군 단위 이하에서 출생한 겨우, 무직으로 지낸 경우, 무교인 겨우, 입원 경험이 없는 경우에 기질성 뇌증후군의 빈도가 높았다. The authors studied organic brain syndrome, using organic brain syndrome scale of the Diagnostic Interview Schedule for DSM-III, in the subjects of 65 males and 231 females at the homes for the aged in the Taegu and Kyong-buk areas. The authors collected the data during the period from June to August. 1986, and applied ANOVA and x²-test in order to compare various psyhologic factors in relation to the organic brain syndrome. The results could be summarized as follows : The elderly males(15%) showed high OBS scores of 12 and over, while ninety elderly females(39%) showed the same scores. Among those psychosocial factors, age, education, birth place, occupation, religion, history before institutionalization are signifiantly related to the OBS scores.

自然界 抗酸菌에 關한 硏究 : 2. 實驗的 非定型抗酸菌症에 對하여 2. Experimental mycobacteriosis provoked by atypical mycobacterial species

金聖光,金世鍾,鄭聖德,金周德 최신의학사 1982 最新醫學 Vol.25 No.4

Toloxatone 및 Ethanol이 흰쥐 MAO 활성에 미치는 영향

이희창,정성덕,김진성 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.5

The objectives of this study is to investigate the effect of toloxatone and ethanol on monoamine oxidase(MAO) activity in rat's brain, liver and intestine using tyramine and benzylamine as the substrate. The results were as follows : There was significant differences(p<0.05) in MAO activity of brain, liver and intestine compared to control in toloxatone administered group with tyramine and benzylamine as the substrate. But MAO activity was significantly inhibited in higher toloxatone concentration as using benzylamine as the substrate rather than using the tyramine as substrate. There was significant differences(p<0.05) in MAO activity compared to control only in the concentration of 5×10(???)¹ M and 1 M in ethanol administered group. Specifically, in comparative analysis of EC(???), MAO activities were more significantly inhibited in the tyramine using group than the benzylamine using group in toloxatone administered group, and MAO activity was significantly inhibited in lower toloxatone concentration at intestine rather than brain and liver. But ethanol administered group was not significantly inhibited. These results suggest that toloxatone has more specific affinity to MAO but not in the case of ethanol.

自然界 抗酸菌에 關한 硏究 : 1. 土壤抗酸菌의 分離同定方法에 對하여 1. Isolation and Identification Method of Acid-Fast Bacilli from Soil

金聖光,金世鍾,鄭聖德,金周德 최신의학사 1978 最新醫學 Vol.21 No.7