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유방암세포주에서 고농도 5-fluorouracil의 세포주기 조절효과
장정순,양중일,장세호,이원섭,이종석,안명주,박병규,Jang, Joung Soon,Yang, Jung Ill,Chang, Seho,Lee, Won Sup,Lee, Jong Seok,Ahn, Myung-Ju,Park, Byung-Kiu 대한면역학회 2002 Immune Network Vol.2 No.1
Background: Chemotherapy with 5-fluorouracil (5-FU) has been one of the mainstay in breast cancer treatment. The effects of high dose 5-FU on cell cycle regulation were studied in breast caner cells. Methods: A breast cancer cell line MCF-7 was used. Protein expressions of G1/S cyclins, $p21^{Waf1/Cip1}$, cdk2, E2F1 and retinoblastoma were tested by western blot analysis. Immunoprecipitation and immune complex kinase assay were done for the assessment of E2F1/RB interacton and the activity of cdk2 respectively. Results: $p21^{Waf1/Cip1}$ expression was barely detectable in control cells. With addition of 5-FU level of $p21^{Waf1/Cip1}$ were induced and cyclin D3 level was decreased as cell growth decreases. In accordance with increased expression of $p21^{Waf1/Cip1}$, cyclin E-associated cdk2 kinase activity was reduced. Retinoblastoma protein (RB) became dephosphorylated and E2F-1 binding activity with RB was increased. Conclusion: In this situation of high concentration of 5-FU breast cancer cells tend to be G1/S cell cycle arrested. Overexpression of $p21^{Waf1/Cip1}$ and dephosphorylation of RB may mediate the effectss of 5-FU by inhibiting E2F-1 activity, which contributes to G1/S cell cycle arrest. These results could be an indicating landmark for further study of high dose chemotherapy with 5-FU.
위암 침윤 염증세포의 thymidine phosphorylase (TP): TP의 예후와 종양 신혈관생성과의 관계
장정순 ( J Soon Jang ),이종석 ( Jong Seok Lee ),고경혁 ( Gyung Hyuck Ko ),하우송 ( Woo Song Ha ),이원섭 ( Won Sup Lee ),김동훈 ( Dong Hoon Kim ),강기문 ( Ki Mun Kang ),김활웅 ( Hwal Woong Kim ) 대한내과학회 2005 대한내과학회지 Vol.68 No.5
배경 : Thymidine phosphorylase (TP)는 thymidine 에서 thymine으로 변화하는데 관여하는 효소로 종양의 신 혈관 형성에도 관여한다. 최근 TP의 발현이 종양세포 외에 종양 침윤염증세포에서도 발현됨이 보고되고 이 역시 종양의 신혈관 형성에 관여 하고 예후에도 영향을 보이는 것이 보고됨에 따라 본 연구자들은 종양 세포와 종양 침윤 염증 세포에서의 TP 발현을 각각 분리하여 평가하고 이것을 바탕으로 신혈관 생성과 종양의 예후 Background : Thymidine phosphorylase (TP) is an enzyme catalyzing the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. TP plays a role in angiogenesis. Evidences suggest that infiltrating inflammatory cells adjacent cancer
채규영(Gyu Young Chai),장정순(Jeong Soon Jang),이종석(Jong Seok Lee) 대한방사선종양학회 1995 Radiation Oncology Journal Vol.13 No.1
Purpose : This study was done to evaluate preliminarily the role of intraluminal brachytherapy in the radiation treatment of non-metastatic esophageal cancer. Methrials and Methods : We analyzed follow-up result of 21 patients treated at the dept, of therapeutic radiology in Gyeongsang national university hospital between April, 1989 and August, 1992. All patients received neoadjuvant chemotherapy(%-FU, Cispl-atin). Fifteen patients were treated with external beam alone and in ramaining 6 patients, the external beam radiotherapy followed by intraluminal brachytherapy was done. Results : Among 21 patients, 7 patients showed complete tumor regression after completion of radiotherapy. But 2 of these complete responder recurred at the site of primary disease, so ultimate local control rate was 23.8%(5/21). Local control rate according to radiation treatment modality was 6.7%(1/15) in patients treated with external irradiation only, and 66.7% in patients treated with combined external irradiation and intraluminal brachytherapy. The 2 year NED survival rate was 6.6% in the former and 66.7% in the latter. Conclusion: Although there should be consideration about case selection for addition of intraluminal brachytherapy, intraluminal brachytherapy may be considered as on of the method to enhance the local control probability of esophageal cancer.
강직성 척추염과 병발한 원발성 부갑상선기능 항진증 1 예
김성윤,정파종,이중달,전용철,김태화,박병권,장정순,금주섭 대한내과학회 1990 대한내과학회지 Vol.39 No.4
Ankylosing spondylitis is the prototype of seronegative spondylarthrities. It is mainly an articular disease which shows spinal symptoms and is known to accompany extra-articular manifestations which may affect all the systems of the body: prostate, eye, lung, cardiovascular, kidney, nervous system, and bowels. The pathogenesis of anlylosig spondylitis is uncertain, but there is some evidence that environmental factors play a role. Klebsiella, for example, are suspected to evoke an abnormal cross reaction with HLA-B27 antigen. The etiology of primary hyperparathyroidism is also unknown. The action of excessive parathyrlid hormone on the bone and kidney usually results in hypercalcemia, the biochemical hallmark of the disease. In most patients, it is now detected by routine measurement of serum calcium. While most atients are relatively asymptomatic, some have symptoms and signs related to hypercalcemia, hypercalciuria, or osteitis fibrosa cystica. Single gland involvement (adenoma) appears in 80% of the patients, multiple gland involvement (hyper-plasia) in 20%, and less than 2% are carcinomatous. A 32-year-old male patient was diagnosed and has been treated as HLA-B27 positive ankylosing spondylitis, On routine examination, the appearance of hypercalcemia led us to suspect primary hyperparathyroidism. Radioimmunoassay was conducted two times to detect serum parathyroid hormone levels, while 24-hour urine calcium and phosphorus level tests, an ultrasono-graphic exam, and other tests were done for the diagnosis. A partial parathyroidectomy was perfarment suring neck exploration. The other remaining parathyroid glands were grossly normal. The biopsy specimen consisted of water clear cells with no evidence of fat tissue. There was no recurrence of symptoms or signs of primary hyperparathy roidism after partial parathyroidectomy. The pathologic diagnosis was consistent with parathyroid adenoma. There are some reports of primary hyperparathyroidism and its association with rheumatologic diseases-rheumatoid arthritis, SLE, and scleroderma-but no reports with ankylosing spondylitis. Awareness of other disease coincidence or association with ankylosing spondylitis or primary hyperpatiathyroidism is necessary.