곽향(藿香) 추출물(抽出物)이 장운동(腸運動)에 미치는 영향(影響)

이정수,손창규,조정효,신장우,유화승,이연월,이남헌,윤담희,조종관,Lee, Jung-Soo,Son, Chang-Gue,Cho, Jung-Hyo,Shin, Jang-Woo,Yoo, Hwa-Seung,Lee, Yeon-Weol,Lee, Nam-Heon,Yun, Dam-Hee,Cho, Chong-Kwan 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4

Objectives : 본 연구는 암환자의 위장관 기능장애를 개선시킬수 있는 보다 효과적인 약물개발의 일환으로 곽향 추출물의 장운동에 미치는 영향을 평가하기 위해 수행되어졌다. Methods : 생리적인 상태에서 곽향추출물이 장운동에 미치는 영향을 알아보기 위해 장운동촉진제인 carbachol과 곽향추출물을 실험쥐들에게 투여후 15분후 charcoal meal을 먹여서 charcoal meal의 소장내 통과 정도를 비교 측정하였다. 또, loperamide, scopolamine, nicotine으로 장운동을 억제시켜 놓은 실험쥐들에 15분 간격으로 곽향 추출물과 charcoal meal을 먹인 후 역시 charcoal meal의 소장내 통과 정도를 비교 측정하였다. Results : 곽향 추출물은 생리상태에서는 장운동에 영향을 미치지 않았다. 곽향추출물은 loperamide와 scopolamine으로 유발된 장운동 억제상태에 대하여 부분적으로 영향을 끼쳤다. 그러나 nicotine으로 유발된 상태에 대해서는 영항을 끼치지 않았다. Conclusion : 곽향 추출물은 소화관 기능부전 완화에 효과적으로 작용하는 천연물이라 추론할 수 있다.

Inhibitory Effect of Taurine on HOCl-and $NH_2Cl-induced$ Degradation of Hyaluronic Acid

이정수,이경용,이광수,Lee, Chung-Soo,Lee, Kyung-Yong,Lee, Kwang-Soo The Korean Society of Pharmacology 1992 대한약리학잡지 Vol.28 No.2

외인성 taurine이 HOCl, $NH_2Cl$과 그밖의 산화성 물질에 의한 hyaluronic acid의 변성에 미치는 영향을 관찰하였다. HOCl, $NH_2Cl$과 그밖의 산화성 물질에 대한 taurine의 제거 작용을 조사하였다. Taurine의 항 산화 작용을 또한 치올 화합물의 작용과 비교 관찰하였다. Hyaluronic acid의 점성도는 HOCl과 $NH_2Cl$에 의하여 뚜렷하게 용량에 따라 감소하였다. Hyaluronic acid에 대한 HOCl의 변성 효과는 $NH_2Cl$에 의한 것보다 현저하였다. Taurine은 HOCl과 $NH_2Cl$에 의한 hyaluronic acid의 변성을 효과적으로 용량에 따라 억제하였다. HOCl의 변성 효과는 DMSO에 의하여 뚜렷하게 억제되었다. $Fe^{2+}$과 $H_2O_2$에 의한 hyaluronic acid의 변성은 catalase와 DMSO에 의하여 억제되었으나 taurine의 영향은 받지 않았다. Xanthine과 xanthine oxidase의 변성 작용은 SOD와 catalase에 의하여 효과적으로 억제되었으나 taurine의 영향은 받지 않았다. HOCl은 taurine, DMSO, GSH와 MPG에 의하여 유의하게 분해되었다. 파장 250 nm에서의 HOCl의 흡광도와 파장 242 nm에서의 $NH_2Cl$의 흡광도는 taurine의 첨가로 유의하게 증가하였다. $NH_2Cl$과 GSH 또는 MPG의 상호 작용으로 초기에 최대의 흡광도가 관찰되었으나, 이러한 흡광도는 반응 시간에 따라 점차적으로 감소하였다. $Fe^{2+}$와 $H_2O_2$의 존재하에서 OH 의 생성은 catalase와 DMSO에 의하여 억제되었으나 taurine의 영향은 받지 않았다. DABCO와 DABA에 반응하는 자외선 조사에 따른 $^1O_2$의 생성은 taurine의 영향을 받지 않았다. GSH와 MPG는 HOCl의 변성 작용을 뚜렷하게 억제하였다. 이상의 결과로 부터 hyaluronic acid의 변성을 포함한 조직 구성성분의 산화성 손상에 있어서 taurine의 보호 작용은 산소 유리 라디칼에 대한 제거 작용과 관계없으며 HOCl과 $NH_2Cl$에 대한 제거 작용 그리고 taurine과 HOCl 또는 $NH_2Cl$의 복합체 형성에 기인할 것으로 시사된다. Taurine의 치올 기가 HOCl과 $NH_2Cl$에 의한 변성에 부분적으로 보호 작용을 나타 낼 것으로 추정된다. Effect of exogenous taurine on HOCl, $NH_2Cl$ and other oxidants-induced degradation of hyaluronic acid was investigated. The scavenging action of taurine on HOCl, $NH_2Cl$ and other oxidants was examined. The antioxidant action of taurine was also compared with that of thiol compounds. Viscosity of hyaluronic acid was markedly decreased by HOCl and $NH_2Cl$ on a dose dependent fashion. The degradative effect of HOCl on hyaluronic acid was greater than that of $NH_2Cl$. Taurine effectively inhibited HOCl-and $NH_2Cl-induced$ degradation of hyaluronic acid in a dose dependent fashion. The degradative effect of HOCl was markedly inhibited by DMSO. $Fe^{2+}$ plus $H_2O_2-induced$ degradation of hyaluronic acid was inhibited by catalase and DMSO but not affected by taurine. The desradative action of xanthine and xanthine oxidase was effectively inhibited by SOD and catalase but not affected by taurine. HOCl was significantly decomposed by taurine, DMSO, GSH and MPG. Both absorbance of HOCl at 250 nm and absorbance of $NH_2Cl$ at 242 nm were significantly increased by the addition of taurine. Interaction of $NH_2Cl$ with GSH or MPG showed an initial peak absorbance, but these absorbances were gradually decreased with time. OH production in the presence of $Fe^{2+}$ and $H_2O_2$ was inhibited by catalase and DMSO but not affected by taurine. Taurine did not affect $^1O_2$ production by U.V. irradiation which is responsible for DABCO and DABA. GSH and MPG markedly inhibited the degradative action of HOCl. These results suggest that the protective action of taurine on oxidants-induced damages of tissue components, including degradation of hyaluronic acid may be attributable to both its scavenging action on HOCl and $NH_2Cl$ and the complex formation of taurine with HOCl or $NH_2Cl$ without scavenging action on oxygen free radicals. Sulfhydryl group of taurine appears to show partially a protective action on HOCl-and $NH_2Cl-induced$ degradation.

비접촉 눈 깜박임 측정 안경형 디바이스를 이용한 실시간 스펠러의 구현

이정수,이홍지,이원규,임용규,박광석,Lee, Jeong Su,Lee, Hong Ji,Lee, Won Kyu,Lim, Yong Gyu,Park, Kwang Suk 대한의용생체공학회 2015 의공학회지 Vol.36 No.6

We proposed blink based online speller for the locked-in syndrome (LIS) patients, paralyzed in nearly all voluntary muscles expect for the eyes, with a simple and easy-to-use eye blink detection glasses. Electrooculogram (EOG) is the golden standard method of eye movement or blink measurement with Ag/AgCl electrodes. However, this method has several drawbacks such as skin irritation and dehydration of conductive gel. To resolve the shortcomings, we used a blink detection system based on a transparent capacitively coupled electrode, which is conductive indium tin oxide (ITO) films. The films make it possible to measure eye blink without direct skin contact and obstruction of field of view. We finally developed user-friendly blink based online speller with the blink detection system. To classify voluntary and non-voluntary blink, we used the double blink for command of the speller. The online speller experiment result with six healthy subjects shows that mean accuracy is 98.96% and letter per minute (LPM) is 4.73, which are better result by comparison with conventional P300 or auditory brain-computer interface (BCI) paradigm. The result of the experiment demonstrates the possibility of applying the proposed system as a communication method for the LIS patients.

멀티미디어 컨텐트 보호를 위한 디지털 워터마크

이정수,김회율,이의택,Lee, J.S.,Kim, H.Y.,Lee, E.T. 한국전자통신연구원 1998 전자통신동향분석 Vol.13 No.3

멀티미디어 산업의 확장과 인터넷과 같은 네트워크의 보편화로 인해 멀티미디어 컨텐트의 사용이 급증하고 있다. 또한, 이러한 네트워크 망을 통한 상업적 거래가 확대됨에 따라 멀디미디어 컨텐트(정지영상, 동영상, 오디오, 문서 등)의 지적소유권, 저작권을 보호하려는 노력이 있었다. 워터마크는 멀티미디어 컨텐트에 사용자 정보를 감춤으로써 효과적으로 저작권 및 소유권을 보호할 수 있는 도구이다. 따라서 본 논문에서는 워터마크가 갖추어야 할 요건 및 멀티미디어 컨텐트에 워터마크를 내장하는 여러 가지 방법을 소개하고, 상업적으로 이용되고 있는 워터마크 시스템을 살펴보았다.

국민의 식생활과 건강보조식품의 필요성에 관한 연구

이정수 대구산업정보대학 1995 논문집 Vol.9 No.2

As mentioned above,we know that the intake of food by people in our country has nearly approched the encouraged amount of nutrition. Based on this fact, many nutritionists conclude that there is no health impediment due to malnutrition, for the nutritive condition of Korean people today is much better than that in the past,and the intake of food and the encouraged amount of nutrition are nearly balanced. Nevertheless, we should not overlook a few points:imperfection of the encouraged amount of nutrition itself;probable imbalance of nutrition due to excessive intake of manufactured food and fast food;the menace to human health due to theaggravation of environmental pollution ; and probable malnutrition due to the destruction of nutrients during the process of cooking because of imperfect education for nutrition. Therefore, in order to maintain the necessary balance of perfact nutrition, we should duly consider the following points : 1. Elimination of environmental pollution. 2. Consumption of food and drink with natural nutrition(without the process of manufacture and cooking) if possible. 3. Reduction of the intake of manufactureed food as much as possible. 4. Consumption of high fiber food and low carbohydrate food if possible. Putting aside various points of view,we can see that the condition of human health is always threatened by various factor even though the dietary life for human health has nearly approached the encouraged amount of nutrition. Therefore, we should empasize the necessity of preventive measure or improvement of supplemental food for human health.

스트립 바이너리에서 합성곱 신경망을 이용한 컴파일러 정보 추출 기법

이정수,최현웅,허준영,Lee, Jungsoo,Choi, Hyunwoong,Heo, Junyeong 한국인터넷방송통신학회 2021 한국인터넷방송통신학회 논문지 Vol.21 No.4

스트립 바이너리는 디버그 심볼 정보가 삭제된 바이너리이며, 역공학 등의 기법을 통한 바이너리 분석이 어렵다. 기존의 바이너리 분석 툴은 디버그 심볼 정보에 의존하여 바이너리를 분석하기 때문에 이러한 스트립 바이너리의 특징이 적용된 악성코드를 감지하거나 분석하는데 어려움이 있다. 이러한 문제를 해결하기 위해 스트립 바이너리의 정보를 효과적으로 추출할 수 있는 기술의 필요성이 대두되었다. 본 논문에서는 바이너리 파일의 바이트 코드가 컴파일러 버전, 최적화 옵션 등에 따라 매우 상이하게 생성된다는 점에 착안하여 효과적인 컴파일러 버전 추출을 위해 스트립 바이너리 대상으로, 전체 바이트 코드를 읽어 이미지화 시킨 후 이를 합성곱 신경망에 적용, 정확도 93.5%을 달성하여 스트립 바이너리를 기존보다 더욱 효과적으로 분석할 수 있는 계기를 제공한다. The strip binary is a binary from which debug symbol information has been deleted, and therefore it is difficult to analyze the binary through techniques such as reverse engineering. Traditional binary analysis tools rely on debug symbolic information to analyze binaries, making it difficult to detect or analyze malicious code with features of these strip binaries. In order to solve this problem, the need for a technology capable of effectively extracting the information of the strip binary has emerged. In this paper, focusing on the fact that the byte code of the binary file is generated very differently depending on compiler version, optimazer level, etc. For effective compiler version extraction, the entire byte code is read and imaged as the target of the stripped binaries and this is applied to the convolution neural network. Finally, we achieve an accuracy of 93.5%, and we provide an opportunity to analyze stripped binary more effectively than before.

지르코니아 표면 가공에 따른 상변이

이정수,심정석,정형호,Lee, Jung-Soo,Shim, Jeong-Seok,Jung, Hyung-Ho 대한치과기공학회 2010 대한치과기공학회지 Vol.32 No.2

Purpose : This study aimed to find out the effects of treatments on the surface of Zirconia. Methods : To this end, we selected six treatments that have been used widely: steam cleaning, 2bar & 6bar sand blasting, grinding by green stone point, grinding by diamond bur, and grinding by diamond bur with water spray. Results : The results of our study showed that monoclinic rate increased from all six treatments. Monoclinic rate varied by treatments, ranged from 0.6% (steam cleaning) to 6.5% (6bar sand blasting). These values from all six treatments were below ISO 13356 standard, which is 25%. Also, we found that two treatments (green stone point and diamond bur) increased roughness of surface of Zirconia. Conclusion : This study concluded that phase changes of Zirconia were not significant by using six treatments we employed.

'춘광' 배추의 준고랭지 여름철 재배 방법에 따른 생육과 저장 특성

이정수,Lee, Jung-Soo 한국포장학회 2021 한국포장학회지 Vol.27 No.1

고온기 준고랭지에서 재배한 배추의 생육과 저장에 미치는 영향을 구명하고자 하였다. '춘광' 배추를 홍천에서 재배 방법(노지 및 시설 재배)에 따른 생육 특성과 수확 후 저장 시 특성을 조사하였다. 수확 후 생육은 시설 재배한 배추가 생체중과 엽두께에서 노지 재배와 차이를 보였지만, 가식부인 결구 부분에서는 큰 차이를 보이지 않아, 재배 방법에 따른 생육에 미치는 영향을 언급하기 어려웠다. 준고랭지에서 재배한 '춘광' 배추의 저장 시 생체중이나 정선 손실률, 수분함량 등에서 유의 차이를 보였다. 동일 지역에서 시설과 노지로 재배를 달리한 경우 생체중량이나 정선 손실률은 시설 재배가 변화폭이 더 커서 유의 차이를 보였으며, 수분함량은 다소 낮아지는 것으로 나타났다. 본 연구를 통해 고온기 배추의 수확 후 저장 시 차이가 나타났음을 확인하고, 수확 전 요인이 저장까지 영향을 미치는 유기적인 관계를 확인하였다. 농산물에 대한 생산성 위주의 연구가 주류를 이루었으나, 앞으로는 생산뿐만 아니라 저장 동안의 영향을 확인 할 필요가 있다. This experiment was conducted to determine the effects of the pre- and post-harvest variable factors on the processed product of kimchi cabbage cultivated in semi-highland at summer time. Kimchi cabbage cultivar 'Chun Gwang' was grown in an open field and/or under a plastic greenhouse condition; it was stored at 0? after harvesting with low-density polyethylene (LDPE) film packaging. The pre-harvest characteristics growth parameters, fresh weight, head weight, no of leaves, leaf thickness, firmness, moisture content etc. were evaluated. The evaluated postharvest characteristics were fresh weight loss, appearance, trimming loss, SPAD value, moisture content and hue angle. The results show that the fresh weight and leaf thickness were higher in 'Chun Gwang' kimchi cabbages grown in the greenhouse than those in the field. However, the other evaluated factors were not affected by the type of cultural method. During the storage, the cabbage continued to decrease in fresh weight loss, trimming loss and moisture content. When compared to the kimchi cabbage showed significant difference in the fresh weight loss, trimming loss and moisture content during storage. It was confirmed that both cultural methods indoor- and outdoor did not show head growth parameters of 'Chun Gwang' kimchi cabbages on semi-high land at summer time. Although no difference in the growth before storage was observed, the evaluated characteristics like fresh weight loss etc. were influenced by cultural method as a pre-harvest factor. This study suggests that there were to be affected by pre-harvest factor during storage after harvest. In this study, an integrated management system combining relationship between processed agricultural products and their pre- and post-harvest factors.

전통민속마을 소방방재 기본구상 - 아산 외암민속마을을 중심으로 -

이정수,이왕기,오규형,신교영,권흥순,Lee, Jeong-Soo,Lee, Wang-Kee,Oh, Kyu-Hyung,Shin, Kyo-Young,Kwon, Heung-Soon 한국건축역사학회 2010 건축역사연구 Vol.19 No.1

This research has set up the fire protection and early suppression plan for Asan Oeam folk village which is composed of traditional wooden building instinct or complex. The results of this study are as follows. 1. The traditional wooden buildings require attentive considerations about the fire property of the Waga and the straw roofed house. Especially, as the straw roofed house has property that the transfer and development of the fire is fast. Therefore we studied on the transferring possibilities of the fire dangerous instinct through measuring the distance from of the eaves edge and trees in neighboring house. 2. This research proposes the tools for the priority protective building through consideration of fire risk and cultural priority because the fire prevention for all is impossible at the same time. 3. The most important thing is preserve the cultural identities of traditional folk village in establishing the fire hydrant and fire prevention facilities. Traditional folk village landscape should be considered.

포장과 저장온도가 '백다다기' 오이 선도에 미치는 영향

이정수,김기빈,김하연,정다혜,최다경,채예림,박미희,장민선,홍윤표,Lee, Jung-Soo,Kim, Gibin,Kim, Hayeon,Jeong, DaHye,Chei, Da Kyoung,Chea, Ye Rim,Park, Me Hea,Jang, Min Sun,Hong, Yuun Pyo 한국포장학회 2021 한국포장학회지 Vol.27 No.2

The evaluation of package temperature for fresh preservation of cucumber was investigated. The fresh cucumber is available in markets of Korea during whole seasons, for the help of farmer, distributor and consumer. Cucumbers were stored within cardboard boxes packaging covered with low density polyethylene (LDPE) at different temperatures (5, 10, 15 and 20℃). Changes in weight loss, hue angle, firmness, moisture content and general appearance (shape of cucumber) were investigated during storage of cucumbers. General appearance index with non-packaging decreased more than with LDPE film packaging at 5℃ and 10℃. During storage of cucumbers, general appearance index as freshness showed packaging effect at low temperature than room temperature. In the fresh weight loss, the packaged cucumbers were less reduced than that of the non-packaging ones. At color change, Hue angle of cucumber stored within low temperature with film packaging decreased gradually during storage. However remarkable change in hue angle were observed in cucumber within LDPE film packaging treatments of 15℃ and 20℃ storage. The effect of hue angle with packaging appears differently depending on the storage temperature conditions. The firmness and moisture content of cucumber flesh were not affected by packaging and storage temperature. In this experiment, cucumbers packaged with LDPE film at 5℃ and 10℃ were the most desirable for extending the quality. These results suggest that packaging of low temperature treatments in combination could be effective in prolonging the shelf life of cucumber.