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      • KCI등재

        담뱃갑 경고그림이 청소년 흡연행태에 미치는 영향

        김보라(金寶羅), 권영주(權寧周) 한국공공관리학회 2019 한국공공관리학보 Vol.33 No.1

        본 연구는 담뱃갑 경고그림이 흡연 청소년의 흡연행태에 미치는 영향을 분석하는 것이 목적이다. 이를 위하여 교육부 · 보건복지부 · 질병관리본부가 실시한 제13회 청소년온라인 건강행태조사 자료를 활용하여 분석을 진행하였다. 분석 결과, 담뱃갑 경고그림은 흡연량에 영향을 미치지 않는 것으로 나타났으나, 금연 시도율에는 영향을 미치는 것으로 나타났다. 담배는 중독성과 의존성이 높기 때문에 담배에 대한 의존성과 중독성이 높은 상태에서는 경고그림에 대한 공포, 위협 소구가 제대로 작동하지 않았을 가능성이 있고, 혐오 그림에 대한 반발로 일종의 흡연량이 오히려 늘어나는 ‘부메랑 효과'가 있었을 가능성도 있는 것으로 보인다. 금연 시도율에서는 흡연량과 상반되는 결과를 보이며 청소년이 금연을 생각하고 시도하게끔 만드는 데에는 도움을 줄 수 있는 것으로 보인다. 이를 통해 담뱃갑 경고그림이 청소년으로 하여금 흡연의 위해성과 위험성을 인식하게 하고 금연을 유도하는 데에는 성공적인 것으로 평가된다. 그러나 이것이 흡연량을 감소시키며 궁극적으로는 완전히 금연할 수 있도록 하는 데에는 별도의 노력과 지원이 필요한 것으로 보인다.

      • KCI등재

        Transarterial Embolization Treatment for Aberrant Systemic Arterial Supply to the Normal Lung: A Case Report and Literature Review

        김보라,조정현,박병호 대한영상의학회 2017 대한영상의학회지 Vol.76 No.6

        A 24-year-old man presented with dyspnea on exertion and intermittent blood-tinged sputum. He was diagnosed with aberrant systemic arterial supply to the normal lung (ASANL) based on the results of imaging studies. The patient was successfully treated with transarterial embolization using coils and a vascular plug and his symptoms disappeared during the follow-up. Herein, we reported the imaging findings of ASANL, differential diagnoses, and its treatment options. In addition, we reviewed the relevant literature.

      • KCI등재후보SCOPUS

        Effectiveness of a Combined Therapy of Long-Acting Injectable Risperidone and Psychosocial Intervention for Relapse Prevention in Patients with Schizophrenia

        김보라,이상혁,최태규,서신영,Yong,Woo,Kim,Ki,Hwan,Yook,Eun,Hee,Lee 대한정신약물학회 2008 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.6 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Objective:Schizophrenia is a chronic disorder usually characterized by relapses alternating with periods of full or partial remission. To reduce relapse and rehospitalization rates, new long-acting injectable antipsychotics are needed. In addition, the most effective treatment is expected to include psychosocial intervention such as relapse prevention programs for patients with schizophrenia. Therefore, we examined whether combined therapy involving psychosocial intervention for relapse prevention (PIRP) and longacting injectable risperidone could reduce relapse and rehospitalization rates among outpatients with schizophrenia. Methods:We conducted a prospective study of 65 subjects with schizophrenia who participated in the PIRP program for 1 year. The PIRP program consisted of insight-gaining (psychoeducation on medication and symptoms), relapse prevention, screening for early signs for relapse, and crisis intervention. Outcome measures were efficacy as determined by the Brief Psychiatric Rating Scale (BPRS), Clinical Global Impressions (CGI), and Global Assessment of Functioning (GAF); relapse rate; and associative variables of relapse and medication compliance. Results:Repeated-measure analysis of variance (ANOVA) showed that the combined therapy significantly improved the scores for the BPRS (p<0.01), CGI (p<0.01), and GAF (p<0.01) by 6 and 12 months of the study, compared with baseline scores. Overall, the 2-year relapse rate of the combined-therapy subjects was 37.1%. Logistic regression analysis showed that medication compliance was a predictor of 2-year relapse (p=0.03). Multiple regression analysis also revealed that medication compliance was related to early treatment discontinuation (p=0.00) and 2-year relapse (p=0.00). Conclusion:These findings indicate that combined therapy can be effective in maintaining medication compliance and reducing BPRS scores, suggesting a role for combined therapy in maintaining medication compliance and reducing schizophrenia symptoms. Studies with larger sample sizes are needed to examine whether these results apply to the overall schizophrenic population.

      • KCI등재

        국내자생식물 메탄올추출물의 Wnt/β-catenin 신호전달체계에 대한 효과

        김보라,김현수 한국자원식물학회 2016 한국자원식물학회지 Vol.29 No.5

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        The Wnt/β-catenin signaling pathway is mandatory in adipogenesis. In this study, we investigated the applicability of functional materials for the treatment of obesity by examining Wnt/β-catenin pathway reporter activity related to adipocyte differentiation inhibiting with korean native plant extracts. The luciferase activity of HEK 293-TOP cells increased the reporter activity approximately 152% and 130% by treatment with Sanguisorba officinalis and Thuja orientalis, respectively. Ricinus communis were represented about 90% higher activity, two samples(Rosa rugosa and Sophorae Flos) showed 80% higher activity than the control. Three samples of plant extracts (Zanthoxylum piperitum, Pueraria thunbergiana, Solanum nigrum) were about 70% higher activity compared with the non-treated control. Cytotoxicity of plant extracts was not detected in the rat neural stem cells. These results suggest that the selected eight plant extracts are safe compounds. Our findings indicate that Wnt/β-catenin pathway reporter activity could be used for high throughput screening system. In addition, the plant extracts selected as candidates for adipocyte differentiation inhibiting may be potential therapeutic agents for obesity, it will be exploring the possibility of developing an anti-obesity materials through further experiments with selected plant extracts.

      • KCI등재

        러시아어와 체코어의 s 동반구문 유형비교

        김보라 중앙대학교 외국학연구소 2017 외국학연구 Vol.- No.41

        This paper is an attempt to account for the typology of comitative constructions in Russian and Czech. There are roughly two types of languages in terms of the distribution of comitative constructions. One is a language that does not allow a comitative construction with singular pronominal conjuncts, like Russian. The other is a language in which a structure with a singular pronominal conjunct is possible, like Czech. The paper explores the syntactic structure and why there exist different distributions in Slavic languages. Vassilieva (2001) has claimed that there are two types of plural comitative constructions in Russian: DP-complement and coordination. In contrast, Ionin & Matushansky (2003) proposed that all of the comitative structures are base-generated as adjuncts to an argument DP. In the first part of the paper, I describe various syntactic tests I tried in order to draw a distinction between adjunction and coordination and propose that the Czech comitatives with a singular pronominal can be analyzed as a coordination construction. The second part of the paper addresses the question of how to explain the various distributions of the comitatives in Czech and Russian. Following Stassen's (2001) assumption on the typology of comitatives, Czech shows a stronger tendency toward being an AND-language than Russian, which is considered a mixed WITH-language. In addition, the tendency is related to the case and tense system of the language.

      • KCI등재

        Acoustic technology-assisted rapid proteolysis for high-throughput proteome analysis

        김보라,이후근,천후엔창,한나영,박종문,유웅식 한국분석과학회 2011 분석과학 Vol.24 No.6

        Recent developments and improvements of multiple technological elements including mass spectrometry (MS) instrument, multi-dimensional chromatographic separation, and software tools processing MS data resulted in benefits of large scale proteomics analysis. However, its throughput is limited by the speed and reproducibility of the protein digestion process. In this study, we demonstrated a new method for rapid proteolytic digestion of proteins using acoustic technology. Tryptic digests of BSA prepared at various conditions by super acoustic for optimization time and intensity were analyzed by LC-MS/MS showed higher sequence coverage in compared with traditional 16 hrs digestion method. The method was applied successfully for complex proteins of a breast cancer cells at 30 min of digestion at intensity 2. This new application reduces timeconsuming of sample preparation with better efficiency, even with large amount of proteins, and increases highthroughput process in sample preparation state.

      • KCI등재

        군 조직구성원의 정보보안 정책준수 의도 및 태도에 영향을 미치는 요인에 관한 탐색적 연구: 정보통신단 부대원을 중심으로

        김보라,신지훈,김범수 한국국방연구원 2018 국방정책연구 Vol.34 No.2

        본 연구는 군 조직구성원의 정보보안 정책 준수 의도와 태도를 이해하기 위해 합리적 선택이론과 계획된 행동이론을 바탕으로 설문을 구성해 자료를 수집한 후 구조방정식모형 분석을 통해 연구 모형을 검증하였다. 그 결과 정보보안 정책 준수 의도에 영향을 미치는 요인은 정책에 대한 주관적 규범과 정책 준수에 대한 태도로 나타났다. 그리고 정책 준수 태도에 영향을 미치는 요인은 군에 대한 충성심, 정책 준수로 인한 내재적 이익과 보안 안전성, 정책 미준수로 인한 보안 취약성과 제재로 나타났다. 이 중 제재는 정책 준수 태도에 부정적인 영향을 미치는 것으로 나타났다. 본 연구는 군 조직 정보보안을 인적자원 관리 차원에서 다룬 실증 연구로서 향후 군 조직 내 정보보안 인적자원 관리를 위한 기초 자료로 활용될 수 있을 것이다. With special interests in the military, this study examined what would influence soldier's intention and attitude on their information security policy compliance (ISPC). Structural equation modeling analyses of 332 soldiers' data showed that the ISPC intention was affected by subjective norms and ISPC attitude. Then, the ISPC attitude was affected by one's perceived security safety or security vulnerability, intrinsic benefits, and the loyalty to the military. This study, unlike other technology-oriented studies, focuses on human resources. Thus, it can contribute to the development of future information security management strategies for soldiers.

      • KCI등재

        The activation of PPAR-α and Wnt/β-catenin by Paeonia lactiflora root supercritical carbon dioxide extract

        김보라 한국응용과학기술학회 2019 한국응용과학기술학회지 Vol.36 No.4

        The root of Paeonia lactiflora has been used in Chinese medicine. We conducted to check the comparative qualities of ethanol solvent extraction (PLE) and supercritical carbon dioxide extraction (PLS) of P. lactiflora root. PLE had higher antioxidant and polyphenol contents than PLS. But, PLS were significantly increased peroxisome proliferator-activated receptor (PPAR)-α. In addition, PLS inhibited the adipocyte differentiation of 3T3-L1 cells. When treated with the extract at a concentration of 100 μg/mL, the Wnt/β-catenin pathway reporter luciferase activity of HEK 293-TOP cells increased approximately by 3-folds compared to that of the untreated control group. These results indicate that P. lactiflora supercritical carbon dioxide extract may serve as a cosmeceutical for improving skin barrier function and the treatment of obesity.

      • KCI등재

        The Activation of PPAR-a and Wnt/β-catenin by Luffa cylindrica Supercritical Carbon Dioxide Extract

        김보라 한국생약학회 2019 Natural Product Sciences Vol.25 No.4

        Luffa cylindrica (LC) is a very fast-growing climber and its fruit have been considered as agricultural wastes. We conducted to check the comparative qualities of ethanol solvent extraction (LCE) and supercritical carbon dioxide extraction (LCS) of L. cylindrica fruit and seed. LCS had higher antioxidant and polyphenol contents than LCE. LCS were significantly increased peroxisome proliferator-activated receptor (PPAR)-a and involucrin expression as epidermal differentiation marker in 3D skin equivalent model. LCS also showed antimicrobial activity against Staphylococcus aureus, a causative bacteria in atopic dermatitis. In addition, LCS inhibited the adipocyte differentiation of 3T3-L1 cells. When treated with the extract at a concentration of 100 μg/mL, the Wnt/β-catenin pathway reporter luciferase activity of HEK 293-TOP cells was increased approximately by 2-folds compared to that of the untreated control group. These results indicate that L. cylindrica supercritical carbon dioxide extract may serve as a cosmeceutical for improving skin barrier function and the treatment of obesity.

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