보골지(補骨脂)의 Peroxynitrite 제거 기전

장용석,민건우,정지천,Jang, Yong-Suk,Min, Gun-Woo,Jeong, Ji-Cheon 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2

Objective : Peroxynitrite $(ONOO^-)$, formed from the reaction of $O_2^-$ and NO, is a cytotoxic species that can oxidize several cellular components such as proteins, lipids and DNA. It has been implicated in the aging process and age-related disease such as Alzheimer's disease, rheumatoid arthritis, cancer and atherosclerosis. The aim of this study was to investigate scavenging activities of $ONOO^-$ and its precursors. NO and $O_2^-$ and its scavenging mechanism using fluorescent probes, DCFDA, DAF-2 and DHR 123.. Methods : Psoralea corylifolia was crushed. The crushed Psoralea corylifolia was extracted 3 times, each time with 3 volumes of methyl alcohol at $60^{\circ}C$ for 24 h. The extract was filtered and evaporated under reduced pressured using a rotary evaporator to yield 16g. This was done to investigate scavenging activities of $ONOO^-$, NO, $O_2^-$ and its scavenging mechanism using fluorescent probes, DCFDA, DAF-2 and DHR 123. Results : After Psoralea corylifolia was added authentic $ONOO^-,\;{\cdot}\;O_2^-$ and NO was markedly scavenged. Also, $ONOO^-$ induced by $O_2^-$ and NO (these derived from SIN-1) was inhibited. The data showed a decrease in $ONOO^-$ mediated nitration of tyrosine through electron donation after Psoralea corylifolia was added. Data showed a dose-dependent correlation with inhibition of nitration of bovine serum albumin induced by $ONOO^-$, Furtheremore, LPS-induced ROS and RNS generation was blocked. Conclusions: These results suggest potential for use of Psoralea corylifolia as an effective $ONOO^-$ scavenger to counter the aging process and age-related diseases.

Notes on Unrecorded Fleshy Fungi of Cordyceps in Korea

장용석,홍순우,Jang, Yong-Suk,Hong, Soon-Woo The Korean Society of Mycology 1986 韓國菌學會誌 Vol.14 No.1

동충하초 속에 속하는 균류로 여겨지는 40여 개체의 표본을 관찰한 결과 6종의 한국산 미기록종이 동정되었기에 보고하는 바이다. 미기록 종은 벌유충 동충하초(Cordyceps alboperitheciata), 파리 동충하초(Cordyceps discoideocapitata), 균핵 동충하초(Cordyceps intermedia), 검은 동충하초(Cordyceps nigrella), 붉은 동충하초(Cordyceps roseostromata), 딱정벌레 동충하초(Cordyceps scarabaeicola) 등이다. 여기에 인용된 표본은 서울대학교 미생물학과 표본실에 보관되어 있다. More than 40 samples of the genus Cordyceps were collected and investigated. Among them, six species were confirmed as unrecorded ones in Korea. Unrecorded species were Cordyceps alboperitheciata, Cordyceps discoideocapitata, Cordyceps intermedia, Cordyceps nigrella, Cordyceps roseostromata and Cordyceps scarabaeicola.

林堂遺蹟의 空間構成과 그 變化

장용석(Jang, Yong-Suk) 한국상고사학회 2002 한국상고사학보 Vol.37 No.-

본고는 임당유적에서 조사된 분묘, 방어시설 및 생활유적을 통하여 이들 유적들이 어떻게 공간을 구성하고 있으며, 시간의 흐름에 따라 어떠한 변화과정을 나타내는지, 그리고 공간구성이 나타내는 의미가 무엇인지를 살펴보는 것이 목적이다. 따라서 이상을 요약하면 다음과 같다. 먼저, 임당유적의 성립은 목관묘단계부터이며, 유적의 형성직후부터 경산지역을 대표하는 중심유적으로 발전하였다. 둘째, 분묘요구는 목관묘단계, 목곽묘단계, 고총고분단계로 구분하였으며, 각 단계별로 분묘군의 입지가 변화함을 확인하였다. 즉 목관묘단계는 유적의 서쪽과 중앙에서 동쪽으로, 목곽묘단계는 동쪽과 중앙에서 서쪽으로, 고총고분단계는 서쪽과 중앙에서 동쪽으로 변화하였다. 이러한 변화현상이 일률적으로 나타나는 원인은 임당유적을 형성한 집단이 아닌 하나의 집단임을 나타내는 자료로 판단된다. 셋째, 방어시설은 원삼국시대의 환호와 삼국시대의 토성으로 구분된다. 환호시설은 대규모의 토목공사인 점을 생각하면 그 자체만으로도 중심취락의 존재를 반영하고 있으며, 토성의 축조(A.D. 4C 전반~A.D. 4C 중반)는 강력한 정치체의 출현시점으로 볼 수 있으며, 이때부터 임당유적은 국읍으로 성장하기 시작하였다. 넷째, 취락시설은 F지구와 I지구에서 조사되었으며, F지구는 토성의 설치로 인하여 3C 후반에 취락의 설치가 종료된다. 취락의 설치가 종료된 후 이곳에는 토성이 축조되었다. 그리고 I지구는 계속적으로 취락지로 사용되다 6C 중반 이후에는 중심취락지구로 발전하였다. The pater is intended to know how the site make up space, how they are transformed as time goes, and what the space-construction means, through the site of life, institutions of defense, and tombs investigated in Limdang Site in Kyoungsan. The summary is as follows. 1. Limdang Site are formed from a step of wooden coffin tombs and developed into a center of site on the behalf of Kyoungsan region soon after the formation of the site. 2. The tomb-bodies are divided into wooden coffin tomb step, wood chambered tomb step, and high mound tombs step. It is confirmed that the location of tombs group are transformed according to each step. Namely, wooden coffin tombs step is form the west and the center into the east, wood chambered tombs step is form the east and the center into the west, high mound tombs step is form the west and the center into the west. It is judged that the reason this is presented unifdrmly is that the group that formed Limdang Site is not different but same. 3. An institution of defense is classified into a ditch enclosure of Proto-Three Kingdom Period and a mud wall of Three Kingdom Period. An institution of the ditch enclosure itself is a mirrow of the existence of the central-settlement in considerations of engineering public works on a large scale, the mud wall structure(A.D. 4C the first A.D. 4C mid) is considered as a point of time of appearance of a strong political system. Form this time, Limdang Site started to be developed into a main village-town. 4. the institution of settlement is investigated in F region and I region. In F region is finished the establishment of settlement in the late of 3C because of the establishment of a mud wall. And then the mud wall is builded. I region continues to be used as the settlement-region and is developed into a central settlement region after the middle of 6C.

플랜지의 공정해석

장용석(Yong-Suk Jang),황병복(Beong-Bok Hwang) 한국소성가공학회 1999 압출 및 인발 심포지엄 Vol.1999 No.5

TPS 기반 3D face dense correspondence

장용석(Yong Suk Jang),설태인(Tae In Seol),정선태(Sun-Tae Chung),김부균(Boo-Gyoun Kim) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.11

Photo-realistic 3D face modeling is important for 3D avatar, 3D game, 3D face recognition, and etc. One of the most important issues in constructing photo-realistic 3D face modeling is to solve 3D dense correspondence problem. In this paper, we propose a simple but improved 3D correspondence algorithm using 3D TPS and nearest neighbor search. The effectiveness of the proposed method is verified by experiments.

연구논문 : 한국의 사회적 자본과 갈등: 사회적 자본의 다면적 속성에 대한 재조명

장용석 ( Yong Suk Jang ),정장훈 ( Jang Hoon Jeong ),조문석 ( Mun Seok Cho ) 한국조사연구학회 2009 조사연구 Vol.10 No.2

본 연구는 다원화된 한국사회의 사회통합 및 갈등해소를 위한 방안을 사회적 자본에서 찾고자 하였다. 이를 위해 사회적 자본을 (1) 일반적 타자에 대한 신뢰, (2) 국가 공공영역에 대한 신임, (3) 연줄망과 연결망을 포괄하는 네트워크, (4) 공동체 의식으로 구분하였고, 사회적 자본이 잠재된 갈등의식을 나타내는 갈등잠재지수에 어떤 영향을 미치고 있는지를 실증적으로 분석하여 다음과 같은 사실을 발견하였다. 첫째, 일반적 타자에 대해 신뢰가 높은 사람은 사회통합 지향적 경향을 보여 주었다. 둘째, 국가 공공영역의 절차적 공정성 및 민주적 운영을 신뢰하고 있는 사람들 역시 사회통합 지향적 경향을 보여 주었다. 하지만 특정 정권에 대해 신뢰가 높은 사람은 오히려 갈등 지항적 경향을 보여주었다. 셋째, 폐쇄적 연줄망을 활용하는 사람들은 갈등지향적인 반면, 개방적 연결망을 활용하는 사람들은 사회통합 지향적이었다. 넷째, 공동체규범의 내면화 정도는 사람들의 사회 통합적 지향성과 아무런 관련이 없었다. 이러한 결과들이 갖는 함의는 다음과 같다. 다원화된 한국사회의 실질적 사회통합을 위한 사회적 자본은 학연, 혈연 지연과 같은 전통적인 폐쇄적 연결망에 기반한 것이 아니라, 익명의 일반적 타자들에 대한 신뢰와 느슨하게 연결된 개방적 연결망에 기반해야 한다. 또한 실질적 사회통합은 공정한 국정운영 시스템에 대한 신임에 기초해야 하는 것이지, 특정 기관 혹은 정파에 대한 맹목적 신뢰에 기초해서는 안 된다. This paper explores how multiple facets of social capital in Korea affects social conflict. The notion of social capital is composed of several elements including (1) social trust in generalized others (2) confidence in public sector fairness and the principles of democracy (3) social networks and closures and (4) community spirit and collective norms. We particularly examine how these multiple dimensions of social capital affect an individual`s tendency of social conflict orientation. The findings address the following four points. First, an individual, who trusts generalized others in a society, is less likely to be exclusive and conflict-oriented. Second, the more an individual has confidence in the efficacy of democratic processes and public sector fairness, the more (s)he is likely to be social integration oriented. When an individual, in contrast, gives strong support to a particular party (or government in power), the person is more likely to be conflict oriented. Third, an individual who mobilizes exclusive social closures to solve a problem is more likely to be conflict oriented. However, an individual who maintains a variety of inclusive social networks is more likely to be social integration oriented. Finally, the internalization of collective norms does not affect directly the tendency of individual`s social conflict orientation. Increasing social capital at the individual level does not automatically guarantee societal level conflict resolutions. Rather, building extensive social closures based on strong family or hometown ties, school connections, political interests has detrimental effects on social integration and conflict resolutions. More, constructive social integration in a society requires higher level of open social networks, consistent administrative and democratic procedures, and social trust in generalized others.

융합사회와 거버넌스

장용석(Jang, Yong Suk),조문석(Cho, Munseok),정장훈(Chung, Jang Hoon),김용현(Kim, Yonghyun),최정윤(Choi, JungYoon) 한국이론사회학회 2011 사회와 이론 Vol.18 No.-

본 연구에서는 다양하고 이질적인 사회문화적 요소들이 조화를 이루는 융합사회의 개념에 대해서 논의하고, 이러한 사회문화적 융합이 한국사회의 거버넌스를 어떻게 변화시키고 있는지 분석하였다. 융합사회에서는 ‘공생ㆍ참여ㆍ행복ㆍ역능’ 등 새로운 가치들이 주목받고, 공식적이고 폐쇄적인 운영원리와 개방적이고 유연한 지배구조가 혼합된 새로운 거버넌스가 출현하여 사회 전반을 변화시킨다. 특히, 융합사회에서 발견되는 새로운 가치 중 국가의 통치구조와 사회의 지배구조에 커다란 변화를 가져온 두 가지 개념은 ‘공생’과 ‘참여’이다. 이와 같은 새로운 시대의 변화를 이해하기 위해 본 연구는 다음의 두 가지 내용에 초점을 맞추었다. 첫째, 대통령 연설문에 대한 정량적 텍스트 분석을 통해서 현 대통령의 국정운영철학이 발전에서 ‘공생’을 지향하는 방향으로 전환되고 있음을 분석하였다. 둘째, 전통적인 폐쇄적 형태의 관리방식을 채택하고 도구적 합리성을 강조하였던 공공영역에서 ‘참여’가 중요한 패러다임으로 등장함을 고찰하였다. 결론적으로, 본 연구는 융합사회의 새로운 가치와 작동원리의 동역학을 이해하는 것은 다가오는 미래의 새로운 사회질서를 파악하는 데 있어 중요한 기초 작업임을 시사한다. This article explores the emergence of a new society in which disparate ideas coexist in concord. In this new era, values such as symbiosis, empathy, contentment, and empowerment are highlighted. They emerge as a form of governance, that is the package of formal rules and informal institutions. Based on the analyses on presidential speeches and public management process in South Korea, it is shown that there has been a remarkable paradigm shift from emphasizing values such as development and elitism toward underlining values such as coexistence and participation. The findings are discussed in relation to the changing governance system and its impact on individual actors as well as society at large.

수치해석을 이용한 근해안강망 어구 모델링과 거동분석

장용석 ( Yong-suk Jang ),이춘우 ( Chun-woo Lee ),최규석 ( Kyu-suk Choi ) 한국수산해양기술학회 2021 수산해양기술연구 Vol.57 No.4

The Korean stow net is a fishing method that utilizes the changing direction of the net entrance with the tidal current. This study attempted to obtain basic data from the recent offshore stow net fisheries to improve the gear by analyzing the dynamic behavior of the nets affected by current speed and direction using computer simulations. A numerical calculation was performed at a current speed of 0.5 knot between 2.5 knot at each 0.5 knot. The time taken for the gear opening was the longest from 0.5 knot at 1,500 seconds and the shortest from 2.5 knot at 450 seconds in the simulations. In all cases, the net width and tension at net deployment gradually decreased as the current speed decreased. However, the net height tended to increase inversely proportional to the current speed. During the net rotation, the net height was maintained at all cases. The net width and tension fluctuated, but the regularity was very low. In this study, the calculated simulation data showed that the opening efficiency decreased proportional to the current speed. The opening efficiency is related to the catching efficiency; therefore, it is necessary to improve the gear to enhance its opening efficiency.

뎅기열 백신 개발 현황

장용석 ( Yong-suk Jang ) 대한인수공통전염병학회 2018 창립총회 및 학술대회 초록집 Vol.2018 No.1

Dengue virus is a positive single-stranded RNA virus included in Flavivirus genus of Flaviviridae family. Dengue virus has an icosahedral capsid with envelope and a causative agent of dengue fever and more severe dengue hemorrhagic fever. Dengue virus is a mosquito-borne virus and transmitted by Aedes genus mosquitoes. Four different serotypes of dengue virus are reported and currently no successful vaccines are on the market except Dengavaxia^TM although it also has potential weakness. One of the most important hurdles to overcome in dengue vaccine development is the phenomenon of antibody-dependent enhancement and low and ineffective antibody induced by primary infection and/or vaccination induces the enhanced dengue virus infection at the secondary virus exposure. Here, current status of dengue vaccine development will be summarized. In addition, research progress on subunit dengue vaccine development study will be discussed. (This study was supported by 2014K1B1A1073861 through the National Research Foundation (NRF) funded by the Korean Ministry of Science, ICT & Future Planning.)

3D 형태 모델 기반 3D 얼굴 모델링

장용석(Yong Suk Jang),정선태(Sun-Tae Chung),김부균(Boo-Gyoun Kim),김석호(Seok Ho Kim),조성원(Seongwon Cho) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7

3D face modeling is important for face recognition, game, avatar, and etc. In this paper, we present a simple 3D face modeling method based 3D generic shape model. The 3D generic model is constructed by the 3D mean shape obtained from 3D scan face data. The 3D structure of facial feature points of the face to be modeled is sought by applying factorization method in SfM to several 2D face images. Overall fitting of the generic 3D face model into the sought 3D facial feature points is done by using 3D Procrustes analysis and detailed matching is achieved by replacing the facial feature points of the transformed generic 3D face model with the sought 3D facial feature points. The effectiveness of the proposed method is shown by experiments.