소음인(少陰人) 태음병(太陰病) 심하비증(心下?證)의 병증약리(病證藥理) 고찰

서영광,이지원,이준희,최원철,이의주,고병희,Seo, Young-Kwang,Lee, Ji-Won,Lee, Jun-Hee,Choi, Won-Cheol,Lee, Eui-Ju,Kho, Byung-Hee 사상체질의학회 2010 사상체질의학회지 Vol.22 No.3

1. Objective: Gastric Stuffiness (心下?證) in the Soeumin Taeeum symptomatology (少陰人 太陰病) in Sasang Constitutional Medicine shows an interesting evolutionary process. Originally found in the texts of Sanghanlun (傷寒論), the perspectives regarding the symptoms of Gastric Stuffiness were expanded by many medical scholars and Lee Jema. To comprehend the Jema's concept of Taeeum symptomatology and utilize his prescription clinically, it deserves to study on the Gastric Stuffiness in Donguisuseowon (東醫壽世保元). 2. Methods: Many texts including Sanghanlun (傷寒論) and Dongeuibogam (東醫寶鑑) were reviewed in order to track the evolutionary process concerning the symptoms of Gastric Stuffiness. Also, Lee Jema's works including the different versions of Donguisuseowon (東醫壽世保元) were reviewed to examine the development of Lee's concepts regarding the Gastric Stuffiness in the Soeumin Taeeum symptomatology. 3. Results and Conclusions: 1) Most of the previous concepts on Gastric Stuffiness were generally similar to those found in Sanghanlun, especially in that they addressed Yang deficiency of the middle triple energizeer as the central pathogenic process. 2) Lee Jema's views on the epigastric discomfort in the Soeumin Taeeum symptomatology evoloved over time and culminated in the finalized pathology and therapeutics appearing in his last work, the Shinchuk version of Donguisuseowon (東醫壽世保元). 3) 4 kinds of prescription which invented by Lee Jema to treat the Gastric Stuffiness in the Soeumin Taeeum symptomatology can be matched to the prescription of Sanghanlun respectively. However through evolutionary process of Jema's prescriptions, the indication of them expanded: not only to treat Gastric Stuffiness but to diverse symptoms of Soeumin.

열다한소탕으로 호전된 태음인 호산구성대장염 환자 1례

이지원,김진영,오혜원,이의주,고병희,이준희,Lee, Ji-Won,Kim, Jin-Young,Oh, Hye-Won,Lee, Eui-Ju,Koh, Byung-Hee,Lee, Jun-Hee 사상체질의학회 2015 사상체질의학회지 Vol.27 No.4

Objectives The aim of this study was to report an improvement on the symptoms of Eosinophilic Colitis (EC) by Yeoldahanso-tang.Methods The patient was diagnosed with Taeumin Ganyeol-paeJo Symptomatology and treated with Yeoldahanso-tang. The gastroendoscopy and eosinophilic infitration of mucosa of colitis are investigated. Also patient's subjective symptom of abdominal pain was scored using the Numerical Rating Scale(NRS) during the treatment period. And the number of defecation in a day is also used to decide the degree of colitis.Results and Conclusions The patient had been treated from December 13, 2014 to August 8, 2015. Eosinophilic infiltration of colon was disappeared after the treatment although chronic inflammation still existed. Subjective pain of abdominal pain was measured as NRS 6~8 at the beginning of the remedy, but diminished through the treatment sessions and became NRS 0 in the end. The number of defecation was in average 3, and at the endpoint it became 1. In conclusion, this study suggests that Sasang constitutional Medicine used for treating EC of Taeumin may be effective.

소양인(少陽人) 망음증(亡陰證)의 치방(治方)에 대한 고찰(考察)

이지원,이준희,고병희,이의주,Lee, Ji-Won,Lee, Jun-Hee,Koh, Byung-Hee,Lee, Eui-Ju 사상체질의학회 2011 사상체질의학회지 Vol.23 No.1

1. Background: This is the first documented study on the four medications for the Mangeum symptomatology (亡陰證) in the Soyangin disease category. The four medications, Hyeongbangsabaek-san (荊防瀉白散), Jeoryeongchajeonja-tang (猪?車前子湯), Hyeongbangjihwang-tang (荊防地黃湯), and Hwalseokgosam-tang (滑石苦蔘湯), were comparatively analyzed on their compositive principles and respective symptomatologies. 2. Methods: Previous literature, including classical works on earlier Sasang Constitutional Medicine (different editions of Donguisusebowon and Dongmuyugo), were reviewed for relevant material on the Mangeum medications. 3. Results and Conclusions: 1) Hyeongbangsabaek-san (荊防瀉白散) is used in pathologies of early stages of invasion of the internal heat in the lower-most burn-center (locus related to the Kidney system). 2) Jeoryeongchajeonja-tang (猪?車前子湯) is used when pathogenic dampness-heat invades the lower-most burn-center (locus related to the Kidney system). 3) Hyeongbangjihwang-tang (荊防地黃湯) is used to treat deficient heat involving injury of the lower-most burn-center (locus related to the Kidney system). 4) Hwalseokgosam-tang (滑石苦蔘湯) is used when the lower-most burn-center (locus related to the Kidney system) is in the early stages of exhaustion, expecially accompanied by concomitant dampness-heat. 5) The Mangeum symptomatology (亡陰證) was fully understood only after the completion of the 1901 Sinchuk edition (辛丑本) of Donguisusebowon (東醫壽世保元).

열다한소탕(熱多寒少湯)으로 양수(兩手) 진전(振顫), 안면(顔面) 상열감(上熱感), 어미삽(語微澁)을 치료한 태음인(太陰人) 환자 1예(例)

이지원,장현수,김윤희,이준희,이의주,고병희,Lee, Ji-Won,Jang, Hyun-Su,Kim, Yun-Hee,Lee, Jun-Hee,Lee, Eui-Ju,Koh, Byeong-Hee 사상체질의학회 2009 사상체질의학회지 Vol.21 No.1

1. Objective This case study reports a Taeeumin patient experiencing hand tremor, heat flash, and mild dysarthria who improved with Yeoldahansotang medication. 2. Method The patient's subjective and objective symptoms were observed daily, and the VAS scores for the main symptoms (hand tremor, heat flash, and mild dysarthria) were recorded daily throughout hospitalization period. 3. Result The patient's general conditions improved by the end of hospitalization, and VAS score dropped dramatically from VAS 10, VAS 10, VAS 10 to VAS 0, VAS 0.5, VAS 3 for hand tremor, heat flash, and mild dysarthria, respectively. 4. Conclusion The patient responded well to Yeoldahansotang, one of the main medicaments for the Joyeol (dry-heat) symptomatic pattern, which indicates that Yeoldahansotang can be used to treat the Joyeol symptomatic pattern even when the textbook indications are not evident as long as the Joyeol pathology is recognizable from other symptoms.

미역취뿌리 추출물이 성장기 흰쥐의 골대사에 미치는 영향

이지원,박정현,이효주,이인선,Lee Ji-Won,Park Jung-Hyun,Lee Hyo-Joo,Lee In-Seon 한국생명과학회 2005 생명과학회지 Vol.15 No.2

본 연구에서는 3주령의 암컷 흰쥐를 이용하여 미역취뿌리 추출물이 골대사에 미치는 영향을 조사하고자 미역취뿌리 메탄올 추출물을 10, 50, 100 mg/kg/day의 농도로 음용수에 희석하여 9주간 사육시켰다. 매주 체중과 사료효율을 측정한 결과, 대조군에 비해 체중의 변화나 사료효율에는 유의적으로 차이가 없는 것으로 보아 미역취 뿌리 추출물에 대한 기본적 독성은 없고, 성장에 미치는 영향은 없는 것으로 사료되었다. 그리고 3주 간격으로 소변으로 배출되는 Ca과 P의함량을 ICP로 분석 한 결과, 10 mg/kg/day농도로 음용한 군에서 유의적으로 감소됨을 확인 할 수 있었고 혈액으로 유리되는 Ca과 P의 함량 또한 섭취군에서 유의적으로 감소되는 것을 확인하였다. 또한 섭취 후 9주째에 양에너지 방사선 골밀도 측정기(dual energy x-ray absorptiometry, DEXA)를 이용하여 척추, 대퇴골, 골반의 골밀도와 골무기질 함량을 측정한 결과, 메탄을 추출물을 음용한 군의 척추 골밀도가 대조군에 비해 유의적으로 높게 나타났으며, 글 무기질 함량 또한 대퇴골과 골반에서 대조군에 비해 유의적으로 높게 나타났다. 따라서 미역취뿌리 메탄을 추출물의 음용이 암컷 흰쥐에서 골밀도 및 골함량에 유의하게 작용하고 또한 골대사 과정에서 유리되는 Ca와 P의 대사과정에 작용하여 유리되는 Ca과 P의 양을 감소시켜 이상의 결과로 미뤄볼 때, 적절한 미역취뿌리 추출물의 투여는 흰쥐의 성장에 대해 부작용이나 독성없이 골밀도와 골무기질 함량을 높였으며 앞으로 조골세포 기능 저하로 인한 골대사 질환에 사용되어 질 수 있을 것이다. To investigate the bioactivities of Solidago virga-aurea var. gigantea Mig. Root (SVR), we studied the effect of a SVR methanol extract on the activity of bone metabolism. Spraque-Dawley three-week-old female rats were randomly assigned to groups as follows : non-supplemented rats and supplemented with SVR at 10, 50, 100 mg/kg bw/day. Every week determined weight gain and food intake, urine and blood examination of mineral content of calcium and phosphorus was performed each at experimental periods of 3 and 9 weeks respectively; bone mineral density and bone mineral content were also assayed. There were no significant differences in body weight or feed efficiency ratio levels. However, the biological value of calcium and phosphorus excretion in the group supplemented with SVR extract decreased significantly more than that in the group not supplemented with SVR extract. Also, spine BMD, femur BMC and pelvis BMC per weight were significantly greater on SVR extract supplemented groups than that of the control group. In conclusion, it might be expected that methanol extract of SVR does not impair the growth of rats and may improve bone metabolism in rats.

사상체질의학적 병리관에 의한 "상한론(傷寒論)" 태양병(太陽病)의 재해석

이지원,신승원,곽상협,김영준,이준희,Lee, Ji-Won,Shin, Seung-Won,Kwak, Sang-Hyup,Kim, Yeong-Jun,Lee, Jun-Hee 사상체질의학회 2010 사상체질의학회지 Vol.22 No.3

1. Objectives: Purpose of this paper is to study the reinterpretation of Taeyang disease(太陽病) in "Shanghanlun(傷寒論)" based on the pathologic perspective of Sa-sang Constitutional Medicine by comparing factors as pathologic mechanisms, clinical symptoms, and remedies. 2. Methods: The texts referred to pathologic mechanisms, clinical symptoms, and remedies of Taeyang disease(太陽病) described in "Donguisusebowon Gabobon(東醫壽世保元 甲午本)", "Donguisusebowon Sinchookbon(東醫壽世保元 辛丑本)", and Shanghanlun(傷寒論)" in "Donguibogam(東醫寶鑑)" were analysed. 3. Results and Conclusions 1) Early phase of Ulgwang symptomatic pattern(鬱狂證 初證) and of Mangyang symptomatic pattern(亡陽證初證) of Kidney Heat-based Exterior Heat disease(腎受熱表熱病), a category of Soeumin(少陰人) diseases, were described by adopting pathologic models of Taeyang-sangpung symptomatic pattern(太陽傷風證) and Sanghan-hyeol symptomatic pattern(傷寒血證) from "Sanghanlun(傷寒論)". 2) Soyang-sangpung symptomatic pattern(少陽傷風證) of Spleen Cold-based Exterior Cold diseae (脾受寒表寒病) and Hyunggyeok-yeol symptomatic pattern(胸膈熱證) of Stomach Heat-based Interior Heat disease(胃受熱裏熱病), categories of Soyangin(少陽人) diseases, were described by adopting pathologic models of Taeyang-yangsangpunghan symptomatic pattern(太陽兩傷風寒證), Soyang-sangpung symptomatic pattern(少陽傷風證) and Tayangbyong-sahak symptomatic pattern(太陽病似?證) from "Sanghanlun(傷寒論)". 3) Baechu-pyo symptomatic pattern(背?表病輕證) and Hangual symptomatic pattern(寒厥證) of Esophagus Cold-based Exterior Cold disease(胃脘受寒表寒病), a category of Taeeumin(太陰人) diseases, was described by adopting pathologic models of Taeyang-sanghan symptomatic pattern(太陽傷寒證) and Hangual symptomatic pattern(寒厥證) from "Sanghanlun(傷寒論)". 4) Je-Ma Lee reinterpreted various diseases classified as Taeyang disease(太陽病) with the pathologic perspective of Sa-sang Constitutional Medicine. Different from existing medicine, diseases were analysed and treated by the standard, constitution of the patient.

국내 대학도서관 정리부서 현황과 조직 변화에 대한 인식 연구

이지원,Lee, Ji-Won 한국비블리아학회 2014 한국비블리아학회지 Vol.25 No.1

이 연구는 도서관 정리부서 변화 요인을 조사하고 국내 대학도서관 정리부서 조직 현황과 변화에 관한 사서들의 인식을 살펴봄으로써, 정리부서 조직 개선을 위한 변화와 발전 방향을 파악하고자 하였다. 도서관 정리부서의 변화의 주요 요인은 분담편목과 아웃소싱, 그리고 다양한 형태의 전자자원과 이에 대한 메타데이터 생성이었다. 국내 32개 대학도서관 정리부서 담당자를 대상으로 정리부서 현황과 조직 변화에 대한 인식을 조사 분석한 결과, 대부분 정리전문사서의 양성, 정리부서 체제의 변화가 필요한 시점이라고 응답하였으며, 전통적인 편목과 함께 전자자원에 대한 메타데이터 업무가 통합된 형태로 운영되는 것이 바람직하다고 인식하고 있었다. 하지만 현재까지는 대학도서관 전반적으로 메타데이터 관련 업무가 분산되어 있었고, 정리부서 내에서 담당하지 않는 메타데이터 관련 업무에 대한 파악이 부족한 것으로 조사되었다. This study investigated organizational changes in technical services of university libraries and analysed librarians' perception on the changes of technical service department by the survey to 32 technical service librarians. It also identified several factors that have changed work environment of technical departments such as the shared cataloging and outsourcing, and electronic resources in various formats and creation of metadata for these resources. Most librarians agreed that university libraries have to foster technical librarians' professioanal development to cope with emerging changes of technical services. They also recognized that the integration of traditional cataloging and metadata management is an important issue of orgranizational changes. Contrary to librarians' perception, technical service librarians were not fully awared of the procedure of metadata related works in other departments. Furthermore metadata creation and management were also conducted in several departments of libraries without proper control.

산지하천 호안의 합리적 설계를 위한 제언 - 역학설계법을 적용한 기존호안 평가

이지원,최채복,박상덕,Lee, Ji-Won,Choe, Chae-Bok,Park, Sang-Deok 한국수자원학회 2011 물과 미래(한국수자원학회지) Vol.44 No.11

ENA-A(ENA actimineral resource A) 이온수가 MC3T3-E1 조골세포의 활성과 분화에 미치는 영향

이지원,전상경,김현정,이인선,Lee, Ji-Won,Jeon, Sang-Kyung,Kim, Hyun-Jeong,Lee, In-Seon 한국생명과학회 2006 생명과학회지 Vol.16 No.6

Culture of osteoblast is extremely valuable in analyzing biological features that are specific to bone. ENA-A, ENA actimineral resource A, is a seaweed origin alkaline water. To investigate the bioactivity of ENA which act on bone metabolism, we studied the effects of a ENA on the activity of osteoblast MC3T3-E1 cells. ENA (1, 2, 4%) dose-dependently increased survival (p<0.05) and alkaline phosphatase activity (p<0.05) on MC3T3-E1 cell. And examined histochemistry and nodule formation according to the time course. To determine the expression patterns of bone-related proteins during the MC3T3-E1 osteoblast-like cell differentiation by using RT-PCR. This study suggest that ENA may promote the function of osteoblastic cells and play an important role in bone formation. 골조직은 골아세포, 파골세포, 골세포 등으로 구성되며, 골개조시 여러 인자가 세포증식, 분화, 활성화 및 골대사 조절에 관여한다. 이때 조골세포의 활성은 골형성에 중요하므로, 본 연구에서는 MC3T3-E1 조골세포주를 이용하여 해조류로 조제한 알칼리의 ENA-A 이온수가 조골세포의 증식과 분화활성에 미치는 영향을 조사하였다. 먼저 ENA-A 이온수가 조골세포의 성장에 미치는 영향을 MTT 검색법으로 조사 한 결과, ENA-A 이온수 2% 처리시 대조군과 비교하여 134% 증가하여 조골세포에 대해 높은 성장률을 보였다. 또한 ALP 효소 활성에 미치는 영향을 9일간 배양하여 그 변화를 측정하였다. 결과, 농도 1, 2, 4, 8% 처리시 112, 150, 188%까지 ALP 활성을 증가시켰다. ENA-A 이온수는 다시 ALP 효소 염색법과 Alizarin Red 염색으로 조골세포의 ALP활성유도, 분화와 석회화 형성능을 재확인하였으며 골기질 유전자의 발현의 변화도 확인하였다. 이에 본 연구결과를 통해 각종 무기질 성분을 함유한 ENA 이온수가 조골세포의 분화시에 hydroxyapatite 형성에 영향을 줌으로써 골다공증 예방에 효과가 있을것으로 생각하여 이를 보고하는 바이다.

중만분소환 추출물이 Palmitate로 유발된 비알코올성 지방간 HepG2 cell 모델에 미치는 영향

이지원,최창원,전상윤,한창우,하예진,Lee, Ji-won,Choi, Chang-won,Jeon, Sang-yun,Han, Chang-woo,Ha, Ye-jin 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.3

Objectives: This study was performed to investigate the anti-lipogenic effect and the mechanism of Jungmanbunso-hwan extract (JMBSH) on a cellular model of non-alcoholic fatty liver disease (NAFLD) caused by palmitate in HepG2 cells.Methods: The JMBSH was prepared, andHepG2 cells were treated with various concentrations of JMBSH in order to perform an MTT assay. The HepG2 cells were cultivated in palmitate-containing media with or without extract of JMBSH. The intracellular lipid content in the HepG2 cells was examined. The effects of JMBSH on sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD-1), and AMP-activated protein kinase (AMPK) activation in HepG2 cells were measured.Results: JMBSH did not reduce HepG2 cell viability under 1,000 μg/mL. JMBSH considerably decreased intracellular lipid accumulation caused by palmitate in HepG2 cells. JMBSH repressed expression of SREBP-1c, which mediates the induction of lipogenic genes (ACC, FAS, and SCD-1). JMBSH also activated AMPK, which plays animportant role in the regulation of hepatic lipid metabolism.Conclusions: This study suggested that JMBSH relieves hepatic steatosis by repressing SREBP-1c, which mediates the induction of lipogenic genes. The anti-lipogenic effect of JMBSH may also be related to the activation of AMPK. Therefore, JMBSH could potentially be applied to NAFLD treatment after further clinical studies.