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원도희,권순미,조미란,남상윤,이범준,윤영원,오기완,한상배,홍진태 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to know the effect of macrophage on human colon cancer cell growth. The results showed that co-culture of colon cancer cells with macrophage inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophage, RAW 264.7 cells as well as activated THP-1 cells accompanied with down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines; IL-1 receptor antagonist (IL-1ra), and IL-10 were increased in macrophages. Blocking of STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished cancer cell growth of colon cancer, and expression of IL-1ra and IL-10. Moreover, neutralization of IL-1ra and IL-10 with antibodies, reversed macrophages-induced cancer cell growth inhibition. These data showed that IL-1ra and IL-10 released from macrophage inhibits colon cancer cell growth through inhibition of STAT3 pathway.