The Comparison of Seasonal Ginsenoside Composition Contents in Korean Wild Simulated Ginseng (Panax ginseng) which were Cultivated in Different Areas and Various Ages

양병욱,이재범,이정민,조민수,변재경,김형천,고성권 한국생약학회 2019 Natural Product Sciences Vol.25 No.1

The ginsenoside content was compared with wild simulated ginseng (Panax ginseng) collected every season at 11 wild simulated ginseng plantations in Korea. As a result, the total saponin of 7 years old wild simulated ginseng showed the highest content of 4.5% in spring sampling wild simulated ginseng, 2.0% in summer sampling wild simulated ginseng, 1.2% in winter sampling wild simulated ginseng and 1.0% in autumn sampling wild simulated ginseng. And also, the total saponin of 10 years old wild simulated ginseng showed the highest content of 3.9% in spring sampling wild simulated ginseng, summer sampling wild simulated ginseng (1.8%), winter sampling wild simulated ginseng (1.6%) and autumn sampling wild simulated ginseng (0.6%). Therefore, the total saponin of spring sampling wild simulated ginseng was about 4.5 - 6.5 times higher than that of autumn sampling wild simulated ginseng regardless of cultivation period.

초단파 식초 융합 처리에 의한 섬오가피의 페놀성 성분 변화

양병욱,고성권,김성기 한국화장품미용학회 2019 한국화장품미용학회지 Vol.9 No.2

The purpose of this study was to develop a functional cosmetics new material of Acanthopanacis Caulis (Acanthopanax koreanum) extracts with the high concentration of eleutheroside E and syringaresinol known as the functional ingredient of Acanthopanacis Cortex. Vinegar (about 14% acidity) was added to the extract of Acanthopanax koreanum stem and processed under several microwave (departure frequency 2,450MHz, regular high frequency output 700W) process conditions. The content of eleutheroside E and total phenolic component was the highest at 3 minutes of microwave vinegar fusion process. In addition, syringaresinol showed the highest content at 20 minutes of microwave vinegar fusion process, and it is expected to utilize new materials of functional cosmetics using Acanthopanax koreanum stem. 섬오가피 줄기 엑스에 대한 초단파 식초 융합 처리에 의한 페놀성 성분 변화를 검토한 결과, 오가피의 주요한 생리활성 성분인 eleutheroside E와 총 페놀성 성분 함량은 초단파 식초 융합 3분 처리시 가장 높은 함량을 나타내었고, 미백 및 피부노화 방지에 효능이 있음이 밝혀진 syringaresinol은 초단파 식초 융합 20분 처리시 가장 높은 함량을 나타내었으며, 이를 이용한 섬오가피 기능성화장품 신소재 활용이 기대된다.

비인두 유두상 선암종의 비내시경적 치료 1예

양병욱,박민주,안병훈 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.6

Low-grade nasopharyngeal papillary adenocarcinoma is an unusual nasopharyngeal tumor. This malignant tumor originates in the epithelium and exhibits adenocarcinomatous differentiation and indolent behavior. Macroscopically, these tumors are pedunculated polypoid masses that arise on the roof of the nasopharynx. Microscopically, they are characterized by papillary and glandular epithelial proliferation. We report a case of a 25-year-old woman who presented with a papillary adenocarcinoma on the roof of nasopharynx; in describing the case, we have focused on the histological features and endoscopic management of the tumor. The tumor was completely excised via nasal endoscopic approach. Immunohistochemical analysis of the tumor was performed based on a differential diagnosis of metastatic papillary thyroid carcinoma. The testing involved thyroid transcription factor-1, thyroglobulin, and epithelial membrane antigen analysis. The patient remained disease-free for over 6 months after the surgical excision performed via nasal endoscopic approach.

수삼의 지역별 연근별 인삼 비사포닌 성분 함량 비교

양병욱,임병옥,고성권,Yang, Byung-Wook,Im, Byung-Ok,Ko, Sung-Kwon 대한약학회 2006 약학회지 Vol.50 No.4

This study was carried out to obtain the basic information for non-saponin contents that can be used to index fresh ginseng roots (Panax ginseng C. A. Meyer) cultivated in the Republic of Korea and China. Non-saponin components in fresh gingeng roots which were cultivated in various areas and ages in Korea were determined. Acidic polysaccharide, total polysaccharide, crude polyacetylene were quantitatively analyzed by using the method of spectrophotometric determination, while the total protein was analyzed by using Lowry method. The results show that there were no statistically significant differences for the average contents of four non-saponins among 4-years-old, 5-years-old, and 6-years-old fresh ginseng roots. Additionally, this study assessed the average contents of non-saponin components in 4-years-old fresh ginseng roots (Panax ginseng C. A. Meyer) which were cultivated in Korea and China. The result showed that the average contents of crude polyacetylene and acidic polysaccharide were statistically significant. Four-years-old fresh ginseng roots cultivated in Korea had the higher average contents of crude polyacetylene and acidic polysaccharide than those cultivated in China. However the average contents of total polysaccharide and total protein had no statistically significant difference.

세라믹 물질을 적용한 축열 연소기에 관한 실험 연구 ( Experimental Study on Regenerative Combustor using Ceramic Material )

양병욱,정경현,이신민,임인권 대한기계학회 1999 대한기계학회 춘추학술대회 Vol.- No.-

홍삼의 추출 시간 및 온도에 따른 Ginsenosides 함량 비교분석

양병욱,한성태,고성권 한국생약학회 2006 생약학회지 Vol.37 No.4

This study compared the contents of ginsenoside according to the extract conditions of red ginseng to provide basic information for developing functional food using red ginseng. According to the result, the content of crude saponin was highest in 72 hours of extraction at 82 o C (RG-823). The content of prosapogenin (ginsenoside Rh1, Rh2, Rg2, Rg3) was highest in 48 hours of extraction, and followed by 72 and 24 hours at 82 o C. And at 93 o C the prosapogenin contents were highest in the order of 48 hours, and next in 24 and 72 hours. In addition, ginsenoside Rb1, Rb2 Rc and Re were not detected in 72 hours of extraction at 93 o C (RG-933) presumedly due to hydrolysis, but ginsenoside Rd, Rf and Rg1 were detected as long as 72 hours of extraction. These results show that protopanaxatriol group is relatively more resistant to heat than protopanaxadiol group.

발효 오갈피나무 수피의 리그난 비당체 고농도 함유 조건 최적화

양병욱(Byung-Wook Yang),고성권(Sung-Kwon Ko) 한국화장품미용학회 2018 한국화장품미용학회지 Vol.8 No.2

The purpose of the study is to develop a new process to manufacture high content of lignan aglycon (syringaresinol) from Acanthopanacis Caulis Cortex (Acanthopanax sessiliflorus) extract. Saccharomyces cerevisiae liquid culture fermentation transformed glycoside component (eleutheroside E and E1) of Acanthopanacis Caulis Cortex into aglycon component (syringaresinol). The transformation process from lignin glycosides to lignan aglycon was monitored by HPLC to optimize the fermentation conditions. AS-48 (liquid cultured mixture by Saccharomyces cerevisiae for 48 hours at 28 ℃) had the highest content of syringaresinol (9.411%). However, other mixtures (AS-24, AS-72, AS-144, and AS-168) had less than 9.0% in the content of syringaresinol. However, unfermented Acanthopanacis Caulis Cortex (AS) did not contain syringaresinol.

두통, 좌측 안검 하수, 시력 저하를 주소로 내원한 Tolosa-Hunt Syndrome 1례

문명기,양병욱,홍석진,이경철 대한비과학회 2016 Journal of rhinology Vol.23 No.2

Cavernous sinus syndrome (CSS) is defined as the involvement of two or more of the third, fourth, fifth (V1, V2) or sixth cranial nerves or involvement of only one of them in combination with a neuroimaging-confirmed lesion in the cavernous sinus. Some cases of CSS are attributed to Tolosa-Hunt syndrome (THS), an idiopathic inflammatory disease of the cavernous sinus. THS is characterized by painful ophthalmoplegia due to granulomatous inflammation in the cavernous sinus. THS is a diagnosis of exclusion that requires a vigorous series of differential diagnoses, and corticosteroid therapy is known to dramatically resolve clinical findings of THS. We report a case of a patient with painful ophthalmoplegia associated with vision loss, which was suspected to be THS. This patient followed a relatively typical clinical course of THS on steroid pulse therapy. We emphasize the differential diagnosis of THS, its presentation, and treatment.

고려인삼의 Cytochrome P450 및 P-Glycoprotein 매개 약물상호작용에 미치는 영향

남기열,양병욱,신왕수,박종대 한국생약학회 2018 생약학회지 Vol.49 No.2

A drug interaction is a situation in which a substance affects the activity of a drug, synergistically or antagonistically, when both are administered together. It has been shown that orally taken ginsenosides are deglycosylated by intestinal bacteria to give ginsenosides metabolites, which has been considered to be genuine pharmacological constituents and to exhibit drug interactions. Animal experimental results demonstrated that ginsenoside metabolites play an important role in the inhibitory or inductive action of both CYPs (cytochrome p450) and P-gp (p-glycoprotein), thereby can be applied as metabolic modulator to drug interactions. Very few are known on the possibility of drug interaction if taken the recommended dose of ginseng, but it has been found to act as CYPs inductor and P-gp inhibitor in any clinical trial, suggesting the risk that side effects will occur. It has been recently reported that interactions might also exist between ginseng and drugs such as warfarin, phenelzine, imatinib and raltegravir. Moreover, medicinal plants are increasingly being taken in a manner more often associated with prescription medicines. Therefore, considering the extensive applications of ginseng for safety, the aim of this review is to present a comprehensive overview of ginseng and drug interactions based upon pharmacodynamic and pharmacokinetic evidences.

고려인삼(Panax ginseng)과 미국삼(Panax quinquefolium)의 승열작용에 대한 비교 고찰

남기열,양병욱,신왕수,박종대 한국생약학회 2018 생약학회지 Vol.49 No.3

It has been extensively known in the high temperature regions such as southern China and south east Asia that Korean ginseng(Panax ginseng) intake raises body heat, while American ginseng(Panax quinquefolium) lowers it, based upon oriental medicine. This is likely due to the misunderstanding of the conception that Korean ginseng shows a warm property, resulting in enhanced blood circulation and stimulation of metabolism. It’s further supported by the fact that current scientific studies have shown no notable side-effects. Moreover, it has been demonstrated in animal experimental test that Korean ginseng shows a complementary effect in a high temperature environment, together with scientific evidence of a preventive effect of ginseng saponin against cold conditions, suggesting it to exhibit an adaptogenic effect normalizing the body under abnormal body conditions. However, there is a shortage of studies published concerning comparative clinical and animal studies of Korean and American ginsengs, and also, on natives of high temperature countries. Therefore, a further placebo-controlled clinical study has to be considered to elucidate scientifically clinical evaluation of Korean and American ginsengs on the body heat. In this article, we summarize the scientific publications reporting the clinical comparative study of Korean and American ginsengs on body heat response.