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소화성궤양 환자에서 저용량 clarithromycin 3제요법의 Helicobacter pylori 제균효과
정명아 ( Myeong A Cheong ),김태헌 ( Tae Hun Kim ),박영숙 ( Young Sook Park ),이진혁 ( Jin Hyuk Lee ),주연호 ( Yeon Ho Joo ),최일주 ( Il Ju Choi ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 우리나라에서는 H. pylori의 첫 치료로 PPI, amoxacillin과 clarithromycin의 3제요법이 추천되고 있다. Clarithromycin의 용량은 500mg을 하루 2회 복용하는 것이 추천되나, 250mg을 하루 2회 복용하는 저용량 Clarithromycin 3제요법의 H. pylori 제균 효과에 대하여는 아직 논란이 있는 실정이다. Omeprazole을 사용한 3제요법에 대한 국내의 보고에서 clarithromycin
류마티스관절 활막세포에서의 Receptor Activator of NF-kB Ling (RANKL)의 발현 및 파골세포 생성
주영실 ( Yeong Shil Joo ),정명아 ( Myeong A Cheong ),신동혁 ( Dong Hyuk Sheen ),임미경 ( Mi Kyoung Lim ),심승철 ( Seung Cheol Shim ),정덕환 ( Duke Whan Chung ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
Objective: A number of soluble factors which play important role in the pathophysiology of rheumatoid synovitis are also known to be involved in osteoclast differentiation and activation through RANKL (Receptor activator of NF-κB ligand). To investigate the importance of RANKL in the pathogenesis of bone erosion in rheumatoid arthritis (RA) patients, we analyzed the expression of RANKL and Osteoprotegerin (OPG) and examined the formation of osteoclasts in rheumatoid synovial fibroblasts under the influence of various osteotropic factors. Methods: Primary culture synoviocytes or fibroblast-like synoviocytes isolated from synovial tissues of 8 RA patients were cultured and treated with IL-1β (2 ng/ml), TNF-α(2 ng/ml), INF-γ (1000 /ml), IL-15 (10 ng/ml), IL-12 (10 ng/ml), dexamethasone (10(-9) M), PMA (10 ng/ml) or 1,25 (OH)2D3 (10(-9) M) for 18 hours. Expression RANKL or OPG mRNA was measured by semiquantitative RT-PCR within linear amplification condition. TRAP (+) MNC (tartrate resistant acid phosphatase-positive multinucleated cell) formation was induced from primary culture synoviocytes or in coculture system of synovial fibroblasts with PBMCs in the presence of M-CSF and 1,25 (OH)2D3. Results: 1. The intensity of base-line expression was different from patient to patient. Primary culture synoviocytes and synovial fibroblasts express RANKL and OPG mRNA with decreasing intensity when they are passaged. 2. Expresssion of RANKL mRNA was significantly increased by 1,25 (OH)2D3 and IL-1β (158.8±21% and 197.2±17% of controls, p<0.05 and p<0.005, respectively), while decreased significantly by dexamethasone (25.6±4.6% of controls, p<0.005). Expression of RANKL mRNA was significantly increased by IL-1β and decreased by dexamethasone, in a dose- and time-dependant manner. 3. TRAP (+) MNCs are formed from primary culture synoviocytes or in coculture system of synovial fibroblasts and PBMC in the presence of M-CSF and 1,25 (OH)2D3. Dexamethasone clearly inhibited TRAP (+) MNCs formation from synovial cells. Conclusion: The regulatory mechanism for the expression of RANKL or OPG in rheumatoid synoviocytes might be different from that in bone marrow cells. Modulating the expression of these molecules could have potential therapeutic implication targeting bone destruction in RA.
척추 골관절염 환자에서의 골밀도와 골다공증성 척추골절의 빈도와의 관계
박준섭 ( Jun Sup Park ),주영실 ( Yeong Shil Joo ),최윤선 ( Yun Sun Choi ),정명아 ( Myeong A Cheong ),하형근 ( Hyung Keun Ha ),정인수 ( In Su Jung ),김시민 ( Si Min Kim ),김병준 ( Byoung Joon Kim ),안규정 ( Kyu Jeung Ahn ),최영길 ( 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.1
Objective: To investigate the association between bone mineral density (BMD) and osteoporotic compression fractures in radiographic spinal osteoarthritis (OA) patients. Methods: Subjects were 382 female patients (ages 45 to 85) from outpatient clinic for osteoporosis and rheumatic diseases. BMD was measured at lumbar spine and hip by dual X-ray absorptiometry (Hologic QDR 2000). The standard anteroposterior and lateral plain radiographs of thoracic and lumbar spine were taken to define spinal OA and vertebral compression fractures. Radiographic spinal OA was defined by grade of disc degeneration and facet joint degeneration. Frequency of vertebral fractures was compared between spinal OA and control patients in relation to their BMD, age, weight, body mass index (BMI) and years post menopause. Results: Higher proportion of fracture cases were observed in spinal OA patients than non-spinal OA patients (34.1%, 44/129 vs. 18.2%, 46/253, p<0.001) despite comparable mean BMD (0.836±0.152 vs. 0.834±0.185, p=0.89) and older mean age (65.8±8.5 vs. 57.8±10.3, p<0.001). In subjects of ages from 65 to 74, spinal OA patients showed significantly higher BMD than non-spinal OA patients (0.784±0.125 vs. 0.719±0.119, p=0.007), but the frequency of fractures seems to be higher than that of non-spinal OA patients (44.9%, 22/50 patients vs. 34%, 19/55 patients, p=0.58). When all study subjects were stratified according to their spine BMD (normal, osteopenia, and osteoporosis), significantly higher proportion of vertebral compression fractures was noted in spinal OA than non-spinal OA patients in osteopenia group (38.5% vs. 13.5%, p<0.001). Conclusion: Higher BMD does not seem to be translated directly into decreased risk of osteoporotic compression fractures in spinal OA patients. Careful assessment of risk factors for osteoporotic fractures and newer methods for assessing bone strength in this group of patients are needed.