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김상규,성상민 한국독립영화협회 2019 한국독립영화협회 기타간행물 Vol.2018 No.-

갑상선 휘틀세포암(Hurthle Cell Carcinoma)의 임상적 특징 및 예후인자

이잔디(Jandee Lee),이승환(Seong Hwan Lee),최수윤(Su-Yun Choi),남기현(Kee-Hyun Nam),정웅윤(Woong Youn Chung),소의영(Eui-Young Soh),박정수(Cheong Soo Park) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.2

Purpose: Hurthle cell carcinoma (HCC) of the thyroid gland is a rare disease that represents 3% of all thyroid carcinomas. HCC has been known as a more aggressive disease than the usual differentiated thyroid carcinoma. However, the biologic behavior and optimal treatment have come under considerable debate in recent years. This study was performed to evaluate the clinicopathologic features and treatment outcome of HCC. Methods: From April 1986 to August 2006, 18 patients with HCC and 216 patients with pure follicular carcinoma (PFC) underwent thyroidectomy at our institutions with a mean follow-up of 114 (range: 6∼253) months. The clinicopathologic characteristics and treatment outcome of each group were compared, and the prognostic factors for disease-free survival were analyzed. Results: There were 14 women and 4 men with a mean age of 50 (range: 26∼76) years. Compared with PFC patients, all of clinicopathologic features of HCC patients were different (gender, age, tumor size, multifocality, angioinvaion, invasion to adjacent structures, the subclassification and initial distant metastasis), but the high incidence of bilaterality was similar to the PFC patients (P<0.0001). The causespecific survival (CSS) rates at 10 years were 83.4% in the HCC patients and 89.3% in the PFC patients (P=0.702). Older age (greater than 45) (P=0.0125) and initial distant metastasis (P<0.0001) in the HCC patients, and an older age (P<0.0001), male gender (P=0.0039), angioinvasion (P= 0.0122), invasion to adjacent structures (P<0.0001), a widely invasive type (P=0.004) and initial distant metastasis (P<0.0001) in the PCC patients were independent prognostic factors for survival. Conclusion: After accounting for important biologic behaviors, patients with HCC had similar clinicopathologic characteristics and prognosis compared with that of the PFC patients. Therefore, HCC should be managed using the same treatment strategy as PFC.

황달과 담즙외루술이 백서의 간재생에 미치는 영향

유석진,왕희정,소의영,김주형,김욱환,김명욱 아주대학교 1996 아주의학 Vol.1 No.2

We underlook this study to evaluate the effects of obstructive jaundice and external biliary drainage on regenerating capacity after partial hepatectomy. Male Sprague-Dawley rats aged 10 to 12 weeks were used. Each animal was lightly anesthetized with ether. Using cut-down technique, a polyethylene tube of an outer diameter of 0.965mm was inserted into the proximal common, bile duct and fixed in place. Then two groups of rats were made; GroupⅠ with only simple external drainage group and Group Ⅱ with jaundice. In group Ⅱ, rats were jaunduced by ligating the external end of the tube from extrahepatic bile ducts for 5 days and then the jaundice was reliered. Seventy percent hepatectomy was carried out using the method of Higgins-Anderson at 1, 3, and 5 days after biliary decompression in Group I, and at 0, 1, 3 and 5 days after biliary decompression in Group Ⅱ. Both resected livers from the partial hepatectomy and the remnant livers regenerated for 24 hours were stored at - 70℃. From the collected liver specimens, the degree of regeneration was measured by the proliferative index using flow cytometry. The results was the following; 1. The regeneration capacity of the hepatectomized liver in Group I was decreased in proportion to the time elapsed. 2. An obstructive jaundice itself markedly increased the regenerating capacity of the liver. 3. The regenerating capacity of hepatectomized liver was not inhibited by the obstructive jaundice. 4. The external biliary drainage suppressed regenerating capacity of the liver at the early stage of obstructive jaundice. In conclusion, the regenerating capacity of partially hepatectomized liver was not inhibited by early obstructive jaundice. And was significantly suppressed by external biliary drainage. It is suggested that the loss of bile is a serious negative effect on liver cell proliferation.

갑상선절제술 환자에서 Ondansetron, Droperidol 혹은 두 약제의 혼합 투여가 술후 오심, 구토에 미치는 영향

이숙영,김진수,이영석,길현주,최민협,한상건,소의영 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.36 No.5

Background : Thyroidectomy has been a surgical procedure associated with a high incidence of postoperative nausea and vomiting (PONV), and conventional antiemetics cannot prevent PONV effectively. In this study, we compared the efficacy and safety of ondansetron 70μg/kg, droperidol 10μg/kg and combination of both drugs to placebo in the prevention of PONV. Methods : Seventy-six patients undergoing thyroidectomy were randomized to receive placebo (Group I, n=20), ondansetron 70μg/kg (Group II, n=19), droperidol 10μg/kg (Group III, n=18) and combination of both drugs (Group IV, n=19). The effects of these regimens on the incidence and severity of PONV and adverse events were analyzed for the 0 to 1 hour and 1 to 24 hours postoperative periods. Results : In the 0 to 1 hour postoperative periods, the incidence of symptom free (no nausea and retching or vomiting) paients were 60% for placebo, 68.4% for ondansetron (p>0.05 versus placebo group), 88.9% for droperidol (p<0.05 versus placebo group), and 94.7% foination of both drugs (p<0.05 versus placebo and ondansetron group). In the 1 to 24 hours postoperative period, the incidence of symptom free patients were 35% for placebo, 52.6% for ondansetron (p>0.05 versus placebo group), 77.8% for droperidol (p<0.05 versus placebo group), and 78.9% for combination of both drugs (p<0.05 versus placebo group). Overall, during the first 24 hours postoperatively, the incidence of symptom free patients were 30% for placebo, 42.1% for ondansetron (p>0.05 versus placebo group), 77.8% for droperidol (p<0.05 versus placebo and ondansetron group), and 73.7% for combination of both drugs (p<0.05 versus placebo and ondansetron group). Also, there were no significant differences between the droperidol and droperidol plus ondansetron group. Among the side effects associated with antiemetics, headache and dizziness incidence was higher. Conclusions : Droperidol and combination of ondansetron plus droperidol was superior to placebo, and ondansetron for prevention of PONV during tt 24 hours postoperative period. (Korean J Anesthesiol 1999; 36: 834∼840)

분화된 갑상선암 수술 후 초치료에 있어서 Tc-99m Pertechnetate을 이용한 진단 스캔의 유용성 : Iodine-131 스캔과의 비교 A Comparative Study with Iodine-131

김경래,윤석남,김수지,박찬희,황경훈,소의영 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.4

Purpose: A prospective comparison was made between imaging with Tc-99m pertechnetate (Tc-99m) and Ioine-131 (I-131) for the detection of residual and metastatic tissue after total thyroidectomy in patients with well-differentiated thyroid carcinoma. Materials and Methods: Initially our patients had imaging with Tc-99m, followed by I-131 within 3 days. The study included 21 patients who had ablation with high dose of I-131 ranging from 100 mCi to 150 mCi. Planar and pinhole images were acquired for both Tc-99m and I-131. Diagnostic images of Tc-99m and I-131 were compared with post-therapy images. Degree of uptake on Tc-99m and I-131 images was scored by four point scale and compared. Results: The results of the Tc-99m study were: 16 of 19 studies (84%) were positive on simple planar images, but 19 of 20 studies (95%) were positive on pinhole images. Conventional I-131 diagnostic imaging on the other hand showed that all studies (100%) were positive on both planar and pinhole images. There was a significant difference in degree of uptake between Tc-99m and I-131 planar images (p<0.05). Only one case of Tc-99m scintigraphy was negative on both planar and pinhole studies (false negative). There was no distant metastasis on the therapeutic I-131 images. Conclusion: Tc-99m scan using pinhole in certain clinical situations is an alternative to the I-131 scan in detecting thyroid or lymph node metastasis prior to the first ablative treatment after thyroidectomy for well-differentiated thyroid carcinoma. (Korean J Nucl Med 2000;34:285-93)