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7, 12-dimethylbenz[a]anthracene(DMBA)로 유발된 햄스터 협낭암에서 chlorophylln의 암예방효과에 관한 실험적 연구
윤규호(Kyu Ho Yoon) 대한구강악안면외과학회 2000 대한구강악안면외과학회지 Vol.26 No.2
Carcinogenesis is a multi-stage process that generally consists of at least three steps; initiation, promotion, and progression. If one of these carcinogenic steps were suppressed or delayed, the cancer could be prevented. Cancer chemoprevention is defined to be inhibition or reversal of the carcinogenic process by the specific chemical agents and is a novel approach to cancer management alternative to conventional chemotherapy. Chlorophylln(CHL), a water-soluble derivative of chlorophyll, containing sodium and copper, has been known to be strong antimutagen in several test systems, but its mechanism of antimutagenic action is unknown. In the present experiment, the possibility of CHL as chemopreventive drugs on 7,12-dimethylbenz[a]anthracene(DMBA)-induced hamster buccal pouch carcinogenesis was investigated by mutagenicity test, carcinogenicity test, and frequency or spectrum of H-ras mutations in the both of DMBA-induced and chlorophylln-pretreated-DMBA induced tumor by polymerase chain reaction and non-isotopic restriction fragment length polymorphism. The treatment of CHL reduced the yields and multiplicity of the 0.5% DMBA-induced tumor, 86% to 62.5% and 3.7±0.6 to 1.4±0.3, respectively. The occurrence of histidine revertant by 20μmole DMBA was inhibited 25.6 to 81.7% by 1 to 5μM CHL in a dose-dependent manner. The mutation rates of H-ras gene in DMBA-induced and CHL-pretreated-DMBA induced tumor were 96%, 94% of which the most mutations were in codon 12/13. These results suggest that CHL inhibits the carcinogenic action of DMBA by the formation of complex between CHL and DMBA or the inhibition of the activation of DMBA in vivo. But CHL did not affect the mutation rates or its spectrum in already formed tumor.
한지훈(Ji-Hoon Han)윤규호(Kyu-Ho Yoon),정정권(Jeong-Kwon Cheong),배정호(Jung-Ho Bae),이설옥( Hsueh-Yu Li),오영일(Young-Il Oh),신재명(Jae-Myung Shin),백지선(Jee-Seon Baik),박관수( Kwan-Soo Park) 대한구강악안면외과학회 2011 대한구강악안면외과학회지 Vol.37 No.6
Synovial sarcoma (SS) is a malignant soft tissue tumor comprising 5-10% of all soft tissue sarcomas. This tumor normally occurs in the paraarticular regions of the extremities but is rare in head and neck sites. SS is sometimes difficult to diagnose because it can mimic benign lesions both clinically and radiologically. This paper presents a rare case of a SS of the buccal space of a 25-year old man. The histology examination and immunohistochemistry of the mass led to a diagnosis of synovial sarcoma. The patient was treated primarily with a surgical resection, followed by radiotherapy and chemotherapy. The follow up examination 17-months after surgery showed no signs of tumor relapse or metastasis.
나혜정,윤규호,정정권,배정호,김해린,조규홍,신재명,백지선,Na, Hye-Jung,Yoon, Kyu-Ho,Cheong, Jeong-Kwon,Bae, Jung-Ho,Kim, Hae-Lin,Jo, Kyu-Hong,Shin, Jae-Myung,Baik, Jee-Seon 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.4
Sialolithiasis is the most commom disease of salivary gland. The main symptoms are pain and swelling of the involved gland during eating. It can occur at any age but patients in their third to fifth decade present most cases. Males are more frequently affected than females. Most sialoliths are located within the duct system of the submandibular gland. Submandibular sialoliths close to the hilum of the gland tend to become large and ovoid shape, whereas sialoliths in the duct tend to be elongated. Commonly, sialoliths measure from 1 mm to less than 10 mm, and larger than 15 mm are considered rare. In one case we have removed a giant sialolith which was located in a wharton's duct and in the other case we have removed multiple sialolith including a giant sialolith which were also located in a Wharton's duct. We report these 2 cases with literature reviews.
최민혜,윤규호,정정권,박관수,신재명,김해린,나혜정,Choi, Min-Hye,Yoon, Kyu-Ho,Cheong, Jeong-Kwon,Park, Kwan-Soo,Shin, Jae-Myung,Kim, Hae-Lin,Na, Hye-Jung 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.3
Solitary fibrous tumor (SFT) is a neoplasm that arises most commonly in pleura. Although SFT occasionally occurs in extrapleural locations, the incidence in the oral cavity is rare. SFT is benign in almost cases and surgical excision is the effective treatment. SFT occurred in the left cheek of a 60-year-old man presented with a painless submucosal mass. The tumor was surgically removed. Immunohistochemical study showed that tumoral cells were negative for SMA, S-100, but positive for Bcl-2, CD34. SFT is easily over-diagnosed if strict criteria are not carefully applied, and strict diagnostic criteria are necessary to avoid confusion of SFT with more aggressive lesions.
최문경,윤규호,박관수,정정권,신재명,백지선,박지현,Choi, Mun-Kyung,Yoon, Kyu-Ho,Park, Kwan-Soo,Cheong, Jeong-Kwon,Shin, Jae-Myung,Baik, Jee-Sun,Park, Ji-Hyun 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.5
Angiomyoma is the vascular type of leiomyoma that the tumor cells are originated from vascular smooth muscle cells. It's frequently found in the subcutaneous tissues of the lower extremities. Such case of an angiomyoma within the oral cavity is rarely found. From a series of 7748 smooth muscle tumors of all types, only 0.06% were found in the oral cavity. This is a rare case of a young woman appeared with oral angiomyoma located in the left mandibular posterior region with plain radiograph, CT and histologic review.
배정호,윤규호,박관수,정정권,신재명,홍성철,Bae, Jung-Ho,Yoon, Kyu-Ho,Park, Kwan-Soo,Cheong, Jeong-Kwon,Shin, Jae-Myung,Hong, Sung-Chul 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.1
Mucoepidermoid carcinoma is one of the most common malignant salivary gland neoplasm. It occurs over a wide age range, and is most common in the parotid gland and usually appears as an asymptomatic swelling. Pain or facial nerve palsy may develop. Minor salivary gland tumors also typically appear as asymptomatic swellings, which are sometimes fluctuant and have blue or red color that can be mistaken clinically for a mucocele. Histopathologically the mucoepidermoid carcinoma is composed of a mixture of mucous-producing cells and squamous (epidermoid) cells. Low-grade tumors show prominent cyst formation, minimal cellular atypia, and relatively high proportion of mucous cells. Mucoepidermoid carcinoma of the minor salivary glands are treated usually by assured surgical excision. For low-grade neoplasm, only a modest margin of surrounding normal tissue may need to be removed, but high-grade or large tumors warrant wider resection. Postoperative radiation therapy also may be used for more aggressive tumors. Mucoepidermoid carcinoma of the oral minor salivary glands generally have a good prognosis, because they are mostly low-to intermediate grade tumors. We present a case of mucoepidermoid carcinoma managed with surgical enucleation and postoperative irradiation and a good clinical result with review of literatures.
양측성으로 하악골에 순차적으로 발생한 방사선골괴사증: 증례보고
김해린,윤규호,박관수,정정권,배정호,권준,박군찬,신재명,백지선,Kim, Hae-Lin,Yoon, Kyu-Ho,Park, Kwan-Soo,Cheong, Jeong-Kwon,Bae, Jung-Ho,Kwon, Jun,Park, Gun-Chan,Shin, Jae-Myung,Baik, Jee-Seon 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.3
Radiation therapy for malignancy of head and neck leads to secondary effects, such as mucositis, xerostomia, dental caries and osteoradionecrosis. Osteoradionecrosis is a delayed complication which causes chronic pain, infection and constant deformity after necrosis. It occurs spontaneously or after primary oncologic surgery, dental extraction or by trauma of prosthesis. To reduce the incidence of osteoradionecrosis, appropriate antibiotic usage, atraumic procedure, tension-free primary suture and hyperbaric oxygen therapy are essential. This case is about a 74 years old woman who was treated for osteoradionecrosis after extraction of right lower molar at year 2006. She had received radiation therapy for angiosarcoma on tongue at year 2004. At year 2008 the patient came to our hospital for extraction of the opposite premolar but despite careful treatment, osteoradionecrosis occurred again. She was successfully treated by surgical procedure so we report this case.
김현우,윤규호,박관수,정정권,반재혁,유명수,Kim, Hyun-Woo,Yoon, Kyu-Ho,Park, Kwan-Soo,Jung, Jung-Kwon,Ban, Jae-Hyurk,You, Myung-Soo 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.1
함치성낭종은 병소의 크기 및 인접 구조물과의 관계 등에 따라 개창술 및 적출술, 감압조대술 등 여러 방법으로 치료할 수 있다. 본 증례에서는 여러 함치성낭종의 치료를 위해 감압조대술 시행하였고, 수술 후 낭종 내부에 매복된 미성숙 영구치는 병소의 크기가 줄어듦에 따라 모두 정상 맹출하였다. 또한 하악 제3대구치를 포함하는 광법위한 크기의 함치성낭종에 소파술을 동반한 감압조대술을 시행한 결과, 낭막의 악성변이가 발견되었음에도 불구하고 인접 구조물의 손상 없이 이상적인 치료 결과를 얻었다. 감압조대술은 광범위한 병소의 적출 시 야기될 수 있는 악골 및 주위 인접 구조물의 손상을 최소화하고, 특히 젊은 환자에서 낭종 내에 포함된 영구치의 보존 및 맹출유도를 위한 가장 적절한 치료법이다. 그러나 수술 후에 지속적인 경과관찰 또한 치료계획에 포함되어야 한다. Dentigerous cyst is one of the most prevalent types of odontogenic cysts in the jaw. Usually dentigerous cysts begin to develope through an accumulation of fluid between remnants of the enamel organ and subjacent tooth crown which is developing or submerged. The teeth most often involved are mandibular third molars, maxillary canines, and mandibular premolars. And the cysts usually occur in the second or third decade of life. The treatment of dentigerous cysts-enucleation, marsupialization, and fenestration-is dictated by the size, environmental structures of the lesion, and desirability of conserving involved tooth. Marsupialization is a conservative technique which allows the reduction or elimination of cystic lesion by making it an accessory compartment of the oral cavity in the case where complete enucleation is not desirable. Marsupialization is thought to be the most suitable method of treatment for the conserving of the involved tooth, thus guiding eruption of it. We report the positive outcome got from marsupialization in dentigerous cysts with review of literature.
하악 구치부에 발생한 Bisphosphonate Related Osteonecrosis of Jaw의 치험례
박재안,윤규호,정정권,배정호,유경하,조규홍,신재명,백지선,Park, Jae-An,Yoon, Kyu-Ho,Cheong, Jeong-Kwon,Bae, Jung-Ho,You, Kyung-Ha,Jo, Kyu-Hong,Shin, Jae-Myung,Baik, Jee-Seon 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.5
Bisphosphonates are synthetic analogue and have high affinity on bone remodeling site. Since they have a long half-reduction time, they accumulate at bone and act for a long time. They are widely used in osteo-porosis derived from imflammatory bowel disease or postmenopausal osteoporosis patient for bone mineral density improvement. In addition, they neutralize hypercalcemia owing to bone metastasis of malignancy. However, a jaw bone necrosis was recently reported in some patients who have taken bisphosphonates for a long time. It is called Bisphosphonate Related Osteonecrosis of Jaws (BRONJ). It can come spontaneous-ly, but more often after oral surgery including tooth extraction. In this case, a 80-year-old woman was treated with bisphosphonate (sodium alendronate) for 2 years to improve bone mineral density. She had her left lower second molar tooth extracted at local clinic. After extraction, she had inflammatory symptoms like a pain, a cheek swelling, and a discharge of pus. She was referred to our clinic for treatment. We treated meticulously from dressing to surgery. After following up about 1.5 years, the jaw lesion was successfully healed. So we report this case.
매복과잉치 및 영구치 동시 발거 후 임플란트의 즉시 식립 증례
권준,윤규호,박관수,정정권,신재명,최민혜,나혜정,Kwon, Jun,Yoon, Kyu-Ho,Park, Kwan-Soo,Cheong, Jeong-Kwon,Shin, Jae-Myung,Choi, Min-Hye,Na, Hye-Jung 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.4
Supernumerary teeth are extra teeth or tooth-like structures which may have either erupted or unerupted in addition to the 20 deciduous teeth and the 32 permanent teeth. Clinicians sometimes confront unerupted supernumerary teeth where implants would be placed. Many clinicians consider immediate placement of implant into an extracted socket as an effective technique compared to the conventional method of waiting several months for bone healing, because of the advantages such as reduction of treatment period, preservation of alveolar bone and soft tissue, etc. We could hardly find the case of immediate placement of implant after extraction of impacted supernumerary teeth and permanent teeth together. Therefore we report the case of immediate implantation following extraction of impacted supernumerary teeth and poor periodontal conditioned permanent teeth.