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이규섭,김원희,신반철,김경리,강기주,박상원,조혜원 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.7
본 저자들은 25세 미산부에서 발생한 다발성 전이를 동반한 거대난소 내배엽동종양을 경험 하여 수술후 6차이 걸처 BEP 복합화학요법을 시행한 후 지금까지 4개월째 추적관찰 중인 데, 현재 재발의 증거가 관찰되지 않고있어 이에 간단한 문헌고찰과 함께 보고하는 바이다. The endodermal sinus tumor(EST) is the second most frequent malignant germ cell tumor of the ovary, primarily affecting children and young adults. Earlier reports described that EST had the extremely poor prognosis and almost uniformly fatal outcome, but recently with adequate surgery, combination chemotherapy using cisplatin, vinblastine, bleomycin, actinomycin D, cyclophosphamide and meticulous monitoring with serum alpha-fetoprotein(AFP) titers determined by radioimmunoassay(RIA). its survival rates is markedly improved. The authors experienced a caes of huge endodermal sinus tumor of the ovary in 25-year old nulligravida complaining abdominal pain and abdominal distension that had begun one month earlier. The authors report this case with a brief review of the literatures.
이종학,김종화,김규현,신반철,이순애,고경혁,최원준,강태길 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.11
난소에서 발생하는 섬유육종은 주로 폐경기 이후에 발생하는 것으로 알려진 매우 드물고 치 명적인 종양이다. 본 저자들은 본원 산부인과에서 난소에서 일차적으로 기인한 거대 난소 섬유육종 1례를 경험하였기에 문헌적 고찰과 함께 보고하는 바이다. Fibromatous tumors of the ovary are considered to originate from specialized ovarian stromal cells and account for approximately 4% of all ovarian neoplasms. There are divided into two subtypes : one is cellular fibromas with one to three mitotic figures per ten high power field(HPF), which were mostly benign and frequent, the other is fibrosarcoma with higher mitotic counts, which were always malignant and very rare. We have met a case of large ovarian fibrosarcoma which have six mitotic figures per ten high power field. So we report this case with the brief review of literatures.
이종학,김종화,백원영,신반철,백상호,이순애,김명옥,이봉희,최완성 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.12
사람 태반에서 GnRH가 존재하는가 또한 자체합성되는가를 형태학적으로 확인하고 나아가서 GnRH 또는 GnRH mRNA가 태반내의 어느 부위에 주로 위치하며 이들의 분포가 임신시기에 따라 어떠한 변화가 있는지를 조사하기 위하여 임신중의 각 시기별 태반조직을 실험대상으로 GnRH에 대한 면역조직화학과 GnRH mRNA에 대한 in situ hybridization을 시행한 결과 다음과 같은 소견을 얻었다. 1. 사람 태반 조직내의 cytotrophoblast, syncytiotrophoblast, villous stroma 세포에서 GnRH peptide와 GnRH mRNA가 동정되었다. 2. GnRH peptide와 GnRH mRNA의 양성반응은 임신 전기간에 걸쳐 cytotrophoblast와 syncytiotro phoblast에서 거의 비슷하게 나타났으며 villous stroma에서는 임신이 진행함에 따라 점차적으로 강하게 나타났다. 이상의 소견으로 볼때 사람의 태반내에 국소적으로 GnRH 또는 GnRH 유사물질이 생성되어 존재하며 이들은 임신의 유지에 필요한 호르몬의 합성 및 분비에 조절인자로 작용할 가능성이 있으며 부분비(paracrine) 또는 자가분비(autocrine)역할을 할 것으로 사료된다. Localization of the GnRH and its mRNA was performed in the human placentas by immunohistochemistry and in situ hybridization techniques. Human placentas in first, second, and third trimester of normal pregnancy were obtained. These placentas were fixed with 4% paraformaldehyde and embedded in OCT compund, and sectioned by cryostat. For immunohistochemical study, avidin-biotin peroxidase complex(ABC) method and immunofluorescence method were employed and for in situ hybridization histochemistry, digoxigenin-dCTP labeled cDNA and ^35S labeled RNA probes were used and followed by autoradiography. GnRH and its mRNA were localized in the cytotrophoblast, syncytiotrophoblast, and villous stromal cells of the human placental villi. The distribution and intensity in GnRH immunohistochemistry were showed to be similar to those in GnRH mRNA in situ hybridization histochemistry. GnRH immunoreactivity and its mRNA signals were identified nearly constantly in both the cytotrophoblast and syncytiotrophoblast cells throughout gestation. However, those in the villous stromal cells were shown to be gradually increased with placental development, although not in the cells of early placenta. These results suggest that the local GnRH or GnRH-like substance may be synthesized in the human placental villi and may, thus, represent a local paracrine or autocrine role in endocrine control mechanism within the placenta.
GnRH - receptor mRNA의 임신 시기별 발현 양상
백원영(Won Young Paik),신반철(Ban Cheol Shin),신정규(Jeong Gyu Shin),최원준(Won Jun Choi),이순애(Soon Ae Lee),이종학(Jong Hak Lee),최완성(Wan Sung Choi),김명옥(Myeong Ok Kim) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12
N/A Objective: Our previous study demonstrated that the placental GnRH and GnRH mRNA did not parallel the time course of hCG secretion, though it is thought to be one of the potential paracrine regulators of hCG secretion from the trophoblasts. The present study was designed to examine the potential variation in GnRH-receptor mRNA expression in the placenta, which may account for the GnRH-mediated action of hCG secretion during pregnancy. Methods: Human placentas in firt, second, and third trimester of normal pregnancy were obtained. These placentas were fixed with 4% paraformaldehyde and embedded in OCT compound, and sectioned by cryostat. For in situ hybridization, S labeled RNA probes were used and followed by autoradiography. Results: The GnRH-receptor mRNA signals were present in both cytotrophoblast and syncytiotrophoblast cell layers. Signal intensities varied with gestational ages and were abundant at 6-7 weeks, peaked at 9-12weeks, declined at 14 and 24 weeks, and were barely detectable at term. The present study demonstrates that GnRH-receptor mRNA exhibits changes paralleling the time course of hCG secretion during pregnancy Conclusion: These data provide mechanistic understanding that the paracrine/autocrine regulation of hCG secretion by placental GnRH is mediated through an increase followed by a decline in GnRH-receptor mRNA expression from the first trimester to term placenta.
심장기형과 폐기형을 동반한 Meckel-Gruber Syndrome 1 례
이종학,김종화,백원영,김규현,신반철,한성천,최원준,김진성 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.9
저자들은 임신 36주의 임산부를 산전초음파로 태아기형을 진단하고 임신 종결후 신생하 부 검을 시행한 결과 비교적 빈도가 낮은 발병률을 보이는 심장기형 및 폐기형을 동반한 Meckel-Gruber Syndrome 1례를 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. The major features of Meckel-Gruber Syndrome are occipital encephalocele, postaxial polytactyly, and polycystic kidneys. This syndrome is lethal and its cause is still unknown due to rarity. At present, autosomal recessive is thoughth to be as one of the causes. The importance of recognizing this sysdrome is the high risk of recurrence (one in four)in future pregnancies. A case of Meckel-Gruber Syndrome combined cardiac anomaly and pulmonary anomaly of very lower incidence is presented with a brief literature review and autopsy.