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온영근(Young Keun On),성지동(Ji Dong Sung),김효수(Hyo Soo Kim),김철호(Cheol Ho Kim),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi),서정돈(Jung Don Seo),이영우(Young Woo 대한내과학회 1996 대한내과학회지 Vol.50 No.1
N/A Objectives: Identification of the coronary arterial lesion susceptible to accelerated progression of the atherosclerosis may provide important clinical information in the management of the patients with coronary artery diseases(CAD) or when revascularization procedures are planned especially in patients with multiple coroanry arterial lesions, We performed this study in order to evaluate 1) the changing pattems of coronary artery disease and 2) the possible factors for either progression or regression of the coronary arterial lesion in patients with angina pectors. Methods: 56 patients with angina pectoris who undertook repeated coronary arteriography (CAG) over an interval of 1 year or more were enrolled in the study. Patients who got PTCA, CABG, or thrombolytic therapy were excluded as well as vasospastic angina on initial coronary arteriography. Criteria for the progression and regression were the changes of the luminal narrowing of the coronary arterial segment by 20% or more, Results: Upon follow-up CAG, progression of the coronary arterial lesion was found in 55% of the patients, regression in 18% and no significant changes in 27%. Progression of the lesion was more frequently found in patients with multivessel disease and there was a tendency for new or prgressive lesion in the left anterior descending artery teritory than in any other coronary arteries. Among CAD risk factors, diabetes mellitus was more frequently associated with the progression of the coronary arterial lesion. Conclusion: The coronary arterial lesions in patients with angian pectoris are more frequently progressive rather than stationary or regressive, with a tendency for new or progressive lesion in the left anteior descending coroanry artery territory
온영근(Young Keun On),김상현(Sang Hyun Kim),김효수(Hyo Soo Kim),김철호(Cheol Ho Kim),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi),서정돈(Jung Don Seo),이영우(Young Woo 대한내과학회 1995 대한내과학회지 Vol.49 No.5
N/A Objectives: Different patterns of coronary atherosclerotic involvement between acute myocardial infarction and chronic stable angina have been suggested, however, little data are available in Korean patients. Methods: 22acute myocardial infarction patients (509years, 21males) as his first clinical manifestation and 33chronic stable angina patients(556years, 21males) with at least 2years' duration undertook coronary arteriography. Clinical coronary artery disease risk factors, indices of coronary atherosclerotic involvement such as number of diseased vessels, stenosis score, diffusiveness of the lesion and extent of collaterals were compared between two groups. Results: Compared to acute myocardial infarction group, chronic stable angina group showed more advanced coronary arterial involvement in terms of number of involved vessels(2.0±0.8 vs. 1.1±0.4, p<0.01), stenosis score(6.9±4.3 vs. 2.5±1.0, p<0.01) and diffusiveness(58% vs. 14%, p<0.01), However, prevalence of risk factors for the coronary artery disease were similar in two groups. Conclusion: More advanced coronary arterial involvement in patients with chronic stable angina, compared to that in patients with acute myocardial infarction, might suggest different pathogenetic mechanisms between two disease entities.
고콜레스테롤혈증 환자에서 내피의존성 혈관반응에 대한 스타틴과 비타민 C의 효과에 대한 연구
온영근(Young Keun On),성지동(Ji Dong Sung),채인호(In Ho Chae),김철호(Cheol Ho Kim),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi) 대한내과학회 2001 대한내과학회지 Vol.60 No.3
N/A Background : Hypercholesterolemia is firmly established as a risk factor for the development of atherosclerosis. However the exact mechanism of hypercholesterolemia-related damage to the arterial wall and its relation to the atherosclerotic process are not well known. The endothelium plays an important role for the regulation of vascular tone and the endothelial function is impaired in the presence of risk factors early in the process of atherosclerosis. Assessment of endothelial function appears to be a valuable tool for the diagnosing and therapeutic monitoring of coronary artery disease. Lipid lowering agents and anti-oxidants are known to improve endothelial dysfunction in hypercholesterolemic patients, respectively. The purpose of this study is to investigate whether vitamin C has additional benefit on endothelial function of statin-treated hypercholesterolemic patients. Methods : The endothelial function was estimated using venous occlusion plethysmography (VOP) in 9 hypercholesterolemic patients and 11 healthy volunteers. The strain guage was connected to plethysmograph to record the forearm volume change. A rapid cuff inflator was used to inflate the arm cuff to 40 mmHg instantaneuosly thus occluding venous return from the forearm. The measurement of forearm volume change was repeated for 7 times each stage. The patients in the hypercholesterolemic (HC) group were treated with the statin, then examined again. The change of the forearm blood flow (FBF) was measured with the acetylcholine infusion through brachial artery and also with intra-arterial vitamin C. Results : Endothelium-dependent vasodilatation was significantly impaired in the HC group compared to the control group (15.9±0.9 mL/min/100mL forearm tissue, vs 8.9±0.6 mL/min/100mL forearm tissue, mean±standard error of mean, p<0.05). The FBF increased significantly after statin therapy (8.9±0.6 vs 25.2±1.4 mL/min/100mg forearm tissue, p<0.05). Vitamin C infusion in these patients results in additional improvement in FBF (25.2±1.4 vs 31.9±2.1, p<0.05). Conclusion : Endothelium-dependent vasodilatation was significantly impaired in the HC group compared to the control group. The FBF increased significantly after statin therapy. Vitamin C seems to have additional benefit on the endothelial function of statin-treated hypercholesterolemic patients.(Korean J Med 60:206-214, 2001)
온영근 ( Young Keun On ) 대한내과학회 2011 대한내과학회지 Vol.81 No.4
Atrial fibrillation (AF) is the most common cardiac arrhythmia and its prevalence is expected to increase with increasing age. The risk of stroke also increases substantially with age. There are three strategies for the management of AF, that is, rate control, rhythm control and anticoagulation for prevention of embolism. Antiarrhythmic drugs are usually used for rhythm control as first line therapy but there are some limitations in using antiarrhythmic drugs for AF. Catheter ablation of AF should be considered as second line therapy. The primary indication for catheter ablation is the presence of symptomatic AF refractory or intolerant to antiarrhythmic medication. Warfarin is more effective effective in preventing stroke than aspirin and combination aspirin- clopidogrel. Despite its proven efficacy, warfarin is often not well tolerated by patients, has a very narrow therapeutic range, and has a high risk for bleeding complications. Echocardiography and autopsy studies showed that the left atrial appendage (LAA) was the source of thrombi in more than 90% of patients with non-valvular AF. Percutaneous catheter-based devices have been developed to close and thereby effectively exclude the LAA from the systemic circulation. (Korean J Med 2011;81:428-433)
허혈성 심질환에서 산화된 저밀도 지단백과 염증지표에 관한 연구
서존 ( Jon Suh ),변정득 ( Jeong Duk Byun ),온영근 ( Young Keun On ),현민수 ( Min Su Hyon ),김성구 ( Sung Koo Kim ),권영주 ( Young Joo Kwon ) 대한내과학회 2003 대한내과학회지 Vol.64 No.5
목적 : 허혈성 심질환의 발생기전에 산화된 저밀도 지단백 및 관상동맥의 염증이 관여하는 것으로 알려져 있다. 이에 산화된 저밀도 지단백과 염증지표들을 허혈성 심질환의 표현군에 따라 비교하였다. 방법 : 142명의 대상환자들을 대상으로 관상동맥 조영술을 실시하였고, 107명의 허혈성 심질환(안정형 협심증 58명, 불안정형 협심증 30명, 급성 심근경색증19명)환자와 관상동맥 조영술상 관상동맥 질환이 없는 35명을 정상 대조군으로 분류하였다. 각 임상적 분 Background : There is increasing evidence that inflammation is an important determinant of the development of atherosclerosis and that oxidation of low-density lipoprotein (LDL) obviously plays an important role in the pathogenesis of atherosclerosis. We
젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구
이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1
Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.
온영근,현민수,김성구,권영주 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Cushing's syndrome is produced by the hypersecretion of adrenal glucocorticoids and is characterized by moon face, central obesity, disappearance of diurnal variation of plasma cortisol and unsuppressibility of plasma cortisol by low dose dexamethasone. We report two cases of adrenal mass manifested with hypertension. One of the cases is adrenal macronodular hyperplasia and the other case is adrenal adenoma. Abdominal CT revealed well defined adrenal tumor in both cases. Laparoscopic adrenalectomy was performed and hypertension disappeared after operation.