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박효 ( Hyo Park ),신동혁 ( Dong Hyuk Sheen ),임미경 ( Mi Kyoung Lim ),심승철 ( Seung Cheol Shim ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.6
본 논문의 Table 5의 내용과 타국제학술지의 Table 내용의 동일함이 확인되어 편집위원회 회의결과 해당논문을 게재철회 하기로 결정하였습니다. http://dx.doi.org/10.4078/jrd.2012.19.4.173
박효 ( Hyo Park ),신동혁 ( Dong Hyuk Sheen ),임미경 ( Mi Kyoung Lim ),심승철 ( Seung Cheol Shim ) 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.4
Systemic lupus erythematosus (SLE) is an autoimmune disorder affected by multiple genetic, hormonal and environmental factors, which makes it impossible to identify the exact cause of this ailment by only investigating SLE patients, who are genetically heterogeneous, and live in various environments. Therefore, the study of mouse models of lupus has provided valuable clues to help identify, and to validate, novel molecular pathways and targets implicated in the pathogenesis of the disease. While there is no perfect model to reflect all the disease phenotypes observed in human patients, disease subsets are represented in various animal models, which allows modulation of a particular pathophysiological pathway, resulting in the possibility of dissecting its specific contribution to disease development. Spontaneous mouse models of lupus have led to identification of numerous susceptibility loci, from which several candidate genes have been found, while induced models of lupus have provided insight into the role of environmental factors, as well as a better understanding of the cellular mechanisms by which SLE develops. Animal models also allow us to screen and evaluate potential preventive and therapeutic agents. Correlation of specific pathways in animal models to subsets of human disease offers the unique possibility of more accurate preclinical predictions of efficacy for single or combinatorial therapeutic approaches in the clinic. Here, we introduce various animal models of SLE, and review current data focused on genetic factors that are associated with susceptibility or phenotypes of lupus, leading into the present understanding of the genetic basis in lupus pathogenesis.
허민영 ( Min Young Her ),신동혁 ( Dong Hyuk Sheen ),김태환 ( Tae Hwan Kim ) 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.1
The conventional approach to treatment of patients with ankylosing spondylitis (AS) have been rather limited in the last decades. Evidence is accumulating that tumor necrosis factor (TNF) blocker is highly effective in AS. This article reviews the most recent and the most pertinent advances in the treatment in AS. TNF blocker have been evaluated in a number of randomized controlled trials in AS and have been demonstrated to be effective in disease activity, function, and quality of life in these patients. TNF blocker is emerging as the best therapeutic option available for patients with AS.
류마티스 관절염에서 간침범을 동반한 이차성 유전분증 -메토트렉세이트와 저용량 스테로이드에 의해 호전된 증례의 보고-
한윤주 ( Yoon Ju Han ),송찬호 ( Chan Ho Song ),신동혁 ( Dong Hyuk Sheen ),양상석 ( Sang Seok Yang ),이지연 ( Jee Youn Lee ),임용성 ( Yong Seong Lim ),송영욱 ( Yeong Wook Song ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3
Amyloidosis is a heterogenous group of often fatal disorders characterized by extracellular deposition of a proteinaceous material with a unique fibrillar form in various tissues and organs. Presenting with severe hepatomegaly, a 46 year-old man who has suffered with rheumatoid arthritis lasting more than 12 years was confirmed to have secondary amyloidosis by liver biopsy. After treatment with methotrexate and low dose prednisolone, we have observed clinical improvement in which hepatomegaly was resolved remarkably. This is the first published case report of a patient with rhuematoid arthritis complicated by liver amyloidosis which partially regressed after treatment with methotrexate and prednisolone.
이정찬 ( Jung Chan Lee ),박정진 ( Jeong Jin Park ),신동혁 ( Dong Hyuk Sheen ),최영미 ( Young Mi Choi ),박남규 ( Nam Gyu Park ),김우규 ( Woo Kyu Kim ),이윤종 ( Yun Jong Lee ),이은봉 ( Eun Bong Lee ),송영욱 ( Yeong Wook Song ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.2
Objective: To determine the effectiveness of pulsed electromagnetic fields (PEMF) in the treatment of knee osteoarthritis (OA). Methods: In this randomized, placebo-controlled, double-blind trial, 51 patients with knee OA, diagnosed according to the criteria of the American College of Rheumatology, were treated with PEMF or placebo. Eleven patients failed to attend after screening and were excluded from analysis. Treatment consisted of 3 half-hour periods of exposure per week over 6 weeks in a specially designed cylindrical device that emits low-frequency pulsed electromagnetic fields (25 gauss, 12 Hz). The primary outcome measure was reduction in pain on movement using a 10 cm visual analog scale. Secondary outcome measures included joint swelling and tenderness, the Lequesne index, and overall evaluations of improvement by the patient and examining physician. Evaluations were made at baseline, 3 week and 6 week during treatment and 4 weeks after finishing treatment. Results: There were no significant differences between PEMF and placebo groups in respect of any outcome measures after treatment. Range of motion and knee swelling tended to be improved in the PEMF group. There were no clinically relevant adverse effects attributable to PEMF treatment. Conclusion: These results suggest that the PEMF treatment has no clinically significant benefits in patients with knee OA resistant to conventional treatment. The larger studies are needed to confirm the efficacy of PEMF therapy in knee OA.
류마티스관절 활막세포에서의 Receptor Activator of NF-kB Ling (RANKL)의 발현 및 파골세포 생성
주영실 ( Yeong Shil Joo ),정명아 ( Myeong A Cheong ),신동혁 ( Dong Hyuk Sheen ),임미경 ( Mi Kyoung Lim ),심승철 ( Seung Cheol Shim ),정덕환 ( Duke Whan Chung ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
Objective: A number of soluble factors which play important role in the pathophysiology of rheumatoid synovitis are also known to be involved in osteoclast differentiation and activation through RANKL (Receptor activator of NF-κB ligand). To investigate the importance of RANKL in the pathogenesis of bone erosion in rheumatoid arthritis (RA) patients, we analyzed the expression of RANKL and Osteoprotegerin (OPG) and examined the formation of osteoclasts in rheumatoid synovial fibroblasts under the influence of various osteotropic factors. Methods: Primary culture synoviocytes or fibroblast-like synoviocytes isolated from synovial tissues of 8 RA patients were cultured and treated with IL-1β (2 ng/ml), TNF-α(2 ng/ml), INF-γ (1000 /ml), IL-15 (10 ng/ml), IL-12 (10 ng/ml), dexamethasone (10(-9) M), PMA (10 ng/ml) or 1,25 (OH)2D3 (10(-9) M) for 18 hours. Expression RANKL or OPG mRNA was measured by semiquantitative RT-PCR within linear amplification condition. TRAP (+) MNC (tartrate resistant acid phosphatase-positive multinucleated cell) formation was induced from primary culture synoviocytes or in coculture system of synovial fibroblasts with PBMCs in the presence of M-CSF and 1,25 (OH)2D3. Results: 1. The intensity of base-line expression was different from patient to patient. Primary culture synoviocytes and synovial fibroblasts express RANKL and OPG mRNA with decreasing intensity when they are passaged. 2. Expresssion of RANKL mRNA was significantly increased by 1,25 (OH)2D3 and IL-1β (158.8±21% and 197.2±17% of controls, p<0.05 and p<0.005, respectively), while decreased significantly by dexamethasone (25.6±4.6% of controls, p<0.005). Expression of RANKL mRNA was significantly increased by IL-1β and decreased by dexamethasone, in a dose- and time-dependant manner. 3. TRAP (+) MNCs are formed from primary culture synoviocytes or in coculture system of synovial fibroblasts and PBMC in the presence of M-CSF and 1,25 (OH)2D3. Dexamethasone clearly inhibited TRAP (+) MNCs formation from synovial cells. Conclusion: The regulatory mechanism for the expression of RANKL or OPG in rheumatoid synoviocytes might be different from that in bone marrow cells. Modulating the expression of these molecules could have potential therapeutic implication targeting bone destruction in RA.
김진현 ( Jin Hyun Kim ),송영욱 ( Yeong Wook Song ),이정찬 ( Jung Chan Lee ),신동혁 ( Dong Hyuk Sheen ),박남규 ( Nam Gyu Park ),이윤종 ( Yun Jong Lee ),이은봉 ( Eun Bong Lee ),김현아 ( Hyun Ah Kim ),김윤근 ( Yun Keun Kim ),박병주 ( 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.2
Objective: To investigate the risk factors for symptomatic knee osteoarthritis (OA) in Koreans Methods: A total of 1,194 persons consisting of 588 men and 606 women (mean age±SD, 48.9±14.0 years) were enrolled in rural and urban areas or in a hospital of Korea between september 2000 and august 2001. All participants were interviewed about symptoms of knee OA and possible risk factors including age, sex, occupation, body mass index (BMI), smoking, age of menarche, menopause and hormone replacement therapy and examined. Knee radiograph was obtained in all participants with knee symptoms. Symptomatic knee OA was defined according to clinical criteria or clinical and radiographic criteria for classification of osteoarthritis of the knee by Altman. Results: Of 1,194 participants, symptomatic knee OA was found in 189 persons (15.8%) and multivariate analysis showed that female (OR=5.66, 95% CI 3.42∼9.38), aging (OR=1.10, 95% CI 1.08∼1.12), living in rural area (OR=3.83, 95% CI 2.27∼6.45) and BMI over 25 kg/m2 (OR=2.26, 95% CI 1.42∼3.59) were risk factors. Age (older than 70 years, OR=1.08, 95% CI 1.04∼1.12) and living in rural area (OR=5.39, 05% CI 1.94∼14.96) were associated with symptomatic knee OA in men and age (older than 40 years, OR=1.11, 95% CI 1.07∼1.16), living in rural area (OR=2.46, 95% CI 1.17∼5.17), and BMI over 25 kg/m2 (OR=3.45, 95% CI 1.63∼7.29) in women. Conclusion: The risk factors for symptomatic knee OA were aging, female, living in rural area and high BMI in Koreans.
유지형 ( Jihyung Yoo ),김낙민 ( Nak Min Kim ),성우경 ( Wookyung Sung ),명진철 ( Jin Cheol Myeong ),윤수아 ( Su A Yun ),이동규 ( Dong Kyu Lee ),임미경 ( Mi Kyoung Lim ),신동혁 ( Dong Hyuk Sheen ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.4
베체트병에서 말초 신경계 침범은 아주 드물게 보고되었다. 저자들은 베체트병 환자에서 갑작스러운 근육 위약감이 발생하여 진행하는 증상과 신경전도검사에서 확인된 길랑-바레 증후군을 진단하였고, 약물 치료 후 증상이 호전됨을 경험하여 문헌으로 보고하는 바이다. Behcet’s disease (BD) is a multi-systemic inflammatory disease of unknown origin that affects nearly all organs including the nervous system. Although the neurological involvement is less frequent than other major presentations, it is important because it can produce severe disabilities. Peripheral nervous system manifestations are relatively rare in BD. Although few cases of peripheral neuropathy or myopathy have been reported in BD, they are cases of multiple neuropathies, sensorimotor peripheral neuropathy, or neuropathy autonomic dysfunction. Guillain-Barre syndrome (GBS), also known as an acute inflammatory demyelinating polyneuropathy, is an acute demyelinating polyradiculopathy of uncertain etiology. No case of GBS associated with BD in Korea has been reported. Herein we report on a patient of BD who suffered from weakness of extremities and was diagnosed as GBS. (J Rheum Dis 2015;22:246-249)