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유시천,윤찬종 한국패키지디자인학회 2001 상품문화디자인학연구 Vol.10 No.-
From agriculture society to industrial society and currently progressing through information intellectual society, these stages of processes developed into the information technology. Which means it's for different environment than using the Internet communication line to get an information and purchasing products. Due to the information society the Internet became the central axis and human beings more rapid, more convenience, and Electronic Transaction are so brisk that product's Brand-package-Design has become more and more important. In the Electronic Transaction, Brand package design is consider same in general trade, and it's inexpensive way to protect the trade mark and considering distinctiveness that consumers are purchasing through picture which means on line, so that picture image should be updated for trade mark and package and it's the active role of the design following the information society. A successful Electronic Transaction is using the mass media to advertising for publicizing promotion membership, and events which has been considered usual practices but beyond that there's packing which should not be has pass over. Now a boundless development and competition of Electronic Transaction has been in progress repeatedly. In an information society of Twenty-First century. Let's be the best Electronic Transaction era.
임상연구 : 흉부 척추옆블록시 적절한 바늘거치를 위한 해부학적 고찰
유시현 ( Sie Hyeon Yoo ),서환주 ( Hwan Joo Seo ),김천숙 ( Chun Sook Kim ),안기량 ( Ki Ryang Ahn ),강규식 ( Kyu Sik Kang ),정진헌 ( Jin Hun Jung ),천경아 ( Kyung Ah Chun ),김종분 ( Jong Bun Kim ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.2
Background: Thoracic paravertebral blockade (TPVB) can be effective in many clinical settings. However, many clinicians are reluctant to use this technique due to its adverse effects such as pneumothorax. The aim of this study was estimate the appropriate depth and width for safe needle positioning. Methods: The depth from skin to the paravertebral space (PVS) and the width from the spinous process (SP) to the PVS and the lateral tip of the transverse process (LTTP) were measured in all available sections from 84 patients examined by chest computed tomography (CT). The correlation between age, gender, body mass index (BMI) and each measured value was analyzed. Results: All 828 sections from the 84 patients aged between 19 and 65 years old were evaluated. The minimum and maximum values of the mean depth from the skin to PVS were 40.3-52.4 mm in men and 41.2-55.9 mm in women. The minimum and maximum values of the mean width from the SP to LTTP were 29.2-34.6 mm in men and 23.7-31.0 mm in women. At every thoracic level, the depth to PVS was similar in both genders but the width from the SP to the NEP in men was significantly higher than in women. Weight significantly influenced the width from the SP to LTTP in men but height and BMI did not. Also weight and BMI significantly influenced the depth from skin to PVS in almost all of the thoracic region at both sex, but height did not influence the depth from skin to PVS in both sex. Conclusions: We report clinically useful estimates that may be used to help avoid side effects such as pneumothorax and achieve a successful thoracic paravertebral blockade. (Korean J Anesthesiol 2007; 53: 188~93)
신규 건강기능식품소재 ‘EGCG 고함유 녹차추출물(EGTE)’의장기안정성 평가
천세인,허은지,윤민지,최상운,류건식,유시용 한국생약학회 2018 생약학회지 Vol.49 No.4
‘EGCG(epigallocatechin gallate) rich Green Tea extract(EGTE)’ was prepared by a convenient chromatographical manner using water and alcohol which was regarded as the most suitable and appropriate process for food manufacturing. The EGCG content in EGTE was estimated above 97%. Analysis of polyphenol components in green tea, i.e., catechin(C), epigallocatechin(EGC), epicatechin(EC), epigallocatechin gallate(EGCG), epicatechin gallate(ECG) and caffeine was performed by HPLC. The optimized HPLC method exhibited a good linearity of calibration curve, accuracy and precision. The long-term stability evaluation of EGTE was carried out with a powdered formulation and solution formulation by estimating the color change and measuring the EGCG content by HPLC analysis for one year. The EGCG content of the powdered EGTE stored in a transparent bottle at room temperature was retained over 97% at the end of the experimental period. The EGCG content of 0.1% water solution of EGTE stored in a transparent bottle at RT were observed to decrease below 30%, whereas that stored at 2oC retained over 70%, respectively. These results suggested that a powdered formulation could be recommended for the commercialized nutraceutical product of EGTE rather than a solution formulation.
MECHANISM-BASED INHIBITION OF HUMAN CYTOCHROME P450 1A1 BY RHAPONTIGENIN
CHUN, YOUNG JIN,RYU, SHI YONG,JEONG, TAE CHEON,KIM, MIE YOUNG 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Recently we reported that resveratrol (trans-3,4'.5-trihydroxystii-bene) showed seiective inhibition of receomblnant human cytochrome P4550 (P450) 1A1 in a concantration-dependent manner. The inhibirtion of recombinant human P450 1A1, 1A2, or 1B1 by various hydroxystilbene compounds having a similar structure to resveratrol was investigated using bacterial membranes form a huma P450/NADPH-P450 reductase bicistronic expression system to find new candidates for cancer chemopreventlve gagents. O1 seven compounds tested, rhapomtlgenin (3,3^(1), 5-trihydroxy-4^(1) -me- thoxystilbene) exhibited a potent and selective inhibition of human P450-fold selectivity for P450 1A1 over P450 1A2 and 23-fold selectivity for P450 1A1 over P450 1B1. Rhapontigenin did not show any significant inhibition of ethoxyresorufln O-deethylation (EROD) activity in human liver microsomes, the other human P450s such as P450 2E1, P450 3A4, P450 2D6, P450 2C8, and P450 2C9, or human NADPH-P450 reductase. We have further investigated the inhibition kinetics of P450 1A1 by rhapontigenin. Rhapontigenin inhibited EROD activity of expressed human P450 1A1 in a competitive manner. The loss of EROD activity was time- and concentration dependent. The values for K_(1), and K?? were 0.09 ㎛ and 0.06 min^(-1), respectively. The loss was not blocked by the trapping agents gllutathione, N-acetylcysteine, or dlthlothreltol. These results suggest that rhapontigenin is a potent mechanism-based lnactivator or human P450 1A1 and may be considered as a good candidate for a cancer chemopreventive agent in humans.