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박용규,진선아,안규택,Jun Hyung Kim,박재형,Jae-Hwan Lee,정진옥,성인환,최시완 대한응급의학회 2013 大韓應急醫學會誌 Vol.24 No.5
Extracorporeal life support (ECLS) has been used as an adjunctive therapy to conventional cardiopulmonary resuscitation (CPR) in patients with in-hospital cardiac arrest. However, whether to apply ECLS after prolonged CPR (>30 minutes) is a difficult decision. We present the case of a 49-year-old woman with in-hospital cardiac arrest caused by refractory ventricular fibrillation and rescued by extracorporeal membrane oxygenation (ECMO) during prolonged CPR. The ECMO was implemented 90 minutes after the initiation of CPR and the total duration of CPR was about 5hours. The patient fully recovered and was discharged without neurological complications.
The Curves Exercise Suppresses Endotoxemia in Korean Women with Obesity
진선아,김선경,서희정,김미주,안규택,김준형,박재형,이재환,최시완,정진옥 대한의학회 2017 Journal of Korean medical science Vol.32 No.2
Obesity and metabolic syndrome is a worldwide pandemic and associated with high cardiovascular risk. Metabolic endotoxemia (ME) is thought to be an underlying molecular mechanism. It triggers toll-like receptor 4-mediated inflammatory adipokines and causes a chronic low grade inflammatory status, which results in cardiovascular risk increase. Exercise is the best nonpharmacological treatment to improve prognosis. In this study, we examined the circulating endotoxin level in Korean obese women and investigated effects of exercise on it. Women over body mass index (BMI) 25 kg/m2 participated in a resistance training exercise, Curves. At baseline and after 12 weeks exercise, tests including blood samples were taken. In Korean obese women, the fasting endotoxin was 1.45 ± 0.11 EU/mL. Ingestion of a high calorie meal led to a peak level after 2 hours (postprandial 2 hours [PP2]) and a significant rise over the 4 hours (postprandial 4 hours [PP4]) in it (1.78 ± 0.15 and 1.75 ± 0.14 EU/mL for PP2 and PP4, P < 0.05 vs. fasting). After exercise, BMI and hip circumference were reduced significantly. The total cholesterol (TC) at fasting, PP2 and PP4 were decreased significantly. All levels of circulating endotoxin at fasting, PP2 and PP4 showed reduction. But, the peak change was only significant (baseline vs. 12 weeks for PP2; 1.78 ± 0.15 vs. 1.48 ± 0.06 EU/mL, P < 0.05). We report the circulating endotoxin level in Korean obese women for the first time. Also, we establish that energy intake leads to endotoxemia and exercise suppresses the peak endotoxemia after meal. It suggests an impact for a better prognosis in obese women who follow regular exercise.