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이병언,이남혁,이정안,김상윤,Lee, Byung-Eun,Lee, Nam-Hyuk,Lee, Jung-Ahn,Kim, Sang-Youn 대한소아외과학회 1996 소아외과 Vol.2 No.1
Laparoscopic appendectomy is relatively well-established as an alternative to conventional open appendectomy by many laparoscopic surgeons. However, experience in the pediatric population remains limited. Over a period of 2 years, a total of 155 pediatric patients with acute appendicitis or complicated appendicitis were studied to compare laparoscopic and open appendectomies in childhood. Laparoscopic appendectomy was attempted in 49 patients and completed in 48 patients(98.0%). Open appendectomy was performed in 107 patients. The severity of disease, age, and male to female ratio were similar in both groups. The operation time was shorter in the laparoscopic group than open group but the difference was not significant statistically($43.7{\pm}11.3$ minutes versus $49.0{\pm}21.4$ minutes, p=0.066). In the laparoscopic group, the mean duration of surgery for the former half patients was significantly longer than for the latter half($49.6{\pm}9.2$ minutes versus $38.1{\pm}10.3$ minutes, p=0.001). The mean number of doses of analgesia required postoperatively was significantly less in patients undergoing laparoscopic appendectomy($2.4{\pm}1.8$ versus $3.3{\pm}2.5$, p=0.021). There were only 2(4.2%) wound infections after laparoscopic appendectomy compared with 10(9.3%) complications including 7 wound infections, 1 intestinal obstruction, and 2 pulmonary complications after open appendectomy, but the difference was not significant(p=0.614). Patients undergoing laparoscopic appendectomy had a shorter period of hospitalization($3.2{\pm}2.2$ days versus $6.4{\pm}1.6$ days. p=0.001). The present study suggests that laparoscopic appendectomy shortens operating time and hospital stay with diminished postoperative pain. Laparoscopic appendectomy in children offers advantages over open appendectomy as noted in adults. The authors consider laparoscopic appendectomy to be the reasonable alternative to open appendectomy in children.
김정욱 ( Jeong Wook Kim ),전우규 ( Woo Kyu Jeon ),장세경 ( Sae Kyung Chang ),이정안 ( Jung Ahn Lee ),박동일 ( Dong Il Park ),조용균 ( Yong Kyun Cho ),성인경 ( In Kyung Sung ),손정일 ( Chung Il Sohn ),김병익 ( Byung Ik Kim ),김은정 대한내과학회 2004 대한내과학회지 Vol.67 No.6
목적 : 장관장벽 이상은 폐색성 담관질환에서 발생하며 장내세균전위나 장관내독소혈증과 같은 감염성 합병증을 유발 한다. 본 연구에서는 폐색성 담관질환에서 장관장벽 이상과 임상양상과의 관계를 알아보았다. 방법 : 건강대조군 18명, 양성질환에 의한 폐색성 담관질환자 20명, 악성질환에 의한 폐색성 담관질환자 21명에서 장투과성 검사를 실시하였으며 질환군간 차이와 각종 임상양상과 연관성을 비교하였다. 장투과성 검사는 51Cr-EDTA (51Cr-ethylen Background : Gut barrier dysfunction occurs in experimental models and humans of obstructive biliary disease. This phenomenon promotes infectious complications including bacterial translocation and intestinal endotoxemia. The aims of this study were to ex
비수술적 방법으로 완전소실된 특발성 후복막 섬유증 1예
안혜숙,우승일,정안철,조은경,서창인,이봉화,손진희 대한내과학회 1997 대한내과학회지 Vol.53 No.3S
특발성 후복막 섬유증은 요관박리술 등 수술적 방법이 일차작 치료법이었으나, 스테로이드 투여가 수술적 방법을 대체할 수 있을 것으로 생각된다. 저자들은 특발성 후복막 섬유증으로 입원한 68세 여자에서 스테로이드 투여후 후복막 종물이 소실된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Idiopathic retroperitoneal fibrosis is a chronic inflammatory process due to unknown causes, leading to deposition of the dense sclerotic plaques in the midline, which may obstruct or restrict the movement or the flow of the adjacent organs. It is characterized by nonspecific constitutional symptoms such as nausea, anorexia, constipation, abdominal pain, mild fever and low back pain. It is common in fifth and sixth decades and more predominent in male than in female. It is diagnosed by the imaging findings of IVP, sonogram, CT and MR] with the clinical manifestation and is confirmed by the biopsy of retroperitoneal mass. The mainstay of treatment has been ureterolysis and surgical treatment or often steroid administration. We report a case of idiopathic retroperitoneal fibrosis with regression after steroid administeration without surgical management.
정지형 자전거 운동 훈련이 건강한 여성의 체구성,심폐기능 및 유연성에 미치는 효과
김동옥,최정숙,안혜영,민혜숙,이경숙,박연환,송미령,최명애,최정안,김매자 서울대학교 간호대학 간호과학연구소 1999 간호학 논문집 Vol.13 No.1
The purpose of this study was to determine the changes in body composition, cardiopulmonary function, and flexibility following 8 weeks' bicycle ergometer exercise training. The subjects of this research consisted of healthy adult women between 30 and 40 years of age. Initial intensity of bicycle ergometer exercise was based on the target heart rate equivalent to 55% of maximal oxygen uptake, and intensity of the exercise increased by 5% every 2 weeks. Body composition, cardiopulmonary function at rest and during maximal exercise, as well as flexibility were determined before and after 8 weeks of bicycle ergometer exercise training. Masimal exercise was performed on the treadmill according to Bruce Protocol. The results obtained were as follows; 1. There were o changes in body weight, percent body fat, fat body weight, and lean body weight as well. The ventilation volume for 1 minute, respiratory quotient and expired CO₂ volume have not changed significantly after the training, either. 2. As a result of training, resting systolic and diastolic blood pressure decreased significantly(p<.05) 3. Maximal heart rate, maximal oxygen consumption and maximal running time increased significantly after the training(p<.05) 4. Pelvic flexibility increased slightly after the training, however, it did not reach the statistical significance. Trunk flexion forward increased significantly after the training(p<.05). From these results, it may be concluded that 8 weeks bicycle ergometr training improve the cardiopulmonary function and flexibility in healthy adult women between 30-40 years of age.
Rat 대동맥 평활근 세포에서 배양액내 Nitrite 농도에 미치는 Guanylate Cyclase Inhibitor의 영향
김원준,최형철,조해창,장내성,이정안,김상윤,이광윤 대한혈관외과학회 1999 Vascular Specialist International Vol.15 No.2
Purpose: Nitric oxide (NO) exerts the relaxant effect in vascular smooth muscle cells (VSMC) by activating soluble guanylate cyclase (sGC), which produces cyclic guanidine monophosphate (cGMP) in the cell. This study was undertaken to investigate the mechanism of the inhibitory actions of sGC inhibitors, LY 83583 and methylene blue in the VSMC. Methods: VSMC was primarily cultured from rat aorta and confirmed by immunocytochemistry of anti-smooth muscle myosin antibody. Bacterial lipopolysacchride (LPS), an inducer of inducible nitric oxide synthase (iNOS) and sodium nitroprusside (SNP), an NO donor, were uesd to increase NO within VSMC. The changes in concentrations of nitrite in culture media by an addition of LPS or SNP with a pretreatment of LY 83583 or methylene blue were measured by the spectrophotometry with griess regent and absorbance at 550 nm. Western blot and RT-PCR for iNOS and iNOS mRNA, respectively were performed. Results: LPS and SNP increased nitrite concentration. LY 83583 potentiated the increase in nitrite concentration by LPS and SNP. LY 83583 also increased expressions of iNOS protein and mRNA induced by LPS. Methylene blue has no effect on nitrite concentration increased by LPS or SNP, and it did not affect the expressions of iNOS protein or mRNA induced by LPS. Conclusion: These results suggest that the mechanism of inhibitory actions of LY83583 and methylene blue on sGC are different each other; LY83583 interferes the interaction of sGC and NO resulting positive feedback increase in iNOS gene expression, but methylene blue eliminates NO from cytosol inducing no compensatory effect.