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이인경,윤봉식,김종평,정성현,심규섭,유익동,Lee, In-Kyoung,Yun, Bong-Sik,Kim, Jong-Pyung,Chung, Sung-Hyun,Shim, Gyu-Seop,Yoo, Ick-Dong 한국생약학회 1998 생약학회지 Vol.29 No.3
Seven antioxidative compounds were isolated from chloroform and ethyl acetate extracts of the stem bark of Eucalyptus globulus (Myrtaceae). They were identified as rhamnazin (1), rhamnetin (2), naringenin (3), eriodictyol (4), quercetin (5), taxifolin (6) and dihydrokaempferol-3-rhamnoside (7) on the basis of various spectroscopic analyses. These compounds inhibited lipid peroxidation with $IC_{50}$ values of 0.08-30 ${\mu}g/ml$.
이인경,유인자,정동호,한규훈,윤봉식,유익동,Lee, In-Kyoung,Ryoo, In-Ja,Choung, Dong-Ho,Han, Kyou-Hoon,Yun, Bong-Sik,Yoo, Ick-Dong 한국생약학회 1997 생약학회지 Vol.28 No.3
Hibiscus syriacus L. (Malvaceae) is widely distributed over Korean, China, India and Siberia. The dried flower of Hibiscus syriacus is used as a folk medicine for curing of hematochezia, dysentery, obstruction due to wind-phlegm, regurgitation, and vomiting of food, and the dried root bark is used antipyretic, anthelmintic and antifungal agents. From a chloroform extract of root bark of this plant, compound I, II, and III were isolated and the structures were elucidated by various spectroscopic analyses. These compounds were identified as syringaresinol. E-N-feruloyltyramine, and Z-N-feruloyltyramine, respectively and were isolated from this plant for the first time. Compound II and III exhibited lipid peroxidation inhibitory activities with $IC_{50}$ of 15.5 and 28.6 ${\mu}g/ml$, respectively.
꾸지 뽕나무로부터 분리한 flavonoid 계 화합물의 암세포성장 저해 및 항산화 활성
이인경(In Kyoung Lee),송경식(Kyung Sik Song),김창진(Chang Jin Kim),김환묵(Hwan Muk Kim),오구택(Goo Taeg Oh),유익동(Ick Dong Yoo) 한국응용생명화학회 1994 Applied Biological Chemistry (Appl Biol Chem) Vol.37 No.2
Five cytotoxic and antioxidative flavonoids were isolated from the stem bark of Cudrania tricuspidata by consecutive purification using HP-20, silicagel and prep-HPLC. They were identified as taxifolin, orobol, eriodictyol, dihydrokaempferol and steppogenin by means of spectral studies. The antioxidative activities (IC_(50)) assayed by TBA method of these compound 1∼5 to were 6, 3, 3, $gt;50, and 10 ㎍/㎖, respectively. The effect on the growth inhibition (IC_(50)) of these compounds against P388 cell line were found to be 0.18, 3.3, 15 and 6.2 ㎍/㎖, respectively in the order of compound 2 to 5.
근치적 위절제술을 받은 위암 환자의 수술 시기별 체중, 불안, 우울과 삶의 질과의 관계
이인경(Lee, In Kyoung),최자윤(Choi, Ja Yun) 대한종양간호학회 2014 Asian Oncology Nursing Vol.14 No.4
Purpose: The purpose of this study was to identify the relationship of quality of life (QoL) with body weight, anxiety, and depression according to perioperative period. Methods: Data were secondarily analyzed from 30 gastric cancer patients. Results: There were positive relationships of anxiety with depression (r=.42, p=.019) and appetite symptoms of QoL (r=.41, p=.023) at preoperative day one. There were negative relationships of body weight with physical function of QoL (r=-.40, p=.026), and positive relationships of anxiety with depression (r=.37, p=.044) and constipation symptom of QoL (r=.38, p=.034) at postoperative day 7. Also, at postoperative one month, there were positive relationships of body weight with physical function (r=-.45, p=.011) and constipation symptom (r=.37, p=.039). There was a negative relationship of anxiety with emotional function (r=-.39, p= .035), a negative relationship of depression with physical function (r=-.43, p= .018), and a positive relationship of depression with finance (r=.39, p=.034). Conclusion: Oncology nurses should consider diverse factors during the early postoperative period to increase QoL. Also, appropriate and timely interventions should be provided to minimize the negative influence on QoL.
기와층버섯 추출물의 항비만활성, 항암활성 및 단회경구독성시험
강은희(Eun-Hee Kang),이인경(In-Kyoung Lee),황미현(Mi-Hyun Hwang),최재영(Jae-Young Choi),창즐치앙(Zhi-Qiang Chang),이만휘(Man-Hee Rhee),윤봉식(Bong-Sik Yun),강성철(Cheng-Zhe Jiang),김길수(Kil-Soo Kim),박승춘(Seung-Chun Park) 한국독성학회 2007 Toxicological Research Vol.23 No.3
In this study, we investigated the in vitro anti-obesity, anti-cancer activity and single oral dose toxicity of Inonotus xeranticus extracted by methanol (INXM) or ethyl acetate (INXE). In order to investigate anti-obestity effect of Inonotus xeranticus extracts, the 3T3-L1 cells were treated with these extracts at various concentrations(1, 10, 100 and 300 ㎍/㎖). It was observed that 3T3-L1 cells treated with 100 ㎍/㎖ of Inonotus obliquus ethyl acetate extract (INOE), INXM and INXE, in the absence of differentiation cocktail (0.5 mM isobutylmethylxanthine (IBMX) 1 μM dexamethasone, 1 ㎍/㎖ insulin), differentiated at a rate of 78.5, 80.9, and 76.4% respectively. Differentiation rates of 86.6% and 83.4% were observed in 3T3-L1 cells which were treated with differentiation cocktail at 100 ㎍/㎖ of INXM and INXE, respectively. The anti-cancer effect of Inonotus xeranticus extracts was investigated using a method of sulforhodamine B in sarcoma 180 cell line. The cells were treated with these extracts (1, 10, 100 and 300 ㎍/㎖) for 48 hours. The growth of cells which were treated with 300 ㎍/㎖ of INXM was inhibited by 80.1%. The growth of sarcoma 180 cells which were treated with 100 and 300 ㎍/㎖ of INXE was inhibited by 74.7% and 64.5%, respectively. In single oral dose toxicity study, no differences were observed between control and treated groups in clinical signs, body weight gains, and feed and water consumptions. The results indicated that Inonotus xeranticus extracts did not show any toxic effects at 2,000 ㎎/㎏ in mice, and the LD?? of these extracts was found to be higher than 2,000 ㎎/㎏ in this experiment. From the above results, Inonotus xeranticus methanol and ethyl acetate extracts might have useful clinical applications in the management of cancer and obesity and may also be useful as a medicinal food.
장병태(Byung-Tae Jang),이인경(In-Kyoung Lee),황치정(Chi-Jung Hwang) 한국정보과학회 1996 정보과학회논문지 : 시스템 및 이론 Vol.23 No.4
공간 자료를 분석하는 기본 도구인 등치선도를 자동적으로 생성하는 알고리즘을 제안한다. 정규 격자 자료에 적용되는 본 알고리즘은 한 단위 격자를 4개의 꼭지점과 중심점에 의해 나뉘어진 8개의 선분으로 구성된 사각형으로 정의하여 사용한다. 그리고자 하는 등치선의 레벨값이 단위 격자의 4꼭지점에 할당된 격자 값과 각각 같지 않다고 가정하면 통과 등치선은 한 단위 격자의 8개의 선분 중 오직 3-6개의 선분과 만나고 이 결과로 한 단위 격자에서 발생 가능한 등치선의 유형은 7개의 유형으로 분류 가능하다. 한 단위 격자를 통과하는 등치선의 유형을 고정시킴으로써 단위 격자 내에서 발생할 수도 있는 등치선의 교차점 연결에 따른 모호성을 해결하고 알고리즘을 단순화시킬 수 있다. 제안된 알고리즘을 여려 종류의 자료 형태에 대해 실험한 결과 기존의 상용 소프트웨어에 비해 오차율이 적고 자료에 대한 적응성(flexibility)이 양호함을 증명하였다. This study presents algorithm to automatically generate a contour map which is a basic tool for analyzing the spatial data. This algorithm, which is designed for the regular grid data, operates on a subgrid with the 8 edges which consist of the lines connecting four nodes and the center point. It is recognized and proved that a contour line intersects 3~6 edges in a subgrid, if we have the constraint that the contour line value is not equal to each of the four node-values, and as the result, the crossed contour line patterns in a subgrid are classified by 7 possible cases. Based on these contour line patterns, this algorithm can solve the ambiguous connection problem for intersection points. The algorithm is validated and tested on a number of possible data sets.