http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The Prolyl Hydroxylase Domain 2 (PHD2) Deficiency Enhances Maximal Exercise Capacity
신준철 한국운동생리학회 2024 운동과학 Vol.33 No.1
PURPOSE: Hypoxic training is beneficial for improving endurance performance. Hypoxia-inducible factor (HIF) is a key transcription factor that regulates the hypoxic-responsive pathway. Stabilization of HIF by inactivating prolyl hydroxylase domain protein 2 (PHD2) under low oxygen tension, triggers angiogenesis, erythropoiesis, and glycolysis. Glycolytic capacity is essential to perform anaerobic exercise. This study aims to verify whether the upregulation of glycolytic metabolism under the hypoxic-responsive pathway enhances exercise capacity. METHODS: We employed tamoxifen-inducible conditional PHD2 knock-out (KO) mice that exhibited stabilized HIF-alpha. To evaluate anaerobic exercise capacity, a rodent treadmill exercise test was performed. RNA sequencing (RNA-seq) analysis was conducted using C2C12 myoblasts after PHD2 siRNA transfection. RESULTS: PHD2KO mice exhibited increased red blood cell counts, hemoglobin, and hematocrit values, along with enhanced maximal exercise performance compared to littermate wild-type (WT) mice. PHD2 deficiency promoted maximal exercise capacity and resulted in lower blood lactate levels. RNAseq analysis revealed that PHD2-deficient myoblasts increased the expression of genes related to glycolysis, gluconeogenesis, and muscle contraction. CONCLUSIONS: These findings suggest that PHD2 deficiency-induced activation of the hypoxic-responsive pathway enhances maximal exercise capacity.
CIGS 박막 태양전지 CBD-CdS buffer 층에 관한 연구
신준철,조성희,이상협,송찬문,임동건,양계준 한국교통대학교 2015 한국교통대학교 논문집 Vol.50 No.-
Cadmium sulfide (CdS), belonging to a II–VI compound semiconductor, is widely used for solar cells, optical detectors, and optoelectronic devices. It is a suitable window material for many heterojunction solar cells. chemical bath deposition (CBD) process conditions for depositing CdS buffer layers was studied for high efficiencies of CIGS thin film solar cell. They were analyzed in terms of structural, optical and electrical properties of CdS films according to the [S2-]/[Cd2+] ratio. In the case of Cd concentration higher than S concectration, CdS thin films were formed mainly by cluster-by-cluster formation due to the homogeneous reaction between Cd and S in the solution. Therefore the grain size increased and the transmittance decreased. As the reaction temperatures were increased, the deposition rate of CdS films prepared by CBD was increased and the grain size was large due to increasing reaction rate in solution, also optical transmittance of the films in visible lights was increased on rising reaction temperatures.
1-Ethyl-7-methyl-1, 8-naphthyridin-4-one-3-carboxylic acid의 결정구조에 관한 연구
조소라,김문집,신준철 순천향대학교 기초과학연구소 1995 순천향자연과학연구 논문집 Vol.1 No.1
The crystal structure of 1-ethyl-7-methyl-1, 8-naphthyridin-4-one-3-carboxylic acid has been determined from single crystal x-ray diffraction study ; ??, monoclinic, P2₁/c, a=8.910(2)Å, b=13.145(3)Å, c=9.730(3)Å, β=100.06(2)˚, V=1080.6ų, T=293K, Z=4, Cukα(λ=1.5418Å). The molecular structure was solved by direct method and refined by full-matrix least squares to a final R=0.005 for 1555 unique observed [??] reflections and 166 parameters. The conformation of the molecule is stabilized by an intramolecular O(17)-H(17)…O(14) hydrogen bond [2.525(2)Å, 144.3(10)˚].