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자궁내막증이 있는 불임환자에서 복강액내의 Cytokine에 관한 연구
강정배,박제용,김범,김성주,손우석,김현태,장봉림,Kang, Jeong-Bae,Park, Je-Yong,Kim, Bum,Kim, Sung-Joo,Sohn, Woo-Seok,Kim, Hyun-Tae,Jang, Pong-Rheem 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.1
Objective: The presence of the various cytokines in human peritoneal fluid has been evaluated incompletely. Changes in cytokine levels may be related to activation of peritoneal macrophage and T-lymphocyte, development of endometriosis, and infertility. This study assesses peritoneal fluid levels of interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) in infertile women with endometriosis and normal women without endometriosis. Design: Prospective and case-control study in university hospital. Materials and Methods: Cytokine levels in peritoneal fluid obtained during laparotomy or laparoscopy from 21 patients in infertile patients with endometriosis and 24 controls undergoing laparotomy or laparoscopy with no evidence of pelvic endometriosis were determined by enzyme-linked immunosorbent assay. Results: The mean levels of interleukin-6 in infertile patients with endometriosis and controls were $72.7{\pm}23.7$ pg/ml and $18.5{\pm}9.7$ pg/ml respectively (p=0.02). Similarly, the mean levels of interleukin-8 in infertile patients with endometriosis was significantly higher than that of controls ($445.0{\pm}89.6$, vs $45.1{\pm}48.4$, p=0.04). The mean concentration of interleukin-10 in infertile patients with endometriosis was significantly lower than that of controls ($1.09{\pm}0.04$ vs $2.19{\pm}0.03$, p=0.03). The level of tumor necrosis factor-${\alpha}$ was not significantly different between the two study groups. Conclusions: Increased IL-6 and IL-8 and decreased IL-10 levels in the peritoneal fluid may be related to pathogenesis in the endometriosis and infertility, suggesting that partially contribute to the disturbed immune regulation observed in infertili women with endometriosis.
자궁경부암에서 Cyclooxygenase - 2 의 발현과 혈관신생
민봉식(Bong Sik Min),손우석(Woo Seok Sohn),장기택(Kee Taek Jang),이성원(Sung Won Lee),김홍배(Hong Bai Kim),이용우(Yong Woo Lee),강성원(Sung Won Kang),박양서(Yang Suh Park),장봉림(Pong Rheem Jang) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3
N/A Objective: A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in tumor growth and angiogenesis of gastrointestinal and other cancers. This was the study to determine the relationship between tumor vascularity and COX-2 expression in invasive cervical cancer. Methods: We examined the expression of COX-2 and microvessel density (MVD) by immunohistochemical staining in 21 specimens collected from invasive cervical cancer patients. Results: All specimens showed weak and strong immunoreactivity, with 52.4%strong reactivity. Microvessel count was higher (median 136) in the strong COX-2 immunoreactivity specimens than the weaks (median 90),and MVD was significantly correlated with the COX-2 immunoreactivity (P=0.002). Conclusion: These preliminary data indicate that overexpression of COX-2 may play an important role in carcinogenesis of cervical cancer and this could be partially attributable to modulation of angiogenesis by COX-2.COX-2 maybe a target for future research in the tumorigenesis of the invasive cervical cancer.
전영은 ( Young Eun Jeon ),윤명근 ( Myoung Kun Yoon ),김성주 ( Sung Joo Kim ),장봉림 ( Pong Rheem Jang ),강정배 ( Jung Bae Kang ),박영한 ( Young Han Park1 ),임채춘 ( Chae Chun Rhim ),민수기 ( Soo Kee Min ) 대한주산의학회 2006 Perinatology Vol.17 No.1
Uterine arteriovenous malformations are very rare but potentially life threatening lesions. These lesions may be congenital or acquired, but especially occur in patients with a history of curettage, abortion or pregnancy. Color doppler ultrasonography is the preferred method of diagnosing of arteriovenous malformations. In many cases, hysterectomies are performed. But if patients want pregnancies, embolization therapy and conservative treatment are effective therapy. We have experienced a clinical case of uterine arteriovenous malformation, which is presented with a brief review of literature.
변형된 Shirodkar법을 이용한 양막탈출을 동반한 자궁경부 무력증의 처치 2 예
이지영(Ji Young Lee),박찬우(Chan Woo Park),장봉림(Pong Rheem Jang),박양서(Yang Suh Park),김유곤(You Kon Kim),윤태숙(Tae Suk Yoon) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12
Two patients, bulging fetal membrane accompanied with cervical dilatation & effacement in the late second-trimester, were treated by modified Shirodkar method. Pregnancies were prolonged effectively and viable fetuses were delivered in both cases. Our cases may help make objective decision prior to attempting cerclage placement when cervix is markedly dilated and something should be done to save pregnancy.
김성주 ( Sung Joo Kim ),김창모 ( Chang Mo Kim ),김범 ( Bum Kim ),장기택 ( Kee Taek Jang ),강정배 ( Jung Bae Kang ),장봉림 ( Pong Rheem Jang ),손우석 ( Woo Seok Sohn ),민봉식 ( Bong Sik Min ) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
Aggressive angiomyxoma is a rare pathological condition which affects mainly the soft tissues of the pelvis and perineum in women. It is circumscribed totally or partially and has a infiltrative margin, so it has a tendency for local recurrence. We report a 33-year-old woman who presented with a mass arising within the vaginal wall which was painless, soft and movable like a cyst on palpation. The mass was surgically excised and pathologically proved to be an aggressive angiomyxoma.
유혜리 ( Hye Rhee Yoo ),윤명근 ( Myung Keun Yoon ),박영한 ( Young Han Park ),박혜림 ( Hye Rim Park ),장봉림 ( Pong Rheem Jang ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.9
목적 : 본 연구는 난소암 세포에서 면역조직화학적 염색을 이용하여 FSH 및 LH 수용체의 발현 빈도를 조사하고 난소암 환자에서의 혈중 성선자극호르몬의 농도를 측정하여 난소암 발생과 성선자극호르몬에 대한 관계를 알아보고자 하였다. 연구 방법 : 2002년 1월부터 2003년 7월까지 한림대학교병원 산부인과에 내원하여 난소 종양으로 진단받은 25명의 환자에게서 전자궁 적출술과 양측 부속기 절제술을 통해 난소암 조직을 얻어 면역조직화학적 염색을 시행하였다. Objective : We performed immunohistochemistry for the evaluation of follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR) expression in the ovarian tumors and examined the blood level of the gonadotropins in ovarian cancer patie
박제용(Je Yong Park),김성주(Sung Joo Kim),손우석(Woo Seok Sohn),강정배(Jung Bae Kang),장봉림(Pong Rheem Jang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6
Actinomycosis is a chronic, progressive, suppurative disease which appears to be difficult to establish a correct preoperative diagnosis. Most of pelvic actinomycosis in women are related to a long time intrauterine device(IUD) inserted state. The causative agent is a branching, gram-positive anaerobic or microaerobic organism, not fungi. Ascending infection of the upper genital tract by actinomycosis may be clinically inapparent. We experienced a case of clinically inapparent tuboovarian actinomycosis in a 47-year-o]d women with IUD, discovered pathologically after laparotomy.