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배양한 사람 사구체 내피세포의 Cytokine자극에 따른 접착 분자 및 HLA-DR 발현의 연구
박수길(Su Kil Park),양원석(Won Seok Yang),안한종(Han Jong Ahn),김청수(Choung Soo Kim),이종수(Jong Soo Lee),이재담(Jae Dam Lee) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.2
N/A Background: Glomerular endothelial cells should participate in the process of glomerular disease by expressions of HLA antigens and adhesion molecules. However, few have been known about the regulation of the expression of these molecules in human glomerular endothelial cells(HGEC). The aim of this study was to evaluate the expressions of VCAM-1, ICAM-1 and HLA-DR to see if there are any cytokine-dependent or time-dependent differences. Methods: HGEC were isolated and cultured from the normal portion of the kidneys removed due to renal cell carcinoma, which was confirmed by factor VIII and fluorescent-labeled acetylated LDL. The effects of cytokine on the cell surface expression of VCAM-1, ICAM-1 and HLA-DR were measured by ELISA. Results : ICAM-1 was increased by IL-1 α, TNF- β and IFN- γ. VCAM-1 was increased by IL-1 α and TNF- β, not by IFN- γ. IFN- γ only increased expression of HLA-DR. Basal expression of ICAM-1 was higher than VCAM-1 and HLA-DR. The time course of expression was different according to adhesion molecule. Conclusions : These data showed that the expression of adhesion molecules and HLA-DR in HGEC were regulated differentially by inflammatory and immune-regulatory cytokines.
김우건(Woo Kun Kim),박영환(Young Hwan Park),이규형(Kyoo Hyung Lee),이정신(Jung Shin Lee),박태한(Tae Han Park),안한종(Han Jong Ahn),홍준혁(Jun Hyuk Hong),김청수(Choung Soo Kim) 대한내과학회 1999 대한내과학회지 Vol.57 No.3
N/A Transitional cell carcinoma(TCC) of the bladder is confined to mucosa or submucosa on initial presentation. However, high grade superficial tumors tend to recur and progress to muscle invasive or metastatic diseases. Regardless of radical cystectomy in invasive bladder cancer, a poor prognosis was noted due to local recurrence and distant metastasis in recent studies. In this study, the clinical and pathological factors affecting survival of patients with muscle invasive bladder cancer were analyzed. Methods : A total of 105 patients with histopathologically verified muscle invasive bladder cancer who were admitted to Asan Medical Center between August 1989 and August 1998 were reviewed retrospectively. The clinical manifestations, laboratory findings, and histopathological findings at initial diagnosis were evaluated. Overall survival, disease free survival, and disease specific survival according to many prognostic factors were also analyzed. Results : The factors affecting overall survival of muscle invasive bladder cancer were age, sex, TNM stage, performance status, tumor size, invasion of deep bladder muscle, tumor grade, lymphovascular invasion, and complete resection of tumors. In patients with completely resected bladder cancer by radical cystectomy, tumor size, deep bladder muscle invasion, stage, and lymph node involvement were significant prognostic factors. In patients who had either incomplete resection of bladder cancer or in whom no operation was performed, the survival rate was lower in cases with lymph node involvement or hemoglobin level of less than 10 g/dl. Conclusion : After radical cystectomy, the recurrence rate appeared to be higher in solid tumors with deep bladder muscle invasion and lymphovascular invasion on cystoscopic findings. Overall survival was higher in patients with lower tumor stage, no lymph node involvement, and completely resected bladder cancer. Age and sex had no significant correlation with overall survival. No apparent survival advantage was noted in those patients who received post-operative chemotherapy. However, prospective randomized controlled studies are necessary to evaluate the benefit of adjuvant chemotherapy in muscle invasive bladder cancer. (Korean J Med 57:333-347, 1999)
홍준혁,김현주,김청수,안한종,안태영,김광훈 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1
Malacoplakia is an uncommon granulomatous inflammatory disorder that usually affects the urinary bladder and rarely affects the kidney and the prostate. We report two cases of malacoplakia in genitourinary tract, involving the kindey and prostate, respectively, which were treated with nephrectomy and transurethral resection and antibiotics.