배양(培養)된 혈관(血管) 내피세포(內皮細胞)에서 산화성(酸化性) 세포(細胞) 손상(損傷)에 미치는 성향정기산(星香正氣散)의 보호(保護) 효과(效果)

이동언,김영균,Lee Dong-Uhn,Kim Young-Kyun 대한한의학방제학회 2000 大韓韓醫學方劑學會誌 Vol.8 No.1

Reactive oxygen species (ROS) play an important role in the pathogenesis of a variety of life threatening conditions such as atherosclerosis, myocardial infarction and cerebral stroke. In this study, the effect of Sunghyangchungisan (SHCS) as a cytoproctant against ROS-induced cell injury was studied by investigating its effect on $H_{2}O_2-induced$ cell injury in cultured endothelial cells derived from the human umbilical vein. SHCS effectively proteced the cells against $H_{2}O_2-induced$ injury determined by trypan blue exclusion ability and lactate dehydrogenase (LDH) release. The effect of SHCS was concentration-dependent and the concentrations to inhibit by 50% the cell death and LDH release were $0.9{\pm}0.1$ and $1.2{\pm}0.1\;mg/ml$, respectively. In addition, SHCS effectively protected the cells against t-butylhydroperoside- and menadione-Induced injury as well. SHCS inhibited lipid peroxidation determined by malondialdehyde production. SHCS exerted as an effective scavenger of ROS produced by exposing the cells to $H_{2}O_2$ The activities of the intracellular ROS scavenging enzymes such as superoxide dismutase, catalase and glutathione peroxidase were not Influenced by SHCS.These results indicate that SHCS might exert as an effective cytoprotectant against ROS-induced cell injury. Further intensive studies would provide us insights into mechanisms of the pharmacological actions of SHCS.

비평 - 부산기장보건소

이동언,Lee, Dong-Eon 대한건축사협회 1999 建築士 Vol.1999 No.9

세계, 사인(Sign) 그리고 건축 - 개념적 건축과 창조적 건축의 구분을 위한 시도 -

이동언,Lee, Dong-Eon 한국건축역사학회 1995 건축역사연구 Vol.4 No.2

The main aim of the paper is to reveal what is the sign in art and architecture and what is difference between technology and art. By keeping in mind the suggestions of Heidegger's four different worlds, we become able to discern or elaborate on four different contexts of signs and modes in which the sign can work. World (1) is not conceptualized by selected relations of some of things' aspects with one another; rather, it is constructed by our sensory impressions. The sign of World (1) simply points to other objects occurring in the situation. World (2) emerges as an ontological term, and signifies, in terms of relations that are now brought systematically forth, the Being of those entities of World (1) which we naively perceive or take for granted. The sign of World (2) signifies a constructed world. World (3) is understood as the 'wherein' or environment of beings whose total activity is proven to be inseparable from their circumstances. The sign of World (3) is to recover the perspicuous silence of World (3). The World (4) is the ontological-existential understanding of worldhood. The sign of World (4) is to reveal the conspicuous silence of World (4). Finally, the paper suggests that art including architecture cannot be the sign of World (1), (2) but the one of World (3).

금은화(金銀花) 및 금은화전초(金銀花全草)가 Raw 264.7 cell에서 LPS로 유도된 NO의 생성, iNOS, COX-2 및 cytokine에 미치는 영향

이동언,이재령,김영우,권영규,변성희,신상우,서성일,권택규,변준석,김상찬,Lee, Dong-Eun,Lee, Jae-Ryung,Kim, Young-Woo,Kwon, Young-Kyu,Byun, Sung-Hui,Shin, Sang-Woo,Suh, Seong-Il,Kwon, Taeg-Kyu,Byun, Joon-Seok,Kim, Sang-Chan 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.2

Lonicerae Flos has antibacterial effects against Staphylococcus aureus, streptococci, pneumococci, Bacillus dysenterii, Salmonella typhi, and paratyphoid. It is an antiviral agent. The herb has a cytoprotective effect against $CCl_{4}-induced$ hepatic injury. It has antilipemic action, interfering with lipid absorption from the gut. Nowadays this herb is used mainly in the treatment of upper respiratory infections, such as tonsillitis and acute laryngitis. It is also used in the treatment of skin suppurations, such as carbuncles, and to treat viral conjunctivitis, influenza, pneumonia, and mastitis. Lonicerae Flos is dried flower buds of Lonicera japonica, L. hypoglauca, L. confusa, or L. dasystyla. But, for the most part, we use whole plant of Lonicera japonica, as a flower bud of it. And, little is known of the original copy of effects of whole plant, except for the 'Bon-Cho-Gang-Mok', which is written the effects of flower of Lonicera japonica are equal to effects of leaves and branch of it. The present study was conducted to evaluate the effect of flower and whole plant of Lonicera japonica on the regulatory mechanism of cytokines, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) for the immunological activities in Raw 264.7 cells. In Raw 264.7 cells stimulated with lipopolysaccharide (LPS) to mimic inflammation, flower and whole plant of Lonicera japonica water extracts inhibited nitric oxide production in a dose-dependent manner and abrogated iNOS and COX-2. Flower and whole plant of Lonicera japonica water extract did not affect on cell viability. To investigate the mechanism by which flower and whole plant of Lonicera japonica water extract inhibits iNOS and COX-2 gene expression, we examined the on phosphorylation of inhibitor ${\kappa}B{\alpha}$ and assessed production of $TNF-{\alpha}$, $interleukin-1{\beta}$ $(IL-1{\beta})$ and interleukin-6 (IL-6). Results provided evidence that flower and whole plant of Lonicera japonica inhibited the production of $IL-1{\beta}$, IL-6 and activated the phosphorylation of inhibitor ${\kappa}B{\alpha}$ in Raw 264.7 cells activated with LPS. These findings suggest that flower and whole plant of Lonicera japonica can produce anti-inflammatory effect, which may play a role in adjunctive therapy in Gram-negative bacterial infections, respectively.

맥락주의를 건축이론화 하기 위한 시도(1)

이동언,Lee, Dong-Eon 한국건축역사학회 1999 건축역사연구 Vol.8 No.2

The purpose of this paper is to apply Stephen C. Pepper's contextualism to architecture: to interpret the former in the light of architectural theory, and ultimately to liberate architecture from the Western 'Idea' and return it to its context. The major concepts of Pepper used in the paper are quality, texture, spread, change, fusion, strand and context. Pepper's contextualism makes us realize that architecture cannot be separated from its context where human beings, history, neighborhood, and nature are all interpenetrating, and create a quality. Contextualism thus teaches us to make an effort to understand the region where we belong, and to create an architectural device that interrelates form and function of an architecture with its space-time environment, or its strand, texture and context.

우리건축의 기본방향설정을 위한 현상학적 탐색

이동언,Lee, Dong-Eon 한국건축역사학회 1999 건축역사연구 Vol.8 No.3

The purpose of this phenomenological inquiry is to suggest a positive direction for Korean architecture to pursue. In order to have the inquiry, we need Heidegger's term, 'World 3.' To discuss works of art and architecture as created is also to discuss such works as creative, that is, as realities which add themselves to the creativity of a world which is never complete except by our going with the venture of creativity, which is in Heidegger's term World 3. Through it, our ground is transformed into an ever changing but ever self-recovering World. If all of this has any fundamental significance for architecture and if this significance cannot be neglected in favor of other considerations, the work of architecture does not enter into the world as a thing of abstraction or concept. Rather, as a venture, as a tension of the 'World 3,' the work of architecture constantly brings about the transformable truth of the world.

백삼의 건조와 가용성 성분 추출에 미치는 pulsed electric fields(PEF)의 효과

임정호(Jeong Ho Lim),심재민(Jae Min Shim),이동언(Dong Un Lee1),김영호(Young Ho Kim),박기재(Kee-Jai Park) 한국식품과학회 2012 한국식품과학회지 Vol.44 No.6

식품의 가공공정에서 투입되는 에너지의 절감을 위한 방안으로 대표적이 농산물 건조제품인 인삼의 건조과정에서 PEF를 처리함으로써 건조효율에 미치는 영향과 PEF를 처리하여 건조한 인삼인 백삼의 열수 추출과정에서의 추출효율에 미치는 영향을 분석하였다. 4년근 수삼을 2 kV/cm, 200 Hz, 7초의 조건으로 PEF를 처리하여 55±1℃에서 건조한 결과 건조시간을 약 38% 단축시킬 수 있는 결과를 얻었다. 건조한 백삼을 95±1℃로 추출한 결과 무처리에 비해 2 kV/cm, 25 Hz, 7초간 PEF 처리한 건조 백삼, 2 kV/cm, 200 Hz, 7초간 PEF 처리하여 건조한 백삼의 열수 추출물의 고형분 함량, 환원당 함량, 유리당 함량 등에서는 유의적인 차이를 나타내었으나 당도와 진세노사이드 함량에서는 부분적인 유의적 차이만을 나타내었다. 이러한 결과를 감안할 때 수삼에 PEF를 처리함으로써 건조시간을 효과적으로 단축시킬 수 있고 추출시에도 가용성 고형분의 추출시간을 단축할 수 있는 유용한 수단이 될 수 있을 것으로 판단된다. This study was designed to investigate the effect of pulsed electric fields on the drying of ginseng and extraction of dried ginseng to reduce energy-consumption. Fresh ginseng was treated in a PEF system of 1 and 2 kV/cm electric field strength, 25 and 200 Hz of frequency, 30 μs of pulse width and pulse number of 175. The samples were subsequently dried for 26 h at 55±1℃, and the characteristic of hot-water extraction on dried ginseng was investigated. The ginseng pretreated with an intensity of 2 kV/cm (200 Hz, n=175) resulted in a reduction of approximately 38% for drying time. The influence of PEF treatment on the water extraction of dried ginseng at 95±1℃ was also investigated. The application of an electric field intensity of 2 kV/cm (25 and 200 Hz, n=175) increased soluble solid content, significantly reducing sugar content and free sugar content of the extract compared to non-PEF-treated samples.

하이브리드 로켓 시스템을 이용한 농후연소 가스발생장치

이동언(Dongeun Lee),이설하(Sulha Lee),이창진(Changjin Lee) 한국추진공학회 2014 한국추진공학회 학술대회논문집 Vol.2014 No.5

후방연소 하이브리드는 기존 하이브리드와 비슷한 연소과정을 가지고 있지만, 1차 연소에서 농후연소 가스를 생성하며 여기에 추가적으로 (2차적으로) 들어오는 산화제와 2차 연소를 하는 과정을 갖는다. 본 연구는 1단계 목표인 하이브리드 시스템을 적용한 농후 연소 가스 생성이다. 기존 연구들을 바탕으로 당량비 3 이상, 가스온도 1500 K 이하를 목표범위로 설정하였다. 그리고 연료 길이, 연료포트 지름, 연료 타입, 산화제 타입을 바꿔가며 당량비에 영향을 미치는 인자를 실험을 통해 확인하였다. 결과적으로, PMMA연료와 본 실험 조건으로는 최대 당량비 1.69, 가스온도 1970 K 인 농후 연소 가스를 생성하였다. Afterburner hybrid has similar combustion process as classical hybrid, but generating fuel-rich gas and additional oxidizer is added in an afterburning combustion chamber. The main objective of current study is to demonstrate and evaluate the performance improvement comparing to classical hybrid. To do this, first goal is to generate fuel-rich gas with hybrid rocket system with target equivalence ratio of 3 or larger and gas temperature of less than 1500 K, which based on formal studies related to fuel-rich gas generator. To make fuel-rich gas, this study performed tests with different equivalence ratio affecting parameters such as fuel length, fuel port diameter, fuel type and oxidizer type. As a result, with use of PMMA fuel and limitation of experimental set-up, maximum equivalence ratio of 1.69 and gas temperature of 1970 K are presented.

저장 온도 및 상대습도가 비타민 정제 중 수용성 비타민 함량의 변화에 미치는 영향

이재황(Jae-Hwang Lee),김세곤(Sae-Gon Kim),이동언(Dong-Un Lee),박석준(Seok-Jun Park),이진희(Jin-Hee Lee),이강표(Kang-Pyo Lee),김동섭(Dong-Seob Kim),최성원(Sung-Won Choi),백무열(Moo-Yeol Baik) 한국식품과학회 2005 한국식품과학회지 Vol.37 No.6

초고압을 이용한 신선초 녹즙의 살균 및 갈색화 효소의 불활성화

이동언(Dong-Un Lee),박지용(Jiyong Park),이윤범(Yunbom Lee),여익현(Ick-Hyun Yeo) 한국식품과학회 1995 한국식품과학회지 Vol.27 No.6